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The map label for this gene is moeA [H]

Identifier: 146302371

GI number: 146302371

Start: 5612438

End: 5613610

Strand: Reverse

Name: moeA [H]

Synonym: Fjoh_4644

Alternate gene names: 146302371

Gene position: 5613610-5612438 (Counterclockwise)

Preceding gene: 146302383

Following gene: 146302370

Centisome position: 92.07

GC content: 33.5

Gene sequence:

>1173_bases
ATGATAGAAGTTAGTAAAGCCATAGAATTAGTTGAAGCGAATAGCACTAAAATGTCCACAAAGCAGATTTCAATACATAA
AGCTTTAGGATATGTTCTGGCAGAGAAAGTAATTTCGTCAATTAATATGCCTCCATTTCGCCAGTCGGCTATGGATGGAT
ACGCTTTTACCCATAGTATTCGACACCAATATGATATAATTGGAACATCTCAGGCAGGAGATCACAATAATATAAAAATA
AAAAATACAGAAGCAATCCGAATTTTTACCGGTGCTTTTGTTCCGGATGATGCAGATACAGTTGTAATGCAGGAAAACGT
AATGGCAAACAAAAATTCAATTTTGATTGCTGCAATGCCGGAAAAATTTTCAAACGTTCGCCCAAAAGGAGAACAAATTG
CAAAAAATGATGTTGTTTTTGAAGCAGGGACACTGCTTACTCCCGCTGCAATAGGTTTTTTGGCTGGATTAGGAATTACA
GAAGTTGAGGTTTATAAAAAACCTAAAGTCGCCATTTTGGTAACAGGAAACGAATTAGTACAACCGGGAAAGAAACTAAA
AAAAGGAAAGATTTTCGAAAGTAATTCAATTATGCTCGAAGCTGCACTTCAGACTATCGGAATTCAAAAAACAAAAGTTT
ATCACGTAAAGGATAATCTAAAAGCGACAAGAAAAGCCTTAAAAAGCATTTTAAAAAAATACGATATTGTTCTTATTTCC
GGCGGTATTTCTGTTGGAGATTATGATTTTGTAAAAGAAGCTTTATTACAAAACGAAGTAAAAGAACTTTTTTATAAAAT
CAATCAAAAACCGGGAAAACCAATGTTCTTTGGTGCAAAAGATGAAACTTTGGTTTTTGCCCTTCCGGGAAATCCGGCTT
CATCGCTGACTAATTTTTACATTTATGTACTGCCGGCTATAAAAAACAGAATAGGATTTTCTGAAATTCATAAAACAAAA
TTAGTTCGAAAGTTAAATTCAGATATTAAAAATGATACTGGGAAAACATTATTTCTAAAAGCAAAATACGACGAAACTAA
TGTAACTGTCTTAGGCAGTCAAAGCTCAGCTATGCTGAATACATTTGCAGCAGCCAATAGTTTATTAATAGTTCCTCAAA
ATATAGAAGAATACAAAAAAGGACAATTAGTGACTTTACTGCCAATTGATTAG

Upstream 100 bases:

>100_bases
TATACAGCATAAAATAAAATTTAATTTTTTTAACCATCCTACGAATAAATACTTATATTTGCGATAAGTATTTATACTTA
GTTTTTTTCACTCGAATAAA

Downstream 100 bases:

>100_bases
ATTTTAAGAAAATAGAGTCAGGAATAAAGAGAATAGATTTTTGAAAAAGATGATGCAAAACGGTATATAAATAAAAACAT
AAAGCAAGAAAAACGATTAA

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MIEVSKAIELVEANSTKMSTKQISIHKALGYVLAEKVISSINMPPFRQSAMDGYAFTHSIRHQYDIIGTSQAGDHNNIKI
KNTEAIRIFTGAFVPDDADTVVMQENVMANKNSILIAAMPEKFSNVRPKGEQIAKNDVVFEAGTLLTPAAIGFLAGLGIT
EVEVYKKPKVAILVTGNELVQPGKKLKKGKIFESNSIMLEAALQTIGIQKTKVYHVKDNLKATRKALKSILKKYDIVLIS
GGISVGDYDFVKEALLQNEVKELFYKINQKPGKPMFFGAKDETLVFALPGNPASSLTNFYIYVLPAIKNRIGFSEIHKTK
LVRKLNSDIKNDTGKTLFLKAKYDETNVTVLGSQSSAMLNTFAAANSLLIVPQNIEEYKKGQLVTLLPID

Sequences:

