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The map label for this gene is yhdN [H]

Identifier: 146302343

GI number: 146302343

Start: 5580676

End: 5581662

Strand: Direct

Name: yhdN [H]

Synonym: Fjoh_4616

Alternate gene names: 146302343

Gene position: 5580676-5581662 (Clockwise)

Preceding gene: 146302341

Following gene: 146302344

Centisome position: 91.53

GC content: 35.46

Gene sequence:

>987_bases
ATGGAATATAGAAAACTAGGAAACTCAGAACTTGAATTATCAGCAATTACATACGGTGCATTTGCTATTGGCGGAACCAT
GTGGGGCGGAACAGAAAAGAAAGACTCAATAGAATCTGTTCAAGCTTCTATCGATCACGGCGTTACCACAATCGACACTG
CTCCTTTTTACGGATTTGGTTTAAGTGAAGAAATGATCGGTGAAGCTATAAAACCTTATGATCGTTCTAAAATTCAATTA
CTTACCAAATTTGGTTTGGTTTGGGACGGCAGCAACAACGGAAAAGGCGATTTCTTTTTCGAAGCAGACGATAACGGTAA
AAAAGTTCCAATTTACAAATACTCATCAAAAGCAAACGTAATTAAAGAAATCGAAGAAAGTTTAAAACGCCTTCAAACCG
ATTATATCGATTTACTGCAAATTCACTGGCCAGATTCAACAACTCCAATTTCTGAAACAATGGAAGCTGTTGAAACTTTA
ATTCAGCAAGGAAAAATTAGAGCATTCGGAGTAAGTAATTATAATATTGCACAAATTCAGGAAGCACAAAAAACAGTTCA
AATAGCTTCAAACCAAGTAGCTTACAGTATGCTGAATCGCGGAATCGAAGCAGATTTAATTCCGTTTACAGTTGCAGAAA
ACATTGGAATCATTGCTTACAGCCCAATGGAAAGAGGTTTATTGACTGGAAAATATTTCACAGACAGCAAATTAAAAGAA
AACGACCATAGAAACGGTTATTTCGGAAAATTCGATTTGCAGCAGGTAAAAACCTTAATCGAAGAATTAAGCTCTTTAGC
GCATTCAAAACACATTTCAATTTCACAATTGGTTTTACGCTGGACAACTTTACAAAAAGGAATTTCAATTGTTCTAGCAG
GTGCCAGAAACGCAGAACAAGCTATTTCAAACGCCAAAACAATGGATTTCGATTTATCAGCTTCAGAATTGGAGTTTATT
AATCATGCAATTGCTAAAATAAAATAA

Upstream 100 bases:

>100_bases
AGATGCAAATATACCTAAAAAAGACAAATATATACCAAATAAGAATCATAAAAACAGTATAATTTTGCCTCATCAATTTT
AAACACAAAAAATCACAATC

Downstream 100 bases:

>100_bases
TATTTTAAACACATAGAAACATAGTTATACTTTGTCTATAAAGGCGTTTCACTTGCATTAATAAACATAGTCAACGTAAT
CTTATCATTCCGAGGAATGA

Product: aldo/keto reductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MEYRKLGNSELELSAITYGAFAIGGTMWGGTEKKDSIESVQASIDHGVTTIDTAPFYGFGLSEEMIGEAIKPYDRSKIQL
LTKFGLVWDGSNNGKGDFFFEADDNGKKVPIYKYSSKANVIKEIEESLKRLQTDYIDLLQIHWPDSTTPISETMEAVETL
IQQGKIRAFGVSNYNIAQIQEAQKTVQIASNQVAYSMLNRGIEADLIPFTVAENIGIIAYSPMERGLLTGKYFTDSKLKE
NDHRNGYFGKFDLQQVKTLIEELSSLAHSKHISISQLVLRWTTLQKGISIVLAGARNAEQAISNAKTMDFDLSASELEFI
NHAIAKIK

Sequences:

>Translated_328_residues
MEYRKLGNSELELSAITYGAFAIGGTMWGGTEKKDSIESVQASIDHGVTTIDTAPFYGFGLSEEMIGEAIKPYDRSKIQL
LTKFGLVWDGSNNGKGDFFFEADDNGKKVPIYKYSSKANVIKEIEESLKRLQTDYIDLLQIHWPDSTTPISETMEAVETL
IQQGKIRAFGVSNYNIAQIQEAQKTVQIASNQVAYSMLNRGIEADLIPFTVAENIGIIAYSPMERGLLTGKYFTDSKLKE
NDHRNGYFGKFDLQQVKTLIEELSSLAHSKHISISQLVLRWTTLQKGISIVLAGARNAEQAISNAKTMDFDLSASELEFI
NHAIAKIK
>Mature_328_residues
MEYRKLGNSELELSAITYGAFAIGGTMWGGTEKKDSIESVQASIDHGVTTIDTAPFYGFGLSEEMIGEAIKPYDRSKIQL
LTKFGLVWDGSNNGKGDFFFEADDNGKKVPIYKYSSKANVIKEIEESLKRLQTDYIDLLQIHWPDSTTPISETMEAVETL
IQQGKIRAFGVSNYNIAQIQEAQKTVQIASNQVAYSMLNRGIEADLIPFTVAENIGIIAYSPMERGLLTGKYFTDSKLKE
NDHRNGYFGKFDLQQVKTLIEELSSLAHSKHISISQLVLRWTTLQKGISIVLAGARNAEQAISNAKTMDFDLSASELEFI
NHAIAKIK

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=322, Percent_Identity=27.639751552795, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4504825, Length=320, Percent_Identity=27.5, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI27436964, Length=320, Percent_Identity=26.25, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI27436962, Length=320, Percent_Identity=26.25, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI27436966, Length=320, Percent_Identity=25.9375, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI27436971, Length=323, Percent_Identity=25.6965944272446, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI41152114, Length=286, Percent_Identity=26.5734265734266, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI223718702, Length=286, Percent_Identity=26.9230769230769, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI41327764, Length=230, Percent_Identity=29.1304347826087, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI5453543, Length=316, Percent_Identity=25.6329113924051, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788070, Length=321, Percent_Identity=32.0872274143302, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI1788081, Length=319, Percent_Identity=29.7805642633229, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI87081735, Length=329, Percent_Identity=25.8358662613982, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789375, Length=347, Percent_Identity=27.3775216138329, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789199, Length=346, Percent_Identity=26.3005780346821, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI48994888, Length=171, Percent_Identity=32.7485380116959, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787674, Length=214, Percent_Identity=25.7009345794392, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786400, Length=177, Percent_Identity=30.5084745762712, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI212645785, Length=323, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6325169, Length=335, Percent_Identity=29.8507462686567, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323998, Length=328, Percent_Identity=26.5243902439024, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319958, Length=311, Percent_Identity=27.0096463022508, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322615, Length=254, Percent_Identity=23.2283464566929, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319951, Length=221, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320079, Length=203, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646159, Length=237, Percent_Identity=28.6919831223629, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24646155, Length=236, Percent_Identity=30.9322033898305, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36485; Mature: 36485

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRKLGNSELELSAITYGAFAIGGTMWGGTEKKDSIESVQASIDHGVTTIDTAPFYGFG
CCCCCCCCCCEEEEEEEEHHHHCCCEECCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCC
LSEEMIGEAIKPYDRSKIQLLTKFGLVWDGSNNGKGDFFFEADDNGKKVPIYKYSSKANV
CCHHHHHHHCCCCCHHHHHHHHHHCEEEECCCCCCCCEEEEECCCCCEEEEEEECCHHHH
IKEIEESLKRLQTDYIDLLQIHWPDSTTPISETMEAVETLIQQGKIRAFGVSNYNIAQIQ
HHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHH
EAQKTVQIASNQVAYSMLNRGIEADLIPFTVAENIGIIAYSPMERGLLTGKYFTDSKLKE
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCEEEECCHHCCCEECCCCCCCCCCC
NDHRNGYFGKFDLQQVKTLIEELSSLAHSKHISISQLVLRWTTLQKGISIVLAGARNAEQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHH
AISNAKTMDFDLSASELEFINHAIAKIK
HHHCCCCEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEYRKLGNSELELSAITYGAFAIGGTMWGGTEKKDSIESVQASIDHGVTTIDTAPFYGFG
CCCCCCCCCCEEEEEEEEHHHHCCCEECCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCC
LSEEMIGEAIKPYDRSKIQLLTKFGLVWDGSNNGKGDFFFEADDNGKKVPIYKYSSKANV
CCHHHHHHHCCCCCHHHHHHHHHHCEEEECCCCCCCCEEEEECCCCCEEEEEEECCHHHH
IKEIEESLKRLQTDYIDLLQIHWPDSTTPISETMEAVETLIQQGKIRAFGVSNYNIAQIQ
HHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHH
EAQKTVQIASNQVAYSMLNRGIEADLIPFTVAENIGIIAYSPMERGLLTGKYFTDSKLKE
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCEEEECCHHCCCEECCCCCCCCCCC
NDHRNGYFGKFDLQQVKTLIEELSSLAHSKHISