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The map label for this gene is lysR [H]

Identifier: 146342440

GI number: 146342440

Start: 5782979

End: 5783920

Strand: Reverse

Name: lysR [H]

Synonym: BRADO5599

Alternate gene names: 146342440

Gene position: 5783920-5782979 (Counterclockwise)

Preceding gene: 146342441

Following gene: 146342439

Centisome position: 77.57

GC content: 62.85

Gene sequence:

>942_bases
ATGATGACGCTGCGACAGGTCGAGGTCATTCGCGCGGTCATGGTGACCGGCACCATCAACGGCGCCGCGCGGCTCTTGAA
GGTCTCGGCACCCGGCGTGAGCCGCCTGGTGAAATACACCGAGCGCTCGCTCGGCATCCGCTTCTTCCAGCGCCAGAACG
GCCGCTACTTCCCGACGCCCGAAGCACAGAACATCTTCGAGCAGATCAACAGCGTCTACGAGAAGGTCGACGATCTCAGC
TACATCATCTCCAACATCGGCCGCGGCGCGCTGTCAGAGCTGCGCGTCGGCTCGGTGCCGAGCATCTCCCAGGTGATGGT
GCCGCGCGCGATCGAGCGCGTCCGCCGCCGCTATCCCGATCTCGGCATCGACATCAACATTCTCAAGATCGAGGAGGCGA
TCGACTATCTGATGCTGGGCAAGGGCGAGTGCGTGGCGATGAGCTATCGGCTCGATCATTCCGGTCTCGAATTCATGCCG
CTCGCCTCGGGCGAATTGTACTGCATCGTGCCGCCTGGCCATGAACTGGCGGGACGCAAGCAGGTCTCGGCGGCAGAGAT
GACGCGCTATCCGCTGATCGGCATCGACCCGAATGACCCTTACGGCCGCATCATGGCGGAGATCTTTTCGCGCAACAAAC
TGAGCTACAACATTTCGATCAAGGCGCGCTTCGGCACCACCGTGTGCGCGCTCGTGAAAGCCGGGCTCGGCATCGCCGTC
ATCGACCAGTTCACCGTCGCACACGGCGGCTATCCCGGCATCGAGCTGATCAAGATCGCGGAGCCGACGCGGTTCGACAC
CTACATCGCGGTCAAGCGCGGCACTCCGCTGTCTCTCTATGCCGAACACTTCATCGAGTGCCTGCGGACGGAGATGCGCC
CGCTCGAGCCGGGCCGGCGTCAGAGCCCGAGACCCGCGAAAGCAACCAGTGGCAAAAGATAA

Upstream 100 bases:

>100_bases
GCGGCGCCGCCGCGCCCGCGGCCCGTGCCGCGTCCGCCGATCCCGCTGACGCCGCCGGGCAGCCCGTGACGTCCGGGCGC
GTCGGGGAGGGGCCGCGCCG

Downstream 100 bases:

>100_bases
CATGATGTTAGGTTCGGCGGATATTTGGGTAATTGTGTTAGGCGTGGGACGCGCTATCGTCCCCGCCGACATCCATCGCT
CGTGCGGCGATCGCGCGAGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MMTLRQVEVIRAVMVTGTINGAARLLKVSAPGVSRLVKYTERSLGIRFFQRQNGRYFPTPEAQNIFEQINSVYEKVDDLS
YIISNIGRGALSELRVGSVPSISQVMVPRAIERVRRRYPDLGIDINILKIEEAIDYLMLGKGECVAMSYRLDHSGLEFMP
LASGELYCIVPPGHELAGRKQVSAAEMTRYPLIGIDPNDPYGRIMAEIFSRNKLSYNISIKARFGTTVCALVKAGLGIAV
IDQFTVAHGGYPGIELIKIAEPTRFDTYIAVKRGTPLSLYAEHFIECLRTEMRPLEPGRRQSPRPAKATSGKR

Sequences:

>Translated_313_residues
MMTLRQVEVIRAVMVTGTINGAARLLKVSAPGVSRLVKYTERSLGIRFFQRQNGRYFPTPEAQNIFEQINSVYEKVDDLS
YIISNIGRGALSELRVGSVPSISQVMVPRAIERVRRRYPDLGIDINILKIEEAIDYLMLGKGECVAMSYRLDHSGLEFMP
LASGELYCIVPPGHELAGRKQVSAAEMTRYPLIGIDPNDPYGRIMAEIFSRNKLSYNISIKARFGTTVCALVKAGLGIAV
IDQFTVAHGGYPGIELIKIAEPTRFDTYIAVKRGTPLSLYAEHFIECLRTEMRPLEPGRRQSPRPAKATSGKR
>Mature_313_residues
MMTLRQVEVIRAVMVTGTINGAARLLKVSAPGVSRLVKYTERSLGIRFFQRQNGRYFPTPEAQNIFEQINSVYEKVDDLS
YIISNIGRGALSELRVGSVPSISQVMVPRAIERVRRRYPDLGIDINILKIEEAIDYLMLGKGECVAMSYRLDHSGLEFMP
LASGELYCIVPPGHELAGRKQVSAAEMTRYPLIGIDPNDPYGRIMAEIFSRNKLSYNISIKARFGTTVCALVKAGLGIAV
IDQFTVAHGGYPGIELIKIAEPTRFDTYIAVKRGTPLSLYAEHFIECLRTEMRPLEPGRRQSPRPAKATSGKR

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=246, Percent_Identity=27.2357723577236, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI145693105, Length=274, Percent_Identity=21.1678832116788, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787530, Length=292, Percent_Identity=24.3150684931507, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787879, Length=247, Percent_Identity=25.1012145748988, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787806, Length=295, Percent_Identity=24.406779661017, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34882; Mature: 34882

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTLRQVEVIRAVMVTGTINGAARLLKVSAPGVSRLVKYTERSLGIRFFQRQNGRYFPTP
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCEEEEEECCCCCCCCC
EAQNIFEQINSVYEKVDDLSYIISNIGRGALSELRVGSVPSISQVMVPRAIERVRRRYPD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
LGIDINILKIEEAIDYLMLGKGECVAMSYRLDHSGLEFMPLASGELYCIVPPGHELAGRK
CCCEEEEEEHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCCEEEEECCCCHHCCCC
QVSAAEMTRYPLIGIDPNDPYGRIMAEIFSRNKLSYNISIKARFGTTVCALVKAGLGIAV
CCCHHHHHCCCEEEECCCCCHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHCCCCEEE
IDQFTVAHGGYPGIELIKIAEPTRFDTYIAVKRGTPLSLYAEHFIECLRTEMRPLEPGRR
HHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCC
QSPRPAKATSGKR
CCCCCCCCCCCCC
>Mature Secondary Structure
MMTLRQVEVIRAVMVTGTINGAARLLKVSAPGVSRLVKYTERSLGIRFFQRQNGRYFPTP
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCEEEEEECCCCCCCCC
EAQNIFEQINSVYEKVDDLSYIISNIGRGALSELRVGSVPSISQVMVPRAIERVRRRYPD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
LGIDINILKIEEAIDYLMLGKGECVAMSYRLDHSGLEFMPLASGELYCIVPPGHELAGRK
CCCEEEEEEHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCCEEEEECCCCHHCCCC
QVSAAEMTRYPLIGIDPNDPYGRIMAEIFSRNKLSYNISIKARFGTTVCALVKAGLGIAV
CCCHHHHHCCCEEEECCCCCHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHCCCCEEE
IDQFTVAHGGYPGIELIKIAEPTRFDTYIAVKRGTPLSLYAEHFIECLRTEMRPLEPGRR
HHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCC
QSPRPAKATSGKR
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]