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The map label for this gene is phoQ [H]

Identifier: 146339731

GI number: 146339731

Start: 2930648

End: 2932024

Strand: Direct

Name: phoQ [H]

Synonym: BRADO2729

Alternate gene names: 146339731

Gene position: 2930648-2932024 (Clockwise)

Preceding gene: 146339730

Following gene: 146339732

Centisome position: 39.3

GC content: 68.19

Gene sequence:

>1377_bases
ATGCGCCAGAGTTCACTTGCCACCCGGTTGTTCCTGTCCGCGACCGCGTGGCTCGTGGTCATTCTCGCCATCACCGGCAT
CGTGCTGTCCTCGGTCTACCGCAACGCGACCGAGCGCGCCTTCGACCGCCGGCTCAACCTGTACCTCCGCACCTTGATCG
CCGAGGTCGCGACCCCCGACGACCCGCCTGACCGCCAATTCCAGTCGCTCGGCGAGCCCTTGTTCGAGCTGCCGCTCTCC
GGCTGGTACTGGCAGATCACCCGCACCGACACCGAGAAGCCCGAGGTGCGGGCCTCGCGCTCGCTGTGGGACAAGAAGCT
GCCCAAGCTCGAAGAGCAGGGGATCGAGCTGACCGCCGCCGGTATCCGGATCGGCTATGTCGAGGGGCCGGAGAATCAGG
ACCTGCGCATGGTCGAGCGTCCGGTCGATCTCGGCTCCGACGGCAAATTCCTGGTCAGCGTCGCCGGCGATGCCTCGGAG
ATCTTCGACGAGACCCGCAGCTTCGACTACTATCTCGGCGGCACCTTCACCGCGCTCGGAATCGTGCTGCTGCTGACCAC
TATTTTCCAGGTCCGCTATGGCCTCGCGCCGTTGAAGCGCATCTCCGAATCGATCGCCGACATCCGCTCCGGCCGGGCCG
AGCGGCTGGAGGGCGAATTTCCCGTCGAGATCGCGCCGCTGGCCCGCGAGACCAATGCGCTGATCGACGCCAATCGCGAG
ATCGTCGAGCGCGCGCGCACCCATGTCGGCAATCTCGCTCATGCCATCAAGACGCCGCTGTCGGTGATCGTCAACGAAGC
CACGACCCACGCGGCCGATCCGTTCGCCGCGAAGGTGATGGAGCAAGCCGACGTGATGCGCGACCAGGTCGCCCATCATC
TCGAGCGCGCGCGGATCGCGGCGCGCGTGACGATCGTGTCCACGGTCACCGAGGTGGCGCCGGCGATCGAGGCGCTGCGC
CGCACCATGGAGAAGATCTATCGCAATCGGGGCATCGCGGTCGAGGCGACGGCGGATGCCGCCGCGCGGTTTCGCGGCGA
GCGCCAGGATCTGGAGGAGATGGTCGGCAATCTCGTCGACAACGCGTGCAAATGGGCGGCCTCGCGGGTGTCGGTCGAAG
TCGCCGTGGAGCCGCCGACCCAGTCCGGCGCCACGCCGATGCTGCGGATCGTCGTCGATGACGACGGTAGGGGCCTGTCG
GCGGCCGAGCGCGCCCAGGTGCTGCGCCGCGGCCAGCGGCTGGACGAATCCAAGCCTGGATCGGGCCTCGGACTCTCGAT
CGTCACGGATCTCGCCGCGCTCTATGGCGGCCGCCTGACGCTCGGGGACGCGCCGATCGGGGGCCTGCGGGCCGAGCTGC
GACTGCCCGGCGTTTGA

Upstream 100 bases:

>100_bases
GGCTATCTGCTGACCCCGCCACCGACCGCCAGCGCCTGATCCGTCCCGGCGCCCGCCATTCACGGTGGCCGGGCGCCGGC
CGTTTCGCTAATTTGCGGTC

Downstream 100 bases:

>100_bases
CGGGCGGCGAAATTCGCCATCCTAAAGGTGTTCTTAACATCGCGGACGGTAAGGTCGGTGCAGGGGTGCGCGATGTGCGC
TCTCGCCGTGGAAATTTGCA

Product: putative two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MRQSSLATRLFLSATAWLVVILAITGIVLSSVYRNATERAFDRRLNLYLRTLIAEVATPDDPPDRQFQSLGEPLFELPLS
GWYWQITRTDTEKPEVRASRSLWDKKLPKLEEQGIELTAAGIRIGYVEGPENQDLRMVERPVDLGSDGKFLVSVAGDASE
IFDETRSFDYYLGGTFTALGIVLLLTTIFQVRYGLAPLKRISESIADIRSGRAERLEGEFPVEIAPLARETNALIDANRE
IVERARTHVGNLAHAIKTPLSVIVNEATTHAADPFAAKVMEQADVMRDQVAHHLERARIAARVTIVSTVTEVAPAIEALR
RTMEKIYRNRGIAVEATADAAARFRGERQDLEEMVGNLVDNACKWAASRVSVEVAVEPPTQSGATPMLRIVVDDDGRGLS
AAERAQVLRRGQRLDESKPGSGLGLSIVTDLAALYGGRLTLGDAPIGGLRAELRLPGV

Sequences:

>Translated_458_residues
MRQSSLATRLFLSATAWLVVILAITGIVLSSVYRNATERAFDRRLNLYLRTLIAEVATPDDPPDRQFQSLGEPLFELPLS
GWYWQITRTDTEKPEVRASRSLWDKKLPKLEEQGIELTAAGIRIGYVEGPENQDLRMVERPVDLGSDGKFLVSVAGDASE
IFDETRSFDYYLGGTFTALGIVLLLTTIFQVRYGLAPLKRISESIADIRSGRAERLEGEFPVEIAPLARETNALIDANRE
IVERARTHVGNLAHAIKTPLSVIVNEATTHAADPFAAKVMEQADVMRDQVAHHLERARIAARVTIVSTVTEVAPAIEALR
RTMEKIYRNRGIAVEATADAAARFRGERQDLEEMVGNLVDNACKWAASRVSVEVAVEPPTQSGATPMLRIVVDDDGRGLS
AAERAQVLRRGQRLDESKPGSGLGLSIVTDLAALYGGRLTLGDAPIGGLRAELRLPGV
>Mature_458_residues
MRQSSLATRLFLSATAWLVVILAITGIVLSSVYRNATERAFDRRLNLYLRTLIAEVATPDDPPDRQFQSLGEPLFELPLS
GWYWQITRTDTEKPEVRASRSLWDKKLPKLEEQGIELTAAGIRIGYVEGPENQDLRMVERPVDLGSDGKFLVSVAGDASE
IFDETRSFDYYLGGTFTALGIVLLLTTIFQVRYGLAPLKRISESIADIRSGRAERLEGEFPVEIAPLARETNALIDANRE
IVERARTHVGNLAHAIKTPLSVIVNEATTHAADPFAAKVMEQADVMRDQVAHHLERARIAARVTIVSTVTEVAPAIEALR
RTMEKIYRNRGIAVEATADAAARFRGERQDLEEMVGNLVDNACKWAASRVSVEVAVEPPTQSGATPMLRIVVDDDGRGLS
AAERAQVLRRGQRLDESKPGSGLGLSIVTDLAALYGGRLTLGDAPIGGLRAELRLPGV

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=266, Percent_Identity=27.0676691729323, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=21.2996389891697, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786783, Length=489, Percent_Identity=21.4723926380368, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790346, Length=115, Percent_Identity=36.5217391304348, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50228; Mature: 50228

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQSSLATRLFLSATAWLVVILAITGIVLSSVYRNATERAFDRRLNLYLRTLIAEVATPD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DPPDRQFQSLGEPLFELPLSGWYWQITRTDTEKPEVRASRSLWDKKLPKLEEQGIELTAA
CCCHHHHHHHCCHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHCCCEEEEE
GIRIGYVEGPENQDLRMVERPVDLGSDGKFLVSVAGDASEIFDETRSFDYYLGGTFTALG
CEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHCCCEEECHHHHHHH
IVLLLTTIFQVRYGLAPLKRISESIADIRSGRAERLEGEFPVEIAPLARETNALIDANRE
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEECHHHHHHHHHHCCHH
IVERARTHVGNLAHAIKTPLSVIVNEATTHAADPFAAKVMEQADVMRDQVAHHLERARIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARVTIVSTVTEVAPAIEALRRTMEKIYRNRGIAVEATADAAARFRGERQDLEEMVGNLVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHCCCHHHHHHHHHHHHH
NACKWAASRVSVEVAVEPPTQSGATPMLRIVVDDDGRGLSAAERAQVLRRGQRLDESKPG
HHHHHHHHHEEEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
SGLGLSIVTDLAALYGGRLTLGDAPIGGLRAELRLPGV
CCCCHHHHHHHHHHHCCCEEECCCCCCCCEECEECCCC
>Mature Secondary Structure
MRQSSLATRLFLSATAWLVVILAITGIVLSSVYRNATERAFDRRLNLYLRTLIAEVATPD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DPPDRQFQSLGEPLFELPLSGWYWQITRTDTEKPEVRASRSLWDKKLPKLEEQGIELTAA
CCCHHHHHHHCCHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHCCCEEEEE
GIRIGYVEGPENQDLRMVERPVDLGSDGKFLVSVAGDASEIFDETRSFDYYLGGTFTALG
CEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHCCCEEECHHHHHHH
IVLLLTTIFQVRYGLAPLKRISESIADIRSGRAERLEGEFPVEIAPLARETNALIDANRE
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEECHHHHHHHHHHCCHH
IVERARTHVGNLAHAIKTPLSVIVNEATTHAADPFAAKVMEQADVMRDQVAHHLERARIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARVTIVSTVTEVAPAIEALRRTMEKIYRNRGIAVEATADAAARFRGERQDLEEMVGNLVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHCCCHHHHHHHHHHHHH
NACKWAASRVSVEVAVEPPTQSGATPMLRIVVDDDGRGLSAAERAQVLRRGQRLDESKPG
HHHHHHHHHEEEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
SGLGLSIVTDLAALYGGRLTLGDAPIGGLRAELRLPGV
CCCCHHHHHHHHHHHCCCEEECCCCCCCCEECEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]