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The map label for this gene is crt [H]

Identifier: 146340120

GI number: 146340120

Start: 3333018

End: 3333788

Strand: Reverse

Name: crt [H]

Synonym: BRADO3135

Alternate gene names: 146340120

Gene position: 3333788-3333018 (Counterclockwise)

Preceding gene: 146340130

Following gene: 146340119

Centisome position: 44.71

GC content: 66.02

Gene sequence:

>771_bases
ATGGACATGCTCAATCCCCACTGCGGCGTCGACCGTGACAGCCGCGGCGTCGTGCGGCTGACGATCTGCAACGCCGGCAA
GCTCAACATTCTCGGCTCTGCCGCGATTCTCGACGTTCAGACCGGCTTGCAATCGCTTGCATCCGATCCCGGTATTCGCG
CAGTGGTCCTTGCCGGCGAGAGCGAACGCAGCATGATTGGCGGTGCCGATATCCGCGAGATGGCCTCGCTCGACCAGATG
TCGGCGGAAGTCTTCATCTCGCGGTTGGCCGGGCTGTGCGAAGCGGTGAGGAATTTTCCTGCTCCGGTGATCGCGCGGAT
GCCGGGCTGGTGCCTTGGTGGCGGCCTGGAGGTCGCGGCCGCCTGCGATATCCGCATCGCGGCTCATGACGCCAAGTTCG
GCATGCCCGAGGTGCGCGTCGGAATCCCCTCGGTCATTCATGCCGCGCTGCTGCCGCGGCTGATCGGCTGGGGCCGCACG
CGCTGGCTGCTGATGACAGCCGAAACCATCGATGCGCCGACGGCGCTGGCCTGGGGTCTGGTCGATTGGGTGGCCGCGGA
AGGCGCGCTCGACGCTGCGGTCGAACGCACGATCGAATCACTCCTCGCCTGCGGGCCGGATGCGCTCCGGCTGCAGAAGG
CCTTGCTACGGCAATGGGAGGAGCTGCCGCTGAAGGAATCGATCGCGGTTTCGATCGGAGCCTTCGGCCGCGCGTTCCTG
ACCGACGAGCCCAGGCGGCTGATGCAGCATTTCATCGATCGCAAGCGCTAG

Upstream 100 bases:

>100_bases
TGCTCGCTGCAGCTATTTGATGAATTTGAGTTGATCTAAATCAAGACCGTGACACCATTCTCAACAGCCGGAACTCAGCC
GTGCTCATGAGGAGGCGACC

Downstream 100 bases:

>100_bases
AGCCGCAAATTTTTCCAAGTTTTCGACCTCAGCTTCCGGCAGTCTCGCGCGCGCCGTCACCACAAAGTGCACGAGAACGA
CCGTTTGCTTTTCCGGGCTC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MDMLNPHCGVDRDSRGVVRLTICNAGKLNILGSAAILDVQTGLQSLASDPGIRAVVLAGESERSMIGGADIREMASLDQM
SAEVFISRLAGLCEAVRNFPAPVIARMPGWCLGGGLEVAAACDIRIAAHDAKFGMPEVRVGIPSVIHAALLPRLIGWGRT
RWLLMTAETIDAPTALAWGLVDWVAAEGALDAAVERTIESLLACGPDALRLQKALLRQWEELPLKESIAVSIGAFGRAFL
TDEPRRLMQHFIDRKR

Sequences:

>Translated_256_residues
MDMLNPHCGVDRDSRGVVRLTICNAGKLNILGSAAILDVQTGLQSLASDPGIRAVVLAGESERSMIGGADIREMASLDQM
SAEVFISRLAGLCEAVRNFPAPVIARMPGWCLGGGLEVAAACDIRIAAHDAKFGMPEVRVGIPSVIHAALLPRLIGWGRT
RWLLMTAETIDAPTALAWGLVDWVAAEGALDAAVERTIESLLACGPDALRLQKALLRQWEELPLKESIAVSIGAFGRAFL
TDEPRRLMQHFIDRKR
>Mature_256_residues
MDMLNPHCGVDRDSRGVVRLTICNAGKLNILGSAAILDVQTGLQSLASDPGIRAVVLAGESERSMIGGADIREMASLDQM
SAEVFISRLAGLCEAVRNFPAPVIARMPGWCLGGGLEVAAACDIRIAAHDAKFGMPEVRVGIPSVIHAALLPRLIGWGRT
RWLLMTAETIDAPTALAWGLVDWVAAEGALDAAVERTIESLLACGPDALRLQKALLRQWEELPLKESIAVSIGAFGRAFL
TDEPRRLMQHFIDRKR

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4502327, Length=239, Percent_Identity=30.9623430962343, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI194097323, Length=246, Percent_Identity=26.4227642276423, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI68989263, Length=168, Percent_Identity=32.1428571428571, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI20127408, Length=191, Percent_Identity=32.4607329842932, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI31542718, Length=218, Percent_Identity=27.0642201834862, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI70995211, Length=183, Percent_Identity=30.0546448087432, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI221142681, Length=202, Percent_Identity=27.7227722772277, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=30.1204819277108, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788682, Length=219, Percent_Identity=32.4200913242009, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788597, Length=211, Percent_Identity=25.5924170616114, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790281, Length=175, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082183, Length=195, Percent_Identity=29.2307692307692, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17540714, Length=223, Percent_Identity=29.1479820627803, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17560910, Length=245, Percent_Identity=27.3469387755102, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17554946, Length=245, Percent_Identity=26.530612244898, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25145438, Length=243, Percent_Identity=27.1604938271605, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=177, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=173, Percent_Identity=33.5260115606936, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508951, Length=173, Percent_Identity=33.5260115606936, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=181, Percent_Identity=29.2817679558011, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17508953, Length=178, Percent_Identity=32.5842696629214, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17540306, Length=214, Percent_Identity=26.6355140186916, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534483, Length=182, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653139, Length=219, Percent_Identity=31.0502283105023, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI20129971, Length=244, Percent_Identity=29.0983606557377, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24653477, Length=244, Percent_Identity=29.0983606557377, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24583077, Length=198, Percent_Identity=30.3030303030303, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24583079, Length=198, Percent_Identity=30.3030303030303, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19921000, Length=191, Percent_Identity=29.8429319371728, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 27539; Mature: 27539

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMLNPHCGVDRDSRGVVRLTICNAGKLNILGSAAILDVQTGLQSLASDPGIRAVVLAGE
CCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECC
SERSMIGGADIREMASLDQMSAEVFISRLAGLCEAVRNFPAPVIARMPGWCLGGGLEVAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEECCCCEEEE
ACDIRIAAHDAKFGMPEVRVGIPSVIHAALLPRLIGWGRTRWLLMTAETIDAPTALAWGL
EEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHH
VDWVAAEGALDAAVERTIESLLACGPDALRLQKALLRQWEELPLKESIAVSIGAFGRAFL
HHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHC
TDEPRRLMQHFIDRKR
CCCHHHHHHHHHHCCC
>Mature Secondary Structure
MDMLNPHCGVDRDSRGVVRLTICNAGKLNILGSAAILDVQTGLQSLASDPGIRAVVLAGE
CCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECC
SERSMIGGADIREMASLDQMSAEVFISRLAGLCEAVRNFPAPVIARMPGWCLGGGLEVAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEECCCCEEEE
ACDIRIAAHDAKFGMPEVRVGIPSVIHAALLPRLIGWGRTRWLLMTAETIDAPTALAWGL
EEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHH
VDWVAAEGALDAAVERTIESLLACGPDALRLQKALLRQWEELPLKESIAVSIGAFGRAFL
HHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHC
TDEPRRLMQHFIDRKR
CCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]