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The map label for this gene is lpxC [H]

Identifier: 146342491

GI number: 146342491

Start: 5843034

End: 5843993

Strand: Reverse

Name: lpxC [H]

Synonym: BRADO5652

Alternate gene names: 146342491

Gene position: 5843993-5843034 (Counterclockwise)

Preceding gene: 146342492

Following gene: 146342490

Centisome position: 78.37

GC content: 67.08

Gene sequence:

>960_bases
ATGAAATTCAGCAGGCAAACAACGCTTCGTTCGCAAGCCACTGTCACTGGCGTAGGCGTCCACTCTGGCGCGCCGGCCAG
CCTGACGATCGGGCCTGCGCCTGTTGATGCGGGGATCGTGTTCCTCCGCACCGGCCTGGAAGGCGCCGACCGCGAAGTTC
TGGCCTCGTTCGGTTCGGTGATCGCAACGGAGCTGGCGACGGTATTGGGCGACCGCCATGGCCCGTTGGTTTCCACCGCT
GAGCACATCCTCGCCGCGCTGCGCGGCATGGGCGTCGATAACGCTCTGATCGAGGTCGACGGTCCCGAAGTTCCGATCAT
GGACGGCAGCGCTGCGCCGTTCGTTGCGGCGATCGATCAGGCCGGGATCGTCACCCAGTCGGCCGCGCGCCGCTACATCC
AGGTGCTGAAGCCGGTTCAGGTGACGATGGGCGCCTCGATGGGCGAACTGCGTCCCAACAACTCCGGTTTCCGGGTCGAA
GCCGAGATCGACTTCGCCAATCCGGTGATCGGCCGCCAAGCCTATCATTTCGAGCTCAGCCCCGAGCGTTTCCGCCGCGA
GATCTCCCGCGCCCGCACCTTCGGCTGCATGAGCGACGTGGCGCGGTTGTGGAACGCCGGCTTTGCACTGGGCTCCTCGT
TCGACAACACCCTGGTGTTCGACGAGGAGCGGCTGCTGAATCCTGAAGGCCTGCGCTACGCCGACGAGTGCGTCCGCCAC
AAGGTGCTCGACGCGATCGGCGATCTCGCGCTCGCCGGCCTGCCGATGCTCGGCACCTATCGCTCCGTTCGCGGCGGCCA
CAAGCTCAACCACGCCGTCCTGACCGCGCTGATGGCCGATCGGACCGCCTGGCGGGTGGTCGAGGGCGAGACGGTGCGCC
GTCCCCGCGTGGCGGCCGAAGTCGTCGGCGGCATGGTTGGTGGCATGATCGCTCCGGCCTTCGGCCCGGACGTGTCCTGA

Upstream 100 bases:

>100_bases
GGGCTCGTTAAGTTCTGCCGTGACTTGGGGATGCCTGAAAATGAGTCGGTTCGCGAGGGGCGGCCGATGGAGGTTCAGGC
GGGGTCTTGGGCGATCGTCG

Downstream 100 bases:

>100_bases
GCTTTTCGGGCTGGGCCGACTGCGACAGCTCGAATCGATGAGCGTTCGCCCACGTGCTGCGACGTCGCCGCAGCGATGAT
CTTCTAGAAATCTTCGTTAG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKFSRQTTLRSQATVTGVGVHSGAPASLTIGPAPVDAGIVFLRTGLEGADREVLASFGSVIATELATVLGDRHGPLVSTA
EHILAALRGMGVDNALIEVDGPEVPIMDGSAAPFVAAIDQAGIVTQSAARRYIQVLKPVQVTMGASMGELRPNNSGFRVE
AEIDFANPVIGRQAYHFELSPERFRREISRARTFGCMSDVARLWNAGFALGSSFDNTLVFDEERLLNPEGLRYADECVRH
KVLDAIGDLALAGLPMLGTYRSVRGGHKLNHAVLTALMADRTAWRVVEGETVRRPRVAAEVVGGMVGGMIAPAFGPDVS

Sequences:

>Translated_319_residues
MKFSRQTTLRSQATVTGVGVHSGAPASLTIGPAPVDAGIVFLRTGLEGADREVLASFGSVIATELATVLGDRHGPLVSTA
EHILAALRGMGVDNALIEVDGPEVPIMDGSAAPFVAAIDQAGIVTQSAARRYIQVLKPVQVTMGASMGELRPNNSGFRVE
AEIDFANPVIGRQAYHFELSPERFRREISRARTFGCMSDVARLWNAGFALGSSFDNTLVFDEERLLNPEGLRYADECVRH
KVLDAIGDLALAGLPMLGTYRSVRGGHKLNHAVLTALMADRTAWRVVEGETVRRPRVAAEVVGGMVGGMIAPAFGPDVS
>Mature_319_residues
MKFSRQTTLRSQATVTGVGVHSGAPASLTIGPAPVDAGIVFLRTGLEGADREVLASFGSVIATELATVLGDRHGPLVSTA
EHILAALRGMGVDNALIEVDGPEVPIMDGSAAPFVAAIDQAGIVTQSAARRYIQVLKPVQVTMGASMGELRPNNSGFRVE
AEIDFANPVIGRQAYHFELSPERFRREISRARTFGCMSDVARLWNAGFALGSSFDNTLVFDEERLLNPEGLRYADECVRH
KVLDAIGDLALAGLPMLGTYRSVRGGHKLNHAVLTALMADRTAWRVVEGETVRRPRVAAEVVGGMVGGMIAPAFGPDVS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=285, Percent_Identity=43.859649122807, Blast_Score=241, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 33916; Mature: 33916

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFSRQTTLRSQATVTGVGVHSGAPASLTIGPAPVDAGIVFLRTGLEGADREVLASFGSV
CCCCHHHHHHCCCEEEEEECCCCCCCEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHH
IATELATVLGDRHGPLVSTAEHILAALRGMGVDNALIEVDGPEVPIMDGSAAPFVAAIDQ
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEECCCCCCHHHHHCC
AGIVTQSAARRYIQVLKPVQVTMGASMGELRPNNSGFRVEAEIDFANPVIGRQAYHFELS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEECC
PERFRREISRARTFGCMSDVARLWNAGFALGSSFDNTLVFDEERLLNPEGLRYADECVRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHCCCCCCHHHHHHHHH
KVLDAIGDLALAGLPMLGTYRSVRGGHKLNHAVLTALMADRTAWRVVEGETVRRPRVAAE
HHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHEEEECCCCCCCCHHHHH
VVGGMVGGMIAPAFGPDVS
HHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKFSRQTTLRSQATVTGVGVHSGAPASLTIGPAPVDAGIVFLRTGLEGADREVLASFGSV
CCCCHHHHHHCCCEEEEEECCCCCCCEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHH
IATELATVLGDRHGPLVSTAEHILAALRGMGVDNALIEVDGPEVPIMDGSAAPFVAAIDQ
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEECCCCCCHHHHHCC
AGIVTQSAARRYIQVLKPVQVTMGASMGELRPNNSGFRVEAEIDFANPVIGRQAYHFELS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEECC
PERFRREISRARTFGCMSDVARLWNAGFALGSSFDNTLVFDEERLLNPEGLRYADECVRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHCCCCCCHHHHHHHHH
KVLDAIGDLALAGLPMLGTYRSVRGGHKLNHAVLTALMADRTAWRVVEGETVRRPRVAAE
HHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHEEEECCCCCCCCHHHHH
VVGGMVGGMIAPAFGPDVS
HHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA