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The map label for this gene is folK [H]

Identifier: 146339688

GI number: 146339688

Start: 2884686

End: 2885177

Strand: Reverse

Name: folK [H]

Synonym: BRADO2683

Alternate gene names: 146339688

Gene position: 2885177-2884686 (Counterclockwise)

Preceding gene: 146339689

Following gene: 146339687

Centisome position: 38.69

GC content: 69.92

Gene sequence:

>492_bases
ATGGCGAGCGCGCTGATCGCCCTCGGCGGCAATGTCGGCGACGTCAGGGCGACCTTCGTGCAGGCGATCGCGGAGATCTG
CCGGCGCGCCGATGCCACGCTTGTGGCGCGCTCCTCCGACTACATGACGCCGCCCTGGGGCGAGGTGCAGCAGCCACCGT
TCGTCAACGCCTGCATCGCGGTCGAGACGGCGGTCGCCCCGCATCCGCTGCTCGCCATCCTGCATGACGTCGAGCGCCTG
TTCGGCCGCGACCGCGCCCGGGAGACCCGCTGGGGCCCGCGCACGCTCGATCTCGACCTGATCGCCTATGACGATGTGAC
GCTCGACACGCCCGATCTCACACTGCCGCATCCCCGCCTGTTCGAGCGAGGTTTCGTGCTGGTCCCGCTCGCCGAGATCG
TCCCCGAGCGCCGGATTGCCGGCCGCCGGGTGGAAGAGGCGCTGGGCGCTGTTTCACGTGACGGAATCCAGCCGCTGCCT
TCAGCCGAATAG

Upstream 100 bases:

>100_bases
CGCGCCGTGAAGGTGACCGTGCACAAGCCGCATGCGCCGATCGCCGCGATCTTCGAGGATGTCGGCGTCGTGCTGACGCG
CTCGCGGCATCCGTGATCAG

Downstream 100 bases:

>100_bases
CTGACATCTCCGGCGAAACAACCGTTTGGCTTGGCGGTCGCGACGTGGCATTTTGCGCCACAATAATCGCCATAACAGAC
GCTTCCGGGAGATACGGGCC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MASALIALGGNVGDVRATFVQAIAEICRRADATLVARSSDYMTPPWGEVQQPPFVNACIAVETAVAPHPLLAILHDVERL
FGRDRARETRWGPRTLDLDLIAYDDVTLDTPDLTLPHPRLFERGFVLVPLAEIVPERRIAGRRVEEALGAVSRDGIQPLP
SAE

Sequences:

>Translated_163_residues
MASALIALGGNVGDVRATFVQAIAEICRRADATLVARSSDYMTPPWGEVQQPPFVNACIAVETAVAPHPLLAILHDVERL
FGRDRARETRWGPRTLDLDLIAYDDVTLDTPDLTLPHPRLFERGFVLVPLAEIVPERRIAGRRVEEALGAVSRDGIQPLP
SAE
>Mature_162_residues
ASALIALGGNVGDVRATFVQAIAEICRRADATLVARSSDYMTPPWGEVQQPPFVNACIAVETAVAPHPLLAILHDVERLF
GRDRARETRWGPRTLDLDLIAYDDVTLDTPDLTLPHPRLFERGFVLVPLAEIVPERRIAGRRVEEALGAVSRDGIQPLPS
AE

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=136, Percent_Identity=40.4411764705882, Blast_Score=98, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324073, Length=136, Percent_Identity=35.2941176470588, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17841; Mature: 17709

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASALIALGGNVGDVRATFVQAIAEICRRADATLVARSSDYMTPPWGEVQQPPFVNACIA
CCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHH
VETAVAPHPLLAILHDVERLFGRDRARETRWGPRTLDLDLIAYDDVTLDTPDLTLPHPRL
HHHHCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEEEEECCEEECCCCCCCCCHHH
FERGFVLVPLAEIVPERRIAGRRVEEALGAVSRDGIQPLPSAE
HHCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ASALIALGGNVGDVRATFVQAIAEICRRADATLVARSSDYMTPPWGEVQQPPFVNACIA
CCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHH
VETAVAPHPLLAILHDVERLFGRDRARETRWGPRTLDLDLIAYDDVTLDTPDLTLPHPRL
HHHHCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEEEEECCEEECCCCCCCCCHHH
FERGFVLVPLAEIVPERRIAGRRVEEALGAVSRDGIQPLPSAE
HHCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]