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The map label for this gene is fabF [H]

Identifier: 146340291

GI number: 146340291

Start: 3507427

End: 3508692

Strand: Direct

Name: fabF [H]

Synonym: BRADO3314

Alternate gene names: 146340291

Gene position: 3507427-3508692 (Clockwise)

Preceding gene: 146340290

Following gene: 146340292

Centisome position: 47.04

GC content: 65.4

Gene sequence:

>1266_bases
ATGAGGCGGGTTGTCGTCACTGGCCTTGGCATGGTTTCGCCGCTTGGCTGTGGTGTTGAAACGACCTGGCAGCGGATCCT
TCAGGGCAAGAGCGGCGCGCGTGTGATCGGAACGTTTGACGTCTCCGATCTGCCGGCCAAGGTCGCCTGCCAGGTGCCGC
GCGGCGATGGCAGCGACGGCACGTTCAACGCCGATCAGTGGATGGAGCCGAAGGACCAGCGCAAGGTCGACGACTTCATC
ATCTTCGCGATGGCCGCCGCGCGTCAGGCGCTCGATGACGCCAACTGGCACCCCGCCACGGAAGAAGACCGCTGCGCCAC
CGGCACGCTGATCGGCTCCGGCATCGGTGGCCTGTCGGGCATCGCCGACACTGCGATCCTGCTCAAGGAACGCGGTCCGC
GGAAAGTGTCGCCGTTCTTCATTCCGGGACGTCTCATCAATCTCGCCTCGGGTTACGTCTCGATCGAGCACGGCCTCAAG
GGTCCCAATCATTCGGTGGTGACGGCCTGCTCGACAGGCGCGCACGCCATCGGCGATGCGAGCCGGCTGATCGCGCTGGG
CGATGCCGACGTCATGGTGGCCGGCGGCACCGAATCGCCGATCTGTCGAATCGGCATGGCCGGTTTTTGCGCGGCGCGCG
CGCTGTCGACCGGCTTCAACGAGACGCCCGAAAGGGCCTCGCGTCCCTACGACAAGGATCGCGACGGCTTCGTCATGGGC
GAGGGCGCCGGCGTCGTCGTGCTCGAGGAGTATGAGCACGCCAAGGCGCGCGGCGCGCGGATCTACGCCGAGGTGGTCGG
GTATGGCCTGTCGGGCGACGCCTATCACATTACCTCGCCGTCGCCGGATGGCGATGGTGGCTTCCGCAGCATGAGCGCGG
CGTTGAAGCGCGCCGGCATGACGGCCGCCGATCTGGACTACATCAACGCTCACGGCACCTCGACGCAGGTCGGCGACGAG
ATCGAGCTCGGCGCCGTCGAACGTCTGCTCGGCAATGCCGCATCGAAGGTCTCGATGTCCTCGACCAAATCGTCGATCGG
TCACCTGCTGGGTGCTGCCGGTGCCGTCGAAGCGATCTTCAGCATTCTCGCGATTCGCGATAACGTCGCTCCGCCGACGA
TCAATCTGGAGAACCCGTCGGTGGAGACCGCGATCGACCTCGTCCCGCATCAGCCTCGTCAACGCGAGATCAATGTGGCG
CTGTCGAACTCGTTTGGTTTCGGCGGCACCAATGCGTCGGTGATTTTGCGGCGCGTGGTGAGCTAG

Upstream 100 bases:

>100_bases
CGACCGGCCACGATGTGTTGCTCGAACAATGTGACCCGAGGTGCCGCGACGGCCATCTGCCGATCCACAAGCGCTCAAGG
GCGGGTCTGGAGAAACGAAC

Downstream 100 bases:

>100_bases
TGCGGAAGAGCGGAACACCGCGTGACCCTGTTGCGACTTGGTCACGCCGAATTCCGAGTGCAGCCACACTAGAACCCAAC
ACTTCGCGTGTCTTTCGCAG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MRRVVVTGLGMVSPLGCGVETTWQRILQGKSGARVIGTFDVSDLPAKVACQVPRGDGSDGTFNADQWMEPKDQRKVDDFI
IFAMAAARQALDDANWHPATEEDRCATGTLIGSGIGGLSGIADTAILLKERGPRKVSPFFIPGRLINLASGYVSIEHGLK
GPNHSVVTACSTGAHAIGDASRLIALGDADVMVAGGTESPICRIGMAGFCAARALSTGFNETPERASRPYDKDRDGFVMG
EGAGVVVLEEYEHAKARGARIYAEVVGYGLSGDAYHITSPSPDGDGGFRSMSAALKRAGMTAADLDYINAHGTSTQVGDE
IELGAVERLLGNAASKVSMSSTKSSIGHLLGAAGAVEAIFSILAIRDNVAPPTINLENPSVETAIDLVPHQPRQREINVA
LSNSFGFGGTNASVILRRVVS

Sequences:

>Translated_421_residues
MRRVVVTGLGMVSPLGCGVETTWQRILQGKSGARVIGTFDVSDLPAKVACQVPRGDGSDGTFNADQWMEPKDQRKVDDFI
IFAMAAARQALDDANWHPATEEDRCATGTLIGSGIGGLSGIADTAILLKERGPRKVSPFFIPGRLINLASGYVSIEHGLK
GPNHSVVTACSTGAHAIGDASRLIALGDADVMVAGGTESPICRIGMAGFCAARALSTGFNETPERASRPYDKDRDGFVMG
EGAGVVVLEEYEHAKARGARIYAEVVGYGLSGDAYHITSPSPDGDGGFRSMSAALKRAGMTAADLDYINAHGTSTQVGDE
IELGAVERLLGNAASKVSMSSTKSSIGHLLGAAGAVEAIFSILAIRDNVAPPTINLENPSVETAIDLVPHQPRQREINVA
LSNSFGFGGTNASVILRRVVS
>Mature_421_residues
MRRVVVTGLGMVSPLGCGVETTWQRILQGKSGARVIGTFDVSDLPAKVACQVPRGDGSDGTFNADQWMEPKDQRKVDDFI
IFAMAAARQALDDANWHPATEEDRCATGTLIGSGIGGLSGIADTAILLKERGPRKVSPFFIPGRLINLASGYVSIEHGLK
GPNHSVVTACSTGAHAIGDASRLIALGDADVMVAGGTESPICRIGMAGFCAARALSTGFNETPERASRPYDKDRDGFVMG
EGAGVVVLEEYEHAKARGARIYAEVVGYGLSGDAYHITSPSPDGDGGFRSMSAALKRAGMTAADLDYINAHGTSTQVGDE
IELGAVERLLGNAASKVSMSSTKSSIGHLLGAAGAVEAIFSILAIRDNVAPPTINLENPSVETAIDLVPHQPRQREINVA
LSNSFGFGGTNASVILRRVVS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=50.7177033492823, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI223972627, Length=193, Percent_Identity=45.0777202072539, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI41872631, Length=368, Percent_Identity=26.6304347826087, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1787337, Length=419, Percent_Identity=53.2219570405728, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1788663, Length=420, Percent_Identity=36.9047619047619, Blast_Score=248, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=425, Percent_Identity=39.5294117647059, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=44.1509433962264, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=382, Percent_Identity=25.9162303664921, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=263, Percent_Identity=27.3764258555133, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=39.5033860045147, Blast_Score=293, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=48.6997635933806, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19920632, Length=280, Percent_Identity=27.1428571428571, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI221330659, Length=280, Percent_Identity=27.1428571428571, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24581345, Length=295, Percent_Identity=24.7457627118644, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43979; Mature: 43979

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGMVSPLGCGVETTWQRILQGKSGARVIGTFDVSDLPAKVACQVPRGDGSDG
CCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCC
TFNADQWMEPKDQRKVDDFIIFAMAAARQALDDANWHPATEEDRCATGTLIGSGIGGLSG
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCHHH
IADTAILLKERGPRKVSPFFIPGRLINLASGYVSIEHGLKGPNHSVVTACSTGAHAIGDA
HHHHHHHHHCCCCCCCCCEECCCHHHHHHCCEEEEECCCCCCCCCEEEEECCCCCHHCCC
SRLIALGDADVMVAGGTESPICRIGMAGFCAARALSTGFNETPERASRPYDKDRDGFVMG
CEEEEECCCCEEEECCCCCCHHHHCHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEE
EGAGVVVLEEYEHAKARGARIYAEVVGYGLSGDAYHITSPSPDGDGGFRSMSAALKRAGM
CCCCEEEEECCHHHHHCCCEEEEHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCC
TAADLDYINAHGTSTQVGDEIELGAVERLLGNAASKVSMSSTKSSIGHLLGAAGAVEAIF
CHHHCHHEECCCCCCCCCCCCHHHHHHHHHCCHHHHHEHHHHHHHHHHHHHHHHHHHHHH
SILAIRDNVAPPTINLENPSVETAIDLVPHQPRQREINVALSNSFGFGGTNASVILRRVV
HHHHHHCCCCCCEEECCCCCHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHC
S
C
>Mature Secondary Structure
MRRVVVTGLGMVSPLGCGVETTWQRILQGKSGARVIGTFDVSDLPAKVACQVPRGDGSDG
CCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCC
TFNADQWMEPKDQRKVDDFIIFAMAAARQALDDANWHPATEEDRCATGTLIGSGIGGLSG
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCHHH
IADTAILLKERGPRKVSPFFIPGRLINLASGYVSIEHGLKGPNHSVVTACSTGAHAIGDA
HHHHHHHHHCCCCCCCCCEECCCHHHHHHCCEEEEECCCCCCCCCEEEEECCCCCHHCCC
SRLIALGDADVMVAGGTESPICRIGMAGFCAARALSTGFNETPERASRPYDKDRDGFVMG
CEEEEECCCCEEEECCCCCCHHHHCHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEE
EGAGVVVLEEYEHAKARGARIYAEVVGYGLSGDAYHITSPSPDGDGGFRSMSAALKRAGM
CCCCEEEEECCHHHHHCCCEEEEHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCC
TAADLDYINAHGTSTQVGDEIELGAVERLLGNAASKVSMSSTKSSIGHLLGAAGAVEAIF
CHHHCHHEECCCCCCCCCCCCHHHHHHHHHCCHHHHHEHHHHHHHHHHHHHHHHHHHHHH
SILAIRDNVAPPTINLENPSVETAIDLVPHQPRQREINVALSNSFGFGGTNASVILRRVV
HHHHHHCCCCCCEEECCCCCHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]