Click here to switch to the map view.

The map label for this gene is iorA [H]

Identifier: 146339428

GI number: 146339428

Start: 2571340

End: 2571789

Strand: Reverse

Name: iorA [H]

Synonym: BRADO2414

Alternate gene names: 146339428

Gene position: 2571789-2571340 (Counterclockwise)

Preceding gene: 146339429

Following gene: 146339427

Centisome position: 34.49

GC content: 64.44

Gene sequence:

>450_bases
ATGGCAAACCTGACGATTAATGGAAAATCCTATTCGCTCGACGTCGAGCCGGACACGCCGCTGCTGTGGGCGATCCGCGA
GAACGCCGGATTGACCGGCACCAAATATGGCTGCGGCATCGCACAATGCGGGGCCTGCACCGTGCATCTGGACGGCACCG
CCGTGCGCTCCTGCGGGGTCACCGTCTCGGAAGCCGTCGGCAAGCACATCACCACGATCGAAGGCCTGGCGGGCGACAAC
GGCCTGCACAAGGTGCAGCAGGCCTGGCTCGAGAACGACGTTCCGCAATGCGGCTACTGCCAGAGCGGGATGATCATGGC
CGTCGCCGCGCTGCTCAAGGACAATCCGAAGCCGAGCGACCAGGACATCAACGACGCCATCACCAACATCTGCCGCTGTG
GAACCTTCGCGCAGGTGCGCGAGGCGATCCACGCCGCCGCGAACGCCTGA

Upstream 100 bases:

>100_bases
TCCGCGCCGCAAACGCATATTCTTGATTTGAAGGATTCCAACGTTCGCGCCACAGTGCGGCCCTCAGTTCAACTGGCGAG
TTGAACGAAAGGGATCTGCG

Downstream 100 bases:

>100_bases
AGGAGGCCGGCATGAATCAGCACGTGACGCCGCGCCTCAACCGCCGCTCCTTCGTCATCGGCACCGCCGCGCTCGGCGGC
GGCCTCGCGCTCGGGCTCGA

Product: isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MANLTINGKSYSLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHLDGTAVRSCGVTVSEAVGKHITTIEGLAGDN
GLHKVQQAWLENDVPQCGYCQSGMIMAVAALLKDNPKPSDQDINDAITNICRCGTFAQVREAIHAAANA

Sequences:

>Translated_149_residues
MANLTINGKSYSLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHLDGTAVRSCGVTVSEAVGKHITTIEGLAGDN
GLHKVQQAWLENDVPQCGYCQSGMIMAVAALLKDNPKPSDQDINDAITNICRCGTFAQVREAIHAAANA
>Mature_148_residues
ANLTINGKSYSLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHLDGTAVRSCGVTVSEAVGKHITTIEGLAGDNG
LHKVQQAWLENDVPQCGYCQSGMIMAVAALLKDNPKPSDQDINDAITNICRCGTFAQVREAIHAAANA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=155, Percent_Identity=30.9677419354839, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786480, Length=160, Percent_Identity=40, Blast_Score=110, Evalue=4e-26,
Organism=Escherichia coli, GI1789232, Length=138, Percent_Identity=42.7536231884058, Blast_Score=101, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17540638, Length=156, Percent_Identity=37.1794871794872, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17539860, Length=154, Percent_Identity=32.4675324675325, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32566215, Length=158, Percent_Identity=32.9113924050633, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17737937, Length=150, Percent_Identity=34, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24647193, Length=161, Percent_Identity=34.1614906832298, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24647201, Length=154, Percent_Identity=31.8181818181818, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24647199, Length=155, Percent_Identity=32.258064516129, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24647195, Length=161, Percent_Identity=30.4347826086957, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24647197, Length=161, Percent_Identity=30.4347826086957, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15617; Mature: 15486

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLTINGKSYSLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHLDGTAVRSCGV
CCEEEECCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHHHHCCC
TVSEAVGKHITTIEGLAGDNGLHKVQQAWLENDVPQCGYCQSGMIMAVAALLKDNPKPSD
CHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
QDINDAITNICRCGTFAQVREAIHAAANA
CCHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ANLTINGKSYSLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHLDGTAVRSCGV
CEEEECCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHHHHCCC
TVSEAVGKHITTIEGLAGDNGLHKVQQAWLENDVPQCGYCQSGMIMAVAALLKDNPKPSD
CHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
QDINDAITNICRCGTFAQVREAIHAAANA
CCHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]