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The map label for this gene is ndh [H]

Identifier: 146339323

GI number: 146339323

Start: 2452418

End: 2453680

Strand: Direct

Name: ndh [H]

Synonym: BRADO2302

Alternate gene names: 146339323

Gene position: 2452418-2453680 (Clockwise)

Preceding gene: 146339322

Following gene: 146339324

Centisome position: 32.89

GC content: 66.83

Gene sequence:

>1263_bases
TTGGAGCTGGCGACGCGGCTCGGCGACAAATATGGCCGCAAGGGCAAGCTCGACGTCACCCTGGTCGAGCGCAACCGCAC
GCATGTGTGGAAGCCGAAGCTGCATGAGATCGCCGCCGGCAGCATGGACATCTCGGCGCACGAGGTCGACTATCTGGCGC
AGGCCTATTGGCACGGCTTCCACTATCGTATCGGCGACATGATCGGGCTGGATCGCGACAAGCGCGAGGTGCTGGTCGCG
CCCTATCTCGACGCCGAGGGGCGCGAGGTGACGCCGCAGCGCACCATTCCCTATGATGTGCTGGTCATCTCCATCGGCAG
CCAGAACAATGATTTCGGCACGCCGGGAGTCGTCGACCACGCGATCAAGCTGGAGTCGCAGCGCGACGCCCGGCGCTTCC
ACGAGCGTATGATCAATGCCTGCATCCGCGCTCACTCGCAATCGACGCCGATCGCGCTGCATCAGCTGAAGGTCGCGATC
ATCGGCGCCGGCGCCACCGGGGTCGAGCTGGCGGCGGAGCTGCATCGCACGACGCGCGAGGTCGTGGCCTATGGGCTCGA
CCAGGTCGACGCCGAGAAGGACATCAAGATCACGCTGATCGAGGCCGCGCCCCGGGTGCTGCCGGCACTGCCCGAGCGGG
TGTCGAGCGAGACCGGCAAGCTCCTGGAAAGGCTCGGCGTCGAGGTGCTGGTCGGCGCCAAGGTCGCTCAGGTCGCAGCC
GATCACGTCAGCCTCGCCGATGGCCGCGTCATCCCGGCCGAACTGATCGTCTGGGCCGCCGGCGTCAAGGCGCCGGACTT
CCTCAAGGACATCGCGGGGCTGGAGACCAACCGCATCAATCAGCTCGTGGTGAAGCAGACGCTGCAGACCACGCGCGACG
AGCGCATCTTCGCGATAGGCGACTGCTCGGCCTGCGCGTGGGGCGAGCGCGGCAACGTGCCGCCGCGGGCGCAGGCGGCG
CACCAGCAGGCGTCGCATCTCTACAAGCAGATCCCGCGCTTCATCCGGGGCGAGGCGCTCAGCGACTACCGCTACCACGA
TTTCGGCTCGCTGGTCTCGCTCGGCGAGTTCTCGACCGTCGGCTCGATGATGGGCGCGCTGGTCGGCGGCAACCTGGTGT
TCGAGGGGCTGTTCGCGCGCATGATGTATCTGGCGCTGTACAAGATGCACGAATACGCGCTGCATGGCCTCGCCAAGGTC
ACGCTGGACACGCTGGCGCGCCTGATCACCCGCCGCACCGAGCCGCATGTGAAGCTGCATTGA

Upstream 100 bases:

>100_bases
GATAGCGCCGGCGCCGCGGTCGCCCTTGGGGAGGTTGGTGATGGCCGTTGCGCAGTCAGGAGTCCCTCGCGTCGTGATCG
TCGGCGGGGGCGCCGGCGGA

Downstream 100 bases:

>100_bases
TCAATGCCCATGGTACCGCTCCGCGCAGCTGGAGGTTGAACTCTGCATAGCGGTACCGGCGGGGATTTTGCGGTCGCAAA
TTCTTTTGTAAGACCTTAGG

Product: respiratory NADH dehydrogenase 2/cupric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MELATRLGDKYGRKGKLDVTLVERNRTHVWKPKLHEIAAGSMDISAHEVDYLAQAYWHGFHYRIGDMIGLDRDKREVLVA
PYLDAEGREVTPQRTIPYDVLVISIGSQNNDFGTPGVVDHAIKLESQRDARRFHERMINACIRAHSQSTPIALHQLKVAI
IGAGATGVELAAELHRTTREVVAYGLDQVDAEKDIKITLIEAAPRVLPALPERVSSETGKLLERLGVEVLVGAKVAQVAA
DHVSLADGRVIPAELIVWAAGVKAPDFLKDIAGLETNRINQLVVKQTLQTTRDERIFAIGDCSACAWGERGNVPPRAQAA
HQQASHLYKQIPRFIRGEALSDYRYHDFGSLVSLGEFSTVGSMMGALVGGNLVFEGLFARMMYLALYKMHEYALHGLAKV
TLDTLARLITRRTEPHVKLH

Sequences:

>Translated_420_residues
MELATRLGDKYGRKGKLDVTLVERNRTHVWKPKLHEIAAGSMDISAHEVDYLAQAYWHGFHYRIGDMIGLDRDKREVLVA
PYLDAEGREVTPQRTIPYDVLVISIGSQNNDFGTPGVVDHAIKLESQRDARRFHERMINACIRAHSQSTPIALHQLKVAI
IGAGATGVELAAELHRTTREVVAYGLDQVDAEKDIKITLIEAAPRVLPALPERVSSETGKLLERLGVEVLVGAKVAQVAA
DHVSLADGRVIPAELIVWAAGVKAPDFLKDIAGLETNRINQLVVKQTLQTTRDERIFAIGDCSACAWGERGNVPPRAQAA
HQQASHLYKQIPRFIRGEALSDYRYHDFGSLVSLGEFSTVGSMMGALVGGNLVFEGLFARMMYLALYKMHEYALHGLAKV
TLDTLARLITRRTEPHVKLH
>Mature_420_residues
MELATRLGDKYGRKGKLDVTLVERNRTHVWKPKLHEIAAGSMDISAHEVDYLAQAYWHGFHYRIGDMIGLDRDKREVLVA
PYLDAEGREVTPQRTIPYDVLVISIGSQNNDFGTPGVVDHAIKLESQRDARRFHERMINACIRAHSQSTPIALHQLKVAI
IGAGATGVELAAELHRTTREVVAYGLDQVDAEKDIKITLIEAAPRVLPALPERVSSETGKLLERLGVEVLVGAKVAQVAA
DHVSLADGRVIPAELIVWAAGVKAPDFLKDIAGLETNRINQLVVKQTLQTTRDERIFAIGDCSACAWGERGNVPPRAQAA
HQQASHLYKQIPRFIRGEALSDYRYHDFGSLVSLGEFSTVGSMMGALVGGNLVFEGLFARMMYLALYKMHEYALHGLAKV
TLDTLARLITRRTEPHVKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=420, Percent_Identity=48.5714285714286, Blast_Score=407, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6323515, Length=330, Percent_Identity=28.1818181818182, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320118, Length=409, Percent_Identity=24.2053789731051, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323794, Length=364, Percent_Identity=26.3736263736264, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 46492; Mature: 46492

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELATRLGDKYGRKGKLDVTLVERNRTHVWKPKLHEIAAGSMDISAHEVDYLAQAYWHGF
CCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCH
HYRIGDMIGLDRDKREVLVAPYLDAEGREVTPQRTIPYDVLVISIGSQNNDFGTPGVVDH
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHH
AIKLESQRDARRFHERMINACIRAHSQSTPIALHQLKVAIIGAGATGVELAAELHRTTRE
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHEEEEEEEEECCCHHHHHHHHHHHHHHH
VVAYGLDQVDAEKDIKITLIEAAPRVLPALPERVSSETGKLLERLGVEVLVGAKVAQVAA
HHHHCCHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHH
DHVSLADGRVIPAELIVWAAGVKAPDFLKDIAGLETNRINQLVVKQTLQTTRDERIFAIG
HHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEE
DCSACAWGERGNVPPRAQAAHQQASHLYKQIPRFIRGEALSDYRYHDFGSLVSLGEFSTV
CCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
GSMMGALVGGNLVFEGLFARMMYLALYKMHEYALHGLAKVTLDTLARLITRRTEPHVKLH
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC
>Mature Secondary Structure
MELATRLGDKYGRKGKLDVTLVERNRTHVWKPKLHEIAAGSMDISAHEVDYLAQAYWHGF
CCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCH
HYRIGDMIGLDRDKREVLVAPYLDAEGREVTPQRTIPYDVLVISIGSQNNDFGTPGVVDH
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHH
AIKLESQRDARRFHERMINACIRAHSQSTPIALHQLKVAIIGAGATGVELAAELHRTTRE
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHEEEEEEEEECCCHHHHHHHHHHHHHHH
VVAYGLDQVDAEKDIKITLIEAAPRVLPALPERVSSETGKLLERLGVEVLVGAKVAQVAA
HHHHCCHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHH
DHVSLADGRVIPAELIVWAAGVKAPDFLKDIAGLETNRINQLVVKQTLQTTRDERIFAIG
HHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEE
DCSACAWGERGNVPPRAQAAHQQASHLYKQIPRFIRGEALSDYRYHDFGSLVSLGEFSTV
CCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
GSMMGALVGGNLVFEGLFARMMYLALYKMHEYALHGLAKVTLDTLARLITRRTEPHVKLH
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]