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The map label for this gene is ubiB [H]

Identifier: 146337249

GI number: 146337249

Start: 85260

End: 86834

Strand: Direct

Name: ubiB [H]

Synonym: BRADO0076

Alternate gene names: 146337249

Gene position: 85260-86834 (Clockwise)

Preceding gene: 146337248

Following gene: 146337250

Centisome position: 1.14

GC content: 68.0

Gene sequence:

>1575_bases
GTGATCTCCGCACTGACACATATTACGCGGCTCGCCCGGGCCGCCCTGGTGTTCGCGCGCGAGGGCGTGTTCGGCGTCGT
CGATCCGAGTCTGGCGCCGCCGCCGGGTCAGATCGCGCTCAAGCTCGCGCGCCTGGTCGAGCGGCCCGGAGCGAAGTCCG
GACCGCGGCTGTCGCGTGCGCTGGAACGGATGGGTCCGGCCTATCTCAAGCTGGGCCAGTTCCTGGCCACGCGGCCCGAC
GTCGTCGGCGTCGTGATGGCGCGCGATCTCGAATCCCTGCAGGACCGGCTGCCGCCGTTTCCGCAGGCCGAGGCGGAAGC
CGTCATTGCCACCGCGCTCGAACGCCCGATCAGCCAGCTCTACACCTCGCTCGGCCCGCCCGTGGCGGCGGCCTCGATCG
CTCAGGTGCATCGCGGCGAGGTCGAGCGCGACGGCATCCGTCATGCCGTCGCGGTGAAGGTGCTCCGGCCGAACGTGGCG
GCACGCTTCCGCCGCGACCTCGCCGATTTCTTCTTCGTCGCCGAGAAGGCCGAGGCGCATTCCGCCGAGGCGCGGCGCCT
GCGGCTCGTCGAGGTCATCAACACAATGTCGCGTTCGGTCGCGATGGAGATGGATCTCCGGCTCGAAGCCGCCGCGCTGT
CGGAGATGGCGGAGAACATCAAGGACGATCCGGACTTCCGCGTGCCCGCGGTCGACTGGGACCGCACCGCCAACAACGTG
CTCACCATGGAGTGGATCGACGGCATCGCGCTGAACGACCACGCTCGCCTCGCGCAGGCGAATGTCGACCTGCCCGATGT
CGGCCGTAAGGTGATCCAGAGCTTCCTGCGCCACGCGCTGCGCGACGGCTTTTTCCATGCCGACATGCATCCGGGCAATC
TGTTCCTGGACAAGCAGGGCCGGCTGGTCGCGGTCGATTTCGGCATCATGGGCCGGCTCGGCATGAAGGAGCGGCGCTTC
CTCGCGGAAATCCTGCTCGGCTTCATCACCCGCGACTATCGCCGCGTCGCCGAGGTCCATTTCGAGGCCGGCTACGTGCC
GCCGCATCATTCGGTGGAGAATTTCGCCCAGGCCATCCGCGCCATCGGCGAGCCGATCCACAACCGCACGGCCGAAGAGA
TCTCGATGGCCAAGCTGTTGACCCTGCTGCTCGAGGTCACCGGCCTGTTCGACATGCGGACCCGGCCGGAGCTGATCCTC
TTGCAGAAGACCATGGTGGTGGTCGAGGGCGTCGCGCGCGGCTTCGATCCCAGGCTCGATATCTGGAAGGTCGCCGATCC
CGTGGTGCGCGAATGGATCGAGCGCAATCTCGGCTCGCTCGGCCGCATCGAGGGCGCCGTCACCGGCATAGGAGAGCTGG
CCCGTATCACATCCACATTGCCGGTCCTCGCCGCGCGTGCCGCTGCCGTGCTGGAGAACCTGGAGACGATGACCCGCGAC
GGCCTGCGCCTGTCGCCCGAAACCATCGCCGCCATGGGCCGCACCGAAGGCAAGAAGAGCCGCTGGCGCGCCATCGCGCT
GTGGGTCATCGCGCTGACCTTCATCGGCATCCTGTTCGCCGTGCTGCGGCTGTGA

Upstream 100 bases:

>100_bases
CCAATGCCTTCGCCGAGATGATCTCGGCGGCCGGATTCTCCCGCGTCTCCTGGCAGACCCTTTCCGGCGGCATCGTCGCG
CTTCATTCCGGCTGGCGTTT

Downstream 100 bases:

>100_bases
CGCCGACGAGCGACCATCGACAGGCATTAACGCCGCTACGCCCAAGGTGTCATCGCCCGGCTTGACCGGGCGATCCAGTA
CGCTGCGGCCGTCCTGATTG

Product: ubiquinone biosynthesis protein ubiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MISALTHITRLARAALVFAREGVFGVVDPSLAPPPGQIALKLARLVERPGAKSGPRLSRALERMGPAYLKLGQFLATRPD
VVGVVMARDLESLQDRLPPFPQAEAEAVIATALERPISQLYTSLGPPVAAASIAQVHRGEVERDGIRHAVAVKVLRPNVA
ARFRRDLADFFFVAEKAEAHSAEARRLRLVEVINTMSRSVAMEMDLRLEAAALSEMAENIKDDPDFRVPAVDWDRTANNV
LTMEWIDGIALNDHARLAQANVDLPDVGRKVIQSFLRHALRDGFFHADMHPGNLFLDKQGRLVAVDFGIMGRLGMKERRF
LAEILLGFITRDYRRVAEVHFEAGYVPPHHSVENFAQAIRAIGEPIHNRTAEEISMAKLLTLLLEVTGLFDMRTRPELIL
LQKTMVVVEGVARGFDPRLDIWKVADPVVREWIERNLGSLGRIEGAVTGIGELARITSTLPVLAARAAAVLENLETMTRD
GLRLSPETIAAMGRTEGKKSRWRAIALWVIALTFIGILFAVLRL

Sequences:

>Translated_524_residues
MISALTHITRLARAALVFAREGVFGVVDPSLAPPPGQIALKLARLVERPGAKSGPRLSRALERMGPAYLKLGQFLATRPD
VVGVVMARDLESLQDRLPPFPQAEAEAVIATALERPISQLYTSLGPPVAAASIAQVHRGEVERDGIRHAVAVKVLRPNVA
ARFRRDLADFFFVAEKAEAHSAEARRLRLVEVINTMSRSVAMEMDLRLEAAALSEMAENIKDDPDFRVPAVDWDRTANNV
LTMEWIDGIALNDHARLAQANVDLPDVGRKVIQSFLRHALRDGFFHADMHPGNLFLDKQGRLVAVDFGIMGRLGMKERRF
LAEILLGFITRDYRRVAEVHFEAGYVPPHHSVENFAQAIRAIGEPIHNRTAEEISMAKLLTLLLEVTGLFDMRTRPELIL
LQKTMVVVEGVARGFDPRLDIWKVADPVVREWIERNLGSLGRIEGAVTGIGELARITSTLPVLAARAAAVLENLETMTRD
GLRLSPETIAAMGRTEGKKSRWRAIALWVIALTFIGILFAVLRL
>Mature_524_residues
MISALTHITRLARAALVFAREGVFGVVDPSLAPPPGQIALKLARLVERPGAKSGPRLSRALERMGPAYLKLGQFLATRPD
VVGVVMARDLESLQDRLPPFPQAEAEAVIATALERPISQLYTSLGPPVAAASIAQVHRGEVERDGIRHAVAVKVLRPNVA
ARFRRDLADFFFVAEKAEAHSAEARRLRLVEVINTMSRSVAMEMDLRLEAAALSEMAENIKDDPDFRVPAVDWDRTANNV
LTMEWIDGIALNDHARLAQANVDLPDVGRKVIQSFLRHALRDGFFHADMHPGNLFLDKQGRLVAVDFGIMGRLGMKERRF
LAEILLGFITRDYRRVAEVHFEAGYVPPHHSVENFAQAIRAIGEPIHNRTAEEISMAKLLTLLLEVTGLFDMRTRPELIL
LQKTMVVVEGVARGFDPRLDIWKVADPVVREWIERNLGSLGRIEGAVTGIGELARITSTLPVLAARAAAVLENLETMTRD
GLRLSPETIAAMGRTEGKKSRWRAIALWVIALTFIGILFAVLRL

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=273, Percent_Identity=28.2051282051282, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI40254938, Length=295, Percent_Identity=25.7627118644068, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI217035081, Length=308, Percent_Identity=26.2987012987013, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI27363457, Length=322, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI217416386, Length=249, Percent_Identity=27.710843373494, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI34147522, Length=267, Percent_Identity=27.3408239700375, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI2367309, Length=391, Percent_Identity=36.3171355498721, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17559152, Length=285, Percent_Identity=25.9649122807018, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32565180, Length=368, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6325148, Length=436, Percent_Identity=22.9357798165138, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=321, Percent_Identity=24.9221183800623, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24662575, Length=312, Percent_Identity=28.8461538461538, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI22024280, Length=283, Percent_Identity=24.0282685512367, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18859849, Length=288, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57979; Mature: 57979

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISALTHITRLARAALVFAREGVFGVVDPSLAPPPGQIALKLARLVERPGAKSGPRLSRA
CCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHH
LERMGPAYLKLGQFLATRPDVVGVVMARDLESLQDRLPPFPQAEAEAVIATALERPISQL
HHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
YTSLGPPVAAASIAQVHRGEVERDGIRHAVAVKVLRPNVAARFRRDLADFFFVAEKAEAH
HHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SAEARRLRLVEVINTMSRSVAMEMDLRLEAAALSEMAENIKDDPDFRVPAVDWDRTANNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
LTMEWIDGIALNDHARLAQANVDLPDVGRKVIQSFLRHALRDGFFHADMHPGNLFLDKQG
EEEHHHCCEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCC
RLVAVDFGIMGRLGMKERRFLAEILLGFITRDYRRVAEVHFEAGYVPPHHSVENFAQAIR
CEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AIGEPIHNRTAEEISMAKLLTLLLEVTGLFDMRTRPELILLQKTMVVVEGVARGFDPRLD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCCCCCCC
IWKVADPVVREWIERNLGSLGRIEGAVTGIGELARITSTLPVLAARAAAVLENLETMTRD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLRLSPETIAAMGRTEGKKSRWRAIALWVIALTFIGILFAVLRL
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MISALTHITRLARAALVFAREGVFGVVDPSLAPPPGQIALKLARLVERPGAKSGPRLSRA
CCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHH
LERMGPAYLKLGQFLATRPDVVGVVMARDLESLQDRLPPFPQAEAEAVIATALERPISQL
HHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
YTSLGPPVAAASIAQVHRGEVERDGIRHAVAVKVLRPNVAARFRRDLADFFFVAEKAEAH
HHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SAEARRLRLVEVINTMSRSVAMEMDLRLEAAALSEMAENIKDDPDFRVPAVDWDRTANNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
LTMEWIDGIALNDHARLAQANVDLPDVGRKVIQSFLRHALRDGFFHADMHPGNLFLDKQG
EEEHHHCCEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCC
RLVAVDFGIMGRLGMKERRFLAEILLGFITRDYRRVAEVHFEAGYVPPHHSVENFAQAIR
CEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AIGEPIHNRTAEEISMAKLLTLLLEVTGLFDMRTRPELILLQKTMVVVEGVARGFDPRLD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCCCCCCC
IWKVADPVVREWIERNLGSLGRIEGAVTGIGELARITSTLPVLAARAAAVLENLETMTRD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLRLSPETIAAMGRTEGKKSRWRAIALWVIALTFIGILFAVLRL
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA