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The map label for this gene is moaA [H]

Identifier: 146302363

GI number: 146302363

Start: 5606094

End: 5607101

Strand: Reverse

Name: moaA [H]

Synonym: Fjoh_4636

Alternate gene names: 146302363

Gene position: 5607101-5606094 (Counterclockwise)

Preceding gene: 146302364

Following gene: 146302359

Centisome position: 91.97

GC content: 35.22

Gene sequence:

>1008_bases
ATGACAGCCTCTAACACAATTTTGACGGACGGTTTTGGGCGCAGACACAATTATCTGCGCATTTCCCTGCTGGAAAAATG
CAATCTGCGTTGTACGTACTGCATGCCGGCTGATGGAATTGTGCTTTCTCCAAAAGCCAGCTTAATGACGGCTGACGAGA
TTTTTGGTATCGCCCAGACTTTCGCACAAAATGGTGTTGACAAAATACGATTAACAGGCGGTGAACCTTTATTGAGAAAA
GACTTTCCTGAAATTGTTTCTAAATTAGCAGTATTAGATGTTTCTCTCTCTGTAACGACAAACGGAATTTTAATTGACCG
CCATATAGACGTTTTAAAGCAGTTTAATGTCAAAAAAATCAATCTGAGTTTAGATACTTTGGTTTCTTCTAAATTTGCTT
CAATAACGCTTAGAAATCAGTTTGAGAAAGTGATTGATAATCTGCATTTGCTTTTGAATAACGATTTTCAGGTAAAAGTA
AATGTGGTTTTGATAAAAGGGTTTAACGATAATGAAATTGTAGATTTTGTAAAACTGACTCAGTTTCTGCCTATTTCCGT
TCGATTTATAGAATTTATGCCTTTTGCAGGAAACGAATGGGACAGAAGCAAAATGGTATCACAGAACGAAATTTTATCGT
TAGTTGAAACGCAATTTTCATTAGAAGAAATTCAAAAACTAGAAGACGAAAAAAACTTCACTTCAAGAAATTATAAAATA
AAAGGTTTTCAAGGCGATTTCGGAATCATAAGTTCTATCACAAATCCTTTTTGTGACAGTTGCAATAGAATCCGTTTGAC
AGCTGACGGAAAAATAAAAAACTGCCTTTTCTCCAATTCTGAAACTGATTTATTAACTCCTTTTAGAAATGGTGAATCCA
TTGAAAATTTGATTTCGGAATCTATTCAAAATAAAAAGAGAGTTCGCGCCGGAATGTCCGGCATTAATGAGATTAATGAT
CCTGTGCTTCATTCAGACAATCGAAGTATGATTGCGATTGGAGGATAA

Upstream 100 bases:

>100_bases
GTTTTGGCTTTGCCAGGCTCAACAAACGGAGTAAGAGAATCGATGGACGCTGTGTTTCCACATGTAATGCACGTTTTTCA
TATTTTAAAAGGTAAAAACC

Downstream 100 bases:

>100_bases
AAGTTAATTATTAATTATTAATTATTAATTATGAATTATGAATTATTAATTATTAAATAAAAAAAGCTCAACTTTAAGTT
GAGCTTTTTTTATATATTAT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTASNTILTDGFGRRHNYLRISLLEKCNLRCTYCMPADGIVLSPKASLMTADEIFGIAQTFAQNGVDKIRLTGGEPLLRK
DFPEIVSKLAVLDVSLSVTTNGILIDRHIDVLKQFNVKKINLSLDTLVSSKFASITLRNQFEKVIDNLHLLLNNDFQVKV
NVVLIKGFNDNEIVDFVKLTQFLPISVRFIEFMPFAGNEWDRSKMVSQNEILSLVETQFSLEEIQKLEDEKNFTSRNYKI
KGFQGDFGIISSITNPFCDSCNRIRLTADGKIKNCLFSNSETDLLTPFRNGESIENLISESIQNKKRVRAGMSGINEIND
PVLHSDNRSMIAIGG

Sequences:

>Translated_335_residues
MTASNTILTDGFGRRHNYLRISLLEKCNLRCTYCMPADGIVLSPKASLMTADEIFGIAQTFAQNGVDKIRLTGGEPLLRK
DFPEIVSKLAVLDVSLSVTTNGILIDRHIDVLKQFNVKKINLSLDTLVSSKFASITLRNQFEKVIDNLHLLLNNDFQVKV
NVVLIKGFNDNEIVDFVKLTQFLPISVRFIEFMPFAGNEWDRSKMVSQNEILSLVETQFSLEEIQKLEDEKNFTSRNYKI
KGFQGDFGIISSITNPFCDSCNRIRLTADGKIKNCLFSNSETDLLTPFRNGESIENLISESIQNKKRVRAGMSGINEIND
PVLHSDNRSMIAIGG
>Mature_334_residues
TASNTILTDGFGRRHNYLRISLLEKCNLRCTYCMPADGIVLSPKASLMTADEIFGIAQTFAQNGVDKIRLTGGEPLLRKD
FPEIVSKLAVLDVSLSVTTNGILIDRHIDVLKQFNVKKINLSLDTLVSSKFASITLRNQFEKVIDNLHLLLNNDFQVKVN
VVLIKGFNDNEIVDFVKLTQFLPISVRFIEFMPFAGNEWDRSKMVSQNEILSLVETQFSLEEIQKLEDEKNFTSRNYKIK
GFQGDFGIISSITNPFCDSCNRIRLTADGKIKNCLFSNSETDLLTPFRNGESIENLISESIQNKKRVRAGMSGINEINDP
VLHSDNRSMIAIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=337, Percent_Identity=47.1810089020772, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI22027536, Length=337, Percent_Identity=47.1810089020772, Blast_Score=314, Evalue=6e-86,
Organism=Escherichia coli, GI1786999, Length=310, Percent_Identity=33.2258064516129, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32566329, Length=331, Percent_Identity=44.1087613293051, Blast_Score=279, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17561210, Length=331, Percent_Identity=44.1087613293051, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI32566331, Length=306, Percent_Identity=44.7712418300654, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI28574488, Length=337, Percent_Identity=43.620178041543, Blast_Score=291, Evalue=6e-79,
Organism=Drosophila melanogaster, GI28574490, Length=312, Percent_Identity=44.2307692307692, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37666; Mature: 37535

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASNTILTDGFGRRHNYLRISLLEKCNLRCTYCMPADGIVLSPKASLMTADEIFGIAQT
CCCCCEEEECCCCCCCCEEEEEEEHHCCCEEEEEECCCCEEECCCCHHEEHHHHHHHHHH
FAQNGVDKIRLTGGEPLLRKDFPEIVSKLAVLDVSLSVTTNGILIDRHIDVLKQFNVKKI
HHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEECCEEEEHHHHHHHHCCCEEE
NLSLDTLVSSKFASITLRNQFEKVIDNLHLLLNNDFQVKVNVVLIKGFNDNEIVDFVKLT
EEEHHHHHHHHHHEEEHHHHHHHHHHHHEEEECCCEEEEEEEEEEECCCCCHHHHHHHHH
QFLPISVRFIEFMPFAGNEWDRSKMVSQNEILSLVETQFSLEEIQKLEDEKNFTSRNYKI
HHCCCEEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
KGFQGDFGIISSITNPFCDSCNRIRLTADGKIKNCLFSNSETDLLTPFRNGESIENLISE
EEECCCHHHHHHCCCHHHCCCCEEEEEECCCCHHHEECCCCCCEECCCCCCHHHHHHHHH
SIQNKKRVRAGMSGINEINDPVLHSDNRSMIAIGG
HHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEECC
>Mature Secondary Structure 
TASNTILTDGFGRRHNYLRISLLEKCNLRCTYCMPADGIVLSPKASLMTADEIFGIAQT
CCCCEEEECCCCCCCCEEEEEEEHHCCCEEEEEECCCCEEECCCCHHEEHHHHHHHHHH
FAQNGVDKIRLTGGEPLLRKDFPEIVSKLAVLDVSLSVTTNGILIDRHIDVLKQFNVKKI
HHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEECCEEEEHHHHHHHHCCCEEE
NLSLDTLVSSKFASITLRNQFEKVIDNLHLLLNNDFQVKVNVVLIKGFNDNEIVDFVKLT
EEEHHHHHHHHHHEEEHHHHHHHHHHHHEEEECCCEEEEEEEEEEECCCCCHHHHHHHHH
QFLPISVRFIEFMPFAGNEWDRSKMVSQNEILSLVETQFSLEEIQKLEDEKNFTSRNYKI
HHCCCEEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
KGFQGDFGIISSITNPFCDSCNRIRLTADGKIKNCLFSNSETDLLTPFRNGESIENLISE
EEECCCHHHHHHCCCHHHCCCCEEEEEECCCCHHHEECCCCCCEECCCCCCHHHHHHHHH
SIQNKKRVRAGMSGINEINDPVLHSDNRSMIAIGG
HHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11292832 [H]