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The map label for this gene is ilvD [H]

Identifier: 146338873

GI number: 146338873

Start: 1936965

End: 1938638

Strand: Direct

Name: ilvD [H]

Synonym: BRADO1812

Alternate gene names: 146338873

Gene position: 1936965-1938638 (Clockwise)

Preceding gene: 146338872

Following gene: 146338874

Centisome position: 25.98

GC content: 67.03

Gene sequence:

>1674_bases
ATGGGCTTCTATTATCGCTCGTTCCTCAAGAACAGCGGCACGCCGCAGGATCGATTCGAAGGCCGTCCGGTCATCGGCAT
CTGCAACACCTGGTCGGAGCTGACGCCCTGCAACGCGCATTTCCGTGTCATCGCCGAGCACGTCCGCCAGGGCGTGCTCG
ATGCCGGCGGGTACCCACTCGAATTCCCGGTCTCCTCGCTCGGCGAGGTGACGATGCGCCCGACCGCGATGCTGTTCCGC
AACCTCGCCTCGATGGATGTCGAGGAGGCGATCCGCGCGCATCCGCTGGACGGCGTCGTGCTGTTGATGGGCTGTGACAA
GACCACGCCGGCGCTGTTGATGGGCGCGGCCTCGGCCGACCTGCCGGCGATCGGCGTCTCCGGCGGGCCGCAGTTGCGCG
GCGTTTATCGCGGCCAGATCATCGGCTCCGGCACCAACATCATCTCGATGAGCGAGCAACTGCGCGCCGGCGAGATCACC
TTGAAGGAATTCCACGAGGCCGAGGCCGGCATGAACCGCTCCGCTGGCAGCTGCATGACCATGGGCACGGCCTCGACGAT
GGCCTCGATGGTCGAGGCGCTCGGCATCGGCCTGCCGGAGAATGCCGCGATTCCCGCCGCCGACGCGCGCCGCAACCTGC
TCGCGCGCATGGCCGGCCGGCGCATTGTCGAGATGGTTAACGAAGACCTCAAGCCGTCGGACATTCTCACCCGCCAAGCA
TTCGAGAATGCGATCCGCACGCTGGCCGCGATCGGCGGCTCGACCAATGCGGTCGTGCACCTGCTCGCAATCGCGGGCCG
CGTCGGCGTCGAGCTTTCGCTGGACGATTTCGACCGGCTGTGCCGCGACGTGCACTGCCTCGTCGATCTGATGCCGTCGG
GCCGCTTCCTGATGGAGGATTTCTACTACGCCGGCGGTCTGCCGGCGGTGCTGCGCGCGCTCGGCGAGCGCGGCCTGCTG
CACAAGGACGCGCGCACGGTCAACGGCAAGACGCTGTGGGAGAACGTCTCCGAAGCGCCGAACTACAATGCCGAGGTGAT
CACGCCGTTCGAGACGCCGTTCAAGACCGAGGCCGGCATCGCGATCCTCACCGGCAACCTCGCGCCGAACGGCGCGGTCA
TCAAGCCGTCGGCGGCCTCGCCGGAGCTGATGAACCACACGGGACGCGCGGTGGTGTTCGAGAGCGTCGAGGAGATGCAT
GACGCTGTTGACGACGACACTCTCGACATCGACGCCTCCTGCATCATGGTGCTGAAGAACTGCGGGCCGAAGGGCTATCC
GGGCATGGCCGAGGTCGGCAACATGCCGCTGCCTGCAAAAGTGCTGCGCCAGGGTGTGCGCGACATGATCCGCATTTCAG
ACGCGCGGATGTCCGGCACTGCCTACGGGACGGTGGTGCTGCATGTCGCACCGGAGGCCACCGTCGGCGGACCGCTGGCG
CTGGTGAAGAACGGCGACATGATCACGCTCGACGTGCCCGGCCGTCGGCTGCATCTGCATGTCAGCGACGAGGAGCTGGC
CGCGCGCCGCGCCGCCTGGACGCCGCCGAAGCCGCACGCGGAGCGGGGCTATCAGAAGCTCTACATCGATCACGTGCTGC
AGGCCGATCGCGGCGTGGATTTCGACTTCCTGGTCGGCCGCACCGGCTCGCCGGTGCCGCGCGACAATCACTAA

Upstream 100 bases:

>100_bases
GGCGTCATGCGCAGTCGGCTGCACGAACGGACCAGGAATGAGCAACGACAAGTCAGACAAGCAGCTGCGCAGCCAGGCGT
GGTTCGGCCGCCAGGACAAG

Downstream 100 bases:

>100_bases
GAGGTGCCCATGACCGCTTCATCCAGAAAGCTTTACAAGGGCGTCTTCCCGGTCGCGCCGACCATCTTCGACGCCGACGG
CCGTCTCGACCTCGAGGGCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MGFYYRSFLKNSGTPQDRFEGRPVIGICNTWSELTPCNAHFRVIAEHVRQGVLDAGGYPLEFPVSSLGEVTMRPTAMLFR
NLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAASADLPAIGVSGGPQLRGVYRGQIIGSGTNIISMSEQLRAGEIT
LKEFHEAEAGMNRSAGSCMTMGTASTMASMVEALGIGLPENAAIPAADARRNLLARMAGRRIVEMVNEDLKPSDILTRQA
FENAIRTLAAIGGSTNAVVHLLAIAGRVGVELSLDDFDRLCRDVHCLVDLMPSGRFLMEDFYYAGGLPAVLRALGERGLL
HKDARTVNGKTLWENVSEAPNYNAEVITPFETPFKTEAGIAILTGNLAPNGAVIKPSAASPELMNHTGRAVVFESVEEMH
DAVDDDTLDIDASCIMVLKNCGPKGYPGMAEVGNMPLPAKVLRQGVRDMIRISDARMSGTAYGTVVLHVAPEATVGGPLA
LVKNGDMITLDVPGRRLHLHVSDEELAARRAAWTPPKPHAERGYQKLYIDHVLQADRGVDFDFLVGRTGSPVPRDNH

Sequences:

>Translated_557_residues
MGFYYRSFLKNSGTPQDRFEGRPVIGICNTWSELTPCNAHFRVIAEHVRQGVLDAGGYPLEFPVSSLGEVTMRPTAMLFR
NLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAASADLPAIGVSGGPQLRGVYRGQIIGSGTNIISMSEQLRAGEIT
LKEFHEAEAGMNRSAGSCMTMGTASTMASMVEALGIGLPENAAIPAADARRNLLARMAGRRIVEMVNEDLKPSDILTRQA
FENAIRTLAAIGGSTNAVVHLLAIAGRVGVELSLDDFDRLCRDVHCLVDLMPSGRFLMEDFYYAGGLPAVLRALGERGLL
HKDARTVNGKTLWENVSEAPNYNAEVITPFETPFKTEAGIAILTGNLAPNGAVIKPSAASPELMNHTGRAVVFESVEEMH
DAVDDDTLDIDASCIMVLKNCGPKGYPGMAEVGNMPLPAKVLRQGVRDMIRISDARMSGTAYGTVVLHVAPEATVGGPLA
LVKNGDMITLDVPGRRLHLHVSDEELAARRAAWTPPKPHAERGYQKLYIDHVLQADRGVDFDFLVGRTGSPVPRDNH
>Mature_556_residues
GFYYRSFLKNSGTPQDRFEGRPVIGICNTWSELTPCNAHFRVIAEHVRQGVLDAGGYPLEFPVSSLGEVTMRPTAMLFRN
LASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAASADLPAIGVSGGPQLRGVYRGQIIGSGTNIISMSEQLRAGEITL
KEFHEAEAGMNRSAGSCMTMGTASTMASMVEALGIGLPENAAIPAADARRNLLARMAGRRIVEMVNEDLKPSDILTRQAF
ENAIRTLAAIGGSTNAVVHLLAIAGRVGVELSLDDFDRLCRDVHCLVDLMPSGRFLMEDFYYAGGLPAVLRALGERGLLH
KDARTVNGKTLWENVSEAPNYNAEVITPFETPFKTEAGIAILTGNLAPNGAVIKPSAASPELMNHTGRAVVFESVEEMHD
AVDDDTLDIDASCIMVLKNCGPKGYPGMAEVGNMPLPAKVLRQGVRDMIRISDARMSGTAYGTVVLHVAPEATVGGPLAL
VKNGDMITLDVPGRRLHLHVSDEELAARRAAWTPPKPHAERGYQKLYIDHVLQADRGVDFDFLVGRTGSPVPRDNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=598, Percent_Identity=30.9364548494983, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788157, Length=516, Percent_Identity=31.0077519379845, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI2367371, Length=475, Percent_Identity=31.3684210526316, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786464, Length=450, Percent_Identity=33.5555555555556, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=552, Percent_Identity=32.4275362318841, Blast_Score=278, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59900; Mature: 59768

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFYYRSFLKNSGTPQDRFEGRPVIGICNTWSELTPCNAHFRVIAEHVRQGVLDAGGYPL
CCHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
EFPVSSLGEVTMRPTAMLFRNLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAASAD
CCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCHHHEEECCCCC
LPAIGVSGGPQLRGVYRGQIIGSGTNIISMSEQLRAGEITLKEFHEAEAGMNRSAGSCMT
CCEEECCCCCCCCEEEECEEEECCCCEEEHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEE
MGTASTMASMVEALGIGLPENAAIPAADARRNLLARMAGRRIVEMVNEDLKPSDILTRQA
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FENAIRTLAAIGGSTNAVVHLLAIAGRVGVELSLDDFDRLCRDVHCLVDLMPSGRFLMED
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHH
FYYAGGLPAVLRALGERGLLHKDARTVNGKTLWENVSEAPNYNAEVITPFETPFKTEAGI
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCE
AILTGNLAPNGAVIKPSAASPELMNHTGRAVVFESVEEMHDAVDDDTLDIDASCIMVLKN
EEEECCCCCCCCEECCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CGPKGYPGMAEVGNMPLPAKVLRQGVRDMIRISDARMSGTAYGTVVLHVAPEATVGGPLA
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCEE
LVKNGDMITLDVPGRRLHLHVSDEELAARRAAWTPPKPHAERGYQKLYIDHVLQADRGVD
EEECCCEEEEECCCCEEEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FDFLVGRTGSPVPRDNH
EEEEECCCCCCCCCCCC
>Mature Secondary Structure 
GFYYRSFLKNSGTPQDRFEGRPVIGICNTWSELTPCNAHFRVIAEHVRQGVLDAGGYPL
CHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
EFPVSSLGEVTMRPTAMLFRNLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAASAD
CCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCHHHEEECCCCC
LPAIGVSGGPQLRGVYRGQIIGSGTNIISMSEQLRAGEITLKEFHEAEAGMNRSAGSCMT
CCEEECCCCCCCCEEEECEEEECCCCEEEHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEE
MGTASTMASMVEALGIGLPENAAIPAADARRNLLARMAGRRIVEMVNEDLKPSDILTRQA
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FENAIRTLAAIGGSTNAVVHLLAIAGRVGVELSLDDFDRLCRDVHCLVDLMPSGRFLMED
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHH
FYYAGGLPAVLRALGERGLLHKDARTVNGKTLWENVSEAPNYNAEVITPFETPFKTEAGI
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCE
AILTGNLAPNGAVIKPSAASPELMNHTGRAVVFESVEEMHDAVDDDTLDIDASCIMVLKN
EEEECCCCCCCCEECCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CGPKGYPGMAEVGNMPLPAKVLRQGVRDMIRISDARMSGTAYGTVVLHVAPEATVGGPLA
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCEE
LVKNGDMITLDVPGRRLHLHVSDEELAARRAAWTPPKPHAERGYQKLYIDHVLQADRGVD
EEECCCEEEEECCCCEEEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FDFLVGRTGSPVPRDNH
EEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA