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The map label for this gene is sdhB [H]

Identifier: 147674178

GI number: 147674178

Start: 1802641

End: 1803351

Strand: Reverse

Name: sdhB [H]

Synonym: VC0395_A1674

Alternate gene names: 147674178

Gene position: 1803351-1802641 (Counterclockwise)

Preceding gene: 147673431

Following gene: 147675042

Centisome position: 59.63

GC content: 44.3

Gene sequence:

>711_bases
ATGAAACTCAACTTCTCCTTATATCGCTATAATCCGGATGTCGATAACAAACCCTACATGAAAGACTACATTCTTGAGGT
AGAGGAAGGGTCTGACATGATGGTGTTGGATGCTTTGATTCTGCTTAAAGAGCAAGATCCAAGTATTGCTTTCCGCCGCT
CATGCCGTGAAGGGGTTTGTGGCTCGGACGGTCTGAATATGAATGGTAAGAATGGCTTAGCATGTATCACACCTTTGTCT
GCGTTAAAAGGTGACAAAATTGTGATTCGTCCGCTGCCAGGATTACCTGTGGTTCGTGACTTGATTGTCGACATGACTCA
GTTTTACGATAACTATGCGAAAGTTAAGCCTTTCTTGATTGCAGATGATGCATTACCCCCTTCAAGAGAGAACTTGCAAT
CCCCAGAAGAACGGGCGCATTTGGATGGTCTGTACGAGTGTATTATGTGCGCTTGCTGTACCACTTCCTGCCCTTCATTC
TGGTGGAATCCGGATAAATTTATCGGACCTGCAGGTTTGTTGGCTGCTTATCGTTGGTTGATTGATAGCCGTGATACCGC
GACAGATGAACGCTTATCGAATCTTGATGATGCGTTTAGCGTTTTTCGTTGCCACGGCATCATGAACTGTGTCAGTGTTT
GTCCGAAAGGATTAAACCCAACGAAAGCCATTGGACATATTAAGTCCATGTTGATCAATCGTTCAGTTTAA

Upstream 100 bases:

>100_bases
CGGAAACGGAACAGATGAGTAAGCGTGAGGTCAATATGACACCGGTTTACCGTGACCCGTTCCCGCCTAAAGTGCGTACA
TATTAAGGGAGGTACTCAAT

Downstream 100 bases:

>100_bases
ATTGAAAATTGCAGGCCTTCGGGCCTGCCTTTTATAGCTCGGCGATAAGACCGCAGCAAACGTGAAAACTACTGGTTAAG
GGAAAAAAATGCACAACGGC

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKLNFSLYRYNPDVDNKPYMKDYILEVEEGSDMMVLDALILLKEQDPSIAFRRSCREGVCGSDGLNMNGKNGLACITPLS
ALKGDKIVIRPLPGLPVVRDLIVDMTQFYDNYAKVKPFLIADDALPPSRENLQSPEERAHLDGLYECIMCACCTTSCPSF
WWNPDKFIGPAGLLAAYRWLIDSRDTATDERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKSMLINRSV

Sequences:

>Translated_236_residues
MKLNFSLYRYNPDVDNKPYMKDYILEVEEGSDMMVLDALILLKEQDPSIAFRRSCREGVCGSDGLNMNGKNGLACITPLS
ALKGDKIVIRPLPGLPVVRDLIVDMTQFYDNYAKVKPFLIADDALPPSRENLQSPEERAHLDGLYECIMCACCTTSCPSF
WWNPDKFIGPAGLLAAYRWLIDSRDTATDERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKSMLINRSV
>Mature_236_residues
MKLNFSLYRYNPDVDNKPYMKDYILEVEEGSDMMVLDALILLKEQDPSIAFRRSCREGVCGSDGLNMNGKNGLACITPLS
ALKGDKIVIRPLPGLPVVRDLIVDMTQFYDNYAKVKPFLIADDALPPSRENLQSPEERAHLDGLYECIMCACCTTSCPSF
WWNPDKFIGPAGLLAAYRWLIDSRDTATDERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKSMLINRSV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=231, Percent_Identity=51.9480519480519, Blast_Score=253, Evalue=2e-67,
Organism=Escherichia coli, GI1786943, Length=238, Percent_Identity=76.890756302521, Blast_Score=393, Evalue=1e-111,
Organism=Escherichia coli, GI1790596, Length=227, Percent_Identity=36.5638766519824, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17533915, Length=231, Percent_Identity=50.6493506493506, Blast_Score=247, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6322987, Length=230, Percent_Identity=50, Blast_Score=246, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17137106, Length=232, Percent_Identity=52.5862068965517, Blast_Score=259, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24643156, Length=232, Percent_Identity=50.4310344827586, Blast_Score=245, Evalue=2e-65,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26392; Mature: 26392

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNFSLYRYNPDVDNKPYMKDYILEVEEGSDMMVLDALILLKEQDPSIAFRRSCREGVC
CCCEEEEEEECCCCCCCCCHHHHHEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCC
GSDGLNMNGKNGLACITPLSALKGDKIVIRPLPGLPVVRDLIVDMTQFYDNYAKVKPFLI
CCCCCCCCCCCCEEEECHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEE
ADDALPPSRENLQSPEERAHLDGLYECIMCACCTTSCPSFWWNPDKFIGPAGLLAAYRWL
ECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHH
IDSRDTATDERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKSMLINRSV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLNFSLYRYNPDVDNKPYMKDYILEVEEGSDMMVLDALILLKEQDPSIAFRRSCREGVC
CCCEEEEEEECCCCCCCCCHHHHHEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCC
GSDGLNMNGKNGLACITPLSALKGDKIVIRPLPGLPVVRDLIVDMTQFYDNYAKVKPFLI
CCCCCCCCCCCCEEEECHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEE
ADDALPPSRENLQSPEERAHLDGLYECIMCACCTTSCPSFWWNPDKFIGPAGLLAAYRWL
ECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHH
IDSRDTATDERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKSMLINRSV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]