Click here to switch to the map view.

The map label for this gene is kynU [H]

Identifier: 146338600

GI number: 146338600

Start: 1632063

End: 1633256

Strand: Direct

Name: kynU [H]

Synonym: BRADO1528

Alternate gene names: 146338600

Gene position: 1632063-1633256 (Clockwise)

Preceding gene: 146338598

Following gene: 146338601

Centisome position: 21.89

GC content: 68.09

Gene sequence:

>1194_bases
ATGGCGGATTTTTCTCACACAAGATCGCTTTTCAGGATTCCTGAGGGAGTCATCTATCTCGACGGCAATTCGCTCGGCGC
GCTGCCCCTGGCGGTGCCGGGGCGCGTGGCCCGGATGATCGAGGCCGAATGGGGCCAGGAGCTGATCCGCGGCTGGAACA
GCGCCGGCTGGATGGTGCAGCCCCGCCGCGTCGGCGACCGCATCGCCCGGCTGATCGGCGCCGCGCCCGGCACGGTCGTG
ATGGGCGATACGCTCTCGATCAAGGTGTATCAGGCGCTCGCCGCCGCGCTGTCGCTCAATCCGAAGCGCGGCGTGATCCT
GTCCGACAGCGGCAACTTCCCGTCCGATCTCTACATGGCGCAGGGCCTGATCCGCATGCTCGGCGATCGGGCCACATTGA
AAGTTGTCGAGCCCGAGGAGGTCGAAGGCGCGATCGACGACAGCGTCGCCGTGCTGATGCTGACCGAGGTGGACTACCGC
ACGGGCCGCATGCACGACATGAAGGCCCTCACCACGAAGGCGCACGGCGCCGGCGCGCTCACGGTGTGGGATCTCGCGCA
TTCCGCCGGCGCGGTGCCGGTCGATCTCGCCGGCGCGGAGGCCGACTTCGCGGTCGGCTGCACCTACAAATATCTCAATG
GCGGTCCCGGCGCGCCGGCCTTCATCTATGTCGCGCCAGGTCATGCCGACATCGCGCCGCCGGCGCTGTCCGGCTGGATG
GGTCACGAGGCGCCGTTCGCCTTCGATCTCGACTATCGCCCCGGCGGCGGCATCGAGCGGATGCGCATCGGCACGCCGCC
GATCATCGCGCTCGCAGCCCTCGATGCGGCACTCGATGCCTGGGAGGGCGTGTCGATGCAGGATGTGCGTGCGGCCTCGA
TCGCACTGTCGGAGCTGTTCATCGCCGAGGTCGAGAAGCGCTGTCCGTCGCTGACGCTCGCTTCGCCGCGGGATGCGGCG
CGTCGCGGCAGCCAGGTGTCCTTCCGCCATACCGACGGCTACGCGATCATGCGTGCGCTGATCGCGCGCGGCGTGATCGG
CGATTTCCGCGCGCCGGACGCGCTGCGCTTCGGCTTCACGCCGCTCTACATCGGCGAGGCCGAGGTGCGCGGTGCCGTCG
ATATCCTCGAGGATGTCCTGGCCAAGAAGCTGTGGGACAGGCCCGAATATCGCCAGAAGGAGCTCGTGACGTGA

Upstream 100 bases:

>100_bases
CAGAGGCAGATCTCGCGCCGGCGCAGACGAGCCCGCCGGGGCGATCTGGTCTCTTGCGGCCCGAATCATGCATTCAGGAC
GGCGAACAGAGCAAGGCAGC

Downstream 100 bases:

>100_bases
GCAACGCGCCCTACGATCCCGCCACCGAAGGTGCGCGGATGAACTTCAAGGGACGTATGTCCTACGGCGATTACCTGATG
CTGGAGCGCCTGCTCGACGC

Product: putative kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MADFSHTRSLFRIPEGVIYLDGNSLGALPLAVPGRVARMIEAEWGQELIRGWNSAGWMVQPRRVGDRIARLIGAAPGTVV
MGDTLSIKVYQALAAALSLNPKRGVILSDSGNFPSDLYMAQGLIRMLGDRATLKVVEPEEVEGAIDDSVAVLMLTEVDYR
TGRMHDMKALTTKAHGAGALTVWDLAHSAGAVPVDLAGAEADFAVGCTYKYLNGGPGAPAFIYVAPGHADIAPPALSGWM
GHEAPFAFDLDYRPGGGIERMRIGTPPIIALAALDAALDAWEGVSMQDVRAASIALSELFIAEVEKRCPSLTLASPRDAA
RRGSQVSFRHTDGYAIMRALIARGVIGDFRAPDALRFGFTPLYIGEAEVRGAVDILEDVLAKKLWDRPEYRQKELVT

Sequences:

>Translated_397_residues
MADFSHTRSLFRIPEGVIYLDGNSLGALPLAVPGRVARMIEAEWGQELIRGWNSAGWMVQPRRVGDRIARLIGAAPGTVV
MGDTLSIKVYQALAAALSLNPKRGVILSDSGNFPSDLYMAQGLIRMLGDRATLKVVEPEEVEGAIDDSVAVLMLTEVDYR
TGRMHDMKALTTKAHGAGALTVWDLAHSAGAVPVDLAGAEADFAVGCTYKYLNGGPGAPAFIYVAPGHADIAPPALSGWM
GHEAPFAFDLDYRPGGGIERMRIGTPPIIALAALDAALDAWEGVSMQDVRAASIALSELFIAEVEKRCPSLTLASPRDAA
RRGSQVSFRHTDGYAIMRALIARGVIGDFRAPDALRFGFTPLYIGEAEVRGAVDILEDVLAKKLWDRPEYRQKELVT
>Mature_396_residues
ADFSHTRSLFRIPEGVIYLDGNSLGALPLAVPGRVARMIEAEWGQELIRGWNSAGWMVQPRRVGDRIARLIGAAPGTVVM
GDTLSIKVYQALAAALSLNPKRGVILSDSGNFPSDLYMAQGLIRMLGDRATLKVVEPEEVEGAIDDSVAVLMLTEVDYRT
GRMHDMKALTTKAHGAGALTVWDLAHSAGAVPVDLAGAEADFAVGCTYKYLNGGPGAPAFIYVAPGHADIAPPALSGWMG
HEAPFAFDLDYRPGGGIERMRIGTPPIIALAALDAALDAWEGVSMQDVRAASIALSELFIAEVEKRCPSLTLASPRDAAR
RGSQVSFRHTDGYAIMRALIARGVIGDFRAPDALRFGFTPLYIGEAEVRGAVDILEDVLAKKLWDRPEYRQKELVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=403, Percent_Identity=26.7990074441687, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI74101437, Length=252, Percent_Identity=26.5873015873016, Blast_Score=96, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17550466, Length=395, Percent_Identity=28.3544303797468, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323261, Length=420, Percent_Identity=28.8095238095238, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 42637; Mature: 42506

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADFSHTRSLFRIPEGVIYLDGNSLGALPLAVPGRVARMIEAEWGQELIRGWNSAGWMVQ
CCCCHHHHHHHCCCCCEEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
PRRVGDRIARLIGAAPGTVVMGDTLSIKVYQALAAALSLNPKRGVILSDSGNFPSDLYMA
HHHHHHHHHHHHCCCCCCEEECCCEEHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHH
QGLIRMLGDRATLKVVEPEEVEGAIDDSVAVLMLTEVDYRTGRMHDMKALTTKAHGAGAL
HHHHHHHCCCCEEEEECCHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCEE
TVWDLAHSAGAVPVDLAGAEADFAVGCTYKYLNGGPGAPAFIYVAPGHADIAPPALSGWM
EEEEHHHCCCCCEEEECCCCCCEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCHHHCCC
GHEAPFAFDLDYRPGGGIERMRIGTPPIIALAALDAALDAWEGVSMQDVRAASIALSELF
CCCCCEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IAEVEKRCPSLTLASPRDAARRGSQVSFRHTDGYAIMRALIARGVIGDFRAPDALRFGFT
HHHHHHHCCCCEECCCHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEECCC
PLYIGEAEVRGAVDILEDVLAKKLWDRPEYRQKELVT
EEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
>Mature Secondary Structure 
ADFSHTRSLFRIPEGVIYLDGNSLGALPLAVPGRVARMIEAEWGQELIRGWNSAGWMVQ
CCCHHHHHHHCCCCCEEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
PRRVGDRIARLIGAAPGTVVMGDTLSIKVYQALAAALSLNPKRGVILSDSGNFPSDLYMA
HHHHHHHHHHHHCCCCCCEEECCCEEHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHH
QGLIRMLGDRATLKVVEPEEVEGAIDDSVAVLMLTEVDYRTGRMHDMKALTTKAHGAGAL
HHHHHHHCCCCEEEEECCHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCEE
TVWDLAHSAGAVPVDLAGAEADFAVGCTYKYLNGGPGAPAFIYVAPGHADIAPPALSGWM
EEEEHHHCCCCCEEEECCCCCCEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCHHHCCC
GHEAPFAFDLDYRPGGGIERMRIGTPPIIALAALDAALDAWEGVSMQDVRAASIALSELF
CCCCCEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IAEVEKRCPSLTLASPRDAARRGSQVSFRHTDGYAIMRALIARGVIGDFRAPDALRFGFT
HHHHHHHCCCCEECCCHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEECCC
PLYIGEAEVRGAVDILEDVLAKKLWDRPEYRQKELVT
EEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA