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The map label for this gene is zwf [H]

Identifier: 146302527

GI number: 146302527

Start: 5800866

End: 5802395

Strand: Direct

Name: zwf [H]

Synonym: Fjoh_4800

Alternate gene names: 146302527

Gene position: 5800866-5802395 (Clockwise)

Preceding gene: 146302526

Following gene: 146302528

Centisome position: 95.14

GC content: 36.73

Gene sequence:

>1530_bases
ATGACTAAAAATAAACTTAAAAATCCAACAATCATTGTTATTTTTGGAGGAACCGGAGACTTAGCAAAGAGAAAGCTCTT
TCCCGCATTTCAAAATCTGTATCTTGACGGACGTATGTCTGAAAAATTTCAGATTATTGCACTTGGAAGAGCAGAAAAAA
CAGATGAAGATTTCCGCAGTTATGTTTTAGAAAATTTAGAAAATTTTTCAAGAAAAAAAGGCAAGTCAGATCCTGAAACA
GAAAAATTTCTGTCTCACATAACATATCACAGCCTTGATATTGATAAAGAAGAATCTTATCTAAGTTTAAACGAAAAAAT
AAAAGGTTTTGATGAAGCGTTTGGAGAACGTGCCAATCGTCTTTTCTATCTTTCTATAACACCTTCTTTCATTTCTACTA
TTTCCAGCAATATCAAGAAAATTGGTCTTGCTGCAAACCCAAAGCAGGATCGTATTATTATTGAGAAACCATTTGGTTAT
GATAAAACTTCGGCGATTGAGCTGAACGAAATGCTTTCGCAGACTTTTAAAGAAGAACAGATATACAGAATCGATCATTA
TTTAGGTAAAGAAACAGTTCAGAACATTCTGGCTTTCCGATTTGGAAATTCAATGTTCGAACCTTTATGGAGCCGTAATT
TTATTGACTTTGTTCAGATTACAGTAGCAGAAGAAGTGGGTGTAGAAGAACGAGGCGGTTTTTATGAAGGCGTTGGTGCA
TTAAAAGATATGATTCAAAATCACCTGCTTCAAATATTATGTATGACGGCAATGGAAGCACCAGCATCATTAAGTGCCGA
TGATATTCGTAACCGTAAAGCCGATGTTTTAAAATCTATCCGACGCATTAAACCAGAAGAAGTAGATCATTATATAGTAA
GAGGTCAGTACGATGCCGGTACTATAAAAGGAAAAGCTGTTCCCGGATATCGTCAGGATAAAGGAATTGCTCCAGATTCT
AATACTGAAACGTATGTGGCAATGAAGATTTATCTGGATAACTGGAGATGGCAGGGAATTCCGTTTTACCTTCGTACAGG
AAAAAGAATGGAAGAAAAGCAATCATCCATTATAATTCAGTTTAAACCTGTTCCACATTCTTCATTTTCTTATGGAAAAG
AAGGTATGACACCAAACCGACTGATTATCAACATTCAGCCGGCAATGGATATTAAACTGCAGTTTATGACCAAAAAACCA
GGTCTATCACTTTCTTTAAGACCGGCAGAAATGATATTTGATTATTTTTCCTGCTCTACCATGTCGCCGGAAGCTTATGA
AACCTTAATTGCAGATGCATTATTGGGCGATCCTACCCTATTTATGCGCTGGGATCAGGTAGAAGAAGCATGGGATGCAA
TCGACACTATCCAGCAGGTATGGAAAACTACAGCTCCTGTAAATTTCCCAAATTACAAAGCCGGAAGCTGGGGACCAGAA
GAAGCTGATGAACTATTGGCACGCCAGGGACACAAATGGATTCCAAATACACAAACAAAAGAAGAACTTTTAGATGATAC
AGATATATAA

Upstream 100 bases:

>100_bases
CTTTGGGGCTCATACTTACGAACGCATCGACAAAGAAGGTGTTTTCCACACACAATGGGCTGAATAAGCAACTTAAAAAA
AAGCAACACAACTACACACA

Downstream 100 bases:

>100_bases
TACTACAGAAGAAATTAATACTGCAGCGGCAGACCTTTTTACAGCAGCAGCACAAGATGCAATTGCAAAAAGAGGAAAAT
TTACAGCAGTTCTTACTGGA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTKNKLKNPTIIVIFGGTGDLAKRKLFPAFQNLYLDGRMSEKFQIIALGRAEKTDEDFRSYVLENLENFSRKKGKSDPET
EKFLSHITYHSLDIDKEESYLSLNEKIKGFDEAFGERANRLFYLSITPSFISTISSNIKKIGLAANPKQDRIIIEKPFGY
DKTSAIELNEMLSQTFKEEQIYRIDHYLGKETVQNILAFRFGNSMFEPLWSRNFIDFVQITVAEEVGVEERGGFYEGVGA
LKDMIQNHLLQILCMTAMEAPASLSADDIRNRKADVLKSIRRIKPEEVDHYIVRGQYDAGTIKGKAVPGYRQDKGIAPDS
NTETYVAMKIYLDNWRWQGIPFYLRTGKRMEEKQSSIIIQFKPVPHSSFSYGKEGMTPNRLIINIQPAMDIKLQFMTKKP
GLSLSLRPAEMIFDYFSCSTMSPEAYETLIADALLGDPTLFMRWDQVEEAWDAIDTIQQVWKTTAPVNFPNYKAGSWGPE
EADELLARQGHKWIPNTQTKEELLDDTDI

Sequences:

>Translated_509_residues
MTKNKLKNPTIIVIFGGTGDLAKRKLFPAFQNLYLDGRMSEKFQIIALGRAEKTDEDFRSYVLENLENFSRKKGKSDPET
EKFLSHITYHSLDIDKEESYLSLNEKIKGFDEAFGERANRLFYLSITPSFISTISSNIKKIGLAANPKQDRIIIEKPFGY
DKTSAIELNEMLSQTFKEEQIYRIDHYLGKETVQNILAFRFGNSMFEPLWSRNFIDFVQITVAEEVGVEERGGFYEGVGA
LKDMIQNHLLQILCMTAMEAPASLSADDIRNRKADVLKSIRRIKPEEVDHYIVRGQYDAGTIKGKAVPGYRQDKGIAPDS
NTETYVAMKIYLDNWRWQGIPFYLRTGKRMEEKQSSIIIQFKPVPHSSFSYGKEGMTPNRLIINIQPAMDIKLQFMTKKP
GLSLSLRPAEMIFDYFSCSTMSPEAYETLIADALLGDPTLFMRWDQVEEAWDAIDTIQQVWKTTAPVNFPNYKAGSWGPE
EADELLARQGHKWIPNTQTKEELLDDTDI
>Mature_508_residues
TKNKLKNPTIIVIFGGTGDLAKRKLFPAFQNLYLDGRMSEKFQIIALGRAEKTDEDFRSYVLENLENFSRKKGKSDPETE
KFLSHITYHSLDIDKEESYLSLNEKIKGFDEAFGERANRLFYLSITPSFISTISSNIKKIGLAANPKQDRIIIEKPFGYD
KTSAIELNEMLSQTFKEEQIYRIDHYLGKETVQNILAFRFGNSMFEPLWSRNFIDFVQITVAEEVGVEERGGFYEGVGAL
KDMIQNHLLQILCMTAMEAPASLSADDIRNRKADVLKSIRRIKPEEVDHYIVRGQYDAGTIKGKAVPGYRQDKGIAPDSN
TETYVAMKIYLDNWRWQGIPFYLRTGKRMEEKQSSIIIQFKPVPHSSFSYGKEGMTPNRLIINIQPAMDIKLQFMTKKPG
LSLSLRPAEMIFDYFSCSTMSPEAYETLIADALLGDPTLFMRWDQVEEAWDAIDTIQQVWKTTAPVNFPNYKAGSWGPEE
ADELLARQGHKWIPNTQTKEELLDDTDI

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=493, Percent_Identity=36.9168356997972, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI109389365, Length=493, Percent_Identity=36.9168356997972, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI52145310, Length=501, Percent_Identity=29.1417165668663, Blast_Score=189, Evalue=6e-48,
Organism=Escherichia coli, GI1788158, Length=488, Percent_Identity=39.9590163934426, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17538218, Length=503, Percent_Identity=35.5864811133201, Blast_Score=326, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6324088, Length=497, Percent_Identity=36.6197183098592, Blast_Score=306, Evalue=7e-84,
Organism=Drosophila melanogaster, GI24643350, Length=495, Percent_Identity=36.3636363636364, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24643352, Length=495, Percent_Identity=36.3636363636364, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI221513548, Length=485, Percent_Identity=28.659793814433, Blast_Score=215, Evalue=6e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58334; Mature: 58203

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNKLKNPTIIVIFGGTGDLAKRKLFPAFQNLYLDGRMSEKFQIIALGRAEKTDEDFRS
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCCCCHHHHHH
YVLENLENFSRKKGKSDPETEKFLSHITYHSLDIDKEESYLSLNEKIKGFDEAFGERANR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHCCE
LFYLSITPSFISTISSNIKKIGLAANPKQDRIIIEKPFGYDKTSAIELNEMLSQTFKEEQ
EEEEEECHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
IYRIDHYLGKETVQNILAFRFGNSMFEPLWSRNFIDFVQITVAEEVGVEERGGFYEGVGA
HHHHHHHHCHHHHHHHHHHHHCCHHHHHHHCCCCHHHHEEEHHHHCCCHHCCCHHHHHHH
LKDMIQNHLLQILCMTAMEAPASLSADDIRNRKADVLKSIRRIKPEEVDHYIVRGQYDAG
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCC
TIKGKAVPGYRQDKGIAPDSNTETYVAMKIYLDNWRWQGIPFYLRTGKRMEEKQSSIIIQ
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECEEECCCCEEECCCCHHHHHCCCEEEE
FKPVPHSSFSYGKEGMTPNRLIINIQPAMDIKLQFMTKKPGLSLSLRPAEMIFDYFSCST
EECCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEECCHHHHHHHHHHCCC
MSPEAYETLIADALLGDPTLFMRWDQVEEAWDAIDTIQQVWKTTAPVNFPNYKAGSWGPE
CCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
EADELLARQGHKWIPNTQTKEELLDDTDI
HHHHHHHHCCCCCCCCCCCHHHHHCCCCC
>Mature Secondary Structure 
TKNKLKNPTIIVIFGGTGDLAKRKLFPAFQNLYLDGRMSEKFQIIALGRAEKTDEDFRS
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCCCCHHHHHH
YVLENLENFSRKKGKSDPETEKFLSHITYHSLDIDKEESYLSLNEKIKGFDEAFGERANR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHCCE
LFYLSITPSFISTISSNIKKIGLAANPKQDRIIIEKPFGYDKTSAIELNEMLSQTFKEEQ
EEEEEECHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
IYRIDHYLGKETVQNILAFRFGNSMFEPLWSRNFIDFVQITVAEEVGVEERGGFYEGVGA
HHHHHHHHCHHHHHHHHHHHHCCHHHHHHHCCCCHHHHEEEHHHHCCCHHCCCHHHHHHH
LKDMIQNHLLQILCMTAMEAPASLSADDIRNRKADVLKSIRRIKPEEVDHYIVRGQYDAG
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCC
TIKGKAVPGYRQDKGIAPDSNTETYVAMKIYLDNWRWQGIPFYLRTGKRMEEKQSSIIIQ
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECEEECCCCEEECCCCHHHHHCCCEEEE
FKPVPHSSFSYGKEGMTPNRLIINIQPAMDIKLQFMTKKPGLSLSLRPAEMIFDYFSCST
EECCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEECCHHHHHHHHHHCCC
MSPEAYETLIADALLGDPTLFMRWDQVEEAWDAIDTIQQVWKTTAPVNFPNYKAGSWGPE
CCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
EADELLARQGHKWIPNTQTKEELLDDTDI
HHHHHHHHCCCCCCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]