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The map label for this gene is hisC [H]

Identifier: 146343243

GI number: 146343243

Start: 6716312

End: 6717415

Strand: Direct

Name: hisC [H]

Synonym: BRADO6463

Alternate gene names: 146343243

Gene position: 6716312-6717415 (Clockwise)

Preceding gene: 146343242

Following gene: 146343244

Centisome position: 90.07

GC content: 66.12

Gene sequence:

>1104_bases
TTGATGATGAACCGCCCCGTGCCGAACCCCGGCATTCTCGACATCGCGCCCTACACGCCCGGCAAGAGCCCCAAGCCGGA
GCCGGGCCGCAAGGTGTTCAAGCTTTCGGCCAATGAGACCCCGTTCGGCCCGTCGCCGAAGGCGATCGAAGCATTCAAGA
GCGCGGCCACGCATCTCGAGGATTATCCCGAAGGCACCTCGCGTGTGCTGCGCGAGGCGATCGGCCGCACCTACGGCCTC
GATCCCGACCGCATCGTCTGCGGCGCCGGCTCGGATGAACTGCTCAACCTGCTGGCGCACACCTTCCTGCGCGAGGGCGA
CGAGGCGATCTCCACCGCGCATGGCTTCCTGGTGTATCCGATCGCGACGATGGCCTGCGGCGCAAAGAACGTGGTTGCGT
CCGAGACCGAGTACCGCACCGACGTCGACGCGATCCTCGCCGCGGTGACGCCGCGGACCAAGCTGGTGTGGCTCGCCAAC
CCGAACAATCCGACCGGCACCTACATCCCGTTCGACGAGGTCAAGCGGCTGCGCAACGGTCTGCCCTCGCATGTCGTGCT
CGTGCTCGACGCGGCCTATGCCGATTACGTCTCGCGCAACGACTACGAGTTCGGCCTCGAGCTGGTGGCCACCACCGAGA
ACACGGTGGTGACGCACACCTTCTCGAAGATCCACGGCCTCGCCGCGCTGCGCGTCGGCTGGATGTTCGGCCCGGCGCAC
ATCGTCGACGCCATCAACCGCATCCGCGGGCCCTTCAACGTCTCGTCACCGGCCATGCTGGCGGCGGTCGCGGCGATCGA
GGATACCGCGCATCAGCAGATGTCCAAGACGCACACGGAAAAATGGCGCAACTGGCTGAGCGAGGAAATCGGCAAGCTCG
GGCTGAAGGTGACGCCGAGCGTCACGAACTTCATCCTGATCCACTTCCCGACCGAGGAGGGCAAGACGGCGGTCGAGGCC
GACGCATTCCTGACCCGCCGCGGCCTCGTGCTGCGCGCTCTGGCCAACTACAAGCTGCCGAACGCGCTGCGCCTGACCAT
CGGCACCGAGGAAGCCAACCGCCTGGTGGTCGAGGCGCTCAGCGAATTCATGAGGGCCAAGTGA

Upstream 100 bases:

>100_bases
GCAGGCGCCTCGGTGCGCTCCGCGGCCCTCGTCGGCGGCCACGCCAAACGCTATACGGTTCCGAGCTGAGACGCCGCGCG
CCAGTGACCATTCTTCGGAG

Downstream 100 bases:

>100_bases
GCGTCTCTGGACGGTTCGAACGCATCGCGCTGATCGGCTTCGGCCTGATCGGCGGCTCGATCGCACGTGCGGCACGTCTG
CAGGGCGTGGCCGGCGAGAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MMMNRPVPNPGILDIAPYTPGKSPKPEPGRKVFKLSANETPFGPSPKAIEAFKSAATHLEDYPEGTSRVLREAIGRTYGL
DPDRIVCGAGSDELLNLLAHTFLREGDEAISTAHGFLVYPIATMACGAKNVVASETEYRTDVDAILAAVTPRTKLVWLAN
PNNPTGTYIPFDEVKRLRNGLPSHVVLVLDAAYADYVSRNDYEFGLELVATTENTVVTHTFSKIHGLAALRVGWMFGPAH
IVDAINRIRGPFNVSSPAMLAAVAAIEDTAHQQMSKTHTEKWRNWLSEEIGKLGLKVTPSVTNFILIHFPTEEGKTAVEA
DAFLTRRGLVLRALANYKLPNALRLTIGTEEANRLVVEALSEFMRAK

Sequences:

>Translated_367_residues
MMMNRPVPNPGILDIAPYTPGKSPKPEPGRKVFKLSANETPFGPSPKAIEAFKSAATHLEDYPEGTSRVLREAIGRTYGL
DPDRIVCGAGSDELLNLLAHTFLREGDEAISTAHGFLVYPIATMACGAKNVVASETEYRTDVDAILAAVTPRTKLVWLAN
PNNPTGTYIPFDEVKRLRNGLPSHVVLVLDAAYADYVSRNDYEFGLELVATTENTVVTHTFSKIHGLAALRVGWMFGPAH
IVDAINRIRGPFNVSSPAMLAAVAAIEDTAHQQMSKTHTEKWRNWLSEEIGKLGLKVTPSVTNFILIHFPTEEGKTAVEA
DAFLTRRGLVLRALANYKLPNALRLTIGTEEANRLVVEALSEFMRAK
>Mature_367_residues
MMMNRPVPNPGILDIAPYTPGKSPKPEPGRKVFKLSANETPFGPSPKAIEAFKSAATHLEDYPEGTSRVLREAIGRTYGL
DPDRIVCGAGSDELLNLLAHTFLREGDEAISTAHGFLVYPIATMACGAKNVVASETEYRTDVDAILAAVTPRTKLVWLAN
PNNPTGTYIPFDEVKRLRNGLPSHVVLVLDAAYADYVSRNDYEFGLELVATTENTVVTHTFSKIHGLAALRVGWMFGPAH
IVDAINRIRGPFNVSSPAMLAAVAAIEDTAHQQMSKTHTEKWRNWLSEEIGKLGLKVTPSVTNFILIHFPTEEGKTAVEA
DAFLTRRGLVLRALANYKLPNALRLTIGTEEANRLVVEALSEFMRAK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=357, Percent_Identity=25.2100840336134, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786816, Length=308, Percent_Identity=24.6753246753247, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=393, Percent_Identity=25.4452926208651, Blast_Score=97, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40172; Mature: 40172

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMNRPVPNPGILDIAPYTPGKSPKPEPGRKVFKLSANETPFGPSPKAIEAFKSAATHLE
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
DYPEGTSRVLREAIGRTYGLDPDRIVCGAGSDELLNLLAHTFLREGDEAISTAHGFLVYP
HCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHH
IATMACGAKNVVASETEYRTDVDAILAAVTPRTKLVWLANPNNPTGTYIPFDEVKRLRNG
HHHHHCCCCCHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCC
LPSHVVLVLDAAYADYVSRNDYEFGLELVATTENTVVTHTFSKIHGLAALRVGWMFGPAH
CCCEEEEEEEHHHHHHHCCCCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCCHHH
IVDAINRIRGPFNVSSPAMLAAVAAIEDTAHQQMSKTHTEKWRNWLSEEIGKLGLKVTPS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
VTNFILIHFPTEEGKTAVEADAFLTRRGLVLRALANYKLPNALRLTIGTEEANRLVVEAL
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHH
SEFMRAK
HHHHHCC
>Mature Secondary Structure
MMMNRPVPNPGILDIAPYTPGKSPKPEPGRKVFKLSANETPFGPSPKAIEAFKSAATHLE
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
DYPEGTSRVLREAIGRTYGLDPDRIVCGAGSDELLNLLAHTFLREGDEAISTAHGFLVYP
HCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHH
IATMACGAKNVVASETEYRTDVDAILAAVTPRTKLVWLANPNNPTGTYIPFDEVKRLRNG
HHHHHCCCCCHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCC
LPSHVVLVLDAAYADYVSRNDYEFGLELVATTENTVVTHTFSKIHGLAALRVGWMFGPAH
CCCEEEEEEEHHHHHHHCCCCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCCHHH
IVDAINRIRGPFNVSSPAMLAAVAAIEDTAHQQMSKTHTEKWRNWLSEEIGKLGLKVTPS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
VTNFILIHFPTEEGKTAVEADAFLTRRGLVLRALANYKLPNALRLTIGTEEANRLVVEAL
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHH
SEFMRAK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]