>Translated_390_residues
MIEVSKAIELVEANSTKMSTKQISIHKALGYVLAEKVISSINMPPFRQSAMDGYAFTHSIRHQYDIIGTSQAGDHNNIKI
KNTEAIRIFTGAFVPDDADTVVMQENVMANKNSILIAAMPEKFSNVRPKGEQIAKNDVVFEAGTLLTPAAIGFLAGLGIT
EVEVYKKPKVAILVTGNELVQPGKKLKKGKIFESNSIMLEAALQTIGIQKTKVYHVKDNLKATRKALKSILKKYDIVLIS
GGISVGDYDFVKEALLQNEVKELFYKINQKPGKPMFFGAKDETLVFALPGNPASSLTNFYIYVLPAIKNRIGFSEIHKTK
LVRKLNSDIKNDTGKTLFLKAKYDETNVTVLGSQSSAMLNTFAAANSLLIVPQNIEEYKKGQLVTLLPID
>Mature_390_residues
MIEVSKAIELVEANSTKMSTKQISIHKALGYVLAEKVISSINMPPFRQSAMDGYAFTHSIRHQYDIIGTSQAGDHNNIKI
KNTEAIRIFTGAFVPDDADTVVMQENVMANKNSILIAAMPEKFSNVRPKGEQIAKNDVVFEAGTLLTPAAIGFLAGLGIT
EVEVYKKPKVAILVTGNELVQPGKKLKKGKIFESNSIMLEAALQTIGIQKTKVYHVKDNLKATRKALKSILKKYDIVLIS
GGISVGDYDFVKEALLQNEVKELFYKINQKPGKPMFFGAKDETLVFALPGNPASSLTNFYIYVLPAIKNRIGFSEIHKTK
LVRKLNSDIKNDTGKTLFLKAKYDETNVTVLGSQSSAMLNTFAAANSLLIVPQNIEEYKKGQLVTLLPID

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=397, Percent_Identity=33.2493702770781, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI10880983, Length=397, Percent_Identity=33.2493702770781, Blast_Score=194, Evalue=9e-50,
Organism=Escherichia coli, GI1787049, Length=386, Percent_Identity=32.3834196891192, Blast_Score=191, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI25147659, Length=318, Percent_Identity=31.4465408805031, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17562606, Length=368, Percent_Identity=26.3586956521739, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17136978, Length=353, Percent_Identity=33.7110481586402, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24638841, Length=353, Percent_Identity=33.7110481586402, Blast_Score=178, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42929; Mature: 42929

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEVSKAIELVEANSTKMSTKQISIHKALGYVLAEKVISSINMPPFRQSAMDGYAFTHSI
CCCHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHH
RHQYDIIGTSQAGDHNNIKIKNTEAIRIFTGAFVPDDADTVVMQENVMANKNSILIAAMP
HHEEEEEECCCCCCCCCEEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCCEEEEECC
EKFSNVRPKGEQIAKNDVVFEAGTLLTPAAIGFLAGLGITEVEVYKKPKVAILVTGNELV
HHHCCCCCCCHHHHCCCEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCHHH
QPGKKLKKGKIFESNSIMLEAALQTIGIQKTKVYHVKDNLKATRKALKSILKKYDIVLIS
CCCHHHCCCEEECCCCEEHEEHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHCCEEEEE
GGISVGDYDFVKEALLQNEVKELFYKINQKPGKPMFFGAKDETLVFALPGNPASSLTNFY
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEECCCCHHHHHEEE
IYVLPAIKNRIGFSEIHKTKLVRKLNSDIKNDTGKTLFLKAKYDETNVTVLGSQSSAMLN
EEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEECCCHHHHH
TFAAANSLLIVPQNIEEYKKGQLVTLLPID
HHHHCCEEEEEECCHHHHCCCCEEEEEECC
>Mature Secondary Structure
MIEVSKAIELVEANSTKMSTKQISIHKALGYVLAEKVISSINMPPFRQSAMDGYAFTHSI
CCCHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHH
RHQYDIIGTSQAGDHNNIKIKNTEAIRIFTGAFVPDDADTVVMQENVMANKNSILIAAMP
HHEEEEEECCCCCCCCCEEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCCEEEEECC
EKFSNVRPKGEQIAKNDVVFEAGTLLTPAAIGFLAGLGITEVEVYKKPKVAILVTGNELV
HHHCCCCCCCHHHHCCCEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCHHH
QPGKKLKKGKIFESNSIMLEAALQTIGIQKTKVYHVKDNLKATRKALKSILKKYDIVLIS
CCCHHHCCCEEECCCCEEHEEHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHCCEEEEE
GGISVGDYDFVKEALLQNEVKELFYKINQKPGKPMFFGAKDETLVFALPGNPASSLTNFY
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEECCCCHHHHHEEE
IYVLPAIKNRIGFSEIHKTKLVRKLNSDIKNDTGKTLFLKAKYDETNVTVLGSQSSAMLN
EEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEECCCHHHHH
TFAAANSLLIVPQNIEEYKKGQLVTLLPID
HHHHCCEEEEEECCHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]