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The map label for this gene is clpA [C]

Identifier: 146341454

GI number: 146341454

Start: 4742723

End: 4745110

Strand: Reverse

Name: clpA [C]

Synonym: BRADO4545

Alternate gene names: 146341454

Gene position: 4745110-4742723 (Counterclockwise)

Preceding gene: 146341455

Following gene: 146341448

Centisome position: 63.64

GC content: 63.65

Gene sequence:

>2388_bases
ATGCCGACTTTTTCTCAAAGCCTTGAACAATCCCTGCATCGTGCGCTGGCGATTGCCAACGAGCGTCATCATCAATACGC
GACATTGGAACATCTCCTCTTGTCCTTGATCGATGACAGCGATGCAGCGGCCGTGATGCGCGCGTGCAGCGTCGACCTCG
ACAAGCTGCGCGGCAGTCTCGTGAACTACCTCGAAACCGAGTTCGAAAATCTGGTGACGGACGGCAGCGACGACGCCAAG
CCGACCGCGGGTTTCCAGCGCGTGATCCAGCGCGCCGTGATTCACGTTCAGTCATCGGGCCGCGAAGAGGTGACCGGCGC
CAACGTGCTGATCGCGATCTTTGCGGAGCGCGAAAGCCACGCCGCGTACTTCCTGCAAGAGCAGGACATGACGCGCTACG
ACGCCGTGAACTACATCAGCCACGGCATCGCCAAGCGCCCTGGTGTCTCCGAAGCGCGCCCGGTGCGTGGCGTCGACGAA
GAGACCGAGACCAAGGGCAACGAGGACTCCAAGAAAAAGGGCGAGGCGCTGGAAACCTATTGCGTCAATCTCAACAAGAA
GGCCCGCGACGGCAAGATCGATCCGGTGATCGGCCGTAACTCCGAGATCAACCGCGCCATCCAGGTGCTGTGCCGGAGGC
AGAAGAACAATCCGCTGTTCGTCGGCGAAGCCGGCGTTGGCAAGACGGCGATCGCCGAAGGGCTCGCCAAGCGCATCGTC
GACAGCGAGGTTCCCGAGGTGCTGTCCGCGGCGACCGTGTTCTCGCTGGACATGGGCACCTTGCTCGCCGGCACGCGCTA
TCGTGGCGACTTCGAGGAGCGGCTGAAGCAGGTCCTCAAGGAGCTCGAGGCGCACCCGAACGCGATCCTGTTCATCGACG
AGATCCACACCGTGATCGGTGCGGGTGCGACGTCGGGCGGGGCGATGGATGCGTCGAACCTCTTGAAGCCGGCGCTGGCC
TCAGGCTCGATCCGCTGCATGGGCTCGACGACCTACAAGGAATATCGCCAGCACTTCGAGAAGGACCGCGCTTTGGTGCG
CCGGTTCCAGAAGATCGACGTCAACGAACCGTCGGTGGAAGATGCGATCGCGATCCTGAAGGGCCTCAAGCCGTACTTCG
AGGACTATCACCGGCTGAAGTACACCAACGAGGCCATCGAGGCCGCGGTGCAGTTGTCGTCGCGCTACATCCACGACCGC
AAGCTGCCGGACAAGGCGATCGACGTGATCGACGAATCCGGTGCGGCGCAGATGCTGCTCGCCGAAAACAAGCGCAAGAA
GACGATCGGCATCAAGGAGATCGAGACCACGATCGCCACGATGGCGCGCATCCCGCCGAAGAGCGTGTCGAAGGACGACG
CCGAGGTGCTCAAGCATCTTGAGCAGACCCTGAAGCGTGTGGTGTTCGGCCAGGACAAGGCGATCGACTCGCTGTCCGCC
TCGATCAAGCTGGCGCGCGCCGGCCTGCGCGAGCCGGAGAAGCCGATCGGCTGCTACCTGTTCTCGGGTCCGACCGGCGT
CGGCAAGACCGAGGTGGCCAAGCAGTTGGCCTCGACGCTCGGTGTCGAGCTCCTGCGCTTCGACATGTCGGAGTACATGG
AGCGGCACACGGTGTCGCGCCTGATCGGCGCACCTCCGGGATATGTCGGCTTCGACCAGGGCGGCCTCCTGACCGATGGC
GTCGACCAGCATCCGCACTGCGTGGTGCTGCTGGACGAGATCGAGAAGGCGCATCCGGATCTGTACAATGTGCTGCTGCA
GATCATGGATCACGGCCGCCTCACCGACCACAACGGCAAGCAGGTGAACTTCCGCAACGTCATCCTGATCATGACGACGA
ATGCGGGCGCGGCGGACCTCGCCAAGCAGGCGTTCGGCTTCCACCGCTCCAAGCGGGAAGGGGACGACCACGAGGCGATC
AACCGGCAGTTCGCGCCGGAATTCCGCAACCGTCTCGATGCGATCGTCTCGTTCGGCCACCTCTCGGTCGACGTGATCGG
CATGGTGGTGGAGAAGTTCGTGCTACAGCTCGAGGCCCAGCTGGCCGACCGCGACGTCACGATCGAGCTGTCGGAGCCGG
CGAAGGCCTGGCTGATCCAGCACGGCTATGACGAGCAAATGGGTGCGCGCCCGATGGGCCGCGTGATCCAGGAGCACATC
AAGAAGCCGCTGGCCGACGAGGTGCTGTTCGGTAAGCTGAAGAGCGGTGGCCACGTCCGTGTCGTCCTGGTCAAGGACGA
GTCCGGTGTGGACGAGAAGATCGGCTTCGAGTTCGTCGATGGCCCGGTCTCGCCGAAGTCGGAAGTGCCGGCGGCGCGCA
AGCGCAAGCCGAAGTCCGGCGGCGGTCCGAAGGGCCCGGCGCCCAAGGGTCCGCTGGTCAAGGCATGA

Upstream 100 bases:

>100_bases
GGTCTTTTGTCGCACTCGGTTATAACTATATTTGACAAAGGTTGTTGTTGCCTGACCGGGCGGCGGCGATCATGATGGCA
GGGGGCCACAGAGGACGCGC

Downstream 100 bases:

>100_bases
TGCCGGGACGAGAGCATTAAAGGGAAAGGCCGGCTTCGCGCCGGCCTTTTTCTGTTTGGTAGCGTCGTCGATGAAGAGGT
GGGGCCGGATCTTACTCGCG

Product: ATP-dependent specificity subunit of clpA-clpP serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 795; Mature: 794

Protein sequence:

>795_residues
MPTFSQSLEQSLHRALAIANERHHQYATLEHLLLSLIDDSDAAAVMRACSVDLDKLRGSLVNYLETEFENLVTDGSDDAK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLIAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRPGVSEARPVRGVDE
ETETKGNEDSKKKGEALETYCVNLNKKARDGKIDPVIGRNSEINRAIQVLCRRQKNNPLFVGEAGVGKTAIAEGLAKRIV
DSEVPEVLSAATVFSLDMGTLLAGTRYRGDFEERLKQVLKELEAHPNAILFIDEIHTVIGAGATSGGAMDASNLLKPALA
SGSIRCMGSTTYKEYRQHFEKDRALVRRFQKIDVNEPSVEDAIAILKGLKPYFEDYHRLKYTNEAIEAAVQLSSRYIHDR
KLPDKAIDVIDESGAAQMLLAENKRKKTIGIKEIETTIATMARIPPKSVSKDDAEVLKHLEQTLKRVVFGQDKAIDSLSA
SIKLARAGLREPEKPIGCYLFSGPTGVGKTEVAKQLASTLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDG
VDQHPHCVVLLDEIEKAHPDLYNVLLQIMDHGRLTDHNGKQVNFRNVILIMTTNAGAADLAKQAFGFHRSKREGDDHEAI
NRQFAPEFRNRLDAIVSFGHLSVDVIGMVVEKFVLQLEAQLADRDVTIELSEPAKAWLIQHGYDEQMGARPMGRVIQEHI
KKPLADEVLFGKLKSGGHVRVVLVKDESGVDEKIGFEFVDGPVSPKSEVPAARKRKPKSGGGPKGPAPKGPLVKA

Sequences:

>Translated_795_residues
MPTFSQSLEQSLHRALAIANERHHQYATLEHLLLSLIDDSDAAAVMRACSVDLDKLRGSLVNYLETEFENLVTDGSDDAK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLIAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRPGVSEARPVRGVDE
ETETKGNEDSKKKGEALETYCVNLNKKARDGKIDPVIGRNSEINRAIQVLCRRQKNNPLFVGEAGVGKTAIAEGLAKRIV
DSEVPEVLSAATVFSLDMGTLLAGTRYRGDFEERLKQVLKELEAHPNAILFIDEIHTVIGAGATSGGAMDASNLLKPALA
SGSIRCMGSTTYKEYRQHFEKDRALVRRFQKIDVNEPSVEDAIAILKGLKPYFEDYHRLKYTNEAIEAAVQLSSRYIHDR
KLPDKAIDVIDESGAAQMLLAENKRKKTIGIKEIETTIATMARIPPKSVSKDDAEVLKHLEQTLKRVVFGQDKAIDSLSA
SIKLARAGLREPEKPIGCYLFSGPTGVGKTEVAKQLASTLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDG
VDQHPHCVVLLDEIEKAHPDLYNVLLQIMDHGRLTDHNGKQVNFRNVILIMTTNAGAADLAKQAFGFHRSKREGDDHEAI
NRQFAPEFRNRLDAIVSFGHLSVDVIGMVVEKFVLQLEAQLADRDVTIELSEPAKAWLIQHGYDEQMGARPMGRVIQEHI
KKPLADEVLFGKLKSGGHVRVVLVKDESGVDEKIGFEFVDGPVSPKSEVPAARKRKPKSGGGPKGPAPKGPLVKA
>Mature_794_residues
PTFSQSLEQSLHRALAIANERHHQYATLEHLLLSLIDDSDAAAVMRACSVDLDKLRGSLVNYLETEFENLVTDGSDDAKP
TAGFQRVIQRAVIHVQSSGREEVTGANVLIAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRPGVSEARPVRGVDEE
TETKGNEDSKKKGEALETYCVNLNKKARDGKIDPVIGRNSEINRAIQVLCRRQKNNPLFVGEAGVGKTAIAEGLAKRIVD
SEVPEVLSAATVFSLDMGTLLAGTRYRGDFEERLKQVLKELEAHPNAILFIDEIHTVIGAGATSGGAMDASNLLKPALAS
GSIRCMGSTTYKEYRQHFEKDRALVRRFQKIDVNEPSVEDAIAILKGLKPYFEDYHRLKYTNEAIEAAVQLSSRYIHDRK
LPDKAIDVIDESGAAQMLLAENKRKKTIGIKEIETTIATMARIPPKSVSKDDAEVLKHLEQTLKRVVFGQDKAIDSLSAS
IKLARAGLREPEKPIGCYLFSGPTGVGKTEVAKQLASTLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDGV
DQHPHCVVLLDEIEKAHPDLYNVLLQIMDHGRLTDHNGKQVNFRNVILIMTTNAGAADLAKQAFGFHRSKREGDDHEAIN
RQFAPEFRNRLDAIVSFGHLSVDVIGMVVEKFVLQLEAQLADRDVTIELSEPAKAWLIQHGYDEQMGARPMGRVIQEHIK
KPLADEVLFGKLKSGGHVRVVLVKDESGVDEKIGFEFVDGPVSPKSEVPAARKRKPKSGGGPKGPAPKGPLVKA

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=352, Percent_Identity=31.5340909090909, Blast_Score=162, Evalue=9e-40,
Organism=Escherichia coli, GI1787109, Length=746, Percent_Identity=57.7747989276139, Blast_Score=892, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=280, Percent_Identity=55.3571428571429, Blast_Score=300, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6320464, Length=250, Percent_Identity=56, Blast_Score=271, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6323002, Length=364, Percent_Identity=40.3846153846154, Blast_Score=255, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 87554; Mature: 87423

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTFSQSLEQSLHRALAIANERHHQYATLEHLLLSLIDDSDAAAVMRACSVDLDKLRGSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHH
VNYLETEFENLVTDGSDDAKPTAGFQRVIQRAVIHVQSSGREEVTGANVLIAIFAERESH
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQDMTRYDAVNYISHGIAKRPGVSEARPVRGVDEETETKGNEDSKKKGEALETY
CEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHH
CVNLNKKARDGKIDPVIGRNSEINRAIQVLCRRQKNNPLFVGEAGVGKTAIAEGLAKRIV
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHH
DSEVPEVLSAATVFSLDMGTLLAGTRYRGDFEERLKQVLKELEAHPNAILFIDEIHTVIG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHH
AGATSGGAMDASNLLKPALASGSIRCMGSTTYKEYRQHFEKDRALVRRFQKIDVNEPSVE
CCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DAIAILKGLKPYFEDYHRLKYTNEAIEAAVQLSSRYIHDRKLPDKAIDVIDESGAAQMLL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHH
AENKRKKTIGIKEIETTIATMARIPPKSVSKDDAEVLKHLEQTLKRVVFGQDKAIDSLSA
HCCCCHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SIKLARAGLREPEKPIGCYLFSGPTGVGKTEVAKQLASTLGVELLRFDMSEYMERHTVSR
HHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGAPPGYVGFDQGGLLTDGVDQHPHCVVLLDEIEKAHPDLYNVLLQIMDHGRLTDHNGK
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC
QVNFRNVILIMTTNAGAADLAKQAFGFHRSKREGDDHEAINRQFAPEFRNRLDAIVSFGH
EEEECEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCC
LSVDVIGMVVEKFVLQLEAQLADRDVTIELSEPAKAWLIQHGYDEQMGARPMGRVIQEHI
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCHHHCCCHHHHHHHHHH
KKPLADEVLFGKLKSGGHVRVVLVKDESGVDEKIGFEFVDGPVSPKSEVPAARKRKPKSG
HCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHCCCEEECCCCCCHHCCCHHHHCCCCCC
GGPKGPAPKGPLVKA
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
PTFSQSLEQSLHRALAIANERHHQYATLEHLLLSLIDDSDAAAVMRACSVDLDKLRGSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHH
VNYLETEFENLVTDGSDDAKPTAGFQRVIQRAVIHVQSSGREEVTGANVLIAIFAERESH
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQDMTRYDAVNYISHGIAKRPGVSEARPVRGVDEETETKGNEDSKKKGEALETY
CEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHH
CVNLNKKARDGKIDPVIGRNSEINRAIQVLCRRQKNNPLFVGEAGVGKTAIAEGLAKRIV
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHH
DSEVPEVLSAATVFSLDMGTLLAGTRYRGDFEERLKQVLKELEAHPNAILFIDEIHTVIG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHH
AGATSGGAMDASNLLKPALASGSIRCMGSTTYKEYRQHFEKDRALVRRFQKIDVNEPSVE
CCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DAIAILKGLKPYFEDYHRLKYTNEAIEAAVQLSSRYIHDRKLPDKAIDVIDESGAAQMLL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHH
AENKRKKTIGIKEIETTIATMARIPPKSVSKDDAEVLKHLEQTLKRVVFGQDKAIDSLSA
HCCCCHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SIKLARAGLREPEKPIGCYLFSGPTGVGKTEVAKQLASTLGVELLRFDMSEYMERHTVSR
HHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGAPPGYVGFDQGGLLTDGVDQHPHCVVLLDEIEKAHPDLYNVLLQIMDHGRLTDHNGK
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC
QVNFRNVILIMTTNAGAADLAKQAFGFHRSKREGDDHEAINRQFAPEFRNRLDAIVSFGH
EEEECEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCC
LSVDVIGMVVEKFVLQLEAQLADRDVTIELSEPAKAWLIQHGYDEQMGARPMGRVIQEHI
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCHHHCCCHHHHHHHHHH
KKPLADEVLFGKLKSGGHVRVVLVKDESGVDEKIGFEFVDGPVSPKSEVPAARKRKPKSG
HCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHCCCEEECCCCCCHHCCCHHHHCCCCCC
GGPKGPAPKGPLVKA
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]