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The map label for this gene is fumC [H]

Identifier: 146342425

GI number: 146342425

Start: 5767588

End: 5769012

Strand: Direct

Name: fumC [H]

Synonym: BRADO5584

Alternate gene names: 146342425

Gene position: 5767588-5769012 (Clockwise)

Preceding gene: 146342424

Following gene: 146342426

Centisome position: 77.35

GC content: 63.65

Gene sequence:

>1425_bases
ATGGCGACATCAGCGAGTTCATCATCTTCCGGACCGACCCGGACGGAGACCGACAGTTTCGGTCCGATCGAGGTCGCGGC
GGACCGCTATTGGGGCGCCCAGACCGAGCGCAGCCGGCAGAACTTCCGCATCGGCCATGACCGCATGCCCCTCGGCGTGG
TGCACGCGCTGGCGCTGGTGAAGCTGGCCGCGGCCAAGACCAATCGCGAGCTCGGACTACTCGATCCTGCGATGGCTGAC
GCCATTGTCCAGGCCGCACAGGAGATCATCGACGGCAAGCTCGACGACCATTTTCCGCTCGTCGTCTGGCAGACCGGCTC
CGGCACGCAGACCAACATGAACCTCAACGAGGTGATCGCCAATCGTGCCAGCGAGCTGATGGGCGGCGAGCGCGGGACCA
AGAAGCCCGTGCATCCCAACGATCACGTCAACATGAGCCAGTCCTCGAACGACTCCTTCCCCACGGCGATGCATATCGCC
GCAGCGCGGGCGATTTCGGGACATCTGGTGCCGGCGCTGTCGGAGCTGCTGGCGGCGCTCCGCGCCAAGCAGGATGCGTT
CGCGGACATCGTCAAGATCGGCCGCACCCATACCCAGGACGCCACGCCGCTGACGCTCGGCCAGGAGTTCTCCGGCTATG
CCGCGCAGGTCGAGAGCGCAATCACCAGGATCAAGACCGCTGCGCACGATCTGCTGCCGCTCGCCCAGGGCGGCACGGCG
GTCGGCACCGGACTCAACGCTCATCCGGATTTCGCGGGCCTGTTCGCCAGACATGTCGCCGACATCACCGGCCTTGCCTT
CACCACCGCCGCCAACAAATTCGAGGCGCTCGCGTCCAACGACGCCTATGTGTTCGCGCATGGCGCGATCAATGCGGCCG
CCACCGGCCTGTTCAAGATCGCCAATGACATCCGCTTCCTCGGATCGGGCCCGCGCTCGGGGCTCGGCGAATTGATTCTG
CCGGAGAACGAGCCGGGATCGTCGATCATGCCGGGCAAGGTGAACCCGACTCAGTGCGAAGCACTGACGATGGTGTGCTG
CCAGGTGTTCGGCAATCACACCGCCATCACCATGGCCGGCAGCCAGGGCCATTTCGAGTTGAACGTCTACAAGCCGTTGC
TCGCACATTGCATGATGCAGTCCATACAATTACTAGGCGACGCTGCACGTTCGTTCCACGAACATTGCGTGACCGGAATT
CAGGCCGACGAAACGCGGATTCGCGAGCTGATGCAGCGCTCTTTGATGCTCGTAACGGCCCTCGCACCGAAAATCGGCTA
CGACAACGCGGCCAAGGTGGCGAAGACGGCGCACCAGCGCGGCACCACGCTGAAGGAAGAAGCCGTGCGTCTCGGCCTTG
TCTCCGAAGATGAATTCGACCGTCTTGTGCAGCCCGAGAAGATGACGAGGCCCGGAAGATCATGA

Upstream 100 bases:

>100_bases
GTAGGCGCATTCGTCGCGCGCGGAACGGCCAGCGAGCCCATAGATTGACGCATGCTTGAACTGGCCCACGCCGGTTCGCG
ACCAATCATGGGTATCCGAC

Downstream 100 bases:

>100_bases
CGGTAGTCCCGTAGTACTACGGGGGGTGATGCAATTCTCGCTGTTAACCCCTAAAGGATAGTCTCGACTACAAGTTCTGC
TGTGTTTGGTGAATACAAAT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MATSASSSSSGPTRTETDSFGPIEVAADRYWGAQTERSRQNFRIGHDRMPLGVVHALALVKLAAAKTNRELGLLDPAMAD
AIVQAAQEIIDGKLDDHFPLVVWQTGSGTQTNMNLNEVIANRASELMGGERGTKKPVHPNDHVNMSQSSNDSFPTAMHIA
AARAISGHLVPALSELLAALRAKQDAFADIVKIGRTHTQDATPLTLGQEFSGYAAQVESAITRIKTAAHDLLPLAQGGTA
VGTGLNAHPDFAGLFARHVADITGLAFTTAANKFEALASNDAYVFAHGAINAAATGLFKIANDIRFLGSGPRSGLGELIL
PENEPGSSIMPGKVNPTQCEALTMVCCQVFGNHTAITMAGSQGHFELNVYKPLLAHCMMQSIQLLGDAARSFHEHCVTGI
QADETRIRELMQRSLMLVTALAPKIGYDNAAKVAKTAHQRGTTLKEEAVRLGLVSEDEFDRLVQPEKMTRPGRS

Sequences:

>Translated_474_residues
MATSASSSSSGPTRTETDSFGPIEVAADRYWGAQTERSRQNFRIGHDRMPLGVVHALALVKLAAAKTNRELGLLDPAMAD
AIVQAAQEIIDGKLDDHFPLVVWQTGSGTQTNMNLNEVIANRASELMGGERGTKKPVHPNDHVNMSQSSNDSFPTAMHIA
AARAISGHLVPALSELLAALRAKQDAFADIVKIGRTHTQDATPLTLGQEFSGYAAQVESAITRIKTAAHDLLPLAQGGTA
VGTGLNAHPDFAGLFARHVADITGLAFTTAANKFEALASNDAYVFAHGAINAAATGLFKIANDIRFLGSGPRSGLGELIL
PENEPGSSIMPGKVNPTQCEALTMVCCQVFGNHTAITMAGSQGHFELNVYKPLLAHCMMQSIQLLGDAARSFHEHCVTGI
QADETRIRELMQRSLMLVTALAPKIGYDNAAKVAKTAHQRGTTLKEEAVRLGLVSEDEFDRLVQPEKMTRPGRS
>Mature_473_residues
ATSASSSSSGPTRTETDSFGPIEVAADRYWGAQTERSRQNFRIGHDRMPLGVVHALALVKLAAAKTNRELGLLDPAMADA
IVQAAQEIIDGKLDDHFPLVVWQTGSGTQTNMNLNEVIANRASELMGGERGTKKPVHPNDHVNMSQSSNDSFPTAMHIAA
ARAISGHLVPALSELLAALRAKQDAFADIVKIGRTHTQDATPLTLGQEFSGYAAQVESAITRIKTAAHDLLPLAQGGTAV
GTGLNAHPDFAGLFARHVADITGLAFTTAANKFEALASNDAYVFAHGAINAAATGLFKIANDIRFLGSGPRSGLGELILP
ENEPGSSIMPGKVNPTQCEALTMVCCQVFGNHTAITMAGSQGHFELNVYKPLLAHCMMQSIQLLGDAARSFHEHCVTGIQ
ADETRIRELMQRSLMLVTALAPKIGYDNAAKVAKTAHQRGTTLKEEAVRLGLVSEDEFDRLVQPEKMTRPGRS

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=470, Percent_Identity=62.9787234042553, Blast_Score=590, Evalue=1e-168,
Organism=Homo sapiens, GI266458395, Length=59, Percent_Identity=54.2372881355932, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=59.5185995623632, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI87082375, Length=465, Percent_Identity=39.3548387096774, Blast_Score=340, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=62.8260869565217, Blast_Score=607, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=61.7737003058104, Blast_Score=421, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=63.4782608695652, Blast_Score=586, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=61.1713665943601, Blast_Score=576, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=61.1713665943601, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24662684, Length=470, Percent_Identity=58.0851063829787, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=57.5757575757576, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=50.3239740820734, Blast_Score=477, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50556; Mature: 50425

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSASSSSSGPTRTETDSFGPIEVAADRYWGAQTERSRQNFRIGHDRMPLGVVHALALV
CCCCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCCCHHCHHCCCCCCCCCCHHHHHHHHHH
KLAAAKTNRELGLLDPAMADAIVQAAQEIIDGKLDDHFPLVVWQTGSGTQTNMNLNEVIA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
NRASELMGGERGTKKPVHPNDHVNMSQSSNDSFPTAMHIAAARAISGHLVPALSELLAAL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
RAKQDAFADIVKIGRTHTQDATPLTLGQEFSGYAAQVESAITRIKTAAHDLLPLAQGGTA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VGTGLNAHPDFAGLFARHVADITGLAFTTAANKFEALASNDAYVFAHGAINAAATGLFKI
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
ANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEALTMVCCQVFGNHTAITMAG
HHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
SQGHFELNVYKPLLAHCMMQSIQLLGDAARSFHEHCVTGIQADETRIRELMQRSLMLVTA
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LAPKIGYDNAAKVAKTAHQRGTTLKEEAVRLGLVSEDEFDRLVQPEKMTRPGRS
HHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure 
ATSASSSSSGPTRTETDSFGPIEVAADRYWGAQTERSRQNFRIGHDRMPLGVVHALALV
CCCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCCCHHCHHCCCCCCCCCCHHHHHHHHHH
KLAAAKTNRELGLLDPAMADAIVQAAQEIIDGKLDDHFPLVVWQTGSGTQTNMNLNEVIA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
NRASELMGGERGTKKPVHPNDHVNMSQSSNDSFPTAMHIAAARAISGHLVPALSELLAAL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
RAKQDAFADIVKIGRTHTQDATPLTLGQEFSGYAAQVESAITRIKTAAHDLLPLAQGGTA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VGTGLNAHPDFAGLFARHVADITGLAFTTAANKFEALASNDAYVFAHGAINAAATGLFKI
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
ANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEALTMVCCQVFGNHTAITMAG
HHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
SQGHFELNVYKPLLAHCMMQSIQLLGDAARSFHEHCVTGIQADETRIRELMQRSLMLVTA
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LAPKIGYDNAAKVAKTAHQRGTTLKEEAVRLGLVSEDEFDRLVQPEKMTRPGRS
HHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856685; 12597275 [H]