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The map label for this gene is aphA [H]

Identifier: 146338639

GI number: 146338639

Start: 1681143

End: 1682267

Strand: Direct

Name: aphA [H]

Synonym: BRADO1570

Alternate gene names: 146338639

Gene position: 1681143-1682267 (Clockwise)

Preceding gene: 146338627

Following gene: 146338640

Centisome position: 22.55

GC content: 67.29

Gene sequence:

>1125_bases
GTGGTCCGCACGGGACCGCGTGCATTCCATCATCTCTGCTTGTCTCGGCCGTTGCTGCATGCACAATCGTTCGCGCCGGC
GAAAAAGGAGCCAGTCCGCGTGAAGGCCGTCTACACCGAGCTGCATCGCAGCCACGATCCGCAATTCTATCTGGTACGCG
GCGTCATCAAGCGCACCACCGAGCAGCCGGAGCGGGCGGATCGACTGCTGGCAGGCCTGAAGGCCGGCAATCACGAGCTG
GTCGCGCCGATTCAGTTCGGCCAGGAAGCGCGCGCGCGCGTGCACAGTCCGGAATATCTCAATTTCCTGGAGGAGGCCTG
GGACGCATGGGCCGCGCTCAGCGACGCCGGCAGCGAGATGATTCCGAACATGCATCCGGTGCGCAACGCCGCGACCTATC
CGACCCACATCGTCGGACGGCTCGGCTGGCACACGACCGACACCTCGGCGCCGATCGGGCCGGGGACGTGGGCCGGCGCC
TGCGCCGCGACCGACGTCGCGGCCTCGGCGGCGCAGCTGCTGCTCGACGGCGAGGATGCGGTCTACGCCTTGTGCCGGCC
GCCGGGGCACCATGCCTATCGCGACATCGCCTCCGGCTTCTGCTTCATGAACAATTCGGCGATCGCGGCGGCGCATCTGC
GCCAGCGCCACGAGCGGGTGGCGATCCTCGACGTCGACGTCCATCACGGCAACGGCACGCAGGGCATCTTCTACGAGCGG
CCGGACGTCCTGACGATCTCGATCCACGCTGACCCGACGCATTACTATCCGTTTGTCTGGGGCTATGCGCATGAGCGCGG
CGCGGGTGCGGGCCTCGGCGCCAACCTCAACATTCCGCTCGCCTTGAAGAGCGGCGACGACACCTATCTCAAGGCATTCG
AGACCGCGGCGAAGACGATCCATGCCTTCGCGCCTGGCGCGTTGGTCGTCGCGCTCGGACTCGATGCGTCCGAGCATGAT
CCGCTCAAGGGCCTGTCGGTGACGACGCCAGGCTTCCGCCGCATCGGAGCGGCGATCGCGCGGCTCGGCCTTCCCACCGT
ATTCGTGCAGGAGGGCGGCTATCTCTCCGACATCCTCGGTCAGAACCTGACCGCGGTGCTGGCGGGGTTCGAGGAGGCGC
GGTGA

Upstream 100 bases:

>100_bases
CCGAAAGCGTCTCTCCTCAAACCCTCCGTGCCGCATCGCCTTGCGCCAGTGAACTCGCTGACAACATCGTCTGCAAGCCG
GTTCGTTCCGCTGGCTGGAA

Downstream 100 bases:

>100_bases
CGCGCGAAGCCGGCCGTGACGAAAGTAATGGATCTGCTCTGAAATCAGGCACCACCCCGGGGTTCCACGGTTCCATAAAT
GGAGCCTTCCTTAAGCATCA

Product: acetylpolyamine aminohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MVRTGPRAFHHLCLSRPLLHAQSFAPAKKEPVRVKAVYTELHRSHDPQFYLVRGVIKRTTEQPERADRLLAGLKAGNHEL
VAPIQFGQEARARVHSPEYLNFLEEAWDAWAALSDAGSEMIPNMHPVRNAATYPTHIVGRLGWHTTDTSAPIGPGTWAGA
CAATDVAASAAQLLLDGEDAVYALCRPPGHHAYRDIASGFCFMNNSAIAAAHLRQRHERVAILDVDVHHGNGTQGIFYER
PDVLTISIHADPTHYYPFVWGYAHERGAGAGLGANLNIPLALKSGDDTYLKAFETAAKTIHAFAPGALVVALGLDASEHD
PLKGLSVTTPGFRRIGAAIARLGLPTVFVQEGGYLSDILGQNLTAVLAGFEEAR

Sequences:

>Translated_374_residues
MVRTGPRAFHHLCLSRPLLHAQSFAPAKKEPVRVKAVYTELHRSHDPQFYLVRGVIKRTTEQPERADRLLAGLKAGNHEL
VAPIQFGQEARARVHSPEYLNFLEEAWDAWAALSDAGSEMIPNMHPVRNAATYPTHIVGRLGWHTTDTSAPIGPGTWAGA
CAATDVAASAAQLLLDGEDAVYALCRPPGHHAYRDIASGFCFMNNSAIAAAHLRQRHERVAILDVDVHHGNGTQGIFYER
PDVLTISIHADPTHYYPFVWGYAHERGAGAGLGANLNIPLALKSGDDTYLKAFETAAKTIHAFAPGALVVALGLDASEHD
PLKGLSVTTPGFRRIGAAIARLGLPTVFVQEGGYLSDILGQNLTAVLAGFEEAR
>Mature_374_residues
MVRTGPRAFHHLCLSRPLLHAQSFAPAKKEPVRVKAVYTELHRSHDPQFYLVRGVIKRTTEQPERADRLLAGLKAGNHEL
VAPIQFGQEARARVHSPEYLNFLEEAWDAWAALSDAGSEMIPNMHPVRNAATYPTHIVGRLGWHTTDTSAPIGPGTWAGA
CAATDVAASAAQLLLDGEDAVYALCRPPGHHAYRDIASGFCFMNNSAIAAAHLRQRHERVAILDVDVHHGNGTQGIFYER
PDVLTISIHADPTHYYPFVWGYAHERGAGAGLGANLNIPLALKSGDDTYLKAFETAAKTIHAFAPGALVVALGLDASEHD
PLKGLSVTTPGFRRIGAAIARLGLPTVFVQEGGYLSDILGQNLTAVLAGFEEAR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795204, Length=201, Percent_Identity=39.3034825870647, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI30795202, Length=201, Percent_Identity=39.3034825870647, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI148539870, Length=227, Percent_Identity=38.7665198237885, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI17158039, Length=201, Percent_Identity=39.3034825870647, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI169234807, Length=227, Percent_Identity=38.7665198237885, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI13128864, Length=228, Percent_Identity=36.8421052631579, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI8923769, Length=297, Percent_Identity=27.9461279461279, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI153085395, Length=201, Percent_Identity=38.3084577114428, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI62750347, Length=201, Percent_Identity=40.2985074626866, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI62750349, Length=201, Percent_Identity=40.2985074626866, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI20070354, Length=189, Percent_Identity=36.5079365079365, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI262073088, Length=166, Percent_Identity=31.9277108433735, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI13128860, Length=278, Percent_Identity=27.3381294964029, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI13128862, Length=277, Percent_Identity=25.6317689530686, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI226529806, Length=116, Percent_Identity=44.8275862068966, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI293336691, Length=258, Percent_Identity=28.2945736434109, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI262073092, Length=236, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17540334, Length=197, Percent_Identity=39.5939086294416, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193206283, Length=197, Percent_Identity=39.5939086294416, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540332, Length=197, Percent_Identity=39.5939086294416, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17537347, Length=220, Percent_Identity=34.0909090909091, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17508561, Length=265, Percent_Identity=29.811320754717, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193209491, Length=186, Percent_Identity=37.0967741935484, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17534739, Length=166, Percent_Identity=33.1325301204819, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17561978, Length=282, Percent_Identity=27.3049645390071, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25154022, Length=180, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25154020, Length=180, Percent_Identity=27.2222222222222, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=195, Percent_Identity=35.3846153846154, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321244, Length=263, Percent_Identity=26.9961977186312, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323999, Length=168, Percent_Identity=34.5238095238095, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325325, Length=176, Percent_Identity=30.1136363636364, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281360799, Length=185, Percent_Identity=43.2432432432432, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI281360801, Length=185, Percent_Identity=43.2432432432432, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24641720, Length=185, Percent_Identity=43.2432432432432, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24642144, Length=215, Percent_Identity=40, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642142, Length=215, Percent_Identity=40, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642146, Length=215, Percent_Identity=40, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281360899, Length=205, Percent_Identity=41.4634146341463, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24644244, Length=277, Percent_Identity=27.0758122743682, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24657891, Length=166, Percent_Identity=34.9397590361446, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 40438; Mature: 40438

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRTGPRAFHHLCLSRPLLHAQSFAPAKKEPVRVKAVYTELHRSHDPQFYLVRGVIKRTT
CCCCCHHHHHHHHHHCHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCCEEEHHHHHHHCC
EQPERADRLLAGLKAGNHELVAPIQFGQEARARVHSPEYLNFLEEAWDAWAALSDAGSEM
CCHHHHHHHHHHHCCCCCEEEEHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHH
IPNMHPVRNAATYPTHIVGRLGWHTTDTSAPIGPGTWAGACAATDVAASAAQLLLDGEDA
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCE
VYALCRPPGHHAYRDIASGFCFMNNSAIAAAHLRQRHERVAILDVDVHHGNGTQGIFYER
EEEEECCCCCHHHHHHHCCEEEECCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCEEEEC
PDVLTISIHADPTHYYPFVWGYAHERGAGAGLGANLNIPLALKSGDDTYLKAFETAAKTI
CCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
HAFAPGALVVALGLDASEHDPLKGLSVTTPGFRRIGAAIARLGLPTVFVQEGGYLSDILG
HHCCCCEEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHC
QNLTAVLAGFEEAR
CCHHHHHHHHHHCC
>Mature Secondary Structure
MVRTGPRAFHHLCLSRPLLHAQSFAPAKKEPVRVKAVYTELHRSHDPQFYLVRGVIKRTT
CCCCCHHHHHHHHHHCHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCCEEEHHHHHHHCC
EQPERADRLLAGLKAGNHELVAPIQFGQEARARVHSPEYLNFLEEAWDAWAALSDAGSEM
CCHHHHHHHHHHHCCCCCEEEEHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHH
IPNMHPVRNAATYPTHIVGRLGWHTTDTSAPIGPGTWAGACAATDVAASAAQLLLDGEDA
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCE
VYALCRPPGHHAYRDIASGFCFMNNSAIAAAHLRQRHERVAILDVDVHHGNGTQGIFYER
EEEEECCCCCHHHHHHHCCEEEECCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCEEEEC
PDVLTISIHADPTHYYPFVWGYAHERGAGAGLGANLNIPLALKSGDDTYLKAFETAAKTI
CCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
HAFAPGALVVALGLDASEHDPLKGLSVTTPGFRRIGAAIARLGLPTVFVQEGGYLSDILG
HHCCCCEEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHC
QNLTAVLAGFEEAR
CCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]