Click here to switch to the map view.

The map label for this gene is atoB [H]

Identifier: 146340119

GI number: 146340119

Start: 3331689

End: 3332876

Strand: Reverse

Name: atoB [H]

Synonym: BRADO3134

Alternate gene names: 146340119

Gene position: 3332876-3331689 (Counterclockwise)

Preceding gene: 146340120

Following gene: 146340118

Centisome position: 44.7

GC content: 68.69

Gene sequence:

>1188_bases
ATGGCCTCGTTCGATCCCGTCATGATCCTGTCCGCTGCGCGCACGCCGCTCGGCCGCTTCATGGGCGAATTGTCGCCGCT
GCGCGCGCATGAGCTCGGGGCTCACGCGATCAAATCGGCGCTCGAGCGGGCGGCTCTCGCCCCCGAGACAGTCGGAGAGG
TCTTCATGGGCAACGTGCTGCCGGCGGGCCAGGGCCAGGCCCCGGCCCGACAGGCTGCGCGCGGCGCCGGGCTGCCCGAC
GCGACGGGCGCCACCACGATCAACAAGGTCTGCGGCTCCGGGATGAAGGCGACGATGCTGGCGCACGACATCATCCGCGC
CGGCTCCGCCGACATCGTCGTGTCCGGCGGCATGGAAAGCATGAGCAATGCGCCCTATCTGCTCGCAAAGGCGCGCGGCG
GCTACCGCGCCGGTCACGATCGTATTTTCGATCACATGATGTTGGACGGGCTGGAGGACGCCTATGACACCGGCCGCTCG
ATGGGGGACTTCGGCGAGGCCACGGCCGAAGCCTATCAGTTCACGCGCGCCGACCAGGACGCCTACGCCATCGAAACGCT
GACGCGCGCCCGAAAGGCGGTCGAAAGCGGCGCGTTCGCGGCCGAGATCGTGCCGATCACGCTGACGGAAAAATCTGGTC
CGCGGGTGGTGACGAACGACGAGCATCCACTCAAGGTCGATCCAGCCAAAATCCCGGCGCTGAAGGCGGCATTCCGCAAG
GACGGCACCATCACGCCGGCGGCGTCCTCCGCCAATGCCGACGGCGCTGCGGCGCTCGTGCTTGCGACGCGAACGCGCAC
CGAACGCGACGGCCTCCCGGTGATCGCCGAGATCAAGGGACACGCGACGCACAGTCAGGAGCCGCAATGGTTCACGACGG
CGCCGATTCCGGCGATCCGCAAGCTGCTCGACAAGGTCGGTTGGCGGGTCGAGGACGTCGACCTGTTCGAGATCAACGAG
GCGTTCGCCGTGGTCGCCATGGCCGCCCAACGCGACCTCGGCATTCCCCGCGAACGGCTGAACGTCAATGGCGGCGCCTG
CGCGCTGGGCCACCCCATCGGCGCCACCGGCGCCCGGCTGATCGTGACGTTGCTGCACGCGATGCAGACACGTGGTCTGA
GGCGCGGTGTCGCCTCGCTATGCATCGGCGGTGGCGAGGCCACGGCGATCGCACTGGAGCGGCCGTGA

Upstream 100 bases:

>100_bases
GTCTCGCGCGCGCCGTCACCACAAAGTGCACGAGAACGACCGTTTGCTTTTCCGGGCTCTCATTATATGATGATCATCAT
CTTTACTCAGGGAGCCTGTC

Downstream 100 bases:

>100_bases
TGTCCAGAAACGAGGGAACATTGGCATTCATGTCGAACGCTCATTCTGGCAGGATGAGCAAGGCCTCTCCAATCGGACGA
ACTCGATGATCTCGAACCAA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MASFDPVMILSAARTPLGRFMGELSPLRAHELGAHAIKSALERAALAPETVGEVFMGNVLPAGQGQAPARQAARGAGLPD
ATGATTINKVCGSGMKATMLAHDIIRAGSADIVVSGGMESMSNAPYLLAKARGGYRAGHDRIFDHMMLDGLEDAYDTGRS
MGDFGEATAEAYQFTRADQDAYAIETLTRARKAVESGAFAAEIVPITLTEKSGPRVVTNDEHPLKVDPAKIPALKAAFRK
DGTITPAASSANADGAAALVLATRTRTERDGLPVIAEIKGHATHSQEPQWFTTAPIPAIRKLLDKVGWRVEDVDLFEINE
AFAVVAMAAQRDLGIPRERLNVNGGACALGHPIGATGARLIVTLLHAMQTRGLRRGVASLCIGGGEATAIALERP

Sequences:

>Translated_395_residues
MASFDPVMILSAARTPLGRFMGELSPLRAHELGAHAIKSALERAALAPETVGEVFMGNVLPAGQGQAPARQAARGAGLPD
ATGATTINKVCGSGMKATMLAHDIIRAGSADIVVSGGMESMSNAPYLLAKARGGYRAGHDRIFDHMMLDGLEDAYDTGRS
MGDFGEATAEAYQFTRADQDAYAIETLTRARKAVESGAFAAEIVPITLTEKSGPRVVTNDEHPLKVDPAKIPALKAAFRK
DGTITPAASSANADGAAALVLATRTRTERDGLPVIAEIKGHATHSQEPQWFTTAPIPAIRKLLDKVGWRVEDVDLFEINE
AFAVVAMAAQRDLGIPRERLNVNGGACALGHPIGATGARLIVTLLHAMQTRGLRRGVASLCIGGGEATAIALERP
>Mature_394_residues
ASFDPVMILSAARTPLGRFMGELSPLRAHELGAHAIKSALERAALAPETVGEVFMGNVLPAGQGQAPARQAARGAGLPDA
TGATTINKVCGSGMKATMLAHDIIRAGSADIVVSGGMESMSNAPYLLAKARGGYRAGHDRIFDHMMLDGLEDAYDTGRSM
GDFGEATAEAYQFTRADQDAYAIETLTRARKAVESGAFAAEIVPITLTEKSGPRVVTNDEHPLKVDPAKIPALKAAFRKD
GTITPAASSANADGAAALVLATRTRTERDGLPVIAEIKGHATHSQEPQWFTTAPIPAIRKLLDKVGWRVEDVDLFEINEA
FAVVAMAAQRDLGIPRERLNVNGGACALGHPIGATGARLIVTLLHAMQTRGLRRGVASLCIGGGEATAIALERP

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=45.4314720812183, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI148539872, Length=396, Percent_Identity=44.6969696969697, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=35.1898734177215, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4501853, Length=405, Percent_Identity=37.2839506172839, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI4504327, Length=433, Percent_Identity=28.4064665127021, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI194353979, Length=399, Percent_Identity=30.0751879699248, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1788554, Length=389, Percent_Identity=47.5578406169666, Blast_Score=314, Evalue=5e-87,
Organism=Escherichia coli, GI87082165, Length=389, Percent_Identity=42.6735218508997, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=38.0952380952381, Blast_Score=244, Evalue=9e-66,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=33.1670822942643, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=27.9805352798054, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=42.1188630490956, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17535921, Length=390, Percent_Identity=42.3076923076923, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=38.560411311054, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17535917, Length=399, Percent_Identity=34.5864661654135, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=29.2161520190024, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=394, Percent_Identity=43.6548223350254, Blast_Score=299, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=32.9923273657289, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24655093, Length=389, Percent_Identity=44.987146529563, Blast_Score=321, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=44.1025641025641, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=34.3589743589744, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17137578, Length=423, Percent_Identity=29.0780141843972, Blast_Score=154, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41442; Mature: 41311

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASFDPVMILSAARTPLGRFMGELSPLRAHELGAHAIKSALERAALAPETVGEVFMGNVL
CCCCCCCHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
PAGQGQAPARQAARGAGLPDATGATTINKVCGSGMKATMLAHDIIRAGSADIVVSGGMES
CCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCHHH
MSNAPYLLAKARGGYRAGHDRIFDHMMLDGLEDAYDTGRSMGDFGEATAEAYQFTRADQD
HCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
AYAIETLTRARKAVESGAFAAEIVPITLTEKSGPRVVTNDEHPLKVDPAKIPALKAAFRK
HHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEEECCCCCCEECCCHHHHHHHHHHC
DGTITPAASSANADGAAALVLATRTRTERDGLPVIAEIKGHATHSQEPQWFTTAPIPAIR
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCEEECCCHHHHH
KLLDKVGWRVEDVDLFEINEAFAVVAMAAQRDLGIPRERLNVNGGACALGHPIGATGARL
HHHHHHCCEEECCEEEEHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCCCCHHHHH
IVTLLHAMQTRGLRRGVASLCIGGGEATAIALERP
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
>Mature Secondary Structure 
ASFDPVMILSAARTPLGRFMGELSPLRAHELGAHAIKSALERAALAPETVGEVFMGNVL
CCCCCCHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
PAGQGQAPARQAARGAGLPDATGATTINKVCGSGMKATMLAHDIIRAGSADIVVSGGMES
CCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCHHH
MSNAPYLLAKARGGYRAGHDRIFDHMMLDGLEDAYDTGRSMGDFGEATAEAYQFTRADQD
HCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
AYAIETLTRARKAVESGAFAAEIVPITLTEKSGPRVVTNDEHPLKVDPAKIPALKAAFRK
HHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEEECCCCCCEECCCHHHHHHHHHHC
DGTITPAASSANADGAAALVLATRTRTERDGLPVIAEIKGHATHSQEPQWFTTAPIPAIR
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCEEECCCHHHHH
KLLDKVGWRVEDVDLFEINEAFAVVAMAAQRDLGIPRERLNVNGGACALGHPIGATGARL
HHHHHHCCEEECCEEEEHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCCCCHHHHH
IVTLLHAMQTRGLRRGVASLCIGGGEATAIALERP
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]