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The map label for this gene is fumC [H]

Identifier: 146302513

GI number: 146302513

Start: 5783093

End: 5784478

Strand: Direct

Name: fumC [H]

Synonym: Fjoh_4786

Alternate gene names: 146302513

Gene position: 5783093-5784478 (Clockwise)

Preceding gene: 146302512

Following gene: 146302515

Centisome position: 94.85

GC content: 39.47

Gene sequence:

>1386_bases
ATGAAATACAGAATAGAAAAAGACACCATGGGCGAAGTTCAGGTCCCAGCCGATAAATATTGGGGTGCGCAGACAGAACG
TTCTCGAAATAATTTTAAAATTGGAAATTCAGGATCGATGCCTCAGGAAATCATCGAAGGTTTTGCATATCTAAAAAAAG
CGGCAGCTTATGCCAATTATGATCTAGGTGTACTGCCAATAGAAAAAAGAGATGCTATTGCTGCTGTATGCGACGAAATT
CTGGAAGGAAAGCTGGACGATCAATTCCCTCTTGTAATCTGGCAGACAGGTTCAGGAACGCAGAGTAATATGAATGTTAA
TGAAGTAATTGCTAACCGCGCTCAGGTTCTTAAAGGTTTTGAAATTGGTGAAGGCGAGCAATTCATCAAAGCAAATGATG
ATGTCAATAAATCACAGTCATCAAATGACACTTTCCCAACCGGAATGCATATTGCTGCTTACAAAATGGTAGTTGAAACG
ACAATTCCTGGAGTTGAAAAACTGCACGCTACTTTAGTTAAAAAAGCAGCTGAATTTAAAGATGTTGTAAAAATTGGTCG
TACACACTTAATGGACGCAACGCCTTTAACTTTAGGACAGGAAATTTCAGGTTATGCAGCTCAATTAGCATTTGGATTAA
AAGCTTTAAAAAATACTTTAGCACATTTGTCTGAAATCGCTCTTGGAGGAACTGCTGTAGGAACCGGACTAAATACTCCA
AAAGGTTACGATGTAAAAGTTGCCGAATATATTGCAAAGTTTACAAATCATCCTTTTGTAACAGCTGAGAATAAATTTGA
AGCACTTGCAGCACACGATGCAATTGTAGAAACACACGGCGCTTTAAAACAACTGGCAGTTTCGTTAAATAAAATTGCAA
ATGATGTTAGAATGCTGGCATCTGGCCCGCGTTCCGGTATTGGCGAAATTCACATTCCCGAAAACGAACCGGGATCTTCT
ATTATGCCTGGAAAAGTAAATCCAACGCAATGTGAAGCTTTGACAATGGTTTGTGCTCAGGTTATTGGAAACGATATGGC
AATTGCAGTTGGTGGTATGCAGGGACATTATGAACTAAATGTTTTTAAACCTGTTATGGCAGCCAACTTTTTACAATCTG
CACGATTATTGGGGGATGCCTGCGTTTCATTTGATGAACACTGCGCTCAGGGAATCGAACCAAATCACAAACGAATCAAA
GAACTGGTAGACAATTCACTAATGCTGGTTACGGCTTTGAATACTAAAATTGGCTATTATAAAGCTGCCGAAATCGCTCA
AACCGCTCACAAAAACGGAACAACTCTTAAAGAAGAAGCGGTTCGTTTAGGCTATGTAACACCAGAAGATTTTGAAGCCT
GGGTTAAACCGGAAGATATGGTTTAA

Upstream 100 bases:

>100_bases
AGGGCTAGACCTGCTTTTTTCAAAAGAACTTCATTTTTTCAACTCAGAAAATCAAAAATTTAACTGAATACATTTTTACA
AACAACATATTTACAACAAA

Downstream 100 bases:

>100_bases
TTTAATTGTGAATTGTTAATGGTGAATTGTTAATTATCTTATATGATCATTAAAAAAACGAGCTTTCTAAAATTTAGAAA
GCTCGTTTTCAATTTATAAT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MKYRIEKDTMGEVQVPADKYWGAQTERSRNNFKIGNSGSMPQEIIEGFAYLKKAAAYANYDLGVLPIEKRDAIAAVCDEI
LEGKLDDQFPLVIWQTGSGTQSNMNVNEVIANRAQVLKGFEIGEGEQFIKANDDVNKSQSSNDTFPTGMHIAAYKMVVET
TIPGVEKLHATLVKKAAEFKDVVKIGRTHLMDATPLTLGQEISGYAAQLAFGLKALKNTLAHLSEIALGGTAVGTGLNTP
KGYDVKVAEYIAKFTNHPFVTAENKFEALAAHDAIVETHGALKQLAVSLNKIANDVRMLASGPRSGIGEIHIPENEPGSS
IMPGKVNPTQCEALTMVCAQVIGNDMAIAVGGMQGHYELNVFKPVMAANFLQSARLLGDACVSFDEHCAQGIEPNHKRIK
ELVDNSLMLVTALNTKIGYYKAAEIAQTAHKNGTTLKEEAVRLGYVTPEDFEAWVKPEDMV

Sequences:

>Translated_461_residues
MKYRIEKDTMGEVQVPADKYWGAQTERSRNNFKIGNSGSMPQEIIEGFAYLKKAAAYANYDLGVLPIEKRDAIAAVCDEI
LEGKLDDQFPLVIWQTGSGTQSNMNVNEVIANRAQVLKGFEIGEGEQFIKANDDVNKSQSSNDTFPTGMHIAAYKMVVET
TIPGVEKLHATLVKKAAEFKDVVKIGRTHLMDATPLTLGQEISGYAAQLAFGLKALKNTLAHLSEIALGGTAVGTGLNTP
KGYDVKVAEYIAKFTNHPFVTAENKFEALAAHDAIVETHGALKQLAVSLNKIANDVRMLASGPRSGIGEIHIPENEPGSS
IMPGKVNPTQCEALTMVCAQVIGNDMAIAVGGMQGHYELNVFKPVMAANFLQSARLLGDACVSFDEHCAQGIEPNHKRIK
ELVDNSLMLVTALNTKIGYYKAAEIAQTAHKNGTTLKEEAVRLGYVTPEDFEAWVKPEDMV
>Mature_461_residues
MKYRIEKDTMGEVQVPADKYWGAQTERSRNNFKIGNSGSMPQEIIEGFAYLKKAAAYANYDLGVLPIEKRDAIAAVCDEI
LEGKLDDQFPLVIWQTGSGTQSNMNVNEVIANRAQVLKGFEIGEGEQFIKANDDVNKSQSSNDTFPTGMHIAAYKMVVET
TIPGVEKLHATLVKKAAEFKDVVKIGRTHLMDATPLTLGQEISGYAAQLAFGLKALKNTLAHLSEIALGGTAVGTGLNTP
KGYDVKVAEYIAKFTNHPFVTAENKFEALAAHDAIVETHGALKQLAVSLNKIANDVRMLASGPRSGIGEIHIPENEPGSS
IMPGKVNPTQCEALTMVCAQVIGNDMAIAVGGMQGHYELNVFKPVMAANFLQSARLLGDACVSFDEHCAQGIEPNHKRIK
ELVDNSLMLVTALNTKIGYYKAAEIAQTAHKNGTTLKEEAVRLGYVTPEDFEAWVKPEDMV

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=61.5217391304348, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI266458395, Length=79, Percent_Identity=50.6329113924051, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=62.4454148471616, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=41.2147505422993, Blast_Score=345, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=60.3036876355748, Blast_Score=557, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=62.037037037037, Blast_Score=415, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=58.695652173913, Blast_Score=525, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=58.6580086580087, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=58.6580086580087, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=58.2251082251082, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24662684, Length=464, Percent_Identity=55.8189655172414, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=49.4577006507592, Blast_Score=453, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50013; Mature: 50013

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYRIEKDTMGEVQVPADKYWGAQTERSRNNFKIGNSGSMPQEIIEGFAYLKKAAAYANY
CCEECCCCCCCCEECCHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCC
DLGVLPIEKRDAIAAVCDEILEGKLDDQFPLVIWQTGSGTQSNMNVNEVIANRAQVLKGF
CCCEEECCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EIGEGEQFIKANDDVNKSQSSNDTFPTGMHIAAYKMVVETTIPGVEKLHATLVKKAAEFK
CCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DVVKIGRTHLMDATPLTLGQEISGYAAQLAFGLKALKNTLAHLSEIALGGTAVGTGLNTP
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
KGYDVKVAEYIAKFTNHPFVTAENKFEALAAHDAIVETHGALKQLAVSLNKIANDVRMLA
CCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRSGIGEIHIPENEPGSSIMPGKVNPTQCEALTMVCAQVIGNDMAIAVGGMQGHYELN
CCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFKPVMAANFLQSARLLGDACVSFDEHCAQGIEPNHKRIKELVDNSLMLVTALNTKIGYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCCCHH
KAAEIAQTAHKNGTTLKEEAVRLGYVTPEDFEAWVKPEDMV
HHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MKYRIEKDTMGEVQVPADKYWGAQTERSRNNFKIGNSGSMPQEIIEGFAYLKKAAAYANY
CCEECCCCCCCCEECCHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCC
DLGVLPIEKRDAIAAVCDEILEGKLDDQFPLVIWQTGSGTQSNMNVNEVIANRAQVLKGF
CCCEEECCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EIGEGEQFIKANDDVNKSQSSNDTFPTGMHIAAYKMVVETTIPGVEKLHATLVKKAAEFK
CCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DVVKIGRTHLMDATPLTLGQEISGYAAQLAFGLKALKNTLAHLSEIALGGTAVGTGLNTP
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
KGYDVKVAEYIAKFTNHPFVTAENKFEALAAHDAIVETHGALKQLAVSLNKIANDVRMLA
CCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRSGIGEIHIPENEPGSSIMPGKVNPTQCEALTMVCAQVIGNDMAIAVGGMQGHYELN
CCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFKPVMAANFLQSARLLGDACVSFDEHCAQGIEPNHKRIKELVDNSLMLVTALNTKIGYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCCCHH
KAAEIAQTAHKNGTTLKEEAVRLGYVTPEDFEAWVKPEDMV
HHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]