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The map label for this gene is ubiE [H]

Identifier: 146337248

GI number: 146337248

Start: 84502

End: 85263

Strand: Direct

Name: ubiE [H]

Synonym: BRADO0075

Alternate gene names: 146337248

Gene position: 84502-85263 (Clockwise)

Preceding gene: 146337245

Following gene: 146337249

Centisome position: 1.13

GC content: 64.83

Gene sequence:

>762_bases
ATGGATCAGACGGACCAGACCACTCATTTCGGCTTCAGGGACGTGCCACTGGGCGAGAAGCAGACGCTGGTGAACGACGT
GTTTCACAGCGTCGCCTCCCGCTACGACTTGATGAACGACCTGATGTCCGGCGGGCTGCACCGCGTCTGGAAGGACATCA
TGATCAACACGCTGAACCCGCCGAAGAGCGATGCCCCGTTCGCGCTGCTCGACGTGGCGGGCGGCACCGGCGACATTTCC
TTCCGCGCCGCCAAGAAGGCCGGCGCCGGCTTCCACGCCACCGTCTGCGACATCAATGGCGACATGCTCGAGGTCGGCCG
CCAGCGCGCGCTGAAGCAATACCTCGACGACAGGGTGTCGTTCGTCGAGGGCAACGCCGAGAGCCTCGCCTTTCCCGACC
GCTCCTTCGACGCCTATACGATCGCCTTCGGCATCCGCAACGTGCCGCAGATCGACCTGGCGCTGGCCGAGGCCTACCGC
GTGCTCAAGCATGGCGGCCGCTTCCTGTGCCTGGAGTTCTCGACCGTCGAGGTGCCCGGCCTCGACAAGCTCTACGACCT
GTTTTCCTTCAACGTCATTCCGCAGCTCGGCCGCGCCGTGACCGGTGACGCCGAGTCCTATCGCTACCTCGTCGAATCCA
TCCGCCAGTTTCCGCGCCCCAATGCCTTCGCCGAGATGATCTCGGCGGCCGGATTCTCCCGCGTCTCCTGGCAGACCCTT
TCCGGCGGCATCGTCGCGCTTCATTCCGGCTGGCGTTTGTGA

Upstream 100 bases:

>100_bases
TCATTTCACCTTTTGCGTCCTGCGACCATTCACCTTGTCCGGCCGACGTGATAGCGCCTTGGCCGCACCGGCGCTATGGT
GCCGTATCGGAGTAAGGGTG

Downstream 100 bases:

>100_bases
TCTCCGCACTGACACATATTACGCGGCTCGCCCGGGCCGCCCTGGTGTTCGCGCGCGAGGGCGTGTTCGGCGTCGTCGAT
CCGAGTCTGGCGCCGCCGCC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MDQTDQTTHFGFRDVPLGEKQTLVNDVFHSVASRYDLMNDLMSGGLHRVWKDIMINTLNPPKSDAPFALLDVAGGTGDIS
FRAAKKAGAGFHATVCDINGDMLEVGRQRALKQYLDDRVSFVEGNAESLAFPDRSFDAYTIAFGIRNVPQIDLALAEAYR
VLKHGGRFLCLEFSTVEVPGLDKLYDLFSFNVIPQLGRAVTGDAESYRYLVESIRQFPRPNAFAEMISAAGFSRVSWQTL
SGGIVALHSGWRL

Sequences:

>Translated_253_residues
MDQTDQTTHFGFRDVPLGEKQTLVNDVFHSVASRYDLMNDLMSGGLHRVWKDIMINTLNPPKSDAPFALLDVAGGTGDIS
FRAAKKAGAGFHATVCDINGDMLEVGRQRALKQYLDDRVSFVEGNAESLAFPDRSFDAYTIAFGIRNVPQIDLALAEAYR
VLKHGGRFLCLEFSTVEVPGLDKLYDLFSFNVIPQLGRAVTGDAESYRYLVESIRQFPRPNAFAEMISAAGFSRVSWQTL
SGGIVALHSGWRL
>Mature_253_residues
MDQTDQTTHFGFRDVPLGEKQTLVNDVFHSVASRYDLMNDLMSGGLHRVWKDIMINTLNPPKSDAPFALLDVAGGTGDIS
FRAAKKAGAGFHATVCDINGDMLEVGRQRALKQYLDDRVSFVEGNAESLAFPDRSFDAYTIAFGIRNVPQIDLALAEAYR
VLKHGGRFLCLEFSTVEVPGLDKLYDLFSFNVIPQLGRAVTGDAESYRYLVESIRQFPRPNAFAEMISAAGFSRVSWQTL
SGGIVALHSGWRL

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=280, Percent_Identity=50, Blast_Score=256, Evalue=1e-68,
Organism=Escherichia coli, GI48994983, Length=253, Percent_Identity=45.4545454545455, Blast_Score=230, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17557039, Length=249, Percent_Identity=45.3815261044177, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6323526, Length=265, Percent_Identity=46.4150943396226, Blast_Score=216, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24641702, Length=262, Percent_Identity=48.0916030534351, Blast_Score=247, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27973; Mature: 27973

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQTDQTTHFGFRDVPLGEKQTLVNDVFHSVASRYDLMNDLMSGGLHRVWKDIMINTLNP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
PKSDAPFALLDVAGGTGDISFRAAKKAGAGFHATVCDINGDMLEVGRQRALKQYLDDRVS
CCCCCCEEEEEECCCCCCEEEEEHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
FVEGNAESLAFPDRSFDAYTIAFGIRNVPQIDLALAEAYRVLKHGGRFLCLEFSTVEVPG
HHCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECEECCCC
LDKLYDLFSFNVIPQLGRAVTGDAESYRYLVESIRQFPRPNAFAEMISAAGFSRVSWQTL
HHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEC
SGGIVALHSGWRL
CCCEEEECCCCCC
>Mature Secondary Structure
MDQTDQTTHFGFRDVPLGEKQTLVNDVFHSVASRYDLMNDLMSGGLHRVWKDIMINTLNP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
PKSDAPFALLDVAGGTGDISFRAAKKAGAGFHATVCDINGDMLEVGRQRALKQYLDDRVS
CCCCCCEEEEEECCCCCCEEEEEHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
FVEGNAESLAFPDRSFDAYTIAFGIRNVPQIDLALAEAYRVLKHGGRFLCLEFSTVEVPG
HHCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECEECCCC
LDKLYDLFSFNVIPQLGRAVTGDAESYRYLVESIRQFPRPNAFAEMISAAGFSRVSWQTL
HHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEC
SGGIVALHSGWRL
CCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA