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The map label for this gene is fahA

Identifier: 146343718

GI number: 146343718

Start: 7250286

End: 7251554

Strand: Reverse

Name: fahA

Synonym: BRADO6964

Alternate gene names: NA

Gene position: 7251554-7250286 (Counterclockwise)

Preceding gene: 146343719

Following gene: 146343715

Centisome position: 97.25

GC content: 67.14

Gene sequence:

>1269_bases
TTGCCCCACTCTAACGATCCCTCGCTCCGCTCCTTCATCCCGGTCGATCCGACCTCCGATTTTCCGATCCAGAACCTGCC
CTATGGCGTGTTCTCGGCGGCGGACTCGCCGAAGTCCCGCGTCGGCGTCGCCATCGGCGACTACGTGCTCGACCTCGCGG
TGCTCGAGGACGAAGGCCTGCTCGACCTGTCGCCGGCCTACGAGGTGTTCGCGCAACCCTCGCTCAATGCCTTCATGGCG
CTCGGCCCCGCCGTGTGGTCGAGGACGCGCGCGGCGATCAGCGCGTTGTTGCGCGAGGATACTCCGCGGCTGCGCGACGA
CAGGCCGCTGCGCAGCCGCGCGCTGCTGCCGCGCCAGGACGTGACGTTGCATCTGCCGTTCCGCGTCGCCGGCTACACCG
ACTTCTACTCATCGAGGGAGCACGCCACCAATGTCGGAGTGATGTTCCGCGGCAAGGACAACGCGCTGCAGCCGAACTGG
CTGCACATGCCGATCGGCTACAACGGCCGCGCCTCCACGGTTGTCGTGTCCGGCACGAAGGTGCGCCGGCCGCGCGGCCA
GCTCAAGCCGCCGAGCGCCGACGTGCCGAGCTTCGGTCCCTGTAAGCGGCTCGATTTCGAGCTGGAGATGGGCGTCGTCA
TCGGCCAGTCCTCGCGCCTCGGCGAGATGCTGACCGAGGCGCAGGCGGAAGCGATGATCTTCGGCTTCGTGCTGCTCAAC
GACTGGAGCGCGCGCGACATCCAGCAATGGGAATACGTCCCGCTCGGCCCGTTCCAGGCCAAGGCGTTCGCGACCTCGAT
CAGCCCGTGGGTCGTGACGCGGGAGGCGCTGGAACCGTTCCGTATCGCGGGGCCGGCGCAGCAGCCGGTGCCGTTGCCCT
ATCTGCAGCAGAAGAACGCGCAGAACTACGATCTCGCGCTCGAGGTTTCGCTGAGCGCGGGCGCCGCCGCGCGGACCATT
GCGCAAACCAACTTCAAATACATGTACTGGTCGAGCGTCCAGCAACTGATACACCACGCCTCGTCGGGCTGCGCGATGAG
CGTTGGCGACCTCCTTGGCAGCGGCACCATCTCCGGCCCGGACAAGCACCAGCGCGGCAGCCTGTTGGAGATCAGTTGGA
ACGGCACCGAGCCGGTCGAACTCGCAGGCGGCGTGAAGCGCACCTTCCTGGAAGACGGCGACTCGCTCGTCATGCGCGGC
TGGTGCCAGGGCCAAGGCTATCGCGTCGGCTTCGGCGATGTGGAGGGCACGATCGTTGCTGCCGAGTAG

Upstream 100 bases:

>100_bases
ATGGCCGGGCTTGACCCGGCCATCCACGTCTATCAGCCCGCCGGGTGGATATGGATGCCCGGGTCAAGCCCGGGCATGAC
GATCCGTTTGGAGAAGCAGT

Downstream 100 bases:

>100_bases
GCGTCATTGCGAGCGCAGCGAAGCAATCCAGAGTCGCGCGTGCAGTCCTGGATTGCTTCGCTGCGCTCGCAATGACGGCA
AATGCAGTCAGCGGTTCACC

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MPHSNDPSLRSFIPVDPTSDFPIQNLPYGVFSAADSPKSRVGVAIGDYVLDLAVLEDEGLLDLSPAYEVFAQPSLNAFMA
LGPAVWSRTRAAISALLREDTPRLRDDRPLRSRALLPRQDVTLHLPFRVAGYTDFYSSREHATNVGVMFRGKDNALQPNW
LHMPIGYNGRASTVVVSGTKVRRPRGQLKPPSADVPSFGPCKRLDFELEMGVVIGQSSRLGEMLTEAQAEAMIFGFVLLN
DWSARDIQQWEYVPLGPFQAKAFATSISPWVVTREALEPFRIAGPAQQPVPLPYLQQKNAQNYDLALEVSLSAGAAARTI
AQTNFKYMYWSSVQQLIHHASSGCAMSVGDLLGSGTISGPDKHQRGSLLEISWNGTEPVELAGGVKRTFLEDGDSLVMRG
WCQGQGYRVGFGDVEGTIVAAE

Sequences:

>Translated_422_residues
MPHSNDPSLRSFIPVDPTSDFPIQNLPYGVFSAADSPKSRVGVAIGDYVLDLAVLEDEGLLDLSPAYEVFAQPSLNAFMA
LGPAVWSRTRAAISALLREDTPRLRDDRPLRSRALLPRQDVTLHLPFRVAGYTDFYSSREHATNVGVMFRGKDNALQPNW
LHMPIGYNGRASTVVVSGTKVRRPRGQLKPPSADVPSFGPCKRLDFELEMGVVIGQSSRLGEMLTEAQAEAMIFGFVLLN
DWSARDIQQWEYVPLGPFQAKAFATSISPWVVTREALEPFRIAGPAQQPVPLPYLQQKNAQNYDLALEVSLSAGAAARTI
AQTNFKYMYWSSVQQLIHHASSGCAMSVGDLLGSGTISGPDKHQRGSLLEISWNGTEPVELAGGVKRTFLEDGDSLVMRG
WCQGQGYRVGFGDVEGTIVAAE
>Mature_421_residues
PHSNDPSLRSFIPVDPTSDFPIQNLPYGVFSAADSPKSRVGVAIGDYVLDLAVLEDEGLLDLSPAYEVFAQPSLNAFMAL
GPAVWSRTRAAISALLREDTPRLRDDRPLRSRALLPRQDVTLHLPFRVAGYTDFYSSREHATNVGVMFRGKDNALQPNWL
HMPIGYNGRASTVVVSGTKVRRPRGQLKPPSADVPSFGPCKRLDFELEMGVVIGQSSRLGEMLTEAQAEAMIFGFVLLND
WSARDIQQWEYVPLGPFQAKAFATSISPWVVTREALEPFRIAGPAQQPVPLPYLQQKNAQNYDLALEVSLSAGAAARTIA
QTNFKYMYWSSVQQLIHHASSGCAMSVGDLLGSGTISGPDKHQRGSLLEISWNGTEPVELAGGVKRTFLEDGDSLVMRGW
CQGQGYRVGFGDVEGTIVAAE

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=415, Percent_Identity=54.2168674698795, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17568863, Length=420, Percent_Identity=52.3809523809524, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24657182, Length=415, Percent_Identity=48.1927710843374, Blast_Score=406, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 46152; Mature: 46021

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHSNDPSLRSFIPVDPTSDFPIQNLPYGVFSAADSPKSRVGVAIGDYVLDLAVLEDEGL
CCCCCCCCHHEEECCCCCCCCCCCCCCCHHEECCCCCCHHCCEEEHHEEEEEEEECCCCC
LDLSPAYEVFAQPSLNAFMALGPAVWSRTRAAISALLREDTPRLRDDRPLRSRALLPRQD
EECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCC
VTLHLPFRVAGYTDFYSSREHATNVGVMFRGKDNALQPNWLHMPIGYNGRASTVVVSGTK
CEEEECEEEECCHHHHCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCEEEEECCE
VRRPRGQLKPPSADVPSFGPCKRLDFELEMGVVIGQSSRLGEMLTEAQAEAMIFGFVLLN
EECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHEEEEEEEEC
DWSARDIQQWEYVPLGPFQAKAFATSISPWVVTREALEPFRIAGPAQQPVPLPYLQQKNA
CCCCCCCCCCCEECCCCCCHHHHHCCCCCCEEEHHHCCCEEECCCCCCCCCCCHHHHCCC
QNYDLALEVSLSAGAAARTIAQTNFKYMYWSSVQQLIHHASSGCAMSVGDLLGSGTISGP
CCCEEEEEEEECCCCHHHHHHHCCCEEEEHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCC
DKHQRGSLLEISWNGTEPVELAGGVKRTFLEDGDSLVMRGWCQGQGYRVGFGDVEGTIVA
CCCCCCCEEEEEECCCCCHHHCCCHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCEEEE
AE
EC
>Mature Secondary Structure 
PHSNDPSLRSFIPVDPTSDFPIQNLPYGVFSAADSPKSRVGVAIGDYVLDLAVLEDEGL
CCCCCCCHHEEECCCCCCCCCCCCCCCHHEECCCCCCHHCCEEEHHEEEEEEEECCCCC
LDLSPAYEVFAQPSLNAFMALGPAVWSRTRAAISALLREDTPRLRDDRPLRSRALLPRQD
EECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCC
VTLHLPFRVAGYTDFYSSREHATNVGVMFRGKDNALQPNWLHMPIGYNGRASTVVVSGTK
CEEEECEEEECCHHHHCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCEEEEECCE
VRRPRGQLKPPSADVPSFGPCKRLDFELEMGVVIGQSSRLGEMLTEAQAEAMIFGFVLLN
EECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHEEEEEEEEC
DWSARDIQQWEYVPLGPFQAKAFATSISPWVVTREALEPFRIAGPAQQPVPLPYLQQKNA
CCCCCCCCCCCEECCCCCCHHHHHCCCCCCEEEHHHCCCEEECCCCCCCCCCCHHHHCCC
QNYDLALEVSLSAGAAARTIAQTNFKYMYWSSVQQLIHHASSGCAMSVGDLLGSGTISGP
CCCEEEEEEEECCCCHHHHHHHCCCEEEEHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCC
DKHQRGSLLEISWNGTEPVELAGGVKRTFLEDGDSLVMRGWCQGQGYRVGFGDVEGTIVA
CCCCCCCEEEEEECCCCCHHHCCCHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCEEEE
AE
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA