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The map label for this gene is argE [C]

Identifier: 146342966

GI number: 146342966

Start: 6372880

End: 6374262

Strand: Reverse

Name: argE [C]

Synonym: BRADO6149

Alternate gene names: 146342966

Gene position: 6374262-6372880 (Counterclockwise)

Preceding gene: 146342967

Following gene: 146342965

Centisome position: 85.48

GC content: 66.67

Gene sequence:

>1383_bases
ATGACCAGGATTGATGCAATCGCCCGTGCCCGTCAGAGCCTGACCAGCGGTGACTTCCTGGCCGAGCTCGGCCGCCGCGT
CGCCTATCGCACCGAGAGCCTCAATCCCGAGCGGAAAGAGGAGCTCGCATCCTATCTCACCAACGAGCTGACGCCGTCCT
TTGCCGAACTCGGCTTCACCTCCGAGCTCGTGGCCTCGCCGAGCGGCCGCTCGCCGTTCCTGATTGCAACCTGTCATGAG
AGCGACAGCGCCCCGACCGTGCTGAGCTACGGCCATGGTGACACCGTCGACGGCATGACCGGCGAATGGCGTGACGGCCG
CGATCCCTGGTCGGTGACGCCGGCGGGCAATCGCCTTTATGGCCGTGGCACCGCCGACAACAAGGGCCAGCACAGCATCA
ACATGGCGGCGCTGCGCGCGGTGCGCGAGGCCCGCGGCGGCAAGCTCGGCTTCAATGCCAAATTCATCATCGAGATGGGC
GAGGAGATCGGCTCGCCGGATCTCGCCAAGGTGGCCGACCTCAAGCGCGAGGCGCTCAAGGCCGACGTCTTCATCGGCTC
CGATGGCCCGCGGCTGTCGACCGCGCGTCCCACCATCTTTCTCGGCTGCCGCGGCGGCATCCGGCTGCATCTCGACGTCA
ATCTGCGCGAGGGCGGCAATCACTCCGGCAATTGGGGCGGCGTGCTCGCCAACCCCGCCACCATCCTCGCCAATGCGATC
GCGACGCTGGTCGACGGCCACGGCCGCATCAAACTGGAGTCGCTGAAGCCGCCGCGCCTCACCAACGCGATCCGCGCCAT
CCTCGCCGACGTGAAGGTCGAGCCGACCGCCGACGAGCCGGCGCTGTCGGACAATTGGGGCGAGGAAGGTCTGACGCCGG
CGGAGCGGCTGTATGCCTGGAACACGCTCGAGGTGCTGGCGATATCCTCCGGCAATATCGACAAGCCGGCGAACGCGATT
CCGGGCCGCGCCCGCGCCGTGCTGCAACTGCGCTTCGTGGTCGGCACCAAGGTCGACACCATCGTCGAGGACGTGAAGGC
CCATCTCGTCGCACACGGCTTCCCGATGATCGATGTCACCATGACGCAAGGCTTCGCGGCCTCGCGCGCCGACATCGACA
GCCCCTGGATCAAATGGGCCGCGGACTCCATCAGGATGAGCACCGGCAAGCCGCCCGCCGTGCTGCCGAACTTCGGCGGC
TCGCTGCCGAACGACGTGTTTGCCGACGTGCTGAAGATGCCGACCATGTGGGTCCCGCACTCCTACCCCGGCTGCTCGCA
GCACGCGCCGGACGAGCACATTCTTCTGGATGTTACGGAAGAGGCGTTGGGTTTGATGGCGGGACTGTTCTGGGATCTGG
GCGAGTTGCGGAAGCCGCTGTGA

Upstream 100 bases:

>100_bases
CCGAGACCAGGCCGATGCTCTACTGAATTCAAAGCCAGCCCCTTCCGCTGGCCCCATGATCCCGATATGACGCCGCCTTC
GTCGTGACTGGAAAAGCGCC

Downstream 100 bases:

>100_bases
GTTGGGGAGAAGGATGAGAACACCTCGCTTGGAGCCGGTGGTGCTGATCGCTCACTGCTTGAGACGGCTAGGCAAGAGTT
GTTGCGGCGATGTTCATCGC

Product: hypothetical protein

Products: Acetate; Ornithine [C]

Alternate protein names: Peptidase; M20/M25/M40 Family Peptidase; Peptidase Family; Succinyl-Diaminopimelate Desuccinylase; Peptidase Dimerisation Domain Protein; ArgE/DapE/Acy1 Family Protein; Beta-Ala-His Dipeptidase; Peptidase Dimerisation Domain-Containing Protein; Deacylase; Peptidase Dimerization Domain Protein; N-Acyl-L-Amino Acid Amidohydrolase; Acetylornithine Deacetylase; Desuccinylase Deacetylase Or Peptidase; Acetylornithine Deacetylase ArgE; N-Succinyl-Diaminopimelate Deacylase; ArgE/DapE/Acy1 Family Peptidase

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTRIDAIARARQSLTSGDFLAELGRRVAYRTESLNPERKEELASYLTNELTPSFAELGFTSELVASPSGRSPFLIATCHE
SDSAPTVLSYGHGDTVDGMTGEWRDGRDPWSVTPAGNRLYGRGTADNKGQHSINMAALRAVREARGGKLGFNAKFIIEMG
EEIGSPDLAKVADLKREALKADVFIGSDGPRLSTARPTIFLGCRGGIRLHLDVNLREGGNHSGNWGGVLANPATILANAI
ATLVDGHGRIKLESLKPPRLTNAIRAILADVKVEPTADEPALSDNWGEEGLTPAERLYAWNTLEVLAISSGNIDKPANAI
PGRARAVLQLRFVVGTKVDTIVEDVKAHLVAHGFPMIDVTMTQGFAASRADIDSPWIKWAADSIRMSTGKPPAVLPNFGG
SLPNDVFADVLKMPTMWVPHSYPGCSQHAPDEHILLDVTEEALGLMAGLFWDLGELRKPL

Sequences:

>Translated_460_residues
MTRIDAIARARQSLTSGDFLAELGRRVAYRTESLNPERKEELASYLTNELTPSFAELGFTSELVASPSGRSPFLIATCHE
SDSAPTVLSYGHGDTVDGMTGEWRDGRDPWSVTPAGNRLYGRGTADNKGQHSINMAALRAVREARGGKLGFNAKFIIEMG
EEIGSPDLAKVADLKREALKADVFIGSDGPRLSTARPTIFLGCRGGIRLHLDVNLREGGNHSGNWGGVLANPATILANAI
ATLVDGHGRIKLESLKPPRLTNAIRAILADVKVEPTADEPALSDNWGEEGLTPAERLYAWNTLEVLAISSGNIDKPANAI
PGRARAVLQLRFVVGTKVDTIVEDVKAHLVAHGFPMIDVTMTQGFAASRADIDSPWIKWAADSIRMSTGKPPAVLPNFGG
SLPNDVFADVLKMPTMWVPHSYPGCSQHAPDEHILLDVTEEALGLMAGLFWDLGELRKPL
>Mature_459_residues
TRIDAIARARQSLTSGDFLAELGRRVAYRTESLNPERKEELASYLTNELTPSFAELGFTSELVASPSGRSPFLIATCHES
DSAPTVLSYGHGDTVDGMTGEWRDGRDPWSVTPAGNRLYGRGTADNKGQHSINMAALRAVREARGGKLGFNAKFIIEMGE
EIGSPDLAKVADLKREALKADVFIGSDGPRLSTARPTIFLGCRGGIRLHLDVNLREGGNHSGNWGGVLANPATILANAIA
TLVDGHGRIKLESLKPPRLTNAIRAILADVKVEPTADEPALSDNWGEEGLTPAERLYAWNTLEVLAISSGNIDKPANAIP
GRARAVLQLRFVVGTKVDTIVEDVKAHLVAHGFPMIDVTMTQGFAASRADIDSPWIKWAADSIRMSTGKPPAVLPNFGGS
LPNDVFADVLKMPTMWVPHSYPGCSQHAPDEHILLDVTEEALGLMAGLFWDLGELRKPL

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI21071039, Length=414, Percent_Identity=27.7777777777778, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI271398239, Length=468, Percent_Identity=22.6495726495727, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17563146, Length=249, Percent_Identity=29.3172690763052, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319758, Length=359, Percent_Identity=24.7910863509749, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585880, Length=245, Percent_Identity=27.7551020408163, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.5.1.16 [C]

Molecular weight: Translated: 49563; Mature: 49432

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIDAIARARQSLTSGDFLAELGRRVAYRTESLNPERKEELASYLTNELTPSFAELGFT
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCC
SELVASPSGRSPFLIATCHESDSAPTVLSYGHGDTVDGMTGEWRDGRDPWSVTPAGNRLY
HHHHCCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCEEE
GRGTADNKGQHSINMAALRAVREARGGKLGFNAKFIIEMGEEIGSPDLAKVADLKREALK
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHE
ADVFIGSDGPRLSTARPTIFLGCRGGIRLHLDVNLREGGNHSGNWGGVLANPATILANAI
EEEEECCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCCEECCHHHHHHHHH
ATLVDGHGRIKLESLKPPRLTNAIRAILADVKVEPTADEPALSDNWGEEGLTPAERLYAW
HHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHEEC
NTLEVLAISSGNIDKPANAIPGRARAVLQLRFVVGTKVDTIVEDVKAHLVAHGFPMIDVT
CCEEEEEECCCCCCCCCCCCCCHHEEEEEEEHHHCCHHHHHHHHHHHHHHHCCCCEEEEE
MTQGFAASRADIDSPWIKWAADSIRMSTGKPPAVLPNFGGSLPNDVFADVLKMPTMWVPH
ECCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCEECCC
SYPGCSQHAPDEHILLDVTEEALGLMAGLFWDLGELRKPL
CCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRIDAIARARQSLTSGDFLAELGRRVAYRTESLNPERKEELASYLTNELTPSFAELGFT
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCC
SELVASPSGRSPFLIATCHESDSAPTVLSYGHGDTVDGMTGEWRDGRDPWSVTPAGNRLY
HHHHCCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCEEE
GRGTADNKGQHSINMAALRAVREARGGKLGFNAKFIIEMGEEIGSPDLAKVADLKREALK
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHE
ADVFIGSDGPRLSTARPTIFLGCRGGIRLHLDVNLREGGNHSGNWGGVLANPATILANAI
EEEEECCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCCEECCHHHHHHHHH
ATLVDGHGRIKLESLKPPRLTNAIRAILADVKVEPTADEPALSDNWGEEGLTPAERLYAW
HHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHEEC
NTLEVLAISSGNIDKPANAIPGRARAVLQLRFVVGTKVDTIVEDVKAHLVAHGFPMIDVT
CCEEEEEECCCCCCCCCCCCCCHHEEEEEEEHHHCCHHHHHHHHHHHHHHHCCCCEEEEE
MTQGFAASRADIDSPWIKWAADSIRMSTGKPPAVLPNFGGSLPNDVFADVLKMPTMWVPH
ECCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCEECCC
SYPGCSQHAPDEHILLDVTEEALGLMAGLFWDLGELRKPL
CCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-Acetyl-L-ornithine; H2O [C]

Specific reaction: N2-Acetyl-L-ornithine + H2O --> Acetate + Ornithine [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA