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The map label for this gene is moaC [H]

Identifier: 146302364

GI number: 146302364

Start: 5607088

End: 5608002

Strand: Reverse

Name: moaC [H]

Synonym: Fjoh_4637

Alternate gene names: 146302364

Gene position: 5608002-5607088 (Counterclockwise)

Preceding gene: 146302365

Following gene: 146302363

Centisome position: 91.98

GC content: 37.05

Gene sequence:

>915_bases
ATGGTAGATATTACGCATAAAATAAGCACATTAAGAAAAGCAGCGGCAACGGCAATTGTAAAAGTCAGCAAACAGGAAAC
AATTGATGCTGTTGTAAATAATTTAGTGCCCAAAGGCAATGTGTTGGAAATGGCAAAAACAGCAGGATTGTTTGCTGTAA
AAAATACACATTTGTCTATTCCGGACTGCCATCCAATTCCAATTGAATTTACATCGGTTGAATATAAAATTGAAGGTTTA
GAAATCCAGATTATTTTTAATGTAAAAACGGTTTATAAAACCGGAGTTGAGGTCGAGGCGATGCATGGTGCATCAATCGT
AGCGCTTACCATGTACGATATGCTAAAACCTATTGACAAAGAAATCGAAATTTCGACCATTAAATTGATTAATAAAGAAG
GCGGAAAATCGTCTTTCAAAAATAAATTTCCTAATGTTATAAAAGCTGCAGTTTTTGTTTGTTCTGATTCGATTTTTGCA
GGCGATAAAGAAGATCGTTCCGGAAAAACAATTGTAGAAAAATTAGATTCATACGGAGTTGAAACTTCACATTATGAAAT
TATTCCAGACGAATTGGAAATCATTCAGGAAAAAACTAAGGCTTTCGCCAAAGAACATCAGCTGGTAATTTTTACAGGCG
GAACTGGTTTATCACCAAGAGATGTAACGCCGGAAGCTTTATCGCCAATTTTAGAAAGCAGAATTCCGGGAATTGAAGAA
GCTATTCGCAGTTACGGACAACAGAGAATGCCGTATGCAATGCTTTCCAGAAGCGTTGCAGGAACGTTGGGTAAAAGTCT
GGTTTTGGCTTTGCCAGGCTCAACAAACGGAGTAAGAGAATCGATGGACGCTGTGTTTCCACATGTAATGCACGTTTTTC
ATATTTTAAAAGGTAAAAACCATGACAGCCTCTAA

Upstream 100 bases:

>100_bases
AAGCGACAGAAGCCATTGTAAACTGGATTAAAACCGATGTTCCTATTTTTGGGAAAGAAATGTTTGAAAACGATACATTC
ACCTGGAAACAAAATAGTTA

Downstream 100 bases:

>100_bases
CACAATTTTGACGGACGGTTTTGGGCGCAGACACAATTATCTGCGCATTTCCCTGCTGGAAAAATGCAATCTGCGTTGTA
CGTACTGCATGCCGGCTGAT

Product: bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA

Products: NA

Alternate protein names: Molybdenum cofactor biosynthesis protein C; Molybdenum cofactor biosynthesis protein B [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MVDITHKISTLRKAAATAIVKVSKQETIDAVVNNLVPKGNVLEMAKTAGLFAVKNTHLSIPDCHPIPIEFTSVEYKIEGL
EIQIIFNVKTVYKTGVEVEAMHGASIVALTMYDMLKPIDKEIEISTIKLINKEGGKSSFKNKFPNVIKAAVFVCSDSIFA
GDKEDRSGKTIVEKLDSYGVETSHYEIIPDELEIIQEKTKAFAKEHQLVIFTGGTGLSPRDVTPEALSPILESRIPGIEE
AIRSYGQQRMPYAMLSRSVAGTLGKSLVLALPGSTNGVRESMDAVFPHVMHVFHILKGKNHDSL

Sequences:

>Translated_304_residues
MVDITHKISTLRKAAATAIVKVSKQETIDAVVNNLVPKGNVLEMAKTAGLFAVKNTHLSIPDCHPIPIEFTSVEYKIEGL
EIQIIFNVKTVYKTGVEVEAMHGASIVALTMYDMLKPIDKEIEISTIKLINKEGGKSSFKNKFPNVIKAAVFVCSDSIFA
GDKEDRSGKTIVEKLDSYGVETSHYEIIPDELEIIQEKTKAFAKEHQLVIFTGGTGLSPRDVTPEALSPILESRIPGIEE
AIRSYGQQRMPYAMLSRSVAGTLGKSLVLALPGSTNGVRESMDAVFPHVMHVFHILKGKNHDSL
>Mature_304_residues
MVDITHKISTLRKAAATAIVKVSKQETIDAVVNNLVPKGNVLEMAKTAGLFAVKNTHLSIPDCHPIPIEFTSVEYKIEGL
EIQIIFNVKTVYKTGVEVEAMHGASIVALTMYDMLKPIDKEIEISTIKLINKEGGKSSFKNKFPNVIKAAVFVCSDSIFA
GDKEDRSGKTIVEKLDSYGVETSHYEIIPDELEIIQEKTKAFAKEHQLVIFTGGTGLSPRDVTPEALSPILESRIPGIEE
AIRSYGQQRMPYAMLSRSVAGTLGKSLVLALPGSTNGVRESMDAVFPHVMHVFHILKGKNHDSL

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=156, Percent_Identity=39.7435897435897, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI10880983, Length=156, Percent_Identity=39.7435897435897, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI1787001, Length=143, Percent_Identity=38.4615384615385, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1786190, Length=173, Percent_Identity=29.4797687861272, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787000, Length=128, Percent_Identity=30.46875, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17564954, Length=163, Percent_Identity=32.5153374233129, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32566331, Length=140, Percent_Identity=33.5714285714286, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28574492, Length=147, Percent_Identity=37.4149659863946, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574490, Length=147, Percent_Identity=37.4149659863946, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136978, Length=152, Percent_Identity=33.5526315789474, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24638841, Length=152, Percent_Identity=33.5526315789474, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR020817
- InterPro:   IPR012247
- InterPro:   IPR001453
- InterPro:   IPR002820 [H]

Pfam domain/function: PF01967 MoaC; PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 33302; Mature: 33302

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDITHKISTLRKAAATAIVKVSKQETIDAVVNNLVPKGNVLEMAKTAGLFAVKNTHLSI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEEECCEECC
PDCHPIPIEFTSVEYKIEGLEIQIIFNVKTVYKTGVEVEAMHGASIVALTMYDMLKPIDK
CCCCCCCEEEEEEEEEEECEEEEEEEEEEEHHHCCCEEEEECCCHHHHHHHHHHHCCCCC
EIEISTIKLINKEGGKSSFKNKFPNVIKAAVFVCSDSIFAGDKEDRSGKTIVEKLDSYGV
CCEEEEEEEEECCCCCCHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCC
ETSHYEIIPDELEIIQEKTKAFAKEHQLVIFTGGTGLSPRDVTPEALSPILESRIPGIEE
CCCCEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHH
AIRSYGQQRMPYAMLSRSVAGTLGKSLVLALPGSTNGVRESMDAVFPHVMHVFHILKGKN
HHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
HDSL
CCCC
>Mature Secondary Structure
MVDITHKISTLRKAAATAIVKVSKQETIDAVVNNLVPKGNVLEMAKTAGLFAVKNTHLSI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEEECCEECC
PDCHPIPIEFTSVEYKIEGLEIQIIFNVKTVYKTGVEVEAMHGASIVALTMYDMLKPIDK
CCCCCCCEEEEEEEEEEECEEEEEEEEEEEHHHCCCEEEEECCCHHHHHHHHHHHCCCCC
EIEISTIKLINKEGGKSSFKNKFPNVIKAAVFVCSDSIFAGDKEDRSGKTIVEKLDSYGV
CCEEEEEEEEECCCCCCHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCC
ETSHYEIIPDELEIIQEKTKAFAKEHQLVIFTGGTGLSPRDVTPEALSPILESRIPGIEE
CCCCEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHH
AIRSYGQQRMPYAMLSRSVAGTLGKSLVLALPGSTNGVRESMDAVFPHVMHVFHILKGKN
HHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
HDSL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]