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The map label for this gene is phoP [H]

Identifier: 146339730

GI number: 146339730

Start: 2929912

End: 2930586

Strand: Direct

Name: phoP [H]

Synonym: BRADO2728

Alternate gene names: 146339730

Gene position: 2929912-2930586 (Clockwise)

Preceding gene: 146339729

Following gene: 146339731

Centisome position: 39.29

GC content: 65.93

Gene sequence:

>675_bases
GTGCGTCTGCTCGTTGTCGAGGACGATCCGGATCTCAACCGTCAGCTCACCACGGCGCTGAGCGACGCCGGCTACGTCGT
GGACCGTGCGTTCGACGGGGAGGAGGGGCACTATCTGGGCGATAGCGAGCCGTACGACGCGGTCGTGCTCGATATCGGCC
TGCCCAAGATGGACGGCATCTCAGTGTTGGAGGCGTGGCGCCGCAATGGCCGGGCGATGCCGGTCCTGATCCTGACCGCG
CGGGACCGCTGGAGCGACAAGGTGCAGGGCTTCGATGCGGGCGCCGACGATTACGTCGCCAAGCCGTTCCACCTGGAGGA
GGTGCTGGCTCGCATCCGCGCGCTGCTGCGCCGCTCGGCCGGCCACGCTCAGAGCGAACTGACCTGTGGACCGGTGACGC
TCGACACCCGCACGGGTAAGGTCAGCGTGTCGGGCAACCCCGTCAAGATGACTTCACATGAATACCGCCTGCTGTCCTAT
CTGATGCATCATTCCGGCCGGGTCGTGTCGCGCAGCGAACTGGTCGAGCATCTCTATGACCAGGACTTCGACCGCGACTC
GAACACCATCGAGGTGTTCGTCGGCCGCATCCGCAAGAAGCTCGACTGCGACGTCATCCAGACCGTGCGCGGCCTCGGCT
ATCTGCTGACCCCGCCACCGACCGCCAGCGCCTGA

Upstream 100 bases:

>100_bases
AAAAAGTAACCCGGTCGGTCGGGTTCCGTTCATGCACGGTTCACGGCCTTCCGGTTCATCTTGAGGGCGGAAATCGTGCA
GTTCAGCTTTGGAGGCAAGC

Downstream 100 bases:

>100_bases
TCCGTCCCGGCGCCCGCCATTCACGGTGGCCGGGCGCCGGCCGTTTCGCTAATTTGCGGTCATGCGCCAGAGTTCACTTG
CCACCCGGTTGTTCCTGTCC

Product: putative two-component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRLLVVEDDPDLNRQLTTALSDAGYVVDRAFDGEEGHYLGDSEPYDAVVLDIGLPKMDGISVLEAWRRNGRAMPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHLEEVLARIRALLRRSAGHAQSELTCGPVTLDTRTGKVSVSGNPVKMTSHEYRLLSY
LMHHSGRVVSRSELVEHLYDQDFDRDSNTIEVFVGRIRKKLDCDVIQTVRGLGYLLTPPPTASA

Sequences:

>Translated_224_residues
MRLLVVEDDPDLNRQLTTALSDAGYVVDRAFDGEEGHYLGDSEPYDAVVLDIGLPKMDGISVLEAWRRNGRAMPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHLEEVLARIRALLRRSAGHAQSELTCGPVTLDTRTGKVSVSGNPVKMTSHEYRLLSY
LMHHSGRVVSRSELVEHLYDQDFDRDSNTIEVFVGRIRKKLDCDVIQTVRGLGYLLTPPPTASA
>Mature_224_residues
MRLLVVEDDPDLNRQLTTALSDAGYVVDRAFDGEEGHYLGDSEPYDAVVLDIGLPKMDGISVLEAWRRNGRAMPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHLEEVLARIRALLRRSAGHAQSELTCGPVTLDTRTGKVSVSGNPVKMTSHEYRLLSY
LMHHSGRVVSRSELVEHLYDQDFDRDSNTIEVFVGRIRKKLDCDVIQTVRGLGYLLTPPPTASA

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=43.1818181818182, Blast_Score=191, Evalue=3e-50,
Organism=Escherichia coli, GI1789402, Length=216, Percent_Identity=45.8333333333333, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=41.0714285714286, Blast_Score=180, Evalue=6e-47,
Organism=Escherichia coli, GI1790552, Length=216, Percent_Identity=43.0555555555556, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=38.3561643835616, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=33.1877729257642, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=34.3891402714932, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=32.7272727272727, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=34.703196347032, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=32.8767123287671, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.6491228070175, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=222, Percent_Identity=28.8288288288288, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=27.4678111587983, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788550, Length=187, Percent_Identity=29.9465240641711, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=24.4635193133047, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790299, Length=134, Percent_Identity=31.3432835820896, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24967; Mature: 24967

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVVEDDPDLNRQLTTALSDAGYVVDRAFDGEEGHYLGDSEPYDAVVLDIGLPKMDGI
CEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
SVLEAWRRNGRAMPVLILTARDRWSDKVQGFDAGADDYVAKPFHLEEVLARIRALLRRSA
HHHHHHHHCCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GHAQSELTCGPVTLDTRTGKVSVSGNPVKMTSHEYRLLSYLMHHSGRVVSRSELVEHLYD
CCCCCCCCCCCEEEECCCCEEEECCCCEEECCHHHHHHHHHHHHCCCEECHHHHHHHHHH
QDFDRDSNTIEVFVGRIRKKLDCDVIQTVRGLGYLLTPPPTASA
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCEEECCCCCCCC
>Mature Secondary Structure
MRLLVVEDDPDLNRQLTTALSDAGYVVDRAFDGEEGHYLGDSEPYDAVVLDIGLPKMDGI
CEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
SVLEAWRRNGRAMPVLILTARDRWSDKVQGFDAGADDYVAKPFHLEEVLARIRALLRRSA
HHHHHHHHCCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GHAQSELTCGPVTLDTRTGKVSVSGNPVKMTSHEYRLLSYLMHHSGRVVSRSELVEHLYD
CCCCCCCCCCCEEEECCCCEEEECCCCEEECCHHHHHHHHHHHHCCCEECHHHHHHHHHH
QDFDRDSNTIEVFVGRIRKKLDCDVIQTVRGLGYLLTPPPTASA
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA