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The map label for this gene is sdhA [H]

Identifier: 147673431

GI number: 147673431

Start: 1803366

End: 1805132

Strand: Reverse

Name: sdhA [H]

Synonym: VC0395_A1675

Alternate gene names: 147673431

Gene position: 1805132-1803366 (Counterclockwise)

Preceding gene: 147674183

Following gene: 147674178

Centisome position: 59.69

GC content: 49.41

Gene sequence:

>1767_bases
GTGACTATTCCAGTTCGTTCTTTTGACGCCGTAGTAATCGGCGCAGGTGGTGCAGGTATGCGTGCTGCACTACAAATTTC
TGAGCAAGGCCTAACTTGCGCACTGCTTTCAAAAGTGTTTCCAACTCGTTCTCATACGGTATCCGCTCAAGGCGGCATTA
CCGTGGCTTTGGGTAACTCACATAAAGATGATTGGCAGTGGCATATGTATGACACGGTAAAAGGTTCCGACTATATCGGC
GACCAAAATGCCATCGAATACATGTGTAAAAACGGCCCGGAATCCGTGATTGAACTTGAGCGCATGGGGCTACCTTTTTC
TCGTTTTGAGAACGGCACGATTTATCAGCGTCCTTTTGGCGGTCAGTCAAAAGAGTTCGGTGGTGAACAAGCTGCTCGTA
CGGCAGCAGCAGCAGACCGTACTGGTCATGCTCTACTGCACACGCTTTACCAACAAAACGTTAAACATAAAACCACCATT
TTCTCGGAATGGTATGCACTGGATCTGGTGAAAAACCAAGATGGTGCTGTGCTCGGTTGTACTGCAATCTGCATGGAAAC
AGGCGAAATTTGCTACTTCAAAGCCAAAGCAACAGTGCTTGCGACAGGCGGTGCAGGTCGTATTTACGCTTCAACCACCA
ATGCACACATTAACACGGGCGATGGTGTCGGTATGGCTTTGCGTGCTGGCGTACCAATGCAAGATATGGAAATGTGGCAA
TTCCACCCAACGGGTATCGCGGGTGCTGGCGTTCTGGTTACAGAAGGCTGTCGTGGCGAAGGTGGCTATCTGCTGAATAA
AGATGGTGAGCGTTTCATGGAACGTTACGCGCCTAACGCTAAAGATCTAGCAGGTCGCGACGTGGTTGCACGTTCAATGA
TGATCGAAATCCGTGAAGGTCGTGGTTGTGATGGCCCATGGGGTCCACACATCAAACTGAAACTGGATCATTTAGGTCGT
GATGTATTGGAATCTCGCCTACCGGGTATCTGTGAACTATCACGTACCTTTGCTCACGTGGACCCAGTGAAAGAACCTAT
TCCTGTTATCCCAACCTGTCACTACATGATGGGTGGCGTACCAACACAAGTGTCTGGTCAAGCGATCAAACAAGACAGCC
ATGGTAAAGATGTTGAAGTCCAAGGCTTGTTTGCTTGTGGTGAAATCGCTTCTGTATCGGTACATGGTGCCAACCGTTTA
GGCGGCAACTCACTGCTTGATCTGGTGGTATTTGGCCGCGCAACGGGTCTACATCTTGGTGAAACTCTGCGTGCTCAAGC
TGAGGCTCGCCCTGCGACTGCATCGGATATCGAAGCTTCTCTGGCTCGTACTATGCGTTGGGAAAACAGCAAAGGTGGCG
AAGATCCTGTCGTGATTCGTAAAGATCTGCAGCGCTGCATGCAAAACAACTTCTCGGTATTCCGTGAAGGTAAGGCGATG
GCTGAGGGGCTGGAAGAGCTCAAAGTCATCCGCGAACGTTTGAAAAATGCCCATCTGGCGGACAAATCAACCGAATTTAA
CACTCAACGTATTGAGTGTTTAGAGTTGGACAACCTGATGGAAACGGCATTTTCGACTGCAGTAGCGGCAAACTACCGTA
CTGAAAGCCGTGGTGCACATGCGCGTTTTGACTATCCAGAGCGTGATGATGAGAACTGGTTGTGCCACTCAATCTACAAT
CCGGAAACGGAACAGATGAGTAAGCGTGAGGTCAATATGACACCGGTTTACCGTGACCCGTTCCCGCCTAAAGTGCGTAC
ATATTAA

Upstream 100 bases:

>100_bases
CATTAAGTGCTCCAAATTGCGTGCAGGACTGCAACTTGTGGTCATCGCCGTTCTACTTGGATACTTCTTCTCTGGCCTAT
TTGTATTGTGGGGTGCCTAA

Downstream 100 bases:

>100_bases
GGGAGGTACTCAATATGAAACTCAACTTCTCCTTATATCGCTATAATCCGGATGTCGATAACAAACCCTACATGAAAGAC
TACATTCTTGAGGTAGAGGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MTIPVRSFDAVVIGAGGAGMRAALQISEQGLTCALLSKVFPTRSHTVSAQGGITVALGNSHKDDWQWHMYDTVKGSDYIG
DQNAIEYMCKNGPESVIELERMGLPFSRFENGTIYQRPFGGQSKEFGGEQAARTAAAADRTGHALLHTLYQQNVKHKTTI
FSEWYALDLVKNQDGAVLGCTAICMETGEICYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMALRAGVPMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMIEIREGRGCDGPWGPHIKLKLDHLGR
DVLESRLPGICELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQDSHGKDVEVQGLFACGEIASVSVHGANRL
GGNSLLDLVVFGRATGLHLGETLRAQAEARPATASDIEASLARTMRWENSKGGEDPVVIRKDLQRCMQNNFSVFREGKAM
AEGLEELKVIRERLKNAHLADKSTEFNTQRIECLELDNLMETAFSTAVAANYRTESRGAHARFDYPERDDENWLCHSIYN
PETEQMSKREVNMTPVYRDPFPPKVRTY

Sequences:

>Translated_588_residues
MTIPVRSFDAVVIGAGGAGMRAALQISEQGLTCALLSKVFPTRSHTVSAQGGITVALGNSHKDDWQWHMYDTVKGSDYIG
DQNAIEYMCKNGPESVIELERMGLPFSRFENGTIYQRPFGGQSKEFGGEQAARTAAAADRTGHALLHTLYQQNVKHKTTI
FSEWYALDLVKNQDGAVLGCTAICMETGEICYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMALRAGVPMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMIEIREGRGCDGPWGPHIKLKLDHLGR
DVLESRLPGICELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQDSHGKDVEVQGLFACGEIASVSVHGANRL
GGNSLLDLVVFGRATGLHLGETLRAQAEARPATASDIEASLARTMRWENSKGGEDPVVIRKDLQRCMQNNFSVFREGKAM
AEGLEELKVIRERLKNAHLADKSTEFNTQRIECLELDNLMETAFSTAVAANYRTESRGAHARFDYPERDDENWLCHSIYN
PETEQMSKREVNMTPVYRDPFPPKVRTY
>Mature_587_residues
TIPVRSFDAVVIGAGGAGMRAALQISEQGLTCALLSKVFPTRSHTVSAQGGITVALGNSHKDDWQWHMYDTVKGSDYIGD
QNAIEYMCKNGPESVIELERMGLPFSRFENGTIYQRPFGGQSKEFGGEQAARTAAAADRTGHALLHTLYQQNVKHKTTIF
SEWYALDLVKNQDGAVLGCTAICMETGEICYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMALRAGVPMQDMEMWQF
HPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMIEIREGRGCDGPWGPHIKLKLDHLGRD
VLESRLPGICELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQDSHGKDVEVQGLFACGEIASVSVHGANRLG
GNSLLDLVVFGRATGLHLGETLRAQAEARPATASDIEASLARTMRWENSKGGEDPVVIRKDLQRCMQNNFSVFREGKAMA
EGLEELKVIRERLKNAHLADKSTEFNTQRIECLELDNLMETAFSTAVAANYRTESRGAHARFDYPERDDENWLCHSIYNP
ETEQMSKREVNMTPVYRDPFPPKVRTY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=527, Percent_Identity=54.26944971537, Blast_Score=556, Evalue=1e-158,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=82.1428571428571, Blast_Score=976, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=578, Percent_Identity=40.4844290657439, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1788928, Length=567, Percent_Identity=31.3932980599647, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17550100, Length=588, Percent_Identity=51.0204081632653, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17505833, Length=589, Percent_Identity=49.7453310696095, Blast_Score=543, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6322701, Length=591, Percent_Identity=52.9610829103215, Blast_Score=592, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6322416, Length=598, Percent_Identity=53.1772575250836, Blast_Score=588, Evalue=1e-169,
Organism=Drosophila melanogaster, GI17137288, Length=546, Percent_Identity=54.7619047619048, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24655642, Length=546, Percent_Identity=54.7619047619048, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24655647, Length=546, Percent_Identity=54.7619047619048, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24663005, Length=607, Percent_Identity=47.7759472817133, Blast_Score=533, Evalue=1e-151,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64511; Mature: 64380

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPVRSFDAVVIGAGGAGMRAALQISEQGLTCALLSKVFPTRSHTVSAQGGITVALGNS
CCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HKDDWQWHMYDTVKGSDYIGDQNAIEYMCKNGPESVIELERMGLPFSRFENGTIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCEEEECCCC
GQSKEFGGEQAARTAAAADRTGHALLHTLYQQNVKHKTTIFSEWYALDLVKNQDGAVLGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHCEEEEEEEECCCCCEEEH
TAICMETGEICYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMALRAGVPMQDMEMWQ
HHHHHCCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCEEEECCCCHHHCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMIEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHCCHHHHHHHHHEEEECC
RGCDGPWGPHIKLKLDHLGRDVLESRLPGICELSRTFAHVDPVKEPIPVIPTCHYMMGGV
CCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCC
PTQVSGQAIKQDSHGKDVEVQGLFACGEIASVSVHGANRLGGNSLLDLVVFGRATGLHLG
CCCCCCHHHCCCCCCCCEEEEEEEEECCEEEEEECCCCCCCCCHHHHHHEECCCCCCCCC
ETLRAQAEARPATASDIEASLARTMRWENSKGGEDPVVIRKDLQRCMQNNFSVFREGKAM
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHCCHHHHHCCHHH
AEGLEELKVIRERLKNAHLADKSTEFNTQRIECLELDNLMETAFSTAVAANYRTESRGAH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCC
ARFDYPERDDENWLCHSIYNPETEQMSKREVNMTPVYRDPFPPKVRTY
CCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCEECCCCCCCCCCC
>Mature Secondary Structure 
TIPVRSFDAVVIGAGGAGMRAALQISEQGLTCALLSKVFPTRSHTVSAQGGITVALGNS
CCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HKDDWQWHMYDTVKGSDYIGDQNAIEYMCKNGPESVIELERMGLPFSRFENGTIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCEEEECCCC
GQSKEFGGEQAARTAAAADRTGHALLHTLYQQNVKHKTTIFSEWYALDLVKNQDGAVLGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHCEEEEEEEECCCCCEEEH
TAICMETGEICYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMALRAGVPMQDMEMWQ
HHHHHCCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCEEEECCCCHHHCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMIEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHCCHHHHHHHHHEEEECC
RGCDGPWGPHIKLKLDHLGRDVLESRLPGICELSRTFAHVDPVKEPIPVIPTCHYMMGGV
CCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCC
PTQVSGQAIKQDSHGKDVEVQGLFACGEIASVSVHGANRLGGNSLLDLVVFGRATGLHLG
CCCCCCHHHCCCCCCCCEEEEEEEEECCEEEEEECCCCCCCCCHHHHHHEECCCCCCCCC
ETLRAQAEARPATASDIEASLARTMRWENSKGGEDPVVIRKDLQRCMQNNFSVFREGKAM
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHCCHHHHHCCHHH
AEGLEELKVIRERLKNAHLADKSTEFNTQRIECLELDNLMETAFSTAVAANYRTESRGAH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCC
ARFDYPERDDENWLCHSIYNPETEQMSKREVNMTPVYRDPFPPKVRTY
CCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]