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The map label for this gene is nodT [H]

Identifier: 146342522

GI number: 146342522

Start: 5883289

End: 5884776

Strand: Direct

Name: nodT [H]

Synonym: BRADO5684

Alternate gene names: 146342522

Gene position: 5883289-5884776 (Clockwise)

Preceding gene: 146342519

Following gene: 146342523

Centisome position: 78.9

GC content: 71.51

Gene sequence:

>1488_bases
ATGCTCAGCCCCGTGAAGCCCGTCCTGCTCGCCCTCTGCCTCGCCTCCCCGCTGCTCGCCGGCTGCGCCGTCGGGCCCGA
CTACGTCACGCCGGATTTCGGCACGCCGGCGCGCTGGAGCAGCGACCGTAACCAGCCGGCGCAACAGCTCAGGCTCGCGC
AATGGTGGCGCAACCTCGGCGACGCGCCGCTCGATCAGCTGATCGGCGAAGCCGTCAGCGGAAATCTCGACGTCGCCGCG
GCCAAGGCGCGTATCCGCGAGGCGCGCGCGACGCAGCGCCAGGCGGTGGGCGCGCTGTTTCCGACCGTCAGCGGCACCAG
TTCGGCGACCGAGACCCGCAGCGCCGGCTCTACGACGGCCGGCATCGCGATCGCGCCGACCACCTCCAGCCAGTTCCAGG
CTGGCTTCGATTCGAGCTGGGAGCTCGACCTGTTCGGCGCCAACCGCCGCGCCGTCGAGGCGGCCTCCTACGGCGTCGAC
GCCGCCAAGGACGATCTGCGCGCCACGCTGCTGACGCTGATCGGCGACGTCGCCTCGAACTACATCGATGCGCGCGCCTA
TCAGGCGCGGGTCGCGCTGGCGCAGCGCACCGCCGCCTCGCAGCGTGAGACCGCCGCGCTGACGGCGCGCAAGCAGGAGG
CCGGCTCGGCGTCGGCCGTCGACACCGCCAAGGCGAGCGCGCTCGCCGCCAGCACGGAAGCGACCATCCCGACCTATGAG
AGCAGCTACCAGCAGGCGCTGCATCGCCTCGGCGTGCTGCTCGGGCGCGACCCGACCGCGCTCAGCCAGCGGCTGTCCCG
AAGTCTGCCGATCCCCGCGCCGCGCCGGCCGCTGCCGAAGGGCATCCCGGCCGACGTGCTGGTGATGCGTCCCGATATCC
GCAAGGCCGAGCGGCAGCTCGCACAGTTCACCGCGAAGATCGGCCAGGCGACCGCTGCGCTGTATCCGGATATCAGCCTG
ACCGGCACGGTCTCGACATCGGCGCTCAAGCTCGGCGATCTCGGCAAGAGCTCGACCATCGGCTGGTCGATCGGTCCGAG
CCTCTCGGTGCCGATCTTCAACGGCGGCAAGCTGCAGGCAGCGGTCGAGGTCGCGGAAGCGCAGCGCGACGAATATCACG
TCGCCTGGCGCAGCGCGGTTCTGAGCGCGCTCGAGGACGTCGAGAACGCCATCGTCAATCTCGGCCAGGAGCGGCTGCGC
ATCCGCAGCCTGACGGAATCGGCGCGCCGCTATAACGAGGCCGCGCGGCTGTCCCGCGGACTCTACCAGACCGGCTCCAG
CACCTTCCTCGACGTGCTCGACGCCGAGCGCTCGCAATTCACGGCGGAAGACAGCCTGCTCGCGAGCCGCGCCGCCCTCG
CGAAGAACTATGTCGCGCTGGCCAAGGCGCTCGGCGGCGGCTGGAGCGGCCCGATCGACAGCTCGGTGCCGGAGGTCGTC
GACGGCGGCACCGGACCGCATCTCGCGCAGGCCGCCGCGCCTCGATGA

Upstream 100 bases:

>100_bases
AACGGCCATCGCGCCTAAGGCTTGGTGGATCAGACAACCATCAAACAGGGAAGTCCTGCGGCGAGGCTGACCGGCCGGCG
CGGCTCTCCTCCGAACCGCG

Downstream 100 bases:

>100_bases
CCAACTGTAATCCACCAGCGTGCGAAGTCGTCTGATGAATGCACCCCTGCCACAGATGCCCCAGCCGGTCGCGGTCGAGG
ATGGCGTCGCGTCCCCGTCC

Product: multidrug efflux system outer membrane subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MLSPVKPVLLALCLASPLLAGCAVGPDYVTPDFGTPARWSSDRNQPAQQLRLAQWWRNLGDAPLDQLIGEAVSGNLDVAA
AKARIREARATQRQAVGALFPTVSGTSSATETRSAGSTTAGIAIAPTTSSQFQAGFDSSWELDLFGANRRAVEAASYGVD
AAKDDLRATLLTLIGDVASNYIDARAYQARVALAQRTAASQRETAALTARKQEAGSASAVDTAKASALAASTEATIPTYE
SSYQQALHRLGVLLGRDPTALSQRLSRSLPIPAPRRPLPKGIPADVLVMRPDIRKAERQLAQFTAKIGQATAALYPDISL
TGTVSTSALKLGDLGKSSTIGWSIGPSLSVPIFNGGKLQAAVEVAEAQRDEYHVAWRSAVLSALEDVENAIVNLGQERLR
IRSLTESARRYNEAARLSRGLYQTGSSTFLDVLDAERSQFTAEDSLLASRAALAKNYVALAKALGGGWSGPIDSSVPEVV
DGGTGPHLAQAAAPR

Sequences:

>Translated_495_residues
MLSPVKPVLLALCLASPLLAGCAVGPDYVTPDFGTPARWSSDRNQPAQQLRLAQWWRNLGDAPLDQLIGEAVSGNLDVAA
AKARIREARATQRQAVGALFPTVSGTSSATETRSAGSTTAGIAIAPTTSSQFQAGFDSSWELDLFGANRRAVEAASYGVD
AAKDDLRATLLTLIGDVASNYIDARAYQARVALAQRTAASQRETAALTARKQEAGSASAVDTAKASALAASTEATIPTYE
SSYQQALHRLGVLLGRDPTALSQRLSRSLPIPAPRRPLPKGIPADVLVMRPDIRKAERQLAQFTAKIGQATAALYPDISL
TGTVSTSALKLGDLGKSSTIGWSIGPSLSVPIFNGGKLQAAVEVAEAQRDEYHVAWRSAVLSALEDVENAIVNLGQERLR
IRSLTESARRYNEAARLSRGLYQTGSSTFLDVLDAERSQFTAEDSLLASRAALAKNYVALAKALGGGWSGPIDSSVPEVV
DGGTGPHLAQAAAPR
>Mature_495_residues
MLSPVKPVLLALCLASPLLAGCAVGPDYVTPDFGTPARWSSDRNQPAQQLRLAQWWRNLGDAPLDQLIGEAVSGNLDVAA
AKARIREARATQRQAVGALFPTVSGTSSATETRSAGSTTAGIAIAPTTSSQFQAGFDSSWELDLFGANRRAVEAASYGVD
AAKDDLRATLLTLIGDVASNYIDARAYQARVALAQRTAASQRETAALTARKQEAGSASAVDTAKASALAASTEATIPTYE
SSYQQALHRLGVLLGRDPTALSQRLSRSLPIPAPRRPLPKGIPADVLVMRPDIRKAERQLAQFTAKIGQATAALYPDISL
TGTVSTSALKLGDLGKSSTIGWSIGPSLSVPIFNGGKLQAAVEVAEAQRDEYHVAWRSAVLSALEDVENAIVNLGQERLR
IRSLTESARRYNEAARLSRGLYQTGSSTFLDVLDAERSQFTAEDSLLASRAALAKNYVALAKALGGGWSGPIDSSVPEVV
DGGTGPHLAQAAAPR

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=473, Percent_Identity=29.8097251585624, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI2367348, Length=484, Percent_Identity=24.1735537190083, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 52055; Mature: 52055

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSPVKPVLLALCLASPLLAGCAVGPDYVTPDFGTPARWSSDRNQPAQQLRLAQWWRNLG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
DAPLDQLIGEAVSGNLDVAAAKARIREARATQRQAVGALFPTVSGTSSATETRSAGSTTA
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCC
GIAIAPTTSSQFQAGFDSSWELDLFGANRRAVEAASYGVDAAKDDLRATLLTLIGDVASN
CEEEECCCCHHHCCCCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
YIDARAYQARVALAQRTAASQRETAALTARKQEAGSASAVDTAKASALAASTEATIPTYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHH
SSYQQALHRLGVLLGRDPTALSQRLSRSLPIPAPRRPLPKGIPADVLVMRPDIRKAERQL
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHH
AQFTAKIGQATAALYPDISLTGTVSTSALKLGDLGKSSTIGWSIGPSLSVPIFNGGKLQA
HHHHHHHHHHHHHHCCCCEEEECCCHHHEECCCCCCCCCCCEECCCCCCCEEECCCCHHH
AVEVAEAQRDEYHVAWRSAVLSALEDVENAIVNLGQERLRIRSLTESARRYNEAARLSRG
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LYQTGSSTFLDVLDAERSQFTAEDSLLASRAALAKNYVALAKALGGGWSGPIDSSVPEVV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
DGGTGPHLAQAAAPR
CCCCCCHHHHHCCCC
>Mature Secondary Structure
MLSPVKPVLLALCLASPLLAGCAVGPDYVTPDFGTPARWSSDRNQPAQQLRLAQWWRNLG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
DAPLDQLIGEAVSGNLDVAAAKARIREARATQRQAVGALFPTVSGTSSATETRSAGSTTA
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCC
GIAIAPTTSSQFQAGFDSSWELDLFGANRRAVEAASYGVDAAKDDLRATLLTLIGDVASN
CEEEECCCCHHHCCCCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
YIDARAYQARVALAQRTAASQRETAALTARKQEAGSASAVDTAKASALAASTEATIPTYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHH
SSYQQALHRLGVLLGRDPTALSQRLSRSLPIPAPRRPLPKGIPADVLVMRPDIRKAERQL
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHH
AQFTAKIGQATAALYPDISLTGTVSTSALKLGDLGKSSTIGWSIGPSLSVPIFNGGKLQA
HHHHHHHHHHHHHHCCCCEEEECCCHHHEECCCCCCCCCCCEECCCCCCCEEECCCCHHH
AVEVAEAQRDEYHVAWRSAVLSALEDVENAIVNLGQERLRIRSLTESARRYNEAARLSRG
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LYQTGSSTFLDVLDAERSQFTAEDSLLASRAALAKNYVALAKALGGGWSGPIDSSVPEVV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
DGGTGPHLAQAAAPR
CCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]