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The map label for this gene is hppA [H]

Identifier: 146341339

GI number: 146341339

Start: 4625670

End: 4627790

Strand: Reverse

Name: hppA [H]

Synonym: BRADO4423

Alternate gene names: 146341339

Gene position: 4627790-4625670 (Counterclockwise)

Preceding gene: 146341340

Following gene: 146341336

Centisome position: 62.06

GC content: 66.29

Gene sequence:

>2121_bases
ATGTCAGCTTTATGGGTGATCGTGCTCTGCGGAGCGCTGTCGATCGTCTATGCGATCTGGGCCACACAATCGGTGCTCAG
CGCAGACGCCGGCAATGCGCGCATGCAGGAAATCGCGGCGGCCGTGGCCGAGGGCGCTCAGGCCTATCTCCGCCGCCAAT
ATACGACGATCGGAATCGTCGGCGTCGTGATCTTCGTGCTCCTTGCTTATTTCCTCGGCACTCTCGTCGCAGTCGGCTTC
GCGATTGGTGCCATTCTCTCCGGCGCCGCCGGCTTCATCGGAATGAACGTCTCGGTGCGTGCCAACGTTCGCACCGCCCA
GGCGGCGACCACCTCGCTCGCCGGCGGCCTCGAACTCGCCTTCAAGGCCGGCGCCATCACCGGCCTGCTCGTCGCCGGTC
TCGCGCTGCTCGGCGTCACTATCTACTTCGGCGTCCTCACCGGCTTCCTGAAGCTCGCGCCCGACAGCCGCACCGTGATC
GACGCGCTGGTCGCGCTCGGCTTCGGCGCCTCGCTGATCTCGATCTTCGCCCGTCTCGGCGGCGGCATCTTCACCAAGGG
CGCCGACGTCGGCGGCGACCTCGTCGGCAAGGTCGAAGCGGGCATTCCCGAGGATGATCCGCGCAACCCGGCGACCATCG
CCGACAACGTCGGCGACAATGTCGGCGACTGCGCCGGCATGGCGGCCGACCTGTTCGAGACCTACGCGGTGACCGCGGTC
GCCACCATGGTGCTGGCCGCGATCTTCTTCGCCAAATCGTCGCTGCTCGCGAACATGATGACCTTGCCGCTCGCCATCGG
CGGCATCTGCATCCTAACTTCGATCGCCGGCACCTTCTTCGTCAAGCTCGGCGCCAGCCAGTCGATCATGGGCGCGCTGT
ACAAGGGCCTGATCGCGACTGGCGTGCTGTCGCTGGTCGGTCTCGCGATTGCGATCGCTTGGCTGATCGGCTTCGGCAAG
CTCGACGGCGTCGACTACACGGGGTCGGCATTGTTCATCTGCGGCGTCGTCGGCCTCGTCGTCACCGGTCTGATCATCTG
GATCACCGAGTACTACACCGGCACCGACTTCCGCCCGGTGAAGTCGATCGCGGCGGCCTCGGTCACCGGTCACGGCACCA
ACGTGATCCAGGGCCTCGCCATCTCGATGGAGGCGACCGCGCTGCCCGCAATCGTGATCATCGCCGGCATCCTGGTCACC
TACAGCCTCGCCGGCCTGTTCGGCATCGCGATCGCGACCACGACGATGCTGGCGCTCGCCGGCATGATCGTCGCGCTCGA
CGCCTTCGGCCCGGTCACCGACAACGCCGGCGGCATCGCCGAAATGGCCGGTCTGCCCAAGGAGGTCCGCAAGTCGACCG
ACGCGCTCGACGCGGTCGGCAACACCACCAAGGCGGTCACCAAGGGCTATGCGATCGGCTCCGCCGGTCTCGGCGCGCTG
GTGCTGTTCGCGGCATATAACCAGGACCTGCAGTTCTTCATCTCCGACTCCGCCAAGCATCCGTACTTCGCGGGGATCAA
GCCGGACTTCTCGCTGAACAACCCCTACGTCGTGGTCGGCCTGCTGTTCGGTGGCCTGCTGCCGTATCTGTTCGGCGCGA
TGGGCATGACCGCGGTCGGCCGCGCCGCCGGCGCGATCGTGGAGGAGGTGCGCCGCCAATTCCGCGAGAAGCCGGGCATC
ATGCAGGGCACCGACAAGCCTGACTATGGCAAGGCGGTCGACCTGCTGACCAAGGCGGCGATCAAGGAGATGATCATCCC
CTCGCTGCTGCCGGTGCTATCGCCGATCGTGGTCTACTTCCTGATCTACGCGATCGCGGGCGGTGGCGCGGCCGGCAAGT
CGGCGGCGTTCTCGGCCGTCGGCGCCATGCTGCTCGGCGTGATCGTCACCGGTCTCTTCGTCGCGATCTCGATGACCTCG
GGCGGCGGCGCCTGGGACAACGCCAAGAAGTACATCGAGGACGGCCATTTCGGCGGCAAGGGTTCTGACGCCCACAAGTC
GGCCGTCACCGGTGACACCGTCGGCGATCCCTACAAGGACACCGCGGGCCCCGCGGTGAACCCGATGATCAAGATCACCA
ACATCGTGGCCCTGCTGCTGCTGGCGATCCTGGCGCACTGA

Upstream 100 bases:

>100_bases
CGTTCGAGGCGGTTCCGCCCGGAGCTGCCTGACAAGGGGGCGTGCGTCGCACAAGCGCGGCGTGACGTAGTTCAAAAAAG
CAAAGAGCCGAGGAAACTAA

Downstream 100 bases:

>100_bases
GCAACGGAACGGCACTTCAAACAAAGACCCCGCGGTGCGAGCCGCGGGGTCTTGTCATTTCGATATCGTGTTCTGCCGCT
ACTCCGCGGCGCTCTGCCGC

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MSALWVIVLCGALSIVYAIWATQSVLSADAGNARMQEIAAAVAEGAQAYLRRQYTTIGIVGVVIFVLLAYFLGTLVAVGF
AIGAILSGAAGFIGMNVSVRANVRTAQAATTSLAGGLELAFKAGAITGLLVAGLALLGVTIYFGVLTGFLKLAPDSRTVI
DALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTAV
ATMVLAAIFFAKSSLLANMMTLPLAIGGICILTSIAGTFFVKLGASQSIMGALYKGLIATGVLSLVGLAIAIAWLIGFGK
LDGVDYTGSALFICGVVGLVVTGLIIWITEYYTGTDFRPVKSIAAASVTGHGTNVIQGLAISMEATALPAIVIIAGILVT
YSLAGLFGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRKSTDALDAVGNTTKAVTKGYAIGSAGLGAL
VLFAAYNQDLQFFISDSAKHPYFAGIKPDFSLNNPYVVVGLLFGGLLPYLFGAMGMTAVGRAAGAIVEEVRRQFREKPGI
MQGTDKPDYGKAVDLLTKAAIKEMIIPSLLPVLSPIVVYFLIYAIAGGGAAGKSAAFSAVGAMLLGVIVTGLFVAISMTS
GGGAWDNAKKYIEDGHFGGKGSDAHKSAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAILAH

Sequences:

>Translated_706_residues
MSALWVIVLCGALSIVYAIWATQSVLSADAGNARMQEIAAAVAEGAQAYLRRQYTTIGIVGVVIFVLLAYFLGTLVAVGF
AIGAILSGAAGFIGMNVSVRANVRTAQAATTSLAGGLELAFKAGAITGLLVAGLALLGVTIYFGVLTGFLKLAPDSRTVI
DALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTAV
ATMVLAAIFFAKSSLLANMMTLPLAIGGICILTSIAGTFFVKLGASQSIMGALYKGLIATGVLSLVGLAIAIAWLIGFGK
LDGVDYTGSALFICGVVGLVVTGLIIWITEYYTGTDFRPVKSIAAASVTGHGTNVIQGLAISMEATALPAIVIIAGILVT
YSLAGLFGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRKSTDALDAVGNTTKAVTKGYAIGSAGLGAL
VLFAAYNQDLQFFISDSAKHPYFAGIKPDFSLNNPYVVVGLLFGGLLPYLFGAMGMTAVGRAAGAIVEEVRRQFREKPGI
MQGTDKPDYGKAVDLLTKAAIKEMIIPSLLPVLSPIVVYFLIYAIAGGGAAGKSAAFSAVGAMLLGVIVTGLFVAISMTS
GGGAWDNAKKYIEDGHFGGKGSDAHKSAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAILAH
>Mature_705_residues
SALWVIVLCGALSIVYAIWATQSVLSADAGNARMQEIAAAVAEGAQAYLRRQYTTIGIVGVVIFVLLAYFLGTLVAVGFA
IGAILSGAAGFIGMNVSVRANVRTAQAATTSLAGGLELAFKAGAITGLLVAGLALLGVTIYFGVLTGFLKLAPDSRTVID
ALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTAVA
TMVLAAIFFAKSSLLANMMTLPLAIGGICILTSIAGTFFVKLGASQSIMGALYKGLIATGVLSLVGLAIAIAWLIGFGKL
DGVDYTGSALFICGVVGLVVTGLIIWITEYYTGTDFRPVKSIAAASVTGHGTNVIQGLAISMEATALPAIVIIAGILVTY
SLAGLFGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRKSTDALDAVGNTTKAVTKGYAIGSAGLGALV
LFAAYNQDLQFFISDSAKHPYFAGIKPDFSLNNPYVVVGLLFGGLLPYLFGAMGMTAVGRAAGAIVEEVRRQFREKPGIM
QGTDKPDYGKAVDLLTKAAIKEMIIPSLLPVLSPIVVYFLIYAIAGGGAAGKSAAFSAVGAMLLGVIVTGLFVAISMTSG
GGAWDNAKKYIEDGHFGGKGSDAHKSAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAILAH

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 71812; Mature: 71681

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALWVIVLCGALSIVYAIWATQSVLSADAGNARMQEIAAAVAEGAQAYLRRQYTTIGIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVIFVLLAYFLGTLVAVGFAIGAILSGAAGFIGMNVSVRANVRTAQAATTSLAGGLELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEECCHHHHHHHHHHCCCHHHH
FKAGAITGLLVAGLALLGVTIYFGVLTGFLKLAPDSRTVIDALVALGFGASLISIFARLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTAV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAAIFFAKSSLLANMMTLPLAIGGICILTSIAGTFFVKLGASQSIMGALYKGLIAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GVLSLVGLAIAIAWLIGFGKLDGVDYTGSALFICGVVGLVVTGLIIWITEYYTGTDFRPV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
KSIAAASVTGHGTNVIQGLAISMEATALPAIVIIAGILVTYSLAGLFGIAIATTTMLALA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMIVALDAFGPVTDNAGGIAEMAGLPKEVRKSTDALDAVGNTTKAVTKGYAIGSAGLGAL
HHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHH
VLFAAYNQDLQFFISDSAKHPYFAGIKPDFSLNNPYVVVGLLFGGLLPYLFGAMGMTAVG
HHHHHHCCCHHEEEECCCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
RAAGAIVEEVRRQFREKPGIMQGTDKPDYGKAVDLLTKAAIKEMIIPSLLPVLSPIVVYF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIYAIAGGGAAGKSAAFSAVGAMLLGVIVTGLFVAISMTSGGGAWDNAKKYIEDGHFGGK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
GSDAHKSAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAILAH
CCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SALWVIVLCGALSIVYAIWATQSVLSADAGNARMQEIAAAVAEGAQAYLRRQYTTIGIV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVIFVLLAYFLGTLVAVGFAIGAILSGAAGFIGMNVSVRANVRTAQAATTSLAGGLELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEECCHHHHHHHHHHCCCHHHH
FKAGAITGLLVAGLALLGVTIYFGVLTGFLKLAPDSRTVIDALVALGFGASLISIFARLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTAV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAAIFFAKSSLLANMMTLPLAIGGICILTSIAGTFFVKLGASQSIMGALYKGLIAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GVLSLVGLAIAIAWLIGFGKLDGVDYTGSALFICGVVGLVVTGLIIWITEYYTGTDFRPV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
KSIAAASVTGHGTNVIQGLAISMEATALPAIVIIAGILVTYSLAGLFGIAIATTTMLALA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMIVALDAFGPVTDNAGGIAEMAGLPKEVRKSTDALDAVGNTTKAVTKGYAIGSAGLGAL
HHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHH
VLFAAYNQDLQFFISDSAKHPYFAGIKPDFSLNNPYVVVGLLFGGLLPYLFGAMGMTAVG
HHHHHHCCCHHEEEECCCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
RAAGAIVEEVRRQFREKPGIMQGTDKPDYGKAVDLLTKAAIKEMIIPSLLPVLSPIVVYF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIYAIAGGGAAGKSAAFSAVGAMLLGVIVTGLFVAISMTSGGGAWDNAKKYIEDGHFGGK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
GSDAHKSAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAILAH
CCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]