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The map label for this gene is lktC [H]

Identifier: 146343684

GI number: 146343684

Start: 7219287

End: 7219799

Strand: Reverse

Name: lktC [H]

Synonym: BRADO6927

Alternate gene names: 146343684

Gene position: 7219799-7219287 (Counterclockwise)

Preceding gene: 146343685

Following gene: 146343683

Centisome position: 96.82

GC content: 61.99

Gene sequence:

>513_bases
ATGACCGAAACGGCCAAGACTGAAGCTGCAGGTGGCAACTCACGGGCTCATGGAGGCGCTGGCGAAGACACGGCTCAACC
AACGTCGCCGAACATCCCGCGCAATCCTCCGCCGGATGCGGTGCTCGGCCAGGTTGTGTGGCTGATGATGAACATGCCGC
GCTATCGGCACGTCTTCCTCGCGGACCTCGAGTGGATGGTGCTGCCGCCGATCCTTCTCAATCAGTATCGGCTGTTCCGC
GCCGGCGATCACATCGTCGCCTTCGCAGCGTGGGCCTACCTTTCCGAAGAAGCAGAAGCGCGATTGCAGGAACCCAACCC
GCGGCTTGCGCCGACCGACTGGAAAAGCGGTGATCGGCTCTGGCTGATCGACTTGCACGCGCCGTTCGGACAGCAGGAAC
TCGCGCTCAAGGAGCTCGGCGAAACTGCGCTGAAAGGCAAGACCTACAAGATGCATCGATGGACTGCACAGGGCAGGCAG
ACCGTCGAGATCGTGCCGCAGGCGAATTCCTGA

Upstream 100 bases:

>100_bases
TCCGACCCTAGGCGCGCCAAGGTTGGGCAGGCGTTGTCGGTCGCCGCTTTACCTTGGCGAGTGCGCTCATTATAGGTCGC
CGAAAAGGGAGATGTGACAG

Downstream 100 bases:

>100_bases
TTCTCAACCTTTGAGAGTTCTGCTGCGGGCTCACCTTCGTCCGCTTGCAGGACGTGCAGTCTGCGGTCGCGTATCGATCG
CAAACTGTCAGCTTTCCTGT

Product: RTX toxin-activating lysine-acyltransferase

Products: NA

Alternate protein names: Leukotoxin C; Toxin-activating protein C [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MTETAKTEAAGGNSRAHGGAGEDTAQPTSPNIPRNPPPDAVLGQVVWLMMNMPRYRHVFLADLEWMVLPPILLNQYRLFR
AGDHIVAFAAWAYLSEEAEARLQEPNPRLAPTDWKSGDRLWLIDLHAPFGQQELALKELGETALKGKTYKMHRWTAQGRQ
TVEIVPQANS

Sequences:

>Translated_170_residues
MTETAKTEAAGGNSRAHGGAGEDTAQPTSPNIPRNPPPDAVLGQVVWLMMNMPRYRHVFLADLEWMVLPPILLNQYRLFR
AGDHIVAFAAWAYLSEEAEARLQEPNPRLAPTDWKSGDRLWLIDLHAPFGQQELALKELGETALKGKTYKMHRWTAQGRQ
TVEIVPQANS
>Mature_169_residues
TETAKTEAAGGNSRAHGGAGEDTAQPTSPNIPRNPPPDAVLGQVVWLMMNMPRYRHVFLADLEWMVLPPILLNQYRLFRA
GDHIVAFAAWAYLSEEAEARLQEPNPRLAPTDWKSGDRLWLIDLHAPFGQQELALKELGETALKGKTYKMHRWTAQGRQT
VEIVPQANS

Specific function: Involved in fatty acylation of the protoxin (lktA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP [H]

COG id: COG2994

COG function: function code O; ACP:hemolysin acyltransferase (hemolysin-activating protein)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RTX toxin acyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003996 [H]

Pfam domain/function: PF02794 HlyC [H]

EC number: NA

Molecular weight: Translated: 19023; Mature: 18892

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETAKTEAAGGNSRAHGGAGEDTAQPTSPNIPRNPPPDAVLGQVVWLMMNMPRYRHVFL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHEEEE
ADLEWMVLPPILLNQYRLFRAGDHIVAFAAWAYLSEEAEARLQEPNPRLAPTDWKSGDRL
ECCCHHHCCHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
WLIDLHAPFGQQELALKELGETALKGKTYKMHRWTAQGRQTVEIVPQANS
EEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCC
>Mature Secondary Structure 
TETAKTEAAGGNSRAHGGAGEDTAQPTSPNIPRNPPPDAVLGQVVWLMMNMPRYRHVFL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHEEEE
ADLEWMVLPPILLNQYRLFRAGDHIVAFAAWAYLSEEAEARLQEPNPRLAPTDWKSGDRL
ECCCHHHCCHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
WLIDLHAPFGQQELALKELGETALKGKTYKMHRWTAQGRQTVEIVPQANS
EEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8478098 [H]