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The map label for this gene is hpd [H]

Identifier: 146343715

GI number: 146343715

Start: 7248081

End: 7249199

Strand: Reverse

Name: hpd [H]

Synonym: BRADO6961

Alternate gene names: 146343715

Gene position: 7249199-7248081 (Counterclockwise)

Preceding gene: 146343718

Following gene: 146343709

Centisome position: 97.22

GC content: 65.06

Gene sequence:

>1119_bases
ATGGGTCCGTTTCCGCACGATGCGCCGCCTGCCACCATCTCCGCCGACAATCCGATGGGCACCGACGGCTTCGAGTTCGT
CGAATACGCCCATCCCGATGCCGGGCAGTTGCACGCCCTGTTCAAGCTGATGGGCTTTACTGCCGTCGCGCGCCACAAGA
CCAAGGCGATCACGCTGTACCGCCAGGGCGACATCAACTACCTCGTCAACGAGGAGCCGGGCAGCCACGGCCAGGACTTC
GTCGCCGCGCACGGCCCGTGCGCGCCATCGATGGCGTTCCGGGTGGTCGACGCCAGGATGGCTTATGCAAGGGCGATCGC
GCTCGGTGCCGAACCCGCCGATCTGCCTGCACAGCAGAAGACGCTTGACGTACCCGCGCTCAAGGGGATCGGCGGCAGCC
TGCTGTATCTGGTCGATCGCTACGGCGCCAAGGGCGCGGCCTATGACCTCGAATTCGTCTGGATCGGCGCGCGCGACCCG
CGCCCGGCGGGCTCCGGGCTGTACTATATCGATCACCTCACTCACAACGTCCATCGCGGCCGCATGGACGTCTGGGCCGG
CTTCTACGAGAAGCTGTTCAACTTCCGCCAGATCCGCTTCTTCGACATCGAGGGTCGCGCCTCCGGCCTGTTCTCGCGCG
CGCTGACCAGCCCGGACGGCAAGATCCGGATTCCGATCAACGAGGACGCCGGTGATTCCGGGCAGATCGAGGAATATCTG
AAGTCCTATCGCGGGGAGGGCATCCAGCACGTCGCCTGCGGCGCGCGCGACATCTACACGACCGTCGAGGGCCTGCGCGC
CTCAGGCCTGCCGTTCATGCCGTCGCCGCCCGAGACCTATTTCGAGCGCATCGATAGCAGGCTGCCGAAACACGGCGAGG
ACGTCGCGCGTCTCAAGCGCAATGGCATCCTCATCGACGGCGAGGGCGTCGTCGACGGCGGCCAGACCAAGGTGCTGTTG
CAGATCTTCTCAGCCAATGCCATCGGCCCGATCTTCTTCGAGTTCATCCAGCGCAAGGGCGACGACGGTTTTGGCGAAGG
CAACTTCAAGGCGCTGTTCGAATCGATCGAGGAAGACCAGATCCGCCGCGGCGTGCTGAAGGTCGAGGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
ATGCACGGATCGTGCATATCTTGGCGAAAATGACAATGGTTTGCATGCTCCATGCGCCGAATTGGAGAGATCATGGCTCG
ATCAGCCAAGGAGCTTTGCC

Downstream 100 bases:

>100_bases
GACGAGCAGGTTTGCCCGTCATTGCGAGGAGCGGAGCGACGAAGCAATCCAGAGTCCCGCCCTGGCCCTGGATTGCGTCG
CTTCGCTCGCAATGACGGTG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MGPFPHDAPPATISADNPMGTDGFEFVEYAHPDAGQLHALFKLMGFTAVARHKTKAITLYRQGDINYLVNEEPGSHGQDF
VAAHGPCAPSMAFRVVDARMAYARAIALGAEPADLPAQQKTLDVPALKGIGGSLLYLVDRYGAKGAAYDLEFVWIGARDP
RPAGSGLYYIDHLTHNVHRGRMDVWAGFYEKLFNFRQIRFFDIEGRASGLFSRALTSPDGKIRIPINEDAGDSGQIEEYL
KSYRGEGIQHVACGARDIYTTVEGLRASGLPFMPSPPETYFERIDSRLPKHGEDVARLKRNGILIDGEGVVDGGQTKVLL
QIFSANAIGPIFFEFIQRKGDDGFGEGNFKALFESIEEDQIRRGVLKVEAAE

Sequences:

>Translated_372_residues
MGPFPHDAPPATISADNPMGTDGFEFVEYAHPDAGQLHALFKLMGFTAVARHKTKAITLYRQGDINYLVNEEPGSHGQDF
VAAHGPCAPSMAFRVVDARMAYARAIALGAEPADLPAQQKTLDVPALKGIGGSLLYLVDRYGAKGAAYDLEFVWIGARDP
RPAGSGLYYIDHLTHNVHRGRMDVWAGFYEKLFNFRQIRFFDIEGRASGLFSRALTSPDGKIRIPINEDAGDSGQIEEYL
KSYRGEGIQHVACGARDIYTTVEGLRASGLPFMPSPPETYFERIDSRLPKHGEDVARLKRNGILIDGEGVVDGGQTKVLL
QIFSANAIGPIFFEFIQRKGDDGFGEGNFKALFESIEEDQIRRGVLKVEAAE
>Mature_371_residues
GPFPHDAPPATISADNPMGTDGFEFVEYAHPDAGQLHALFKLMGFTAVARHKTKAITLYRQGDINYLVNEEPGSHGQDFV
AAHGPCAPSMAFRVVDARMAYARAIALGAEPADLPAQQKTLDVPALKGIGGSLLYLVDRYGAKGAAYDLEFVWIGARDPR
PAGSGLYYIDHLTHNVHRGRMDVWAGFYEKLFNFRQIRFFDIEGRASGLFSRALTSPDGKIRIPINEDAGDSGQIEEYLK
SYRGEGIQHVACGARDIYTTVEGLRASGLPFMPSPPETYFERIDSRLPKHGEDVARLKRNGILIDGEGVVDGGQTKVLLQ
IFSANAIGPIFFEFIQRKGDDGFGEGNFKALFESIEEDQIRRGVLKVEAAE

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=331, Percent_Identity=28.7009063444109, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI285002264, Length=331, Percent_Identity=28.7009063444109, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI14249394, Length=369, Percent_Identity=28.4552845528455, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17555220, Length=321, Percent_Identity=33.6448598130841, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17550752, Length=211, Percent_Identity=30.8056872037915, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667510, Length=318, Percent_Identity=31.4465408805031, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356105, Length=304, Percent_Identity=31.5789473684211, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40840; Mature: 40708

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPFPHDAPPATISADNPMGTDGFEFVEYAHPDAGQLHALFKLMGFTAVARHKTKAITLY
CCCCCCCCCCCEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEE
RQGDINYLVNEEPGSHGQDFVAAHGPCAPSMAFRVVDARMAYARAIALGAEPADLPAQQK
EECCCEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
TLDVPALKGIGGSLLYLVDRYGAKGAAYDLEFVWIGARDPRPAGSGLYYIDHLTHNVHRG
CCCCCHHHCCCCHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCEEEEEHHHHHHHCC
RMDVWAGFYEKLFNFRQIRFFDIEGRASGLFSRALTSPDGKIRIPINEDAGDSGQIEEYL
HHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHH
KSYRGEGIQHVACGARDIYTTVEGLRASGLPFMPSPPETYFERIDSRLPKHGEDVARLKR
HHHCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
NGILIDGEGVVDGGQTKVLLQIFSANAIGPIFFEFIQRKGDDGFGEGNFKALFESIEEDQ
CCEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
IRRGVLKVEAAE
HHHCEEEEEECC
>Mature Secondary Structure 
GPFPHDAPPATISADNPMGTDGFEFVEYAHPDAGQLHALFKLMGFTAVARHKTKAITLY
CCCCCCCCCCEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEE
RQGDINYLVNEEPGSHGQDFVAAHGPCAPSMAFRVVDARMAYARAIALGAEPADLPAQQK
EECCCEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
TLDVPALKGIGGSLLYLVDRYGAKGAAYDLEFVWIGARDPRPAGSGLYYIDHLTHNVHRG
CCCCCHHHCCCCHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCEEEEEHHHHHHHCC
RMDVWAGFYEKLFNFRQIRFFDIEGRASGLFSRALTSPDGKIRIPINEDAGDSGQIEEYL
HHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHH
KSYRGEGIQHVACGARDIYTTVEGLRASGLPFMPSPPETYFERIDSRLPKHGEDVARLKR
HHHCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
NGILIDGEGVVDGGQTKVLLQIFSANAIGPIFFEFIQRKGDDGFGEGNFKALFESIEEDQ
CCEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
IRRGVLKVEAAE
HHHCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]