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The map label for this gene is bepE [H]

Identifier: 146342613

GI number: 146342613

Start: 5979288

End: 5981837

Strand: Direct

Name: bepE [H]

Synonym: BRADO5777

Alternate gene names: 146342613

Gene position: 5979288-5981837 (Clockwise)

Preceding gene: 146342609

Following gene: 146342616

Centisome position: 80.19

GC content: 65.33

Gene sequence:

>2550_bases
ATGGCGGAATTGTCGAAAAGCTTCCCGCAAGGAATTCAATACGACACGCCGTTCGACACCACCAAGTTCGTCAATGCCTC
GATCCACGAGGTCTACAAGACCTTGATCGAGGCCGGCGTGCTGGTGCTGATCGTGATCCTGATCTTCCTGCAGGACTGGC
GCGCGATGCTGGTGCCGACCACGACGGTGCCGGTGACGATCATCGGCGCCTTCGCGGCGATGGCGGCGCTCGGCTTCACC
ATCAACCTCTCGACCCTGTTCGCCATCGTGCTGGCGATCGGCATCGTGGTGGACGACGCGATCGTCGTCGTCGAGGGCGC
GGCCCACAATATCGAGCGCGGCATGAACGGCCACGACGCGGCGATCCGAGCGATGGACCAGCTGTTCGCACCGATCGTTG
GCGTCACGCTGGTGCTGATCGCCGTGTTCCTGCCCGCCGCCTTTCTGCCCGGCCTCACAGGGAGGATTTACGCCCAATTC
GCGCTGGTCATCGCCGCGACCGCCCTTCTCTCGGCCATCAATGCAGCAATGTTGAAACCGACGCAACGCGCGCTGTGGCT
GCGGCCTCCGGTGCCGGTGGAGAAGCGCAACATCGTCTATCGGGCCTTTAACAATCTCTATGCGCGGCTGGAGCGGCGCT
ACACCAATCTCATCGGGCGGCTTGTCAGGCACAGCACCGCATCCGTCGTCATCGCCCTGATCCTGATCGCAGCCGGCGGC
TATGGATTGTCGCGGGTGCCGACCGGCTTCCTGCCGATCGAGGACCAGGGCTATCTGATCGCCGCCATGCAGCTGCCCGA
CGGCGCCTCGCTGGAGCGGACCCAGAAGGCGCTCGACAGGGTCGGCACCATCGCGAAGGCCACGCCCGGCGTCGCCCAAA
TCATCACCATCGCCGGCATCTCCGCGCTCGACAACAGCGCCAGCCTCGCCAATTCCGGCGTCGCCTACATCATCCTCACG
GACTGGGAGTCGCGCGGCCAGGGTGAGGACCTGCGCTCCCTCGTCTACGGCCTCAACCACAGGCTCGCCGAGGTGATCGA
GGCGCGCAGCCTGGTGCTGCCGCCGCCGCCGATCCAGGGTATCGGCAATGCCGCCGGCTTCGCCATGCAGGTCGAGCTGC
GCGACGGCAACAGCGATTACGCCAAGCTCCAAGCGATGACGTCCGCGATCGTCGCCAGCGCTCAGAGCCAGAGCACGCTG
CAGCGCGTCCAATCGCCGTTCCGCGCCATGGTGCCGCAGTTCGACGTCGAGATCGACCGGGTGAAGACGCAGACCCTCCA
CGTTACCACCGACCAGGTGTTCTCGGCCTTGTCGTCCTACCTCGGCGCCTCCTACGTCAACCAGTTCAACAAGTTCGGCC
GCGTGTTCCAGGTCTATGTGCAGGCCGATTCCACCGCGCGGCTGACGCCGCGGCAGATCGAGAGCCTGATGGTGCGCAAC
CAGAGCGGCGACATGATCCCGCTCGGCACGGTGGCGACGGTCAAGCCCGCGGTCGGACCGTCGCTGATCAGCCTCTACAA
TCTTTATCCCTCCGCCACCGTCGTCGGCCTGCCGGCGCAGGGCTATTCGTCCGGGCAGTCGCTCAAGCTGATGGAACAGA
TCGCGCAACAGACGCTTCCACCGGGCGCGGGTTATGAATGGACTGCGATGTCGTATCAGGAGAAGGCCGTCTCGAATCAG
ATCTATCTCACCTTCGGTCTTGCTCTCCTCCTCGTCTATCTCGTGCTCGCCGGCCAGTATGAAAGCTGGTACGCGCCGGT
CTCAGTCATCCTCGCGGTGCCGCTGTCGCTGCTCGGGCCGATGGCGGTGCTGCTACTGCGTTCGCAGCGGCGTCTCCTTC
AATCCGTTGGCGTCGTAAGCCTTGCGCAGCAGCCCGTTCGAGGCCGCGTCGGTCATGAAGCTGCTGACGAAGGCCAGCGC
CTTGTCATGCCCGAGCGGGACAGCCACCGCCGTCACCGTCTTCTTGAAGGTCTCGTCGAGCACCCGCGTGCCCGGGATCT
TCCTGGCCATCGCGTCGAGCTGGTCGCGCGACAGGGCGAAGGCATCGATCTCGCCTCGCTGCAGCAGGCCGAAGATCTCG
TCATAGGTCTGATAGCCGGTGACGCTGGCGTTCTTCAGATGCGCCTTGGCGCCGCGCATCGTCGTCGTGTTGTTCACGGC
CGCGACCTTGATGCCCGGCTGGTCGAGGGCCGAAAAGCTCGTTACCGGCGAGCCCGGCTTGACGATGTAGGTCGCATCCG
CGACCTCGTAGATCGGGCCGAACGCCATCCTGGTCTCGCGCTCCGGATCCTTCGGCAGGAACGTCACATCCCAGGTGCCC
TTGTCGGCCGCATCGGTGATCTGGCCGGAGTTCTGGTGCACGACGTAGTCGACGGGCACACCGAGCCTGTCGGCCATCGC
GCGGCCGAGATCGACGGGGACGCCGGAATAGCCGGTCTCGGTCCTGGTCGACCAGAACGCGCCGCCCGCGGGGCTGATCG
CGATCGCCACGCGCAGCTTGCCGGTGGGCGCGATCTCGTCCTTCAGCTCGGCGGCTCCGCCGTGAGATGA

Upstream 100 bases:

>100_bases
TGTTTGTTGCTTGCCACTGCCATTGTCTCGACAGTCATTGCATATGGACCGCGGAATGACGCCGAGCAATTCTCCCCGAC
AGTCCCGCTCGACATCGAAG

Downstream 100 bases:

>100_bases
TGTCATCATGCTCGCCACGACGGCCAGCGCCGCCACGAGCAGCCCGCGCCACCGGCCCATCGTTCCCTCCCCGTTGTGTT
GGTGGACATCATGACGTGCG

Product: AcrB family metabolite exporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 849; Mature: 848

Protein sequence:

>849_residues
MAELSKSFPQGIQYDTPFDTTKFVNASIHEVYKTLIEAGVLVLIVILIFLQDWRAMLVPTTTVPVTIIGAFAAMAALGFT
INLSTLFAIVLAIGIVVDDAIVVVEGAAHNIERGMNGHDAAIRAMDQLFAPIVGVTLVLIAVFLPAAFLPGLTGRIYAQF
ALVIAATALLSAINAAMLKPTQRALWLRPPVPVEKRNIVYRAFNNLYARLERRYTNLIGRLVRHSTASVVIALILIAAGG
YGLSRVPTGFLPIEDQGYLIAAMQLPDGASLERTQKALDRVGTIAKATPGVAQIITIAGISALDNSASLANSGVAYIILT
DWESRGQGEDLRSLVYGLNHRLAEVIEARSLVLPPPPIQGIGNAAGFAMQVELRDGNSDYAKLQAMTSAIVASAQSQSTL
QRVQSPFRAMVPQFDVEIDRVKTQTLHVTTDQVFSALSSYLGASYVNQFNKFGRVFQVYVQADSTARLTPRQIESLMVRN
QSGDMIPLGTVATVKPAVGPSLISLYNLYPSATVVGLPAQGYSSGQSLKLMEQIAQQTLPPGAGYEWTAMSYQEKAVSNQ
IYLTFGLALLLVYLVLAGQYESWYAPVSVILAVPLSLLGPMAVLLLRSQRRLLQSVGVVSLAQQPVRGRVGHEAADEGQR
LVMPERDSHRRHRLLEGLVEHPRARDLPGHRVELVARQGEGIDLASLQQAEDLVIGLIAGDAGVLQMRLGAAHRRRVVHG
RDLDARLVEGRKARYRRARLDDVGRIRDLVDRAERHPGLALRILRQERHIPGALVGRIGDLAGVLVHDVVDGHTEPVGHR
AAEIDGDAGIAGLGPGRPERAARGADRDRHAQLAGGRDLVLQLGGSAVR

Sequences:

>Translated_849_residues
MAELSKSFPQGIQYDTPFDTTKFVNASIHEVYKTLIEAGVLVLIVILIFLQDWRAMLVPTTTVPVTIIGAFAAMAALGFT
INLSTLFAIVLAIGIVVDDAIVVVEGAAHNIERGMNGHDAAIRAMDQLFAPIVGVTLVLIAVFLPAAFLPGLTGRIYAQF
ALVIAATALLSAINAAMLKPTQRALWLRPPVPVEKRNIVYRAFNNLYARLERRYTNLIGRLVRHSTASVVIALILIAAGG
YGLSRVPTGFLPIEDQGYLIAAMQLPDGASLERTQKALDRVGTIAKATPGVAQIITIAGISALDNSASLANSGVAYIILT
DWESRGQGEDLRSLVYGLNHRLAEVIEARSLVLPPPPIQGIGNAAGFAMQVELRDGNSDYAKLQAMTSAIVASAQSQSTL
QRVQSPFRAMVPQFDVEIDRVKTQTLHVTTDQVFSALSSYLGASYVNQFNKFGRVFQVYVQADSTARLTPRQIESLMVRN
QSGDMIPLGTVATVKPAVGPSLISLYNLYPSATVVGLPAQGYSSGQSLKLMEQIAQQTLPPGAGYEWTAMSYQEKAVSNQ
IYLTFGLALLLVYLVLAGQYESWYAPVSVILAVPLSLLGPMAVLLLRSQRRLLQSVGVVSLAQQPVRGRVGHEAADEGQR
LVMPERDSHRRHRLLEGLVEHPRARDLPGHRVELVARQGEGIDLASLQQAEDLVIGLIAGDAGVLQMRLGAAHRRRVVHG
RDLDARLVEGRKARYRRARLDDVGRIRDLVDRAERHPGLALRILRQERHIPGALVGRIGDLAGVLVHDVVDGHTEPVGHR
AAEIDGDAGIAGLGPGRPERAARGADRDRHAQLAGGRDLVLQLGGSAVR
>Mature_848_residues
AELSKSFPQGIQYDTPFDTTKFVNASIHEVYKTLIEAGVLVLIVILIFLQDWRAMLVPTTTVPVTIIGAFAAMAALGFTI
NLSTLFAIVLAIGIVVDDAIVVVEGAAHNIERGMNGHDAAIRAMDQLFAPIVGVTLVLIAVFLPAAFLPGLTGRIYAQFA
LVIAATALLSAINAAMLKPTQRALWLRPPVPVEKRNIVYRAFNNLYARLERRYTNLIGRLVRHSTASVVIALILIAAGGY
GLSRVPTGFLPIEDQGYLIAAMQLPDGASLERTQKALDRVGTIAKATPGVAQIITIAGISALDNSASLANSGVAYIILTD
WESRGQGEDLRSLVYGLNHRLAEVIEARSLVLPPPPIQGIGNAAGFAMQVELRDGNSDYAKLQAMTSAIVASAQSQSTLQ
RVQSPFRAMVPQFDVEIDRVKTQTLHVTTDQVFSALSSYLGASYVNQFNKFGRVFQVYVQADSTARLTPRQIESLMVRNQ
SGDMIPLGTVATVKPAVGPSLISLYNLYPSATVVGLPAQGYSSGQSLKLMEQIAQQTLPPGAGYEWTAMSYQEKAVSNQI
YLTFGLALLLVYLVLAGQYESWYAPVSVILAVPLSLLGPMAVLLLRSQRRLLQSVGVVSLAQQPVRGRVGHEAADEGQRL
VMPERDSHRRHRLLEGLVEHPRARDLPGHRVELVARQGEGIDLASLQQAEDLVIGLIAGDAGVLQMRLGAAHRRRVVHGR
DLDARLVEGRKARYRRARLDDVGRIRDLVDRAERHPGLALRILRQERHIPGALVGRIGDLAGVLVHDVVDGHTEPVGHRA
AEIDGDAGIAGLGPGRPERAARGADRDRHAQLAGGRDLVLQLGGSAVR

Specific function: Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics [H]

COG id: COG0841

COG function: function code V; Cation/multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AcrB/AcrD/AcrF (TC 2.A.6) family [H]

Homologues:

Organism=Escherichia coli, GI1786667, Length=630, Percent_Identity=35.8730158730159, Blast_Score=391, Evalue=1e-109,
Organism=Escherichia coli, GI1789666, Length=621, Percent_Identity=37.5201288244767, Blast_Score=387, Evalue=1e-108,
Organism=Escherichia coli, GI1788814, Length=673, Percent_Identity=34.3239227340267, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1789930, Length=610, Percent_Identity=37.2131147540984, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1788390, Length=614, Percent_Identity=23.7785016286645, Blast_Score=169, Evalue=7e-43,
Organism=Escherichia coli, GI1788391, Length=625, Percent_Identity=26.24, Blast_Score=169, Evalue=9e-43,
Organism=Escherichia coli, GI1786788, Length=622, Percent_Identity=20.9003215434084, Blast_Score=109, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001036
- InterPro:   IPR004764 [H]

Pfam domain/function: PF00873 ACR_tran [H]

EC number: NA

Molecular weight: Translated: 91672; Mature: 91540

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELSKSFPQGIQYDTPFDTTKFVNASIHEVYKTLIEAGVLVLIVILIFLQDWRAMLVPT
CCCCCHHCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECC
TTVPVTIIGAFAAMAALGFTINLSTLFAIVLAIGIVVDDAIVVVEGAAHNIERGMNGHDA
CCHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCCHHH
AIRAMDQLFAPIVGVTLVLIAVFLPAAFLPGLTGRIYAQFALVIAATALLSAINAAMLKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
TQRALWLRPPVPVEKRNIVYRAFNNLYARLERRYTNLIGRLVRHSTASVVIALILIAAGG
CHHCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YGLSRVPTGFLPIEDQGYLIAAMQLPDGASLERTQKALDRVGTIAKATPGVAQIITIAGI
CCCCCCCCCCEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SALDNSASLANSGVAYIILTDWESRGQGEDLRSLVYGLNHRLAEVIEARSLVLPPPPIQG
HHCCCCHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IGNAAGFAMQVELRDGNSDYAKLQAMTSAIVASAQSQSTLQRVQSPFRAMVPQFDVEIDR
CCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
VKTQTLHVTTDQVFSALSSYLGASYVNQFNKFGRVFQVYVQADSTARLTPRQIESLMVRN
EEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHCC
QSGDMIPLGTVATVKPAVGPSLISLYNLYPSATVVGLPAQGYSSGQSLKLMEQIAQQTLP
CCCCEEECCCHHCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC
PGAGYEWTAMSYQEKAVSNQIYLTFGLALLLVYLVLAGQYESWYAPVSVILAVPLSLLGP
CCCCCCEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MAVLLLRSQRRLLQSVGVVSLAQQPVRGRVGHEAADEGQRLVMPERDSHRRHRLLEGLVE
HHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHCCCCEEECCCCCCHHHHHHHHHHHC
HPRARDLPGHRVELVARQGEGIDLASLQQAEDLVIGLIAGDAGVLQMRLGAAHRRRVVHG
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHCCC
RDLDARLVEGRKARYRRARLDDVGRIRDLVDRAERHPGLALRILRQERHIPGALVGRIGD
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
LAGVLVHDVVDGHTEPVGHRAAEIDGDAGIAGLGPGRPERAARGADRDRHAQLAGGRDLV
HHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCEEE
LQLGGSAVR
EECCCCCCC
>Mature Secondary Structure 
AELSKSFPQGIQYDTPFDTTKFVNASIHEVYKTLIEAGVLVLIVILIFLQDWRAMLVPT
CCCCHHCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECC
TTVPVTIIGAFAAMAALGFTINLSTLFAIVLAIGIVVDDAIVVVEGAAHNIERGMNGHDA
CCHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCCHHH
AIRAMDQLFAPIVGVTLVLIAVFLPAAFLPGLTGRIYAQFALVIAATALLSAINAAMLKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
TQRALWLRPPVPVEKRNIVYRAFNNLYARLERRYTNLIGRLVRHSTASVVIALILIAAGG
CHHCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YGLSRVPTGFLPIEDQGYLIAAMQLPDGASLERTQKALDRVGTIAKATPGVAQIITIAGI
CCCCCCCCCCEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SALDNSASLANSGVAYIILTDWESRGQGEDLRSLVYGLNHRLAEVIEARSLVLPPPPIQG
HHCCCCHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IGNAAGFAMQVELRDGNSDYAKLQAMTSAIVASAQSQSTLQRVQSPFRAMVPQFDVEIDR
CCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
VKTQTLHVTTDQVFSALSSYLGASYVNQFNKFGRVFQVYVQADSTARLTPRQIESLMVRN
EEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHCC
QSGDMIPLGTVATVKPAVGPSLISLYNLYPSATVVGLPAQGYSSGQSLKLMEQIAQQTLP
CCCCEEECCCHHCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC
PGAGYEWTAMSYQEKAVSNQIYLTFGLALLLVYLVLAGQYESWYAPVSVILAVPLSLLGP
CCCCCCEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MAVLLLRSQRRLLQSVGVVSLAQQPVRGRVGHEAADEGQRLVMPERDSHRRHRLLEGLVE
HHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHCCCCEEECCCCCCHHHHHHHHHHHC
HPRARDLPGHRVELVARQGEGIDLASLQQAEDLVIGLIAGDAGVLQMRLGAAHRRRVVHG
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHCCC
RDLDARLVEGRKARYRRARLDDVGRIRDLVDRAERHPGLALRILRQERHIPGALVGRIGD
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
LAGVLVHDVVDGHTEPVGHRAAEIDGDAGIAGLGPGRPERAARGADRDRHAQLAGGRDLV
HHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCEEE
LQLGGSAVR
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]