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The map label for this gene is hemH [H]

Identifier: 146343058

GI number: 146343058

Start: 6494745

End: 6495842

Strand: Reverse

Name: hemH [H]

Synonym: BRADO6249

Alternate gene names: 146343058

Gene position: 6495842-6494745 (Counterclockwise)

Preceding gene: 146343061

Following gene: 146343057

Centisome position: 87.12

GC content: 61.48

Gene sequence:

>1098_bases
ATGACCGCCGCCATCTCTCTCGACAATGCCAGGTCTGTCGAAGCCAAGCCGGTTGAAGCAAAGCCGGTTGAAGCAAAGCC
TGTCGATTTGAAGCCGTCCTCCGCCGCGAAGACGGAGCGGGTCGGCGTGCTGCTGGTCAATCTCGGTACGCCCGACACGG
CCGATGCCGCCGGCGTGCGCGTCTATCTCAAGGAATTCCTGTCCGATCGCCGCGTGATCGAGGACCAGGGCCTGCTGTGG
AAGATCATTCTCAACGGCATCATCCTGAACGTCCGGCCGCGCAAGAAGGCGAAAGATTACCAGTCGATCTGGAACAATGA
GAAGAACGAATCGCCGCTGAAGACGATCACGCGCGCGCAGAGCGAGAAGCTCGCGGCCGCCATGGCCGACCGCAGCCATG
TCATCGTCGACTGGGCGATGCGCTACGGCAATCCGTCGATGAAGGCGGGCATCGACGGGCTGAAGGCCAAAGGGTGCGAT
CGCATCCTGGTGGTGCCGCTCTATCCGCAATATTCGGCGGCGACCTCGGCAACGGTGTGCGACGAGGCCTTTCGCGTGCT
GACGGAGATGCGCGCGCAGCCGACCATCCGGGTGACGCCGCCCTATTACAACGATGATTTCTACATCGAGGCGCTCGCCG
TCTCGATCGAGGAGCACCTCAAGACGCTGTCGTACACGCCCGAGCTGATCGTGGCCTCGTTCCACGGCATGCCCAAGGAA
TATGTCGACAAGGGCGATCCCTATCGCGAGCAATGCATCGCCACGACCGAGCTGCTGCGCAAGCGGCTCGGCATGGACGA
AACCAAGCTGTTGCTGACCTTTCAATCGCGCTTCGGCTTCTCGGAATGGCTGCAGCCCTACACCGACAAGACCATCGAGA
AGCTCGCCAAGGACGGCGTCAAGCGCATGGCCGTTGTGATGCCGGGCTTTTCCGCCGATTGCCTGGAAACGCTGGAAGAG
ATCTCCGGCGAGAACTGCGAGATCTTCAAGCACAATGGCGGCGAGGAATTTTCCGCTGTGCCATGCCTGAACGACAGTGA
ACCGGGCATGGAGGTCCTGCGGCAATTGGTGCTGCGCGAGCTGCAGGGCTGGCTCTGA

Upstream 100 bases:

>100_bases
GTCATGGCTCCTCCAGCCGGATGACATCGGTGAAATGGCCCTTATCTTGACAACGTTGAAACAAGCCGCCAAGCCACGCC
CTTCACCAGTCACGGGCATC

Downstream 100 bases:

>100_bases
GCATCCTCGGCCGTTGCCGACCGCTAGGTCGGCTTCACGCGGGAACAAGGTTAACGGCCGCGCGGCCGCCGAAATATCTT
TCCTGAACCGCGCCCATCGG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MTAAISLDNARSVEAKPVEAKPVEAKPVDLKPSSAAKTERVGVLLVNLGTPDTADAAGVRVYLKEFLSDRRVIEDQGLLW
KIILNGIILNVRPRKKAKDYQSIWNNEKNESPLKTITRAQSEKLAAAMADRSHVIVDWAMRYGNPSMKAGIDGLKAKGCD
RILVVPLYPQYSAATSATVCDEAFRVLTEMRAQPTIRVTPPYYNDDFYIEALAVSIEEHLKTLSYTPELIVASFHGMPKE
YVDKGDPYREQCIATTELLRKRLGMDETKLLLTFQSRFGFSEWLQPYTDKTIEKLAKDGVKRMAVVMPGFSADCLETLEE
ISGENCEIFKHNGGEEFSAVPCLNDSEPGMEVLRQLVLRELQGWL

Sequences:

>Translated_365_residues
MTAAISLDNARSVEAKPVEAKPVEAKPVDLKPSSAAKTERVGVLLVNLGTPDTADAAGVRVYLKEFLSDRRVIEDQGLLW
KIILNGIILNVRPRKKAKDYQSIWNNEKNESPLKTITRAQSEKLAAAMADRSHVIVDWAMRYGNPSMKAGIDGLKAKGCD
RILVVPLYPQYSAATSATVCDEAFRVLTEMRAQPTIRVTPPYYNDDFYIEALAVSIEEHLKTLSYTPELIVASFHGMPKE
YVDKGDPYREQCIATTELLRKRLGMDETKLLLTFQSRFGFSEWLQPYTDKTIEKLAKDGVKRMAVVMPGFSADCLETLEE
ISGENCEIFKHNGGEEFSAVPCLNDSEPGMEVLRQLVLRELQGWL
>Mature_364_residues
TAAISLDNARSVEAKPVEAKPVEAKPVDLKPSSAAKTERVGVLLVNLGTPDTADAAGVRVYLKEFLSDRRVIEDQGLLWK
IILNGIILNVRPRKKAKDYQSIWNNEKNESPLKTITRAQSEKLAAAMADRSHVIVDWAMRYGNPSMKAGIDGLKAKGCDR
ILVVPLYPQYSAATSATVCDEAFRVLTEMRAQPTIRVTPPYYNDDFYIEALAVSIEEHLKTLSYTPELIVASFHGMPKEY
VDKGDPYREQCIATTELLRKRLGMDETKLLLTFQSRFGFSEWLQPYTDKTIEKLAKDGVKRMAVVMPGFSADCLETLEEI
SGENCEIFKHNGGEEFSAVPCLNDSEPGMEVLRQLVLRELQGWL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=359, Percent_Identity=25.3481894150418, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI60499025, Length=345, Percent_Identity=24.9275362318841, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786681, Length=321, Percent_Identity=42.0560747663551, Blast_Score=251, Evalue=7e-68,
Organism=Drosophila melanogaster, GI17864156, Length=341, Percent_Identity=24.9266862170088, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 40834; Mature: 40703

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAISLDNARSVEAKPVEAKPVEAKPVDLKPSSAAKTERVGVLLVNLGTPDTADAAGVR
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHH
VYLKEFLSDRRVIEDQGLLWKIILNGIILNVRPRKKAKDYQSIWNNEKNESPLKTITRAQ
HHHHHHHHCCCEECCCCCHHEEECCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
SEKLAAAMADRSHVIVDWAMRYGNPSMKAGIDGLKAKGCDRILVVPLYPQYSAATSATVC
HHHHHHHHHCCCEEEEEHHHHCCCCCHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHH
DEAFRVLTEMRAQPTIRVTPPYYNDDFYIEALAVSIEEHLKTLSYTPELIVASFHGMPKE
HHHHHHHHHHHCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHH
YVDKGDPYREQCIATTELLRKRLGMDETKLLLTFQSRFGFSEWLQPYTDKTIEKLAKDGV
HHCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHH
KRMAVVMPGFSADCLETLEEISGENCEIFKHNGGEEFSAVPCLNDSEPGMEVLRQLVLRE
HHEEHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LQGWL
HHCCC
>Mature Secondary Structure 
TAAISLDNARSVEAKPVEAKPVEAKPVDLKPSSAAKTERVGVLLVNLGTPDTADAAGVR
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHH
VYLKEFLSDRRVIEDQGLLWKIILNGIILNVRPRKKAKDYQSIWNNEKNESPLKTITRAQ
HHHHHHHHCCCEECCCCCHHEEECCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
SEKLAAAMADRSHVIVDWAMRYGNPSMKAGIDGLKAKGCDRILVVPLYPQYSAATSATVC
HHHHHHHHHCCCEEEEEHHHHCCCCCHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHH
DEAFRVLTEMRAQPTIRVTPPYYNDDFYIEALAVSIEEHLKTLSYTPELIVASFHGMPKE
HHHHHHHHHHHCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHH
YVDKGDPYREQCIATTELLRKRLGMDETKLLLTFQSRFGFSEWLQPYTDKTIEKLAKDGV
HHCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHH
KRMAVVMPGFSADCLETLEEISGENCEIFKHNGGEEFSAVPCLNDSEPGMEVLRQLVLRE
HHEEHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LQGWL
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA