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The map label for this gene is cobC [H]

Identifier: 146341796

GI number: 146341796

Start: 5115454

End: 5116476

Strand: Direct

Name: cobC [H]

Synonym: BRADO4915

Alternate gene names: 146341796

Gene position: 5115454-5116476 (Clockwise)

Preceding gene: 146341794

Following gene: 146341800

Centisome position: 68.6

GC content: 69.79

Gene sequence:

>1023_bases
ATGGACGACAGAGCGACTAGCACGCGCGTGGATCAGCCGGAAGCCATCGTTCACGGCGGCGATCTCGACGCGATCAGCCG
CCGCTACCCGGATGCGCCACAGCCCTGGATCGACCTGTCGACCGGCATCAATCCCGTCCCCTATCCTCTGCCCGAGCTCC
CGCCGGCAAGCTGGGCGCGCCTGCCGAGCAAGGCCGAGCAGCGCGCGCTGCAGTCTGTGGCCGCGGCGCGCTACGGCGTA
GCGGGCGAGATGATCATTGCCGCGCCGGGCACTCAGGCGCTGCTGCAGATCATGCCGCGGCTGCGCCCGCGATCGCACGT
CGCCGTGCTCGCGCCCACCTATGAGGAGCACGCGCTGTGCTGGCGCCGCGCCGGCCATCGGGTCGAATTGGTCGATGATC
TCGATGCGCTCGCCGCGGCCGATGTTGCAGTGATCGTGAATCCCAACAATCCGACCGGCCGCCTGCAGCCGCTCGATGCG
CTGGGCCGCCTGGCGTCGACCCTGCGCCGGCGCGACGGCCTGCTGGTCGTCGACGAAGCCTTTGCCGATCTGTATCCGCA
CGAAGCAAGCCTTGCGGCCGATCTGCCGCCGGCCACGATCGTGCTGCGCTCGTTCGGCAAGGTCTACGGGCTTGCCGGTA
TACGCCTCGGCTTTGCGATCGGCCCGGACGACATCATCGGGCACATCCGGGACGAGCTCGGGCCGTGGGCGGTCTCGGGT
CCAGCGCTCGCCATCGGAACGGCCGCACTAAGCGACGACGCCTGGCTGCACCAGACACGCGCGCGCCTGGTGCATGATTG
CGCGCGCATCGATGCGCTTCTATCCGACGCCGGATGCACGGCGATCGGCGGCACGCCGCTGTTCCGGCTGATCGCATCGG
TCAGCGGGTCCGACATCGCCGAGCGCCTCGCGCGTCACGGCATTCACGTCCGCCGCTTCCCGGGGCAACCGAGCTGGCTG
CGTTTCGGCCTGCCGGGCGATGAAGCTCAGTGGCAGCGGCTCACGCAGGCGCTTGCCGGCTAG

Upstream 100 bases:

>100_bases
GATCCGCTGCACCAGCATTTGGGGATAGCCGACCGCCGCCTCGAAGAGGAGCGCCGTGAGCGCGAGTGAGACGAACATCG
ATCTCCGCTAAGGGATGGAC

Downstream 100 bases:

>100_bases
CCGAGCACGCAAGCTGCGAGCAGCAGCGTCTCCGTCACCTCGATGCTGGCGCCATGACAGTCGCCGGTGATGCCGCCGAG
CCGCCATTGCCAGTAGAAGG

Product: putative threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MDDRATSTRVDQPEAIVHGGDLDAISRRYPDAPQPWIDLSTGINPVPYPLPELPPASWARLPSKAEQRALQSVAAARYGV
AGEMIIAAPGTQALLQIMPRLRPRSHVAVLAPTYEEHALCWRRAGHRVELVDDLDALAAADVAVIVNPNNPTGRLQPLDA
LGRLASTLRRRDGLLVVDEAFADLYPHEASLAADLPPATIVLRSFGKVYGLAGIRLGFAIGPDDIIGHIRDELGPWAVSG
PALAIGTAALSDDAWLHQTRARLVHDCARIDALLSDAGCTAIGGTPLFRLIASVSGSDIAERLARHGIHVRRFPGQPSWL
RFGLPGDEAQWQRLTQALAG

Sequences:

>Translated_340_residues
MDDRATSTRVDQPEAIVHGGDLDAISRRYPDAPQPWIDLSTGINPVPYPLPELPPASWARLPSKAEQRALQSVAAARYGV
AGEMIIAAPGTQALLQIMPRLRPRSHVAVLAPTYEEHALCWRRAGHRVELVDDLDALAAADVAVIVNPNNPTGRLQPLDA
LGRLASTLRRRDGLLVVDEAFADLYPHEASLAADLPPATIVLRSFGKVYGLAGIRLGFAIGPDDIIGHIRDELGPWAVSG
PALAIGTAALSDDAWLHQTRARLVHDCARIDALLSDAGCTAIGGTPLFRLIASVSGSDIAERLARHGIHVRRFPGQPSWL
RFGLPGDEAQWQRLTQALAG
>Mature_340_residues
MDDRATSTRVDQPEAIVHGGDLDAISRRYPDAPQPWIDLSTGINPVPYPLPELPPASWARLPSKAEQRALQSVAAARYGV
AGEMIIAAPGTQALLQIMPRLRPRSHVAVLAPTYEEHALCWRRAGHRVELVDDLDALAAADVAVIVNPNNPTGRLQPLDA
LGRLASTLRRRDGLLVVDEAFADLYPHEASLAADLPPATIVLRSFGKVYGLAGIRLGFAIGPDDIIGHIRDELGPWAVSG
PALAIGTAALSDDAWLHQTRARLVHDCARIDALLSDAGCTAIGGTPLFRLIASVSGSDIAERLARHGIHVRRFPGQPSWL
RFGLPGDEAQWQRLTQALAG

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=323, Percent_Identity=25.6965944272446, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 36514; Mature: 36514

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDRATSTRVDQPEAIVHGGDLDAISRRYPDAPQPWIDLSTGINPVPYPLPELPPASWAR
CCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHH
LPSKAEQRALQSVAAARYGVAGEMIIAAPGTQALLQIMPRLRPRSHVAVLAPTYEEHALC
CCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCEEEEECCHHHHHHH
WRRAGHRVELVDDLDALAAADVAVIVNPNNPTGRLQPLDALGRLASTLRRRDGLLVVDEA
HHHCCCEEEEHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHH
FADLYPHEASLAADLPPATIVLRSFGKVYGLAGIRLGFAIGPDDIIGHIRDELGPWAVSG
HHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHCCCEEECC
PALAIGTAALSDDAWLHQTRARLVHDCARIDALLSDAGCTAIGGTPLFRLIASVSGSDIA
CCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHH
ERLARHGIHVRRFPGQPSWLRFGLPGDEAQWQRLTQALAG
HHHHHCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDDRATSTRVDQPEAIVHGGDLDAISRRYPDAPQPWIDLSTGINPVPYPLPELPPASWAR
CCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHH
LPSKAEQRALQSVAAARYGVAGEMIIAAPGTQALLQIMPRLRPRSHVAVLAPTYEEHALC
CCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCEEEEECCHHHHHHH
WRRAGHRVELVDDLDALAAADVAVIVNPNNPTGRLQPLDALGRLASTLRRRDGLLVVDEA
HHHCCCEEEEHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHH
FADLYPHEASLAADLPPATIVLRSFGKVYGLAGIRLGFAIGPDDIIGHIRDELGPWAVSG
HHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHCCCEEECC
PALAIGTAALSDDAWLHQTRARLVHDCARIDALLSDAGCTAIGGTPLFRLIASVSGSDIA
CCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHH
ERLARHGIHVRRFPGQPSWLRFGLPGDEAQWQRLTQALAG
HHHHHCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520 [H]