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The map label for this gene is pntB [H]

Identifier: 146338294

GI number: 146338294

Start: 1273845

End: 1275242

Strand: Direct

Name: pntB [H]

Synonym: BRADO1198

Alternate gene names: 146338294

Gene position: 1273845-1275242 (Clockwise)

Preceding gene: 146338293

Following gene: 146338295

Centisome position: 17.08

GC content: 66.31

Gene sequence:

>1398_bases
ATGAACGCCAATCTGTCGGCACTCCTTTATCTCGTGGCGGGTGTGCTGTTCATCCTGTCGCTGCGCGGGCTGTCGAGCCC
GGCCACCAGCCGTCAGGGCAATCTGTTCGGCATGATCGGCATGGCGATCGCCGTCGTGACCACGCTCGCCAGTCATCCGC
CGGCCGATGTGTGGGCCTGGATCCTGGTGATCCTCGGCGTCGCGATCGGCGGCGGCATCGGCGCGGTCATCGCCCGCCGG
GTGCCGATGACGGCAATGCCCGAACTGGTCGCCGCCTTCCACTCGCTGGTCGGCATGGCCGCGGTGCTGGTCGCCGCCGG
CGCCTTCTTCGCGCCGGAAGCGTTCGACATCGGCACGCCCGGCAACATCCATCCGCAGAGCCTGGTCGAAATGTCGCTCG
GCGTCGCGATCGGCGCGCTGACCTTCACCGGCTCAGTCATTGCCTTCCTCAAGCTGTCCGCGCGCATGAGCGGCGCCCCG
ATCATCCTGCCGGCGCGCCACCTCATCAACATCGGCCTCGCCGTCGCGCTGGTGTTCTTCGTCGTGCGCTTGGTGCTGAC
CGGCGGCGGCTTCGACTTCCTGATGGTCACGGTGCTGGCGCTGGCGCTCGGCGTGCTGATGATCATTCCGATCGGCGGCG
CCGACATGCCGGTCGTGATCTCGATGCTGAACTCCTATTCGGGCTGGGCGGCCGCCGGCATCGGCTTCACGCTGGGCAAT
TCGGCCCTGATCATCACCGGCGCGCTGGTCGGCTCCTCCGGCGCGATCCTGTCCTACATCATGTGCCACGCGATGAACCG
GTCCTTCATCTCGGTCATCCTCGGCGGCTTCGGCGGCGAGACGGCCGCAGCCGGCGGCGCAACCGGCGAGCAGAAGCCGG
CCAAGCTCGGCTCGGCTGACGACGCCGCCTTCATCATGAAGAACGCCTCCAAGGTCATCATCGTCCCCGGCTACGGCATG
GCGGTGGCCCAGGCCCAGCACGCGCTGCGCGAGATGGCCGACACCTTGAAGAAGGAAGGCGTCGAGGTGAAGTACGCGAT
TCACCCGGTCGCCGGACGCATGCCCGGCCACATGAACGTGCTGCTCGCCGAAGCCAACGTGCCCTATGACGAGGTGTTCG
AGCTCGAGGACATCAACTCCGAGTTCGCCCAGGCCGACGTCGCGTTCGTGATCGGCGCCAACGACGTCACCAACCCGGCG
GCGGAAGAGGACAAGTCCTCGCCGATCTACGGCATGCCCGTGCTGCAGGTCTGGAAGGCCGGCACCGTGATGTTCATCAA
GCGCTCGCTCGCGTCGGGCTACGCCGGCATCGACAATCCGCTGTTCTACCGCGACAACACGATGATGCTGCTCGGCGACG
CCAAGAAGATGACCGAGAATATCGTGAAGGGCATGTAA

Upstream 100 bases:

>100_bases
ACCCAGCGCATGCTGGCGATGTACAAGAAGAAGTCCAAATAACAACGCCGCACAATAACGCCGCGCGACGCGGGATGACA
GGCACAACGGGGCATCTGCA

Downstream 100 bases:

>100_bases
CCCGTCTTGTCAGGAGCCATCACCGCGTTGAAATGGCTCCTGATTGTCCTGGTGGCGATCTACGCCACCGTGATCGCGGT
GCTGTTCGTGCGTCAGCGCG

Product: pyridine nucleotide transhydrogenase (proton pump) subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MNANLSALLYLVAGVLFILSLRGLSSPATSRQGNLFGMIGMAIAVVTTLASHPPADVWAWILVILGVAIGGGIGAVIARR
VPMTAMPELVAAFHSLVGMAAVLVAAGAFFAPEAFDIGTPGNIHPQSLVEMSLGVAIGALTFTGSVIAFLKLSARMSGAP
IILPARHLINIGLAVALVFFVVRLVLTGGGFDFLMVTVLALALGVLMIIPIGGADMPVVISMLNSYSGWAAAGIGFTLGN
SALIITGALVGSSGAILSYIMCHAMNRSFISVILGGFGGETAAAGGATGEQKPAKLGSADDAAFIMKNASKVIIVPGYGM
AVAQAQHALREMADTLKKEGVEVKYAIHPVAGRMPGHMNVLLAEANVPYDEVFELEDINSEFAQADVAFVIGANDVTNPA
AEEDKSSPIYGMPVLQVWKAGTVMFIKRSLASGYAGIDNPLFYRDNTMMLLGDAKKMTENIVKGM

Sequences:

>Translated_465_residues
MNANLSALLYLVAGVLFILSLRGLSSPATSRQGNLFGMIGMAIAVVTTLASHPPADVWAWILVILGVAIGGGIGAVIARR
VPMTAMPELVAAFHSLVGMAAVLVAAGAFFAPEAFDIGTPGNIHPQSLVEMSLGVAIGALTFTGSVIAFLKLSARMSGAP
IILPARHLINIGLAVALVFFVVRLVLTGGGFDFLMVTVLALALGVLMIIPIGGADMPVVISMLNSYSGWAAAGIGFTLGN
SALIITGALVGSSGAILSYIMCHAMNRSFISVILGGFGGETAAAGGATGEQKPAKLGSADDAAFIMKNASKVIIVPGYGM
AVAQAQHALREMADTLKKEGVEVKYAIHPVAGRMPGHMNVLLAEANVPYDEVFELEDINSEFAQADVAFVIGANDVTNPA
AEEDKSSPIYGMPVLQVWKAGTVMFIKRSLASGYAGIDNPLFYRDNTMMLLGDAKKMTENIVKGM
>Mature_465_residues
MNANLSALLYLVAGVLFILSLRGLSSPATSRQGNLFGMIGMAIAVVTTLASHPPADVWAWILVILGVAIGGGIGAVIARR
VPMTAMPELVAAFHSLVGMAAVLVAAGAFFAPEAFDIGTPGNIHPQSLVEMSLGVAIGALTFTGSVIAFLKLSARMSGAP
IILPARHLINIGLAVALVFFVVRLVLTGGGFDFLMVTVLALALGVLMIIPIGGADMPVVISMLNSYSGWAAAGIGFTLGN
SALIITGALVGSSGAILSYIMCHAMNRSFISVILGGFGGETAAAGGATGEQKPAKLGSADDAAFIMKNASKVIIVPGYGM
AVAQAQHALREMADTLKKEGVEVKYAIHPVAGRMPGHMNVLLAEANVPYDEVFELEDINSEFAQADVAFVIGANDVTNPA
AEEDKSSPIYGMPVLQVWKAGTVMFIKRSLASGYAGIDNPLFYRDNTMMLLGDAKKMTENIVKGM

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=467, Percent_Identity=47.1092077087794, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI122939153, Length=467, Percent_Identity=47.1092077087794, Blast_Score=390, Evalue=1e-108,
Organism=Escherichia coli, GI1787886, Length=471, Percent_Identity=53.0785562632696, Blast_Score=465, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17550456, Length=458, Percent_Identity=47.1615720524017, Blast_Score=380, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 48178; Mature: 48178

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANLSALLYLVAGVLFILSLRGLSSPATSRQGNLFGMIGMAIAVVTTLASHPPADVWAW
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
ILVILGVAIGGGIGAVIARRVPMTAMPELVAAFHSLVGMAAVLVAAGAFFAPEAFDIGTP
HHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GNIHPQSLVEMSLGVAIGALTFTGSVIAFLKLSARMSGAPIILPARHLINIGLAVALVFF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHH
VVRLVLTGGGFDFLMVTVLALALGVLMIIPIGGADMPVVISMLNSYSGWAAAGIGFTLGN
HHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCHHCCCEEECC
SALIITGALVGSSGAILSYIMCHAMNRSFISVILGGFGGETAAAGGATGEQKPAKLGSAD
CEEEEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
DAAFIMKNASKVIIVPGYGMAVAQAQHALREMADTLKKEGVEVKYAIHPVAGRMPGHMNV
CHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEE
LLAEANVPYDEVFELEDINSEFAQADVAFVIGANDVTNPAAEEDKSSPIYGMPVLQVWKA
EEEECCCCHHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCC
GTVMFIKRSLASGYAGIDNPLFYRDNTMMLLGDAKKMTENIVKGM
CHHHHHHHHHHCCCCCCCCCEEEECCEEEEEECHHHHHHHHHCCC
>Mature Secondary Structure
MNANLSALLYLVAGVLFILSLRGLSSPATSRQGNLFGMIGMAIAVVTTLASHPPADVWAW
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
ILVILGVAIGGGIGAVIARRVPMTAMPELVAAFHSLVGMAAVLVAAGAFFAPEAFDIGTP
HHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GNIHPQSLVEMSLGVAIGALTFTGSVIAFLKLSARMSGAPIILPARHLINIGLAVALVFF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHH
VVRLVLTGGGFDFLMVTVLALALGVLMIIPIGGADMPVVISMLNSYSGWAAAGIGFTLGN
HHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCHHCCCEEECC
SALIITGALVGSSGAILSYIMCHAMNRSFISVILGGFGGETAAAGGATGEQKPAKLGSAD
CEEEEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
DAAFIMKNASKVIIVPGYGMAVAQAQHALREMADTLKKEGVEVKYAIHPVAGRMPGHMNV
CHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEE
LLAEANVPYDEVFELEDINSEFAQADVAFVIGANDVTNPAAEEDKSSPIYGMPVLQVWKA
EEEECCCCHHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCC
GTVMFIKRSLASGYAGIDNPLFYRDNTMMLLGDAKKMTENIVKGM
CHHHHHHHHHHCCCCCCCCCEEEECCEEEEEECHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]