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The map label for this gene is zraR [H]

Identifier: 146302774

GI number: 146302774

Start: 6085538

End: 6086701

Strand: Reverse

Name: zraR [H]

Synonym: Fjoh_5047

Alternate gene names: 146302774

Gene position: 6086701-6085538 (Counterclockwise)

Preceding gene: 146302775

Following gene: 146302773

Centisome position: 99.83

GC content: 37.54

Gene sequence:

>1164_bases
ATGAGTAAAATACTAATTATCGAAGACGAAGCAGCGATTAGAAGAGTTTTGGTAAAAATTTTATCAGAAGAAAATGATTC
CTATCAGGTAGATGAAGCCGAAGATGGGGCTGCAGGACTTGAAAAAATAAAAAACAACGATTACGATTTGGTTTTGTGCG
ATATCAAAATGCCAAAAATGGACGGTGTTGAGGTTTTGGAAGAAGCAAAAAAGATAAAACCAGAAATTCCGATGGTCATG
ATATCGGGTCACGGCGATATGGAAACTGCGATTCAGACTATGCGTTTAGGAGCTTTTGATTATATTTCGAAACCGCCGGA
TTTGAATCGTTTATTGAATACTGTCCGCAATGCTTTAGATAAAAAACAATTAGTAGTTGAAAATAAAATTCTAAAGAAAA
AAGTCAGCAAAAATTACGAAATGATTGGTGAGAGCGAATCAATCAATCATATAAAAGTGATGATTGATAAAGTTGCTCCA
ACAGAAGCCAGAGTTTTAATCACGGGACCAAACGGAACCGGAAAAGAATTAGTAGCACATCAATTACACGAAAAAAGCGA
ACGTTCTGGTTTTCCTTTAATCGAAGTAAACTGTGCGGCAATTCCGAGTGAGTTGATTGAAAGTGAGTTATTCGGACACG
TAAAAGGTGCTTTTACATCTGCGGTGAAAGATCGTGCCGGAAAGTTTGAAGCTGCAGATAAAGGAACTATTTTCTTAGAT
GAAATTGGTGACATGAGTCTTTCGGCGCAGGCAAAAGTTTTGCGAGCGTTGCAGGAAAGCATGATTACAAGAGTTGGTGC
CGATAAAGACATTAAAGTTGATGTTCGTGTTGTTGCGGCAACTAATAAAGATTTAAAAACAGAAATTGCCGAAGGTCGTT
TCCGTGAAGATTTATACCACCGTCTGGCAGTAATTTTAATTAAAGTACCGCCTTTAAATGAAAGACGTGATGATATTCCA
GCTTTAATTTCGCATTTTGCAGAGAAAATTGCATCAGAACAAGGAAATGCGGTTAAAGGATTTTCGGCGCAGGCGATACA
ATTATTGCAGGAATATGATTGGACCGGAAATATTCGTGAACTGCGAAATGTTGTAGAAAGATTAATCATTTTAGGAGGCA
GTGAAATCTCCGAAAATGACGTGAAAATGTTCGCAAGCAAGTAA

Upstream 100 bases:

>100_bases
TAAAAGAGATATTACTAATAACAGGTTAAAAGGTAAATGACGACAAAGATTTAAAACTTTGCACCTCTGTGCCTTTGTAA
CTTTGAACCTTAGAAAAAAA

Downstream 100 bases:

>100_bases
AGTGCTTCGCGCTTTAGGCTATAAGCTTTGGGCTTTAAGCTTTTATAGAAACTAAATAATTTTTGCTTACAGCGTTCAGC
TTAAAGCTTAAAGCATAAAA

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSKILIIEDEAAIRRVLVKILSEENDSYQVDEAEDGAAGLEKIKNNDYDLVLCDIKMPKMDGVEVLEEAKKIKPEIPMVM
ISGHGDMETAIQTMRLGAFDYISKPPDLNRLLNTVRNALDKKQLVVENKILKKKVSKNYEMIGESESINHIKVMIDKVAP
TEARVLITGPNGTGKELVAHQLHEKSERSGFPLIEVNCAAIPSELIESELFGHVKGAFTSAVKDRAGKFEAADKGTIFLD
EIGDMSLSAQAKVLRALQESMITRVGADKDIKVDVRVVAATNKDLKTEIAEGRFREDLYHRLAVILIKVPPLNERRDDIP
ALISHFAEKIASEQGNAVKGFSAQAIQLLQEYDWTGNIRELRNVVERLIILGGSEISENDVKMFASK

Sequences:

>Translated_387_residues
MSKILIIEDEAAIRRVLVKILSEENDSYQVDEAEDGAAGLEKIKNNDYDLVLCDIKMPKMDGVEVLEEAKKIKPEIPMVM
ISGHGDMETAIQTMRLGAFDYISKPPDLNRLLNTVRNALDKKQLVVENKILKKKVSKNYEMIGESESINHIKVMIDKVAP
TEARVLITGPNGTGKELVAHQLHEKSERSGFPLIEVNCAAIPSELIESELFGHVKGAFTSAVKDRAGKFEAADKGTIFLD
EIGDMSLSAQAKVLRALQESMITRVGADKDIKVDVRVVAATNKDLKTEIAEGRFREDLYHRLAVILIKVPPLNERRDDIP
ALISHFAEKIASEQGNAVKGFSAQAIQLLQEYDWTGNIRELRNVVERLIILGGSEISENDVKMFASK
>Mature_386_residues
SKILIIEDEAAIRRVLVKILSEENDSYQVDEAEDGAAGLEKIKNNDYDLVLCDIKMPKMDGVEVLEEAKKIKPEIPMVMI
SGHGDMETAIQTMRLGAFDYISKPPDLNRLLNTVRNALDKKQLVVENKILKKKVSKNYEMIGESESINHIKVMIDKVAPT
EARVLITGPNGTGKELVAHQLHEKSERSGFPLIEVNCAAIPSELIESELFGHVKGAFTSAVKDRAGKFEAADKGTIFLDE
IGDMSLSAQAKVLRALQESMITRVGADKDIKVDVRVVAATNKDLKTEIAEGRFREDLYHRLAVILIKVPPLNERRDDIPA
LISHFAEKIASEQGNAVKGFSAQAIQLLQEYDWTGNIRELRNVVERLIILGGSEISENDVKMFASK

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=381, Percent_Identity=45.4068241469816, Blast_Score=343, Evalue=7e-96,
Organism=Escherichia coli, GI1788550, Length=379, Percent_Identity=41.9525065963061, Blast_Score=313, Evalue=9e-87,
Organism=Escherichia coli, GI1790299, Length=379, Percent_Identity=40.3693931398417, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI1788905, Length=352, Percent_Identity=38.9204545454545, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI87082152, Length=245, Percent_Identity=51.4285714285714, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87082117, Length=254, Percent_Identity=45.2755905511811, Blast_Score=241, Evalue=9e-65,
Organism=Escherichia coli, GI1789087, Length=255, Percent_Identity=46.2745098039216, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1789233, Length=231, Percent_Identity=45.8874458874459, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI87081872, Length=235, Percent_Identity=43.8297872340426, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1786524, Length=259, Percent_Identity=40.9266409266409, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1787583, Length=253, Percent_Identity=40.3162055335968, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789828, Length=237, Percent_Identity=36.7088607594937, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081858, Length=206, Percent_Identity=33.0097087378641, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786911, Length=186, Percent_Identity=30.6451612903226, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786784, Length=124, Percent_Identity=31.4516129032258, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788192, Length=110, Percent_Identity=34.5454545454545, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786599, Length=175, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787487, Length=110, Percent_Identity=36.3636363636364, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082012, Length=117, Percent_Identity=32.4786324786325, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=105, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 43001; Mature: 42870

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKILIIEDEAAIRRVLVKILSEENDSYQVDEAEDGAAGLEKIKNNDYDLVLCDIKMPKM
CCCEEEEECHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHCCCCCEEEEEEEECCCC
DGVEVLEEAKKIKPEIPMVMISGHGDMETAIQTMRLGAFDYISKPPDLNRLLNTVRNALD
CCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHH
KKQLVVENKILKKKVSKNYEMIGESESINHIKVMIDKVAPTEARVLITGPNGTGKELVAH
HHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHH
QLHEKSERSGFPLIEVNCAAIPSELIESELFGHVKGAFTSAVKDRAGKFEAADKGTIFLD
HHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
EIGDMSLSAQAKVLRALQESMITRVGADKDIKVDVRVVAATNKDLKTEIAEGRFREDLYH
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHHHHCCHHHHHHHH
RLAVILIKVPPLNERRDDIPALISHFAEKIASEQGNAVKGFSAQAIQLLQEYDWTGNIRE
HHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHH
LRNVVERLIILGGSEISENDVKMFASK
HHHHHHHHHHHCCCCCCCCHHHHHCCC
>Mature Secondary Structure 
SKILIIEDEAAIRRVLVKILSEENDSYQVDEAEDGAAGLEKIKNNDYDLVLCDIKMPKM
CCEEEEECHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHCCCCCEEEEEEEECCCC
DGVEVLEEAKKIKPEIPMVMISGHGDMETAIQTMRLGAFDYISKPPDLNRLLNTVRNALD
CCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHH
KKQLVVENKILKKKVSKNYEMIGESESINHIKVMIDKVAPTEARVLITGPNGTGKELVAH
HHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHH
QLHEKSERSGFPLIEVNCAAIPSELIESELFGHVKGAFTSAVKDRAGKFEAADKGTIFLD
HHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
EIGDMSLSAQAKVLRALQESMITRVGADKDIKVDVRVVAATNKDLKTEIAEGRFREDLYH
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHHHHCCHHHHHHHH
RLAVILIKVPPLNERRDDIPALISHFAEKIASEQGNAVKGFSAQAIQLLQEYDWTGNIRE
HHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHH
LRNVVERLIILGGSEISENDVKMFASK
HHHHHHHHHHHCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]