Click here to switch to the map view.

The map label for this gene is folP [H]

Identifier: 146339690

GI number: 146339690

Start: 2885547

End: 2886404

Strand: Reverse

Name: folP [H]

Synonym: BRADO2685

Alternate gene names: 146339690

Gene position: 2886404-2885547 (Counterclockwise)

Preceding gene: 146339691

Following gene: 146339689

Centisome position: 38.71

GC content: 67.6

Gene sequence:

>858_bases
ATGAGCGCCATCTTGCCGCACGCCGCCTCGGATCTCACCGCGAGCCACCCGCTGCTGCGGCCGTGGCTGGCGCGTCCGTA
TCCGGCCGTCATGGGCATCCTGAACGTCACGCCGGATTCGTTCTCCGACGGCGGCCGTTTCAACGCGCCGGACCGCGCGC
TCGACCAGGCCCAGGCGATGATCGCGGCCGGCGCGGACATCATCGACATCGGAGCCGAGTCGACCCGTCCCTACAAGGGC
GCGGAGCCTGTCACGGCAGATGAAGAGTTGGCGCGGCTCGAACCCGTCCTGCCCGCGATCGTTGCGCTCGGTGTGCCTGT
GTCGATCGACAGTATGAAATCTGAGGTTGTCGATCATGCGCTCAACCATGGCGCTGTGATCGCCAACGATGTCTGGGGCC
TACAGCGCGATCCGGCAATGGCCGATGTGGTCGCCACGCATCGCGCTCCGGTCGTGGTGATGCACAACCGCGCCGCGGTC
GATGCGCAGATCGACATCATTGACGACATGCTCCGCTTCTTCACGCGCTCGCTCGACATCGCCGCCAAGGCCGGCATTCC
CGATGGCAACATCGTGCTCGATCCCGGCATCGGTTTCGGCAAGACCGCCGAGCAGAGCATGCGGGCGCTGGCGCGGCTCG
ATGCGTTCGCGCGCTTCGGCCTGCCGCTTTTGGTCGGCGCCTCGCGCAAGCGTTTCATCAGCTCGGTCGTGACGTCGGAG
CCGCGAGAGCGGCTCGGCGGCTCGATCGCGGCGCATCTGATCGCGGCGCAGCGCGGGGCTGCGATCATCCGGGCGCATGA
CGTCGCCGAGACGGTCCAGGCCGTGCGCGTGGCCGCAAGCATCGAGGCACTGGGATGA

Upstream 100 bases:

>100_bases
GACCCGAAAATCAGCTATTGATCGCACGTCGGGCCGCTGCGCGCCGCTTGTGCAGCGCGACGTCTTGACTCGCCGCTGGC
AACCGCGCAAAGCGGCGGCC

Downstream 100 bases:

>100_bases
CCGATACGATCTTCATCAAGGGCGTCCTCATTCATGCCCGTCACGGCGTGATGGAGCATGAGAGCGAGGTCGGCCAGCGC
TTCGTGATCGATCTCGAGCT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSAILPHAASDLTASHPLLRPWLARPYPAVMGILNVTPDSFSDGGRFNAPDRALDQAQAMIAAGADIIDIGAESTRPYKG
AEPVTADEELARLEPVLPAIVALGVPVSIDSMKSEVVDHALNHGAVIANDVWGLQRDPAMADVVATHRAPVVVMHNRAAV
DAQIDIIDDMLRFFTRSLDIAAKAGIPDGNIVLDPGIGFGKTAEQSMRALARLDAFARFGLPLLVGASRKRFISSVVTSE
PRERLGGSIAAHLIAAQRGAAIIRAHDVAETVQAVRVAASIEALG

Sequences:

>Translated_285_residues
MSAILPHAASDLTASHPLLRPWLARPYPAVMGILNVTPDSFSDGGRFNAPDRALDQAQAMIAAGADIIDIGAESTRPYKG
AEPVTADEELARLEPVLPAIVALGVPVSIDSMKSEVVDHALNHGAVIANDVWGLQRDPAMADVVATHRAPVVVMHNRAAV
DAQIDIIDDMLRFFTRSLDIAAKAGIPDGNIVLDPGIGFGKTAEQSMRALARLDAFARFGLPLLVGASRKRFISSVVTSE
PRERLGGSIAAHLIAAQRGAAIIRAHDVAETVQAVRVAASIEALG
>Mature_284_residues
SAILPHAASDLTASHPLLRPWLARPYPAVMGILNVTPDSFSDGGRFNAPDRALDQAQAMIAAGADIIDIGAESTRPYKGA
EPVTADEELARLEPVLPAIVALGVPVSIDSMKSEVVDHALNHGAVIANDVWGLQRDPAMADVVATHRAPVVVMHNRAAVD
AQIDIIDDMLRFFTRSLDIAAKAGIPDGNIVLDPGIGFGKTAEQSMRALARLDAFARFGLPLLVGASRKRFISSVVTSEP
RERLGGSIAAHLIAAQRGAAIIRAHDVAETVQAVRVAASIEALG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=258, Percent_Identity=45.3488372093023, Blast_Score=198, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=26.4150943396226, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30013; Mature: 29882

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAILPHAASDLTASHPLLRPWLARPYPAVMGILNVTPDSFSDGGRFNAPDRALDQAQAM
CCCCCCCCHHCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
IAAGADIIDIGAESTRPYKGAEPVTADEELARLEPVLPAIVALGVPVSIDSMKSEVVDHA
HHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LNHGAVIANDVWGLQRDPAMADVVATHRAPVVVMHNRAAVDAQIDIIDDMLRFFTRSLDI
HCCCCEEECCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
AAKAGIPDGNIVLDPGIGFGKTAEQSMRALARLDAFARFGLPLLVGASRKRFISSVVTSE
HHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHEECCHHHHHHHHHHHCC
PRERLGGSIAAHLIAAQRGAAIIRAHDVAETVQAVRVAASIEALG
HHHHHCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAILPHAASDLTASHPLLRPWLARPYPAVMGILNVTPDSFSDGGRFNAPDRALDQAQAM
CCCCCCCHHCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
IAAGADIIDIGAESTRPYKGAEPVTADEELARLEPVLPAIVALGVPVSIDSMKSEVVDHA
HHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LNHGAVIANDVWGLQRDPAMADVVATHRAPVVVMHNRAAVDAQIDIIDDMLRFFTRSLDI
HCCCCEEECCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
AAKAGIPDGNIVLDPGIGFGKTAEQSMRALARLDAFARFGLPLLVGASRKRFISSVVTSE
HHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHEECCHHHHHHHHHHHCC
PRERLGGSIAAHLIAAQRGAAIIRAHDVAETVQAVRVAASIEALG
HHHHHCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]