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The map label for this gene is degP [H]

Identifier: 146339742

GI number: 146339742

Start: 2946138

End: 2947724

Strand: Direct

Name: degP [H]

Synonym: BRADO2741

Alternate gene names: 146339742

Gene position: 2946138-2947724 (Clockwise)

Preceding gene: 146339739

Following gene: 146339743

Centisome position: 39.51

GC content: 67.86

Gene sequence:

>1587_bases
ATGACTGACCGTCCGACCGACCTGTCCTCGCTTCCATCCTATCAGAAGCCCCGCCGCGGGCTGTTCTCGGCGCGCAAATT
CGCGCTGATGGCCTCCGTCGTCGCGGGCCTGGGCGTTGCCGCCTATGGCCTGTCGCCGCAGGGCGCGCCGCTCGATTTGT
TCTCGACCTCGGCGCATGCGCAGGTCGCCAACGAGGTCAGCAAGGTCGCGCGTCCCGTCGGCTTTGCCGACATCGTGGAG
CGGGTGAAGCCGTCGGTGATTTCGGTCAAGGTCAACATCGCCGAGAAGGTCGCCAAGAACGACAATGACGACGACACGCC
GTTCCAGCCGGGCTCGCCGATGGAGCGCTTCTTCCGCCGCTTCGGCGGAGAGAACGGCATTCCCGGCATGCCGGGCCGCG
GCGGCCGCGGTGGCGGTCGCGCGGTGACCGGGCAGGGCTCTGGCTTCTTCATTTCGGCCGACGGCTATGCCGTGACCAAC
AACCACGTGGTCGACGGCGCCGACAAGGTCGAGGTGACGACCGACGACGGCAAGACCTACAGCGCCAAGGTGATCGGTAC
CGACCAGCGCACCGACCTGGCGCTGATCAAGGTCGAGGGCGGCTCGAACTTCCCGTTTGCCAAGCTCGCCGACGGCAAGC
CGCGCATCGGCGACTGGGTGCTGGCGGTCGGCAATCCCTTCGGCCTCGGCGGCACCGTGACCGCGGGCATCGTGTCGGCG
GTCGGCCGCGACATCGGCAACGGTCCGTATGACGATTTCATCCAGATCGACGCGCCGGTGAACAAGGGCAACTCGGGTGG
CCCGGCGTTTGACGTCGACGGCAATGTCGTCGGTGTGAACACGGCGATCTACTCACCGTCCGGCGGCAGCGTCGGCATCG
CGTTCTCGATTCCCGCTTCGACGGTGAAGAGCGTGATCGCGCAGCTGAAGGACAACGGCTCAGTCAGCCGCGGCTGGATC
GGCGTGCAGATCCAGCCGGTGACGCAGGACATCGCCGACAGCCTCGGCATGAAGAAGGCGGAAGGCGCGCTGGTCGCCGA
GCCCCAGGCCAACGGTCCGGCGGCGAAGGCGGGCATCGTGTCCGGTGACGTCATCACGGCCGTGAACGGCCAGCCGGTGA
AGGACGCGCGCGAGCTCGCCCGCACCATCGGCGGCATCGCGCCGGGCGCGGCGGTCAAGCTCAACGTGCTGTCGAAGGGC
CAGGAGAAGACCGTCAACCTGACGCTCGGCAAGCTGCCGAACACGGTCGAGGCCAAGGCTGATAACGACAATGGCGACAA
TTCCAGCCCGACCCGCGGCGCCGACGTGCCGAAGCTCGGCATGACGGTGGCGCCGGCGTCGAGCGTGGCCGGAGCCGGCA
AGGACGGCGTCGTGGTCACCGAGGTCGATCCGAAGAGCGCCGCAGCCGATCGCGGCTTCAAGGAAGGCGACGTGATCCTC
GAAGTCGCGGGCAAGTCGGTGACCTCGGCCGGTGATGTGCGCGAGGCGATCAACGCCGCCAAGGCCGACAACAAGAACAG
CGTGCTGATGCGGGTAAAGAGCGGCGGCCAGTCGCGCTTCGTCGCGGTGCCGCTGGCCAAGGGCTGA

Upstream 100 bases:

>100_bases
ACGCCGTAAGGCGGCAAGTCCCATGTTCACTGGCGAACGGGGCGAACAGCCCGGGACACACGTTTAGACCTTGACCAAAA
TCGCTTGCGGAGAAAACCGT

Downstream 100 bases:

>100_bases
CAAGGGCTGACAAGCGCTCAAGGCGCTCACGAGATGGAGGGTTGCCGGCCTGTTGCCCCCGCGCCGGCGGCTCTCCCAGG
GGGCGGGTTTCAAATTCCGC

Product: putative serine protease do-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTDRPTDLSSLPSYQKPRRGLFSARKFALMASVVAGLGVAAYGLSPQGAPLDLFSTSAHAQVANEVSKVARPVGFADIVE
RVKPSVISVKVNIAEKVAKNDNDDDTPFQPGSPMERFFRRFGGENGIPGMPGRGGRGGGRAVTGQGSGFFISADGYAVTN
NHVVDGADKVEVTTDDGKTYSAKVIGTDQRTDLALIKVEGGSNFPFAKLADGKPRIGDWVLAVGNPFGLGGTVTAGIVSA
VGRDIGNGPYDDFIQIDAPVNKGNSGGPAFDVDGNVVGVNTAIYSPSGGSVGIAFSIPASTVKSVIAQLKDNGSVSRGWI
GVQIQPVTQDIADSLGMKKAEGALVAEPQANGPAAKAGIVSGDVITAVNGQPVKDARELARTIGGIAPGAAVKLNVLSKG
QEKTVNLTLGKLPNTVEAKADNDNGDNSSPTRGADVPKLGMTVAPASSVAGAGKDGVVVTEVDPKSAAADRGFKEGDVIL
EVAGKSVTSAGDVREAINAAKADNKNSVLMRVKSGGQSRFVAVPLAKG

Sequences:

>Translated_528_residues
MTDRPTDLSSLPSYQKPRRGLFSARKFALMASVVAGLGVAAYGLSPQGAPLDLFSTSAHAQVANEVSKVARPVGFADIVE
RVKPSVISVKVNIAEKVAKNDNDDDTPFQPGSPMERFFRRFGGENGIPGMPGRGGRGGGRAVTGQGSGFFISADGYAVTN
NHVVDGADKVEVTTDDGKTYSAKVIGTDQRTDLALIKVEGGSNFPFAKLADGKPRIGDWVLAVGNPFGLGGTVTAGIVSA
VGRDIGNGPYDDFIQIDAPVNKGNSGGPAFDVDGNVVGVNTAIYSPSGGSVGIAFSIPASTVKSVIAQLKDNGSVSRGWI
GVQIQPVTQDIADSLGMKKAEGALVAEPQANGPAAKAGIVSGDVITAVNGQPVKDARELARTIGGIAPGAAVKLNVLSKG
QEKTVNLTLGKLPNTVEAKADNDNGDNSSPTRGADVPKLGMTVAPASSVAGAGKDGVVVTEVDPKSAAADRGFKEGDVIL
EVAGKSVTSAGDVREAINAAKADNKNSVLMRVKSGGQSRFVAVPLAKG
>Mature_527_residues
TDRPTDLSSLPSYQKPRRGLFSARKFALMASVVAGLGVAAYGLSPQGAPLDLFSTSAHAQVANEVSKVARPVGFADIVER
VKPSVISVKVNIAEKVAKNDNDDDTPFQPGSPMERFFRRFGGENGIPGMPGRGGRGGGRAVTGQGSGFFISADGYAVTNN
HVVDGADKVEVTTDDGKTYSAKVIGTDQRTDLALIKVEGGSNFPFAKLADGKPRIGDWVLAVGNPFGLGGTVTAGIVSAV
GRDIGNGPYDDFIQIDAPVNKGNSGGPAFDVDGNVVGVNTAIYSPSGGSVGIAFSIPASTVKSVIAQLKDNGSVSRGWIG
VQIQPVTQDIADSLGMKKAEGALVAEPQANGPAAKAGIVSGDVITAVNGQPVKDARELARTIGGIAPGAAVKLNVLSKGQ
EKTVNLTLGKLPNTVEAKADNDNGDNSSPTRGADVPKLGMTVAPASSVAGAGKDGVVVTEVDPKSAAADRGFKEGDVILE
VAGKSVTSAGDVREAINAAKADNKNSVLMRVKSGGQSRFVAVPLAKG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=254, Percent_Identity=35.8267716535433, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI22129776, Length=264, Percent_Identity=34.469696969697, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI24308541, Length=301, Percent_Identity=32.5581395348837, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI7019477, Length=263, Percent_Identity=33.8403041825095, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI1786356, Length=463, Percent_Identity=36.2850971922246, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1789629, Length=472, Percent_Identity=34.3220338983051, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1789630, Length=279, Percent_Identity=36.5591397849462, Blast_Score=168, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24646839, Length=257, Percent_Identity=31.5175097276265, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 53771; Mature: 53640

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRPTDLSSLPSYQKPRRGLFSARKFALMASVVAGLGVAAYGLSPQGAPLDLFSTSAHA
CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEECCCHHH
QVANEVSKVARPVGFADIVERVKPSVISVKVNIAEKVAKNDNDDDTPFQPGSPMERFFRR
HHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHH
FGGENGIPGMPGRGGRGGGRAVTGQGSGFFISADGYAVTNNHVVDGADKVEVTTDDGKTY
HCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCEEEECCEEECCCCEEEEECCCCCEE
SAKVIGTDQRTDLALIKVEGGSNFPFAKLADGKPRIGDWVLAVGNPFGLGGTVTAGIVSA
EEEEEECCCCCCEEEEEEECCCCCCCEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
VGRDIGNGPYDDFIQIDAPVNKGNSGGPAFDVDGNVVGVNTAIYSPSGGSVGIAFSIPAS
HHHHCCCCCCCCEEEEECCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCHH
TVKSVIAQLKDNGSVSRGWIGVQIQPVTQDIADSLGMKKAEGALVAEPQANGPAAKAGIV
HHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCEE
SGDVITAVNGQPVKDARELARTIGGIAPGAAVKLNVLSKGQEKTVNLTLGKLPNTVEAKA
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCEEECC
DNDNGDNSSPTRGADVPKLGMTVAPASSVAGAGKDGVVVTEVDPKSAAADRGFKEGDVIL
CCCCCCCCCCCCCCCCCCCCEEECCCHHHCCCCCCCEEEEECCCCHHHHHCCCCCCCEEE
EVAGKSVTSAGDVREAINAAKADNKNSVLMRVKSGGQSRFVAVPLAKG
EECCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCC
>Mature Secondary Structure 
TDRPTDLSSLPSYQKPRRGLFSARKFALMASVVAGLGVAAYGLSPQGAPLDLFSTSAHA
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEECCCHHH
QVANEVSKVARPVGFADIVERVKPSVISVKVNIAEKVAKNDNDDDTPFQPGSPMERFFRR
HHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHH
FGGENGIPGMPGRGGRGGGRAVTGQGSGFFISADGYAVTNNHVVDGADKVEVTTDDGKTY
HCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCEEEECCEEECCCCEEEEECCCCCEE
SAKVIGTDQRTDLALIKVEGGSNFPFAKLADGKPRIGDWVLAVGNPFGLGGTVTAGIVSA
EEEEEECCCCCCEEEEEEECCCCCCCEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
VGRDIGNGPYDDFIQIDAPVNKGNSGGPAFDVDGNVVGVNTAIYSPSGGSVGIAFSIPAS
HHHHCCCCCCCCEEEEECCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCHH
TVKSVIAQLKDNGSVSRGWIGVQIQPVTQDIADSLGMKKAEGALVAEPQANGPAAKAGIV
HHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCEE
SGDVITAVNGQPVKDARELARTIGGIAPGAAVKLNVLSKGQEKTVNLTLGKLPNTVEAKA
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCEEECC
DNDNGDNSSPTRGADVPKLGMTVAPASSVAGAGKDGVVVTEVDPKSAAADRGFKEGDVIL
CCCCCCCCCCCCCCCCCCCCEEECCCHHHCCCCCCCEEEEECCCCHHHHHCCCCCCCEEE
EVAGKSVTSAGDVREAINAAKADNKNSVLMRVKSGGQSRFVAVPLAKG
EECCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]