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The map label for this gene is gabT [H]

Identifier: 146340387

GI number: 146340387

Start: 3607870

End: 3609171

Strand: Direct

Name: gabT [H]

Synonym: BRADO3420

Alternate gene names: 146340387

Gene position: 3607870-3609171 (Clockwise)

Preceding gene: 146340386

Following gene: 146340388

Centisome position: 48.39

GC content: 67.13

Gene sequence:

>1302_bases
ATGGCCGTCGATCAGGCTGTCAATCCTGCCGCAAACCAGCAATTGCTGGCACGTCGACACGAGGCCGTCGTTCGCGGCGT
GAGCTACGCGACGCCGCTGTTTGCCGACCGGGCCCTCAACAGCGAGGTGTGGGACGTCGAGGGCAAGCGCTATGTCGACT
TCGCCGGCGGCATCGCGGTGCTCAACACCGGCCATTGCCATCCGCATGTCGTAGCCGCGATCCGCGCCCAGCTCGACCGT
TTCACCCACACCTGCTTTCAGGTGCTGCAATACGAGCCTTACGTTCGGCTCTCCGAGCGGCTGAATGCGCTGGCGCCGGT
CGCAGGTCCCGCCAAGTCGATCCTGCTGACCACCGGCGCGGAGGCCACCGAGAACGCCATCAAGATCGCACGCGCCGCCA
CGGGGCGCAGCGGCATCATCGCGTTCACCGGCGCCTTCCATGGCCGCACCGCGCTCGCCAATGCGATGACCGGCAAGGTG
ATGCCCTACAAGAGGCCGTTCGGCCCGCCGTTGCCCGGCATCTGGCACGCGCCATTCCCGGTCGCCGGCAGCAACGTCTC
GGTCGAGGACACGCTCTCCTACATCAACTTCATCTTCAAGGCCGACATCGACGCCTCGCAGGTGGCGGCCATCATCATCG
AGCCGGTCCAGGGCGAAGGCGGCTTCCATCAGGCGCCGCCGGACCTGATGCGCGGCCTGCGCCGGATCTGCGATGCCAAT
GGCATCGTGCTGATCGCCGACGAGGTGCAGACCGGATTCGGCCGCACCGGCAAGATGTTTGCGATGGAGCATTACGACGT
GCAGCCCGACCTGATCTGCGTCGCCAAGAGCCTCGCCGGCGGCATGCCGCTGTCGGGCGTGATCGGCCGCTCGGCGATCA
TGGACGCGGCGGAGCCGGGCGGGCTCGGCGGCACCTATGGCGGCAATCCGCTGGCCTGCGCGGCCGCGCTCGCCGTGCTC
GACGTCTTCGAGCAGGAGAAGCTGGTGGAGCGCGCCAACACAATCGGCGACCGGCTGCGCGCCGCGATCACGCGCTTTTC
CCGCGCCAACAATCTGGTTCCGGTTTCCGGGCCCCGCGGTCCTGGCGCGATGGTTGCATTCGACATCCTCAAGCAGCGCG
GCAGCGATGAGCCGGACCCGGAGATGACCAAGCGTGTGACCCGCGTGGCGCATGAGAATGGTCTGATCCTGTTGTCGTGC
GGCGTAACCGCGAGCACCATCCGGATTCTGGTGCCGCTGACCGCGTCGAACGAGATCGTGGACGAAGGGCTCGCGATCCT
GGAGAAGTGTCTGGCCGCCTGA

Upstream 100 bases:

>100_bases
TCTGGTGCCTTCAAGTCACCCGTCGTGTGGAACAAGCTGATTGATCGCGCCCGCCCTCGGCCTAGCCTCTTGCTCAGTTG
TCCGATGAAGGAGCTGAGCC

Downstream 100 bases:

>100_bases
GGCGGTCGAGATCGAATGCTGGAGGCTGGAGAGTGACTGAAACTGTGGCGGCCGTGCCCAACGATGTGATGGAGCGGCTC
GCCGCCGCCGTGGATGCCAA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MAVDQAVNPAANQQLLARRHEAVVRGVSYATPLFADRALNSEVWDVEGKRYVDFAGGIAVLNTGHCHPHVVAAIRAQLDR
FTHTCFQVLQYEPYVRLSERLNALAPVAGPAKSILLTTGAEATENAIKIARAATGRSGIIAFTGAFHGRTALANAMTGKV
MPYKRPFGPPLPGIWHAPFPVAGSNVSVEDTLSYINFIFKADIDASQVAAIIIEPVQGEGGFHQAPPDLMRGLRRICDAN
GIVLIADEVQTGFGRTGKMFAMEHYDVQPDLICVAKSLAGGMPLSGVIGRSAIMDAAEPGGLGGTYGGNPLACAAALAVL
DVFEQEKLVERANTIGDRLRAAITRFSRANNLVPVSGPRGPGAMVAFDILKQRGSDEPDPEMTKRVTRVAHENGLILLSC
GVTASTIRILVPLTASNEIVDEGLAILEKCLAA

Sequences:

>Translated_433_residues
MAVDQAVNPAANQQLLARRHEAVVRGVSYATPLFADRALNSEVWDVEGKRYVDFAGGIAVLNTGHCHPHVVAAIRAQLDR
FTHTCFQVLQYEPYVRLSERLNALAPVAGPAKSILLTTGAEATENAIKIARAATGRSGIIAFTGAFHGRTALANAMTGKV
MPYKRPFGPPLPGIWHAPFPVAGSNVSVEDTLSYINFIFKADIDASQVAAIIIEPVQGEGGFHQAPPDLMRGLRRICDAN
GIVLIADEVQTGFGRTGKMFAMEHYDVQPDLICVAKSLAGGMPLSGVIGRSAIMDAAEPGGLGGTYGGNPLACAAALAVL
DVFEQEKLVERANTIGDRLRAAITRFSRANNLVPVSGPRGPGAMVAFDILKQRGSDEPDPEMTKRVTRVAHENGLILLSC
GVTASTIRILVPLTASNEIVDEGLAILEKCLAA
>Mature_432_residues
AVDQAVNPAANQQLLARRHEAVVRGVSYATPLFADRALNSEVWDVEGKRYVDFAGGIAVLNTGHCHPHVVAAIRAQLDRF
THTCFQVLQYEPYVRLSERLNALAPVAGPAKSILLTTGAEATENAIKIARAATGRSGIIAFTGAFHGRTALANAMTGKVM
PYKRPFGPPLPGIWHAPFPVAGSNVSVEDTLSYINFIFKADIDASQVAAIIIEPVQGEGGFHQAPPDLMRGLRRICDANG
IVLIADEVQTGFGRTGKMFAMEHYDVQPDLICVAKSLAGGMPLSGVIGRSAIMDAAEPGGLGGTYGGNPLACAAALAVLD
VFEQEKLVERANTIGDRLRAAITRFSRANNLVPVSGPRGPGAMVAFDILKQRGSDEPDPEMTKRVTRVAHENGLILLSCG
VTASTIRILVPLTASNEIVDEGLAILEKCLAA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=415, Percent_Identity=30.8433734939759, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI13994255, Length=445, Percent_Identity=30.561797752809, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI284507298, Length=326, Percent_Identity=31.2883435582822, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI37574042, Length=447, Percent_Identity=27.5167785234899, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI24119277, Length=447, Percent_Identity=26.8456375838926, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI226442709, Length=398, Percent_Identity=27.8894472361809, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI226442705, Length=426, Percent_Identity=26.5258215962441, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI188536080, Length=409, Percent_Identity=26.8948655256724, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI38679950, Length=409, Percent_Identity=26.8948655256724, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI38679946, Length=409, Percent_Identity=26.8948655256724, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789016, Length=422, Percent_Identity=52.3696682464455, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1787560, Length=423, Percent_Identity=52.7186761229314, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI1789759, Length=394, Percent_Identity=33.502538071066, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI145693181, Length=421, Percent_Identity=35.8669833729216, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1788044, Length=400, Percent_Identity=33.75, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1786349, Length=314, Percent_Identity=34.0764331210191, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786991, Length=310, Percent_Identity=32.9032258064516, Blast_Score=138, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=401, Percent_Identity=32.6683291770574, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI32564660, Length=430, Percent_Identity=29.0697674418605, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI71992977, Length=450, Percent_Identity=27.5555555555556, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI25144274, Length=285, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=475, Percent_Identity=24.6315789473684, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71981843, Length=163, Percent_Identity=29.4478527607362, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324432, Length=427, Percent_Identity=30.9133489461358, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6323470, Length=423, Percent_Identity=31.2056737588652, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6321456, Length=421, Percent_Identity=25.41567695962, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=325, Percent_Identity=24, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=34.1584158415842, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI161085790, Length=461, Percent_Identity=28.4164859002169, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI28574759, Length=438, Percent_Identity=28.7671232876712, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI21356575, Length=430, Percent_Identity=30.9302325581395, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI281366494, Length=386, Percent_Identity=26.1658031088083, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667139, Length=386, Percent_Identity=26.1658031088083, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667143, Length=386, Percent_Identity=26.1658031088083, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45917; Mature: 45786

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVDQAVNPAANQQLLARRHEAVVRGVSYATPLFADRALNSEVWDVEGKRYVDFAGGIAV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEECCCCEEEEECCCEEE
LNTGHCHPHVVAAIRAQLDRFTHTCFQVLQYEPYVRLSERLNALAPVAGPAKSILLTTGA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECCC
EATENAIKIARAATGRSGIIAFTGAFHGRTALANAMTGKVMPYKRPFGPPLPGIWHAPFP
CHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
VAGSNVSVEDTLSYINFIFKADIDASQVAAIIIEPVQGEGGFHQAPPDLMRGLRRICDAN
CCCCCCCHHHHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCC
GIVLIADEVQTGFGRTGKMFAMEHYDVQPDLICVAKSLAGGMPLSGVIGRSAIMDAAEPG
CEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
GLGGTYGGNPLACAAALAVLDVFEQEKLVERANTIGDRLRAAITRFSRANNLVPVSGPRG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCC
PGAMVAFDILKQRGSDEPDPEMTKRVTRVAHENGLILLSCGVTASTIRILVPLTASNEIV
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEECCCCHHH
DEGLAILEKCLAA
HHHHHHHHHHHCC
>Mature Secondary Structure 
AVDQAVNPAANQQLLARRHEAVVRGVSYATPLFADRALNSEVWDVEGKRYVDFAGGIAV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEECCCCEEEEECCCEEE
LNTGHCHPHVVAAIRAQLDRFTHTCFQVLQYEPYVRLSERLNALAPVAGPAKSILLTTGA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECCC
EATENAIKIARAATGRSGIIAFTGAFHGRTALANAMTGKVMPYKRPFGPPLPGIWHAPFP
CHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
VAGSNVSVEDTLSYINFIFKADIDASQVAAIIIEPVQGEGGFHQAPPDLMRGLRRICDAN
CCCCCCCHHHHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCC
GIVLIADEVQTGFGRTGKMFAMEHYDVQPDLICVAKSLAGGMPLSGVIGRSAIMDAAEPG
CEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
GLGGTYGGNPLACAAALAVLDVFEQEKLVERANTIGDRLRAAITRFSRANNLVPVSGPRG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCC
PGAMVAFDILKQRGSDEPDPEMTKRVTRVAHENGLILLSCGVTASTIRILVPLTASNEIV
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEECCCCHHH
DEGLAILEKCLAA
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]