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The map label for this gene is aroE [H]

Identifier: 146342439

GI number: 146342439

Start: 5781974

End: 5782855

Strand: Reverse

Name: aroE [H]

Synonym: BRADO5598

Alternate gene names: 146342439

Gene position: 5782855-5781974 (Counterclockwise)

Preceding gene: 146342440

Following gene: 146342438

Centisome position: 77.55

GC content: 66.89

Gene sequence:

>882_bases
GTGCCTGACCTTTCCGCGCTCAAAGCCCGCAAATTCCTGACCGGCTTGATCGGTGCCCCGATCGCGCATTCGGCCTCTCC
AGCCATGCACGAGCATGCTGCGGCTGCGCTCGGTCTGCGCTGCCACTACCAGCTGATCGAGGTCGCCGGCGCCGACCGCG
CGGGCCTGTCGATGCTGCTCGAAGGCGTGCGTCGGCTGGGCTTCGCCGGCGTCAATGTGACCTATCCCTACAAGGAAGCC
GTCGTCGAACTGCTCGACGAGCTCGCGCCGAAGGCGGCGGCGATGGGCGCGGTCAATACCGTCGTCGTGCGCGACGGCCG
GCTGATCGGCCACAACACCGATACGACCGGGTTCGAACGCGCGGTGGCGCCGCTCGTCGGCCAGAGCGGCCGCGGCGTGG
TGGCGCTGATCGGGGCTGGCGGAGTTGGCAAGGCGATCGCCTTCGCACTTGCGAACCTCGAAGTCGCTGGGCTGCGCATC
TATGACATCGAGCGGGCGCGTGCCGAGAAGCTCGCGAAGCTGGTGAGGGCCGGCACAACGGTTAATGTGGTCGACAGCGT
CGAAAGCGCGCTCCAGGGCGCAGTCGGCGTCGTCAATGGAACACCAATTGGCATGCTGCCGAACCGCGGCACGCCGGTTG
CGGATCATCTGCTGCGCGACGATCTCTGGGTCGCTGACGCCGTCTACTCGCCGCTTTGGACGCCGCTGCTGAAGGCGGCG
AAGGCCAGAGGGGCTCAAGTCCTGCTCGGGCGCGAGCTCGCGATCTATCAGGCTGCCGATGCTTTCGAGCTGTTCACCGG
ACTTGCGCCGTCGACCGAAGCGATGGGCGCGGCGTTCGACAATCACATGGCGGAGAGATATCAGGCGGTTGACGCCGCCT
GA

Upstream 100 bases:

>100_bases
TTTGGGTAATTGTGTTAGGCGTGGGACGCGCTATCGTCCCCGCCGACATCCATCGCTCGTGCGGCGATCGCGCGAGGCGG
CAGCAGAGACTGAAGCGAAC

Downstream 100 bases:

>100_bases
GCCGACCGCCAATACGCGGCGGAACACATCGTTCAAGCAAGAAACGCAAACAAGCGTTTAGAGCAGAGGAGGAAACAACG
TGAGATCGATCATCCTGGCC

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NAD(+)-dependent quinate dehydrogenase; QDH [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPDLSALKARKFLTGLIGAPIAHSASPAMHEHAAAALGLRCHYQLIEVAGADRAGLSMLLEGVRRLGFAGVNVTYPYKEA
VVELLDELAPKAAAMGAVNTVVVRDGRLIGHNTDTTGFERAVAPLVGQSGRGVVALIGAGGVGKAIAFALANLEVAGLRI
YDIERARAEKLAKLVRAGTTVNVVDSVESALQGAVGVVNGTPIGMLPNRGTPVADHLLRDDLWVADAVYSPLWTPLLKAA
KARGAQVLLGRELAIYQAADAFELFTGLAPSTEAMGAAFDNHMAERYQAVDAA

Sequences:

>Translated_293_residues
MPDLSALKARKFLTGLIGAPIAHSASPAMHEHAAAALGLRCHYQLIEVAGADRAGLSMLLEGVRRLGFAGVNVTYPYKEA
VVELLDELAPKAAAMGAVNTVVVRDGRLIGHNTDTTGFERAVAPLVGQSGRGVVALIGAGGVGKAIAFALANLEVAGLRI
YDIERARAEKLAKLVRAGTTVNVVDSVESALQGAVGVVNGTPIGMLPNRGTPVADHLLRDDLWVADAVYSPLWTPLLKAA
KARGAQVLLGRELAIYQAADAFELFTGLAPSTEAMGAAFDNHMAERYQAVDAA
>Mature_292_residues
PDLSALKARKFLTGLIGAPIAHSASPAMHEHAAAALGLRCHYQLIEVAGADRAGLSMLLEGVRRLGFAGVNVTYPYKEAV
VELLDELAPKAAAMGAVNTVVVRDGRLIGHNTDTTGFERAVAPLVGQSGRGVVALIGAGGVGKAIAFALANLEVAGLRIY
DIERARAEKLAKLVRAGTTVNVVDSVESALQGAVGVVNGTPIGMLPNRGTPVADHLLRDDLWVADAVYSPLWTPLLKAAK
ARGAQVLLGRELAIYQAADAFELFTGLAPSTEAMGAAFDNHMAERYQAVDAA

Specific function: Catalyzes the NAD(+)-dependent oxidation of both quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate, respectively. Seems to play a key role in the quinate degradation pathway [H]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=278, Percent_Identity=33.8129496402878, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789675, Length=261, Percent_Identity=31.4176245210728, Blast_Score=94, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320332, Length=290, Percent_Identity=28.2758620689655, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.24 [H]

Molecular weight: Translated: 30520; Mature: 30388

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLSALKARKFLTGLIGAPIAHSASPAMHEHAAAALGLRCHYQLIEVAGADRAGLSMLL
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EGVRRLGFAGVNVTYPYKEAVVELLDELAPKAAAMGAVNTVVVRDGRLIGHNTDTTGFER
HHHHHHCCCCCCEECCHHHHHHHHHHHHCHHHHHHCCCEEEEEECCEEECCCCCCCHHHH
AVAPLVGQSGRGVVALIGAGGVGKAIAFALANLEVAGLRIYDIERARAEKLAKLVRAGTT
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCEEECEEEEEHHHHHHHHHHHHHHCCCC
VNVVDSVESALQGAVGVVNGTPIGMLPNRGTPVADHLLRDDLWVADAVYSPLWTPLLKAA
CHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KARGAQVLLGRELAIYQAADAFELFTGLAPSTEAMGAAFDNHMAERYQAVDAA
HCCCCEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PDLSALKARKFLTGLIGAPIAHSASPAMHEHAAAALGLRCHYQLIEVAGADRAGLSMLL
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EGVRRLGFAGVNVTYPYKEAVVELLDELAPKAAAMGAVNTVVVRDGRLIGHNTDTTGFER
HHHHHHCCCCCCEECCHHHHHHHHHHHHCHHHHHHCCCEEEEEECCEEECCCCCCCHHHH
AVAPLVGQSGRGVVALIGAGGVGKAIAFALANLEVAGLRIYDIERARAEKLAKLVRAGTT
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCEEECEEEEEHHHHHHHHHHHHHHCCCC
VNVVDSVESALQGAVGVVNGTPIGMLPNRGTPVADHLLRDDLWVADAVYSPLWTPLLKAA
CHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KARGAQVLLGRELAIYQAADAFELFTGLAPSTEAMGAAFDNHMAERYQAVDAA
HCCCCEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]