Click here to switch to the map view.

The map label for this gene is ilvX [H]

Identifier: 146338533

GI number: 146338533

Start: 1557395

End: 1558945

Strand: Direct

Name: ilvX [H]

Synonym: BRADO1452

Alternate gene names: 146338533

Gene position: 1557395-1558945 (Clockwise)

Preceding gene: 146338530

Following gene: 146338534

Centisome position: 20.89

GC content: 68.34

Gene sequence:

>1551_bases
ATGATGAACGGTGCGGAAAGCCTGGTGCGGACCCTGGTCGCGGGCGGCGTTGACGTCTGCTTTACCAATCCGGGCACCTC
CGAGATGCATTTCGTCGCCGCACTCGACCGGGTCGAAGGGATGCGCTGCGTGCTCGGCCTGTTCGAGGGCGTGGTCACTG
GTGCCGCCGACGGCTATTTCCGCATGAAGGGCACGCCGGCCTCGACGCTGCTGCATCTCGGCCCCGGCCTCGCCAACGGC
CTCGCCAATCTGCACAACGCAAAGAAGGCGCGTTCCGGCATCGTCAACATCGTCGGCCAGCACGCCACCTACCATATCGG
CTTCAACGCGCCGCTGACCTCGGACATCGAAGGCCTGGCGCGGCCGATGTCCGACTGGGTACGGACCTCGCCGAGCGCCA
AGGCGGTGGCGGCCGACGGCGCCGCAGCGATCGCCGCCGCCAAGAGCGCGCCGCCCCAGATCGCCACGCTCATTCTGCCC
GCCGACACCGCCTGGAACGAGGCCGACGGCATCGCCCAGGTTCCCGCCGAGACGCAACGCCCGAGCTATTCGGCCGACGC
GGTCGAGAAGGCGGCCAGGATACTGCACGCCCACGGCCCGGAGACCCTGGTGCTGATGACCGCGGGCGCGCTGACCGAGC
AGGCGCTGACCTTCGCCCAGCAGATCGCCGGCAAGACCGGCTGCCGCGTGATGGGCCAGACCTATCACCCGCGCATGGCG
CGCGGCGCCGGCCGCTTCTCGATCGACCGGATTCCCTATGTGATCGAGCAGGCGCTGCCGATCCTGAAGAACTACAAGCA
CATCGTGCTGGTCGAGGCCAACGACCCCGTCGCCTTCTTCGCCTATCCGAACAAGCCGAGCATGCTCAAGGCGGAGGGCA
CCGAGGTGCACCGCATGACCGCCTGGGGCGAGAACTCGGCCGCGGCGCTGGAAGCGCTCGCCGGCCATCTCGGCGCCAAG
GCAGCCGACGTGAAGCCGCAGGCGCTCACTGAGTTGATCAAGCCGACCGGCGCGCTCAATCACACCACCATCGCGCAGGC
GATCGCCTATGCGATCCCCGAGAATGCGATCATCGTCGACGAATCCATCACCACCGGCCGCGGCTTCTTCCCGCCGACGG
CCGCCGCCAAGCCGCATGACTGGCTGCAGAACATGGGCGGCTCGATCGGCTTCTCGACCCCGGTGGCGACCGGCGCCGCG
GTGGCCTGCCCGGATCGCAAGGTCATGTGTCTCGTCGGCGACGGCAGCGCGATGTACACGATCCAGTCGCTGTGGACCCA
GGCGCGCGAGAATCTCAACGTCGTCACCGTGGTGTTCGCCAACAGGATCTACCAGATCCTGCGCGGCGAGTTCGATGGCG
TCGGCGCCGGCCAGCCCGGCCAGCGCGCCCAGGACATGCTCAAGATCGACCGCCCGACGCTTGACTTCGTCGCCATGGCC
AAAGGCATGGGCGTGCCCGGCCGCGCCGTCACCACGGCGGACGAGTTCAACGCCGCGCTGGCGGAAGCCAATGCGGAGCA
CGGCCCGCGCCTGATCGAAGTCCAGATGTAA

Upstream 100 bases:

>100_bases
CGCCATGGCGATGGCAGCAATGCGGCGACGCCCTTTGACGCCGCGGGCGAACAATGATTGATCTGCGCCAGCTTGAAGAC
ACGGGAACCGACGGGAGAAC

Downstream 100 bases:

>100_bases
GTCGTTTGCCCACGACCGGCGGCCGCAAATCGGCCGCCGGCTGATGGCAGCGTCATTGCCGCATTTTGATGGTTGGCGAC
TCAGCACGACGCGTGTTGAT

Product: hypothetical protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase large subunit; AHAS [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MMNGAESLVRTLVAGGVDVCFTNPGTSEMHFVAALDRVEGMRCVLGLFEGVVTGAADGYFRMKGTPASTLLHLGPGLANG
LANLHNAKKARSGIVNIVGQHATYHIGFNAPLTSDIEGLARPMSDWVRTSPSAKAVAADGAAAIAAAKSAPPQIATLILP
ADTAWNEADGIAQVPAETQRPSYSADAVEKAARILHAHGPETLVLMTAGALTEQALTFAQQIAGKTGCRVMGQTYHPRMA
RGAGRFSIDRIPYVIEQALPILKNYKHIVLVEANDPVAFFAYPNKPSMLKAEGTEVHRMTAWGENSAAALEALAGHLGAK
AADVKPQALTELIKPTGALNHTTIAQAIAYAIPENAIIVDESITTGRGFFPPTAAAKPHDWLQNMGGSIGFSTPVATGAA
VACPDRKVMCLVGDGSAMYTIQSLWTQARENLNVVTVVFANRIYQILRGEFDGVGAGQPGQRAQDMLKIDRPTLDFVAMA
KGMGVPGRAVTTADEFNAALAEANAEHGPRLIEVQM

Sequences:

>Translated_516_residues
MMNGAESLVRTLVAGGVDVCFTNPGTSEMHFVAALDRVEGMRCVLGLFEGVVTGAADGYFRMKGTPASTLLHLGPGLANG
LANLHNAKKARSGIVNIVGQHATYHIGFNAPLTSDIEGLARPMSDWVRTSPSAKAVAADGAAAIAAAKSAPPQIATLILP
ADTAWNEADGIAQVPAETQRPSYSADAVEKAARILHAHGPETLVLMTAGALTEQALTFAQQIAGKTGCRVMGQTYHPRMA
RGAGRFSIDRIPYVIEQALPILKNYKHIVLVEANDPVAFFAYPNKPSMLKAEGTEVHRMTAWGENSAAALEALAGHLGAK
AADVKPQALTELIKPTGALNHTTIAQAIAYAIPENAIIVDESITTGRGFFPPTAAAKPHDWLQNMGGSIGFSTPVATGAA
VACPDRKVMCLVGDGSAMYTIQSLWTQARENLNVVTVVFANRIYQILRGEFDGVGAGQPGQRAQDMLKIDRPTLDFVAMA
KGMGVPGRAVTTADEFNAALAEANAEHGPRLIEVQM
>Mature_516_residues
MMNGAESLVRTLVAGGVDVCFTNPGTSEMHFVAALDRVEGMRCVLGLFEGVVTGAADGYFRMKGTPASTLLHLGPGLANG
LANLHNAKKARSGIVNIVGQHATYHIGFNAPLTSDIEGLARPMSDWVRTSPSAKAVAADGAAAIAAAKSAPPQIATLILP
ADTAWNEADGIAQVPAETQRPSYSADAVEKAARILHAHGPETLVLMTAGALTEQALTFAQQIAGKTGCRVMGQTYHPRMA
RGAGRFSIDRIPYVIEQALPILKNYKHIVLVEANDPVAFFAYPNKPSMLKAEGTEVHRMTAWGENSAAALEALAGHLGAK
AADVKPQALTELIKPTGALNHTTIAQAIAYAIPENAIIVDESITTGRGFFPPTAAAKPHDWLQNMGGSIGFSTPVATGAA
VACPDRKVMCLVGDGSAMYTIQSLWTQARENLNVVTVVFANRIYQILRGEFDGVGAGQPGQRAQDMLKIDRPTLDFVAMA
KGMGVPGRAVTTADEFNAALAEANAEHGPRLIEVQM

Specific function: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=569, Percent_Identity=24.6045694200351, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI87081685, Length=128, Percent_Identity=32.03125, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 54287; Mature: 54287

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNGAESLVRTLVAGGVDVCFTNPGTSEMHFVAALDRVEGMRCVLGLFEGVVTGAADGYF
CCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
RMKGTPASTLLHLGPGLANGLANLHNAKKARSGIVNIVGQHATYHIGFNAPLTSDIEGLA
EECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCEEEEEECCCCCCHHHHHHH
RPMSDWVRTSPSAKAVAADGAAAIAAAKSAPPQIATLILPADTAWNEADGIAQVPAETQR
HHHHHHHHCCCCCCEEECCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEECCCCCCC
PSYSADAVEKAARILHAHGPETLVLMTAGALTEQALTFAQQIAGKTGCRVMGQTYHPRMA
CCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEECCCCCCCHHH
RGAGRFSIDRIPYVIEQALPILKNYKHIVLVEANDPVAFFAYPNKPSMLKAEGTEVHRMT
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCEEECCCCEEEEEE
AWGENSAAALEALAGHLGAKAADVKPQALTELIKPTGALNHTTIAQAIAYAIPENAIIVD
ECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEE
ESITTGRGFFPPTAAAKPHDWLQNMGGSIGFSTPVATGAAVACPDRKVMCLVGDGSAMYT
CCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCHHHH
IQSLWTQARENLNVVTVVFANRIYQILRGEFDGVGAGQPGQRAQDMLKIDRPTLDFVAMA
HHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHH
KGMGVPGRAVTTADEFNAALAEANAEHGPRLIEVQM
HCCCCCCCEEECHHHHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure
MMNGAESLVRTLVAGGVDVCFTNPGTSEMHFVAALDRVEGMRCVLGLFEGVVTGAADGYF
CCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
RMKGTPASTLLHLGPGLANGLANLHNAKKARSGIVNIVGQHATYHIGFNAPLTSDIEGLA
EECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCEEEEEECCCCCCHHHHHHH
RPMSDWVRTSPSAKAVAADGAAAIAAAKSAPPQIATLILPADTAWNEADGIAQVPAETQR
HHHHHHHHCCCCCCEEECCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEECCCCCCC
PSYSADAVEKAARILHAHGPETLVLMTAGALTEQALTFAQQIAGKTGCRVMGQTYHPRMA
CCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEECCCCCCCHHH
RGAGRFSIDRIPYVIEQALPILKNYKHIVLVEANDPVAFFAYPNKPSMLKAEGTEVHRMT
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCEEECCCCEEEEEE
AWGENSAAALEALAGHLGAKAADVKPQALTELIKPTGALNHTTIAQAIAYAIPENAIIVD
ECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEE
ESITTGRGFFPPTAAAKPHDWLQNMGGSIGFSTPVATGAAVACPDRKVMCLVGDGSAMYT
CCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCHHHH
IQSLWTQARENLNVVTVVFANRIYQILRGEFDGVGAGQPGQRAQDMLKIDRPTLDFVAMA
HHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHH
KGMGVPGRAVTTADEFNAALAEANAEHGPRLIEVQM
HCCCCCCCEEECHHHHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]