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The map label for this gene is murB

Identifier: 146342496

GI number: 146342496

Start: 5849978

End: 5850901

Strand: Reverse

Name: murB

Synonym: BRADO5657

Alternate gene names: 146342496

Gene position: 5850901-5849978 (Counterclockwise)

Preceding gene: 146342497

Following gene: 146342495

Centisome position: 78.47

GC content: 67.86

Gene sequence:

>924_bases
GTGAGCTTTCCCGACATCACGCCCGATCTGAAGGCCGCGATGCCCGCGCTGCGCGGACGTCTGCTCGCCAATGAAAGCCT
CGCGCCGCTCACCTGGTTTCGCGTCGGCGGTCCGGCGCAGGTGCTGTTCACGCCGGCCGATGCGGACGACCTCGCCTACT
TCCTGAAGCACCTGCCGGCCGAGCTACCCGTGTACGTCATCGGCGTCGGCTCCAACATGATCGTGCGCGACGGCGGCGTG
CCGGGCGTAGTGATCCGGCTGGCGCCGCGCGCGTTCGGCGAGGTCAAGGCCGAAGGAGACATCATCACGGCTGGCACGGC
AGCGCGCGACAAGCGCGTCGCGGAGGTCGCGGCGTCAGCCGATCTCGCCGGTCTGGAATTCCTGTTCGGCATTCCCGGCA
CCATCGGCGGTGCGCTGCGCATGAATGCCGGCGCCAATGGTGGCGAGACCAAGGACATCCTGGTTGAGGCGACCGCGATC
GATCGCCGGGGCGAGACGCATCGCTTAAGCAATGCCGACATGAAGTTCACCTATCGCGCGAGCGGCACGGACGCGGCGCT
GATCTTCACGGCCGTACGCTTCCGTGGCACCCCGTCCGAACCAGCGGCGATCCGCGCGCGCATGGCCGAGGTGCAGGCGC
ATCGCGAGACGGCGCAGCCGATCCGCGAGAAGACCGGCGGCTCGACCTTCAAGAACCCGCCGGGCCATTCGGCCTGGAAG
CTCGTCGATGCCGCCGGCTGCCGCGGCCTCAAGGTCGGGGGCGCGCAGGTCTCGGAGATGCACTGTAACTTCCTGATCAA
CACAGGCAATGCCACCGCCGACGATATCGAGACGCTCGGCGAGACCGTGCGCGAACGGGTCAAGGCCAGCTCGGGCATCG
AGCTGCAGTGGGAGATCAAGCGGATCGGAGTCAAGGCGAGCTGA

Upstream 100 bases:

>100_bases
CTCGCCAAGCCGGGCGACCTCGTCGTCTGCCTCGGCGCCGGCAACATCACGCAATGGGCCTACGCGCTGCCGAACGAGTT
GAAGGCGCTGGGGTAGGGCG

Downstream 100 bases:

>100_bases
CGACCCGCTTCTTCACGTGACGTCCACGCTGTCGCAACCGCATTCTGAGATCAATCGAGAAACCATTGATGCGCACCACG
ATTCTGTTCGGCGGCTCCAA

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSFPDITPDLKAAMPALRGRLLANESLAPLTWFRVGGPAQVLFTPADADDLAYFLKHLPAELPVYVIGVGSNMIVRDGGV
PGVVIRLAPRAFGEVKAEGDIITAGTAARDKRVAEVAASADLAGLEFLFGIPGTIGGALRMNAGANGGETKDILVEATAI
DRRGETHRLSNADMKFTYRASGTDAALIFTAVRFRGTPSEPAAIRARMAEVQAHRETAQPIREKTGGSTFKNPPGHSAWK
LVDAAGCRGLKVGGAQVSEMHCNFLINTGNATADDIETLGETVRERVKASSGIELQWEIKRIGVKAS

Sequences:

>Translated_307_residues
MSFPDITPDLKAAMPALRGRLLANESLAPLTWFRVGGPAQVLFTPADADDLAYFLKHLPAELPVYVIGVGSNMIVRDGGV
PGVVIRLAPRAFGEVKAEGDIITAGTAARDKRVAEVAASADLAGLEFLFGIPGTIGGALRMNAGANGGETKDILVEATAI
DRRGETHRLSNADMKFTYRASGTDAALIFTAVRFRGTPSEPAAIRARMAEVQAHRETAQPIREKTGGSTFKNPPGHSAWK
LVDAAGCRGLKVGGAQVSEMHCNFLINTGNATADDIETLGETVRERVKASSGIELQWEIKRIGVKAS
>Mature_306_residues
SFPDITPDLKAAMPALRGRLLANESLAPLTWFRVGGPAQVLFTPADADDLAYFLKHLPAELPVYVIGVGSNMIVRDGGVP
GVVIRLAPRAFGEVKAEGDIITAGTAARDKRVAEVAASADLAGLEFLFGIPGTIGGALRMNAGANGGETKDILVEATAID
RRGETHRLSNADMKFTYRASGTDAALIFTAVRFRGTPSEPAAIRARMAEVQAHRETAQPIREKTGGSTFKNPPGHSAWKL
VDAAGCRGLKVGGAQVSEMHCNFLINTGNATADDIETLGETVRERVKASSGIELQWEIKRIGVKAS

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_BRASO (A4YZK1)

Other databases:

- EMBL:   CU234118
- RefSeq:   YP_001207544.1
- ProteinModelPortal:   A4YZK1
- SMR:   A4YZK1
- STRING:   A4YZK1
- GeneID:   5119955
- GenomeReviews:   CU234118_GR
- KEGG:   bra:BRADO5657
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   BSP376:BRADO5657-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 32487; Mature: 32356

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 179-179 ACT_SITE 228-228 ACT_SITE 298-298

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPDITPDLKAAMPALRGRLLANESLAPLTWFRVGGPAQVLFTPADADDLAYFLKHLPA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHCCC
ELPVYVIGVGSNMIVRDGGVPGVVIRLAPRAFGEVKAEGDIITAGTAARDKRVAEVAASA
CCCEEEEEECCCEEEECCCCCEEEEEECCHHHCCEECCCCEEECCCCHHHHHHHHHHHHC
DLAGLEFLFGIPGTIGGALRMNAGANGGETKDILVEATAIDRRGETHRLSNADMKFTYRA
CHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEC
SGTDAALIFTAVRFRGTPSEPAAIRARMAEVQAHRETAQPIREKTGGSTFKNPPGHSAWK
CCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
LVDAAGCRGLKVGGAQVSEMHCNFLINTGNATADDIETLGETVRERVKASSGIELQWEIK
EEHHCCCCEEEECCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEE
RIGVKAS
ECCCCCC
>Mature Secondary Structure 
SFPDITPDLKAAMPALRGRLLANESLAPLTWFRVGGPAQVLFTPADADDLAYFLKHLPA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHCCC
ELPVYVIGVGSNMIVRDGGVPGVVIRLAPRAFGEVKAEGDIITAGTAARDKRVAEVAASA
CCCEEEEEECCCEEEECCCCCEEEEEECCHHHCCEECCCCEEECCCCHHHHHHHHHHHHC
DLAGLEFLFGIPGTIGGALRMNAGANGGETKDILVEATAIDRRGETHRLSNADMKFTYRA
CHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEC
SGTDAALIFTAVRFRGTPSEPAAIRARMAEVQAHRETAQPIREKTGGSTFKNPPGHSAWK
CCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
LVDAAGCRGLKVGGAQVSEMHCNFLINTGNATADDIETLGETVRERVKASSGIELQWEIK
EEHHCCCCEEEECCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEE
RIGVKAS
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA