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The map label for this gene is gmk [H]

Identifier: 146340294

GI number: 146340294

Start: 3511253

End: 3511912

Strand: Direct

Name: gmk [H]

Synonym: BRADO3317

Alternate gene names: 146340294

Gene position: 3511253-3511912 (Clockwise)

Preceding gene: 146340293

Following gene: 146340296

Centisome position: 47.09

GC content: 67.58

Gene sequence:

>660_bases
ATGGCGGCTCACGACGGAAGTTTCGATGGCGTCGAGCGGCGCGGCCTGATGTTCGTGCTCTCGTCGCCGTCGGGCGCGGG
CAAGACGACGCTGTCGCGCATGCTGATCGAGCGCATGCCGGGCCTGCAGATGTCGGTGTCGGCAACGACGCGGCCGATGC
GCCCCGGTGAGGTCGACGGCCGCGACTATCACTTCGTCGACCGCGCGCGCTTCGAGGAGATGGTCAAGCGCAACGAACTG
CTCGAATGGGCGACCGTGTTCGACAACCGTTACGGCACGCCGCGCGGCCCGGTCGAGGCCGCGCTGTCCGCCGGCAAGGA
CGTGCTTTTCGACATCGACTGGCAGGGCACGCAGCAGCTGCGCGAGAAGGCGCGGCAGGACGTCGTCAGCGTCTTCATCC
TGCCGCCGTCGGCCGCAGATCTCGAGAAGCGGCTGCACACGCGCGCGCAGGACTCGCATGACGTGATCCGCGGGCGCATG
AGCCGCGCCAGCCACGAGATGAGTCATTGGGCGGAATACGACTACATCGTCATCAATCGCAACGTCGACGAGGCGTTTGC
CGAGGTGCAGTCGATCCTCAAGGCTGAGCGGCTGAAGCGCGAGCGCCGGACCGGGCTGACGACCTTCGTGCGCGAGCTGC
AGCGCCAGCTCGAGGGCTGA

Upstream 100 bases:

>100_bases
GTGCTCGAAGTCGAACGACATCGAGCTGACGAATATCGGTCTCGAGCTGAAGACCGTGGTCGAGCAGTTTCGCGAACAGG
TTCAGAATCTGGAGTGATCC

Downstream 100 bases:

>100_bases
CGCGCCGTCCGTTCAACCGTTCACGCCCGGCGGCCAAGCCTTGCCAGGATGTCCTGGATGCCGTCGAGCTCGTCATCCTG
CTGAATGCTGCGGGGCCGGG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MAAHDGSFDGVERRGLMFVLSSPSGAGKTTLSRMLIERMPGLQMSVSATTRPMRPGEVDGRDYHFVDRARFEEMVKRNEL
LEWATVFDNRYGTPRGPVEAALSAGKDVLFDIDWQGTQQLREKARQDVVSVFILPPSAADLEKRLHTRAQDSHDVIRGRM
SRASHEMSHWAEYDYIVINRNVDEAFAEVQSILKAERLKRERRTGLTTFVRELQRQLEG

Sequences:

>Translated_219_residues
MAAHDGSFDGVERRGLMFVLSSPSGAGKTTLSRMLIERMPGLQMSVSATTRPMRPGEVDGRDYHFVDRARFEEMVKRNEL
LEWATVFDNRYGTPRGPVEAALSAGKDVLFDIDWQGTQQLREKARQDVVSVFILPPSAADLEKRLHTRAQDSHDVIRGRM
SRASHEMSHWAEYDYIVINRNVDEAFAEVQSILKAERLKRERRTGLTTFVRELQRQLEG
>Mature_218_residues
AAHDGSFDGVERRGLMFVLSSPSGAGKTTLSRMLIERMPGLQMSVSATTRPMRPGEVDGRDYHFVDRARFEEMVKRNELL
EWATVFDNRYGTPRGPVEAALSAGKDVLFDIDWQGTQQLREKARQDVVSVFILPPSAADLEKRLHTRAQDSHDVIRGRMS
RASHEMSHWAEYDYIVINRNVDEAFAEVQSILKAERLKRERRTGLTTFVRELQRQLEG

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=34.5549738219895, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=34.5549738219895, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=34.5549738219895, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI14780902, Length=189, Percent_Identity=27.5132275132275, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI38570142, Length=177, Percent_Identity=27.683615819209, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI261862237, Length=172, Percent_Identity=27.3255813953488, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI119943108, Length=172, Percent_Identity=27.3255813953488, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI262118259, Length=175, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI119943106, Length=152, Percent_Identity=27.6315789473684, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI4505237, Length=175, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI262118263, Length=175, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=48.4375, Blast_Score=191, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193203132, Length=182, Percent_Identity=33.5164835164835, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=182, Percent_Identity=33.5164835164835, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71984092, Length=176, Percent_Identity=31.25, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71988041, Length=185, Percent_Identity=27.5675675675676, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=185, Percent_Identity=27.5675675675676, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=37.3626373626374, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356141, Length=197, Percent_Identity=30.9644670050761, Blast_Score=101, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25021; Mature: 24889

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAHDGSFDGVERRGLMFVLSSPSGAGKTTLSRMLIERMPGLQMSVSATTRPMRPGEVDG
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCC
RDYHFVDRARFEEMVKRNELLEWATVFDNRYGTPRGPVEAALSAGKDVLFDIDWQGTQQL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEECCCCCHHHH
REKARQDVVSVFILPPSAADLEKRLHTRAQDSHDVIRGRMSRASHEMSHWAEYDYIVINR
HHHHHHHHHEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
NVDEAFAEVQSILKAERLKRERRTGLTTFVRELQRQLEG
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AAHDGSFDGVERRGLMFVLSSPSGAGKTTLSRMLIERMPGLQMSVSATTRPMRPGEVDG
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCC
RDYHFVDRARFEEMVKRNELLEWATVFDNRYGTPRGPVEAALSAGKDVLFDIDWQGTQQL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEECCCCCHHHH
REKARQDVVSVFILPPSAADLEKRLHTRAQDSHDVIRGRMSRASHEMSHWAEYDYIVINR
HHHHHHHHHEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
NVDEAFAEVQSILKAERLKRERRTGLTTFVRELQRQLEG
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA