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The map label for this gene is cusR [H]

Identifier: 146339743

GI number: 146339743

Start: 2947985

End: 2948689

Strand: Direct

Name: cusR [H]

Synonym: BRADO2742

Alternate gene names: 146339743

Gene position: 2947985-2948689 (Clockwise)

Preceding gene: 146339742

Following gene: 146339744

Centisome position: 39.54

GC content: 66.24

Gene sequence:

>705_bases
GTGACCGTCGCCCCTGTTTCCGCAATGCGCCTCCTGATCATCGAAGACGACCGCGAGTCCGCCGACTATCTGGTCAAGGC
GTTCCGCGAAGTCGGCCATGTCGCCGATCTCGCCGGCGATGGCGAGGAGGGGCTCGCGATGGCCGAGAGCGGCGATTACG
ACGTGCTAGTGGTCGACCGCATGCTGCCCAAGCGCGACGGCCTGTCGCTGATCGGCGCGCTGCGCGACAAGGGCAACCGC
ACGCCGGTCCTGATCCTGTCCGCGCTCGGCCAGGTCGACGACCGCATCAAGGGCCTGCGCGCCGGCGGCGACGACTATCT
GCCGAAGCCCTACGCCTTCGCCGAGCTGCTCGCCCGCGTCGAGGTGCTGTCGCGGCGTCATGGCGGACCGGCGGAGGAGA
CGACCTACAAGGTCGGCGATCTCGAGCTCGACCGGCTGTCGCATCGCGTCGCGCGCGGCAAGGATGAATTGACCCTGCAG
CCGCGCGAGTTCCGGCTGCTCGAATATCTGATGAAGCATGCCGGGCAGGTGGTCACGCGCACGATGCTCTTGGAGAATGT
CTGGGACTATCACTTCGATCCGCAGACCAACGTAATCGACGTCCACATCTCGCGGCTGCGCTCCAAGATCGACAAGGGGT
TTGACCGCCCGCTGCTCCACACCATCCGCGGCGCGGGGTACATGATCCGTGACGGCCTTCGGTAA

Upstream 100 bases:

>100_bases
AGTCCCCCAGCTTCACCGCCCACTTTCCTGTTGATCACCCCCGGGCTCTCGCCGCCTTGCACGGAAACCGCGGCCGGGCC
ATGTAGATGGACATCCAACC

Downstream 100 bases:

>100_bases
GCTGATCCGCACCACGGCGTTCCGGCTGACGCTGGTCTATCTGCTGTTGTTTGCGCTGTTTGCCGCTTCGCTGCTCGGCT
ACTTCGCCTGGAACACCCGT

Product: putative two-component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTVAPVSAMRLLIIEDDRESADYLVKAFREVGHVADLAGDGEEGLAMAESGDYDVLVVDRMLPKRDGLSLIGALRDKGNR
TPVLILSALGQVDDRIKGLRAGGDDYLPKPYAFAELLARVEVLSRRHGGPAEETTYKVGDLELDRLSHRVARGKDELTLQ
PREFRLLEYLMKHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRSKIDKGFDRPLLHTIRGAGYMIRDGLR

Sequences:

>Translated_234_residues
MTVAPVSAMRLLIIEDDRESADYLVKAFREVGHVADLAGDGEEGLAMAESGDYDVLVVDRMLPKRDGLSLIGALRDKGNR
TPVLILSALGQVDDRIKGLRAGGDDYLPKPYAFAELLARVEVLSRRHGGPAEETTYKVGDLELDRLSHRVARGKDELTLQ
PREFRLLEYLMKHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRSKIDKGFDRPLLHTIRGAGYMIRDGLR
>Mature_233_residues
TVAPVSAMRLLIIEDDRESADYLVKAFREVGHVADLAGDGEEGLAMAESGDYDVLVVDRMLPKRDGLSLIGALRDKGNRT
PVLILSALGQVDDRIKGLRAGGDDYLPKPYAFAELLARVEVLSRRHGGPAEETTYKVGDLELDRLSHRVARGKDELTLQP
REFRLLEYLMKHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRSKIDKGFDRPLLHTIRGAGYMIRDGLR

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=45.7013574660633, Blast_Score=216, Evalue=1e-57,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=41.0958904109589, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=38.9140271493213, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=37.10407239819, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=34.2342342342342, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=34.703196347032, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=32.4324324324324, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.5263157894737, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=30.3964757709251, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=31.981981981982, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788394, Length=232, Percent_Identity=30.6034482758621, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=30.3964757709251, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=28.0701754385965, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=30.6382978723404, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787487, Length=106, Percent_Identity=33.9622641509434, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26275; Mature: 26143

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAPVSAMRLLIIEDDRESADYLVKAFREVGHVADLAGDGEEGLAMAESGDYDVLVVDR
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEEECC
MLPKRDGLSLIGALRDKGNRTPVLILSALGQVDDRIKGLRAGGDDYLPKPYAFAELLARV
CCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
EVLSRRHGGPAEETTYKVGDLELDRLSHRVARGKDELTLQPREFRLLEYLMKHAGQVVTR
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHH
TMLLENVWDYHFDPQTNVIDVHISRLRSKIDKGFDRPLLHTIRGAGYMIRDGLR
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure 
TVAPVSAMRLLIIEDDRESADYLVKAFREVGHVADLAGDGEEGLAMAESGDYDVLVVDR
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEEECC
MLPKRDGLSLIGALRDKGNRTPVLILSALGQVDDRIKGLRAGGDDYLPKPYAFAELLARV
CCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
EVLSRRHGGPAEETTYKVGDLELDRLSHRVARGKDELTLQPREFRLLEYLMKHAGQVVTR
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHH
TMLLENVWDYHFDPQTNVIDVHISRLRSKIDKGFDRPLLHTIRGAGYMIRDGLR
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]