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The map label for this gene is macA [H]

Identifier: 146342523

GI number: 146342523

Start: 5884811

End: 5886103

Strand: Direct

Name: macA [H]

Synonym: BRADO5685

Alternate gene names: 146342523

Gene position: 5884811-5886103 (Clockwise)

Preceding gene: 146342522

Following gene: 146342524

Centisome position: 78.92

GC content: 67.75

Gene sequence:

>1293_bases
ATGAATGCACCCCTGCCACAGATGCCCCAGCCGGTCGCGGTCGAGGATGGCGTCGCGTCCCCGTCCAAGCCGAAACGACG
GCGGCGCTGGCCGCTGATCGTCACCGGCCTGGCCGTGCTGGTGGTGCTCGGCGTCGGCGTCAAGCGCGCGACGCGCAATC
CCAACGCCAATCTCGCCACCGCTCCGGTCACGATCGGCGACATCGAGCAGACCGTGCTCGCGACCGGCACGCTGAAGCCG
GTCAAGCTGGTCGCGGTCGGCGCGCAGGCGTCCGGCCGGCTGGTCGCGCTCAACGTCAAGCTCGGCCAGAAGGTGAAGGC
GGGCGAGCTCATCGCCGAGATCGATTCGCTGACCCAGCAATACACGCTGCGCACCAACGAGGCCGCCTTGCGCAACGTGC
GCGCTCAGCGCGACGAGAAGCAGGCGACGCTGGCGCTCGCCGAGGCGAACCTGGCGCGGCAGCAGACCACGCTGGCGCAG
AAGGCCTCGTCGCGCGCCGACTATGACAGCGCCGAAGCCACCGTGAAGCAGACGCAGGCGCAGATCGCGCAGCTGGAGGC
GCAGCTCGTCGAGGCCGAGGTCGCCATCGAGACGGCGCGGGTGAATCTCGGCTATACCAAGATCACCGCGCCGATCGACG
GCACCGTGCTGTCGATCGTCACTCAGCAGGGCCAGACGGTGAATGCGGTGCAGTCCGCGCCGACCATCGTGGTGCTCGGC
CAGGTCGAGACGATGACCGTGCGTGTCGAGATCTCCGAAGCCGACGTCGTCCGCGTCAAGCCTGGCCAGAACGTCTACTT
CACGATTCTCGGCGATCCCGATCGCCGCTATGAGGCGACGCTGAGATTCATCGAGCCGGCGCCGGAATCGATCAAGAGCG
ATTCGAGCTTCTCGTCCAGCACCACCACGACGTCGAGCAGCAGCAGCACGTCGTCCTCCTCCACCTCGTCGGCGATCTAC
TACAACGGCGTCTTCGACGTTGCCAATACGGACGGGCGGCTCATGACCTACATGACCGCCGAGGTCCACATCCTGCTCGG
CGAGGCCCGCAAGGTGCCGACCATCCCCTCCTCCGCGCTGGGCAATCCCGAACCCGACGGCAGCTATCGCGTTCGCGTGA
TCGACAGCGCCGGCACGGTGCAGAAGCGCGGCGTGCGGATCGGCCTCAACAACAAGATCAGGGCCGAGGTGCACACCGGC
CTGCAGGAGGGCGAGCGCGTCGTGATCTCGGCCGCCAGCGAAGGCCCCAAGCAGACCATCATGCCGCCGCCGCCCGGAGC
CGGAGGTCCATGA

Upstream 100 bases:

>100_bases
TCGGTGCCGGAGGTCGTCGACGGCGGCACCGGACCGCATCTCGCGCAGGCCGCCGCGCCTCGATGACCAACTGTAATCCA
CCAGCGTGCGAAGTCGTCTG

Downstream 100 bases:

>100_bases
TGGCGGAGATCCTGATCGATCTGCAGAATGTCGGACGGCGCTACGCGTCCGGCGAGAGCACCGTCCACGCCTTGCGCGGC
GTCGACATCCAGATCGCGCG

Product: putative accessory protein to ABC-type macrolide transport protein MacB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNAPLPQMPQPVAVEDGVASPSKPKRRRRWPLIVTGLAVLVVLGVGVKRATRNPNANLATAPVTIGDIEQTVLATGTLKP
VKLVAVGAQASGRLVALNVKLGQKVKAGELIAEIDSLTQQYTLRTNEAALRNVRAQRDEKQATLALAEANLARQQTTLAQ
KASSRADYDSAEATVKQTQAQIAQLEAQLVEAEVAIETARVNLGYTKITAPIDGTVLSIVTQQGQTVNAVQSAPTIVVLG
QVETMTVRVEISEADVVRVKPGQNVYFTILGDPDRRYEATLRFIEPAPESIKSDSSFSSSTTTTSSSSSTSSSSTSSAIY
YNGVFDVANTDGRLMTYMTAEVHILLGEARKVPTIPSSALGNPEPDGSYRVRVIDSAGTVQKRGVRIGLNNKIRAEVHTG
LQEGERVVISAASEGPKQTIMPPPPGAGGP

Sequences:

>Translated_430_residues
MNAPLPQMPQPVAVEDGVASPSKPKRRRRWPLIVTGLAVLVVLGVGVKRATRNPNANLATAPVTIGDIEQTVLATGTLKP
VKLVAVGAQASGRLVALNVKLGQKVKAGELIAEIDSLTQQYTLRTNEAALRNVRAQRDEKQATLALAEANLARQQTTLAQ
KASSRADYDSAEATVKQTQAQIAQLEAQLVEAEVAIETARVNLGYTKITAPIDGTVLSIVTQQGQTVNAVQSAPTIVVLG
QVETMTVRVEISEADVVRVKPGQNVYFTILGDPDRRYEATLRFIEPAPESIKSDSSFSSSTTTTSSSSSTSSSSTSSAIY
YNGVFDVANTDGRLMTYMTAEVHILLGEARKVPTIPSSALGNPEPDGSYRVRVIDSAGTVQKRGVRIGLNNKIRAEVHTG
LQEGERVVISAASEGPKQTIMPPPPGAGGP
>Mature_430_residues
MNAPLPQMPQPVAVEDGVASPSKPKRRRRWPLIVTGLAVLVVLGVGVKRATRNPNANLATAPVTIGDIEQTVLATGTLKP
VKLVAVGAQASGRLVALNVKLGQKVKAGELIAEIDSLTQQYTLRTNEAALRNVRAQRDEKQATLALAEANLARQQTTLAQ
KASSRADYDSAEATVKQTQAQIAQLEAQLVEAEVAIETARVNLGYTKITAPIDGTVLSIVTQQGQTVNAVQSAPTIVVLG
QVETMTVRVEISEADVVRVKPGQNVYFTILGDPDRRYEATLRFIEPAPESIKSDSSFSSSTTTTSSSSSTSSSSTSSAIY
YNGVFDVANTDGRLMTYMTAEVHILLGEARKVPTIPSSALGNPEPDGSYRVRVIDSAGTVQKRGVRIGLNNKIRAEVHTG
LQEGERVVISAASEGPKQTIMPPPPGAGGP

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=394, Percent_Identity=38.0710659898477, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI87082036, Length=349, Percent_Identity=28.3667621776504, Blast_Score=85, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 45550; Mature: 45550

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPLPQMPQPVAVEDGVASPSKPKRRRRWPLIVTGLAVLVVLGVGVKRATRNPNANLAT
CCCCCCCCCCCCEECCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCEEE
APVTIGDIEQTVLATGTLKPVKLVAVGAQASGRLVALNVKLGQKVKAGELIAEIDSLTQQ
CCEEECCCHHHEEECCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
YTLRTNEAALRNVRAQRDEKQATLALAEANLARQQTTLAQKASSRADYDSAEATVKQTQA
EEEECCHHHHHHHHHHCCHHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
QIAQLEAQLVEAEVAIETARVNLGYTKITAPIDGTVLSIVTQQGQTVNAVQSAPTIVVLG
HHHHHHHHHHHHHEEEEEEEEECCEEEEECCCCCEEEEEEECCCCEEEHHHCCCEEEEEE
QVETMTVRVEISEADVVRVKPGQNVYFTILGDPDRRYEATLRFIEPAPESIKSDSSFSSS
CEEEEEEEEEECCCCEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCHHHCCCCCCCCC
TTTTSSSSSTSSSSTSSAIYYNGVFDVANTDGRLMTYMTAEVHILLGEARKVPTIPSSAL
CCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEEEEEEEEEEEEECCCCCCCCCCCCC
GNPEPDGSYRVRVIDSAGTVQKRGVRIGLNNKIRAEVHTGLQEGERVVISAASEGPKQTI
CCCCCCCCEEEEEEECCCCHHHCCEEEECCCCEEHHHHCCCCCCCEEEEEECCCCCCCCC
MPPPPGAGGP
CCCCCCCCCC
>Mature Secondary Structure
MNAPLPQMPQPVAVEDGVASPSKPKRRRRWPLIVTGLAVLVVLGVGVKRATRNPNANLAT
CCCCCCCCCCCCEECCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCEEE
APVTIGDIEQTVLATGTLKPVKLVAVGAQASGRLVALNVKLGQKVKAGELIAEIDSLTQQ
CCEEECCCHHHEEECCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
YTLRTNEAALRNVRAQRDEKQATLALAEANLARQQTTLAQKASSRADYDSAEATVKQTQA
EEEECCHHHHHHHHHHCCHHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
QIAQLEAQLVEAEVAIETARVNLGYTKITAPIDGTVLSIVTQQGQTVNAVQSAPTIVVLG
HHHHHHHHHHHHHEEEEEEEEECCEEEEECCCCCEEEEEEECCCCEEEHHHCCCEEEEEE
QVETMTVRVEISEADVVRVKPGQNVYFTILGDPDRRYEATLRFIEPAPESIKSDSSFSSS
CEEEEEEEEEECCCCEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCHHHCCCCCCCCC
TTTTSSSSSTSSSSTSSAIYYNGVFDVANTDGRLMTYMTAEVHILLGEARKVPTIPSSAL
CCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEEEEEEEEEEEEECCCCCCCCCCCCC
GNPEPDGSYRVRVIDSAGTVQKRGVRIGLNNKIRAEVHTGLQEGERVVISAASEGPKQTI
CCCCCCCCEEEEEEECCCCHHHCCEEEECCCCEEHHHHCCCCCCCEEEEEECCCCCCCCC
MPPPPGAGGP
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]