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The map label for this gene is flrC [H]

Identifier: 147673544

GI number: 147673544

Start: 1841800

End: 1843239

Strand: Reverse

Name: flrC [H]

Synonym: VC0395_A1719

Alternate gene names: 147673544

Gene position: 1843239-1841800 (Counterclockwise)

Preceding gene: 147675650

Following gene: 147675704

Centisome position: 60.95

GC content: 50.28

Gene sequence:

>1440_bases
GTGAAGATGGCTCAAAGCAAAGTCTTAATCGTAGAAGATGACGAAGGTCTTCGCGAAGCGTTGATCGACACCTTAGCTTT
AGCGGGTTATGAGTGGCTGGAAGCCGATTGTGCAGAAGATGCCCTGCTCAAACTCAAATCACACAGTGTCGATATTGTGG
TGTCTGATGTGCAAATGGCAGGCATGGGGGGACTCGCTCTGCTGCGCAGTATCAAACAGCACTGGCCGAATTTACCCGTA
CTGCTGATGACCGCTTACGCCAATATTCAAGATGCCGTATCTGCCATGAAAGATGGCGCGATTGACTACATGGCTAAGCC
TTTTGCACCAGAAGTGCTGCTGAATATGGTCAGCCGTTACGCACCAGTAAAGTCAGATGACAACGGCGATGCTGTGGTCG
CGGATACGAAAAGCCTCAAGCTGCTTGCCTTAGCCGATAAAGTGGCGAAGACCGATGCCAACGTGATGATTTTGGGGCCA
AGCGGCTCAGGTAAAGAAGTGATGTCACGTTACATCCACAATGCCTCTCCTCGTAAAGAGGGGCCATTTATTGCGATTAA
CTGCGCGGCAATTCCTGACAACATGTTAGAAGCAACCCTATTCGGTTATGAAAAAGGCGCGTTTACCGGAGCCGTACAAG
CGTGTCCCGGTAAGTTTGAACAAGCCCAAGGTGGCACCATTTTGCTCGATGAGATCAGCGAAATGGATCTGAATCTGCAA
GCGAAACTGCTGCGGGTACTGCAAGAGCGTGAAGTAGAGCGCTTAGGGAGCCGCAAAAGCATCAAGCTCGATGTTCGCGT
GCTCGCAACCAGTAACCGTGACTTGAAACAGTATGTGCAAGCCGGACATTTCCGTGAAGACTTGTACTACCGTTTGAATG
TGTTCCCATTAACCTGGCCAGCCTTATGTGAGCGTAAAGACGATATTGAGCCGCTGGCTAACCATCTGATTGAGCGTCAC
TGCAAAAAGTTAGGTTTACCTGTACCAAGCATTGCGCCTAACGCCATTACTAAACTGCTGAATTACCCATGGCCGGGTAA
TGTGCGTGAGCTGGATAACGTCGTGCAGCGTGCTTTGATCTTAAGTGAAAACGGCCATATTCAAAGTGAGCACATTTTGC
TGGAAGGGGTTGATTGGCATGATGCCAGCAGCTTACAGCAAGCGGTGGCGGGAGAGTCGATGGCTGCGCCGCAGATCAAA
CCTGTTGCAGAGCCCGAAGTGTTTAAGCCCTTAGTGCAAGGTGGTGGGCAAAACAGTAGTTCGCAAAGTTCAGGTTTGGG
TGGTGAGCTGCGCGACCAAGAGTTTGCGATTATTCTTGATACGTTGGCCGAATGTCAGGGACGCCGTAAAGAGATGGCGG
AGAAGCTAGGTATTAGCCCACGCACTTTACGTTACAAACTCGCCAAAATGCGTGATGCAGGGATTGATATCCCCGGTTGA

Upstream 100 bases:

>100_bases
GGCGATTGGAACTGATATCCAAGGAGGGAGAGGGCGCTTGTTTTACCATGTGCATTCCCCTTGAACGTCAGGCAGATAGC
TCAAACTCAGAGACTGGAGA

Downstream 100 bases:

>100_bases
GGGCATGGCATACAAATTGCTCTTTAGAGTTAGGAATGGAATTTTTGAGTCAAACAATTGGCATCAGAGGTAGCAATGAG
ACTTGACGGTTTAAATAACG

Product: flagellar regulatory protein C

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MKMAQSKVLIVEDDEGLREALIDTLALAGYEWLEADCAEDALLKLKSHSVDIVVSDVQMAGMGGLALLRSIKQHWPNLPV
LLMTAYANIQDAVSAMKDGAIDYMAKPFAPEVLLNMVSRYAPVKSDDNGDAVVADTKSLKLLALADKVAKTDANVMILGP
SGSGKEVMSRYIHNASPRKEGPFIAINCAAIPDNMLEATLFGYEKGAFTGAVQACPGKFEQAQGGTILLDEISEMDLNLQ
AKLLRVLQEREVERLGSRKSIKLDVRVLATSNRDLKQYVQAGHFREDLYYRLNVFPLTWPALCERKDDIEPLANHLIERH
CKKLGLPVPSIAPNAITKLLNYPWPGNVRELDNVVQRALILSENGHIQSEHILLEGVDWHDASSLQQAVAGESMAAPQIK
PVAEPEVFKPLVQGGGQNSSSQSSGLGGELRDQEFAIILDTLAECQGRRKEMAEKLGISPRTLRYKLAKMRDAGIDIPG

Sequences:

>Translated_479_residues
MKMAQSKVLIVEDDEGLREALIDTLALAGYEWLEADCAEDALLKLKSHSVDIVVSDVQMAGMGGLALLRSIKQHWPNLPV
LLMTAYANIQDAVSAMKDGAIDYMAKPFAPEVLLNMVSRYAPVKSDDNGDAVVADTKSLKLLALADKVAKTDANVMILGP
SGSGKEVMSRYIHNASPRKEGPFIAINCAAIPDNMLEATLFGYEKGAFTGAVQACPGKFEQAQGGTILLDEISEMDLNLQ
AKLLRVLQEREVERLGSRKSIKLDVRVLATSNRDLKQYVQAGHFREDLYYRLNVFPLTWPALCERKDDIEPLANHLIERH
CKKLGLPVPSIAPNAITKLLNYPWPGNVRELDNVVQRALILSENGHIQSEHILLEGVDWHDASSLQQAVAGESMAAPQIK
PVAEPEVFKPLVQGGGQNSSSQSSGLGGELRDQEFAIILDTLAECQGRRKEMAEKLGISPRTLRYKLAKMRDAGIDIPG
>Mature_479_residues
MKMAQSKVLIVEDDEGLREALIDTLALAGYEWLEADCAEDALLKLKSHSVDIVVSDVQMAGMGGLALLRSIKQHWPNLPV
LLMTAYANIQDAVSAMKDGAIDYMAKPFAPEVLLNMVSRYAPVKSDDNGDAVVADTKSLKLLALADKVAKTDANVMILGP
SGSGKEVMSRYIHNASPRKEGPFIAINCAAIPDNMLEATLFGYEKGAFTGAVQACPGKFEQAQGGTILLDEISEMDLNLQ
AKLLRVLQEREVERLGSRKSIKLDVRVLATSNRDLKQYVQAGHFREDLYYRLNVFPLTWPALCERKDDIEPLANHLIERH
CKKLGLPVPSIAPNAITKLLNYPWPGNVRELDNVVQRALILSENGHIQSEHILLEGVDWHDASSLQQAVAGESMAAPQIK
PVAEPEVFKPLVQGGGQNSSSQSSGLGGELRDQEFAIILDTLAECQGRRKEMAEKLGISPRTLRYKLAKMRDAGIDIPG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=489, Percent_Identity=38.241308793456, Blast_Score=320, Evalue=2e-88,
Organism=Escherichia coli, GI1790437, Length=472, Percent_Identity=37.2881355932203, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1788905, Length=404, Percent_Identity=40.5940594059406, Blast_Score=292, Evalue=4e-80,
Organism=Escherichia coli, GI1790299, Length=483, Percent_Identity=34.7826086956522, Blast_Score=284, Evalue=7e-78,
Organism=Escherichia coli, GI87082117, Length=234, Percent_Identity=50.4273504273504, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1789087, Length=228, Percent_Identity=49.1228070175439, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1789233, Length=218, Percent_Identity=47.7064220183486, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI87082152, Length=226, Percent_Identity=48.2300884955752, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=41.8103448275862, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1787583, Length=261, Percent_Identity=39.463601532567, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786524, Length=228, Percent_Identity=44.2982456140351, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789828, Length=237, Percent_Identity=36.7088607594937, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081858, Length=245, Percent_Identity=32.2448979591837, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1787375, Length=105, Percent_Identity=36.1904761904762, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786911, Length=104, Percent_Identity=30.7692307692308, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786599, Length=110, Percent_Identity=29.0909090909091, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52439; Mature: 52439

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMAQSKVLIVEDDEGLREALIDTLALAGYEWLEADCAEDALLKLKSHSVDIVVSDVQMA
CCCCCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHC
GMGGLALLRSIKQHWPNLPVLLMTAYANIQDAVSAMKDGAIDYMAKPFAPEVLLNMVSRY
CCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHH
APVKSDDNGDAVVADTKSLKLLALADKVAKTDANVMILGPSGSGKEVMSRYIHNASPRKE
CCCCCCCCCCEEEECCCCEEEHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCCC
GPFIAINCAAIPDNMLEATLFGYEKGAFTGAVQACPGKFEQAQGGTILLDEISEMDLNLQ
CCEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCHHCCCCEEEEECHHHCCCCHH
AKLLRVLQEREVERLGSRKSIKLDVRVLATSNRDLKQYVQAGHFREDLYYRLNVFPLTWP
HHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHCCCHHCCEEEEEEEECCCH
ALCERKDDIEPLANHLIERHCKKLGLPVPSIAPNAITKLLNYPWPGNVRELDNVVQRALI
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LSENGHIQSEHILLEGVDWHDASSLQQAVAGESMAAPQIKPVAEPEVFKPLVQGGGQNSS
HCCCCCEECCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
SQSSGLGGELRDQEFAIILDTLAECQGRRKEMAEKLGISPRTLRYKLAKMRDAGIDIPG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKMAQSKVLIVEDDEGLREALIDTLALAGYEWLEADCAEDALLKLKSHSVDIVVSDVQMA
CCCCCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHC
GMGGLALLRSIKQHWPNLPVLLMTAYANIQDAVSAMKDGAIDYMAKPFAPEVLLNMVSRY
CCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHH
APVKSDDNGDAVVADTKSLKLLALADKVAKTDANVMILGPSGSGKEVMSRYIHNASPRKE
CCCCCCCCCCEEEECCCCEEEHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCCC
GPFIAINCAAIPDNMLEATLFGYEKGAFTGAVQACPGKFEQAQGGTILLDEISEMDLNLQ
CCEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCHHCCCCEEEEECHHHCCCCHH
AKLLRVLQEREVERLGSRKSIKLDVRVLATSNRDLKQYVQAGHFREDLYYRLNVFPLTWP
HHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHCCCHHCCEEEEEEEECCCH
ALCERKDDIEPLANHLIERHCKKLGLPVPSIAPNAITKLLNYPWPGNVRELDNVVQRALI
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LSENGHIQSEHILLEGVDWHDASSLQQAVAGESMAAPQIKPVAEPEVFKPLVQGGGQNSS
HCCCCCEECCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
SQSSGLGGELRDQEFAIILDTLAECQGRRKEMAEKLGISPRTLRYKLAKMRDAGIDIPG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]