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The map label for this gene is nadC [H]

Identifier: 146341438

GI number: 146341438

Start: 4728580

End: 4729428

Strand: Reverse

Name: nadC [H]

Synonym: BRADO4529

Alternate gene names: 146341438

Gene position: 4729428-4728580 (Counterclockwise)

Preceding gene: 146341439

Following gene: 146341433

Centisome position: 63.43

GC content: 70.2

Gene sequence:

>849_bases
ATGAGCCTCAATCCACTCTTTCCCTTGCTCTACGAGCCACTGCTCCGTGCGGCGCTGCTGGAGGATCTCGGCCGCGCCGG
CGACATCACCACCGATGCGATCGTGCCCGCCGGGCAGCGCGCTGCCCTGCAGTTGCGGGCGCGCCAGCCCGGCGTGATCG
CCGGCCTCGACGTCGCGCGCTGCGCCTTTCAGACGGTCTCGCCCGAGGTTCGCATGGAGACGATCCGCGGCGACGGCAGC
GTCGTCGCGGCCGGCGATGTGATCGCCACGATCAACGGCCCGGCGCGGGCGCTGCTGACCGGCGAGCGCGTCGCGCTGAA
CTTCCTCTGCCACCTCAGCGGCGTCGCCTCCGCGACGGCCTCGCTGGTCGCGGCCGTGAAGGGCACGCGGGCGCAGATCG
TGTGCACGCGCAAGACGACGCCGGGGCTGCGCGCGCTGGAGAAATATGCGGTGCGCGCGGGTGGGGGCGGCAATCATCGG
TTCGGGCTGGATGATGCGGTCCTGATCAAGGACAACCATATCGCGATTGCCGGCGGCATCGCGGCGGCGATCACCAGGGC
CAAGGCTCATGCCGGCCATCTCGTGAAGATCGAGGTCGAGGTGGACAATCTCGCGCAGCTCGAGCAGGCGCTGAAGCTGG
GCGTCGATGCGGTCCTGCTCGACAACATGACGCCGCCAGAGCTCGAACGCGCCGTCGGCATGGCCCGCGGCAAGGCGATC
ACCGAGGCCTCGGGCCGGATCACCGTCGACACCGCGCCGGCGATCGCGGCGGCGGGTGTCGACCTGATCTCGGTCGGCTG
GATCACGCATTCCTCGGCCGCGCTGGACATCGGGCTCGACGATGCGTGA

Upstream 100 bases:

>100_bases
TGCCCGCCGCGCAGCCGTCCCGTTTTACGTCGTCCTCAGCGATCGCCGCCGCGTGGGAGATTGCGGAGACAGGGCATCCT
TCATTCAGGAGCATCGTATC

Downstream 100 bases:

>100_bases
GCCGTGATCAGCCCTTGAGCGCCGCGATCAGCTTCGCGGCGTTCTCTTCCAGCACCTTCGGGTCCTCCTTGCGGCTGGCC
GGCGGCAGCAGGCTGTCGCC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSLNPLFPLLYEPLLRAALLEDLGRAGDITTDAIVPAGQRAALQLRARQPGVIAGLDVARCAFQTVSPEVRMETIRGDGS
VVAAGDVIATINGPARALLTGERVALNFLCHLSGVASATASLVAAVKGTRAQIVCTRKTTPGLRALEKYAVRAGGGGNHR
FGLDDAVLIKDNHIAIAGGIAAAITRAKAHAGHLVKIEVEVDNLAQLEQALKLGVDAVLLDNMTPPELERAVGMARGKAI
TEASGRITVDTAPAIAAAGVDLISVGWITHSSAALDIGLDDA

Sequences:

>Translated_282_residues
MSLNPLFPLLYEPLLRAALLEDLGRAGDITTDAIVPAGQRAALQLRARQPGVIAGLDVARCAFQTVSPEVRMETIRGDGS
VVAAGDVIATINGPARALLTGERVALNFLCHLSGVASATASLVAAVKGTRAQIVCTRKTTPGLRALEKYAVRAGGGGNHR
FGLDDAVLIKDNHIAIAGGIAAAITRAKAHAGHLVKIEVEVDNLAQLEQALKLGVDAVLLDNMTPPELERAVGMARGKAI
TEASGRITVDTAPAIAAAGVDLISVGWITHSSAALDIGLDDA
>Mature_281_residues
SLNPLFPLLYEPLLRAALLEDLGRAGDITTDAIVPAGQRAALQLRARQPGVIAGLDVARCAFQTVSPEVRMETIRGDGSV
VAAGDVIATINGPARALLTGERVALNFLCHLSGVASATASLVAAVKGTRAQIVCTRKTTPGLRALEKYAVRAGGGGNHRF
GLDDAVLIKDNHIAIAGGIAAAITRAKAHAGHLVKIEVEVDNLAQLEQALKLGVDAVLLDNMTPPELERAVGMARGKAIT
EASGRITVDTAPAIAAAGVDLISVGWITHSSAALDIGLDDA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=278, Percent_Identity=37.7697841726619, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1786299, Length=267, Percent_Identity=42.3220973782771, Blast_Score=168, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321162, Length=250, Percent_Identity=32.8, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29044; Mature: 28913

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNPLFPLLYEPLLRAALLEDLGRAGDITTDAIVPAGQRAALQLRARQPGVIAGLDVAR
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCHHHH
CAFQTVSPEVRMETIRGDGSVVAAGDVIATINGPARALLTGERVALNFLCHLSGVASATA
HHHHHCCCCEEEEEECCCCCEEEECCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHH
SLVAAVKGTRAQIVCTRKTTPGLRALEKYAVRAGGGGNHRFGLDDAVLIKDNHIAIAGGI
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEECHH
AAAITRAKAHAGHLVKIEVEVDNLAQLEQALKLGVDAVLLDNMTPPELERAVGMARGKAI
HHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCEE
TEASGRITVDTAPAIAAAGVDLISVGWITHSSAALDIGLDDA
EECCCEEEEECCCHHHHCCCCEEEEEEEECCCCEEEECCCCC
>Mature Secondary Structure 
SLNPLFPLLYEPLLRAALLEDLGRAGDITTDAIVPAGQRAALQLRARQPGVIAGLDVAR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCHHHH
CAFQTVSPEVRMETIRGDGSVVAAGDVIATINGPARALLTGERVALNFLCHLSGVASATA
HHHHHCCCCEEEEEECCCCCEEEECCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHH
SLVAAVKGTRAQIVCTRKTTPGLRALEKYAVRAGGGGNHRFGLDDAVLIKDNHIAIAGGI
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEECHH
AAAITRAKAHAGHLVKIEVEVDNLAQLEQALKLGVDAVLLDNMTPPELERAVGMARGKAI
HHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCEE
TEASGRITVDTAPAIAAAGVDLISVGWITHSSAALDIGLDDA
EECCCEEEEECCCHHHHCCCCEEEEEEEECCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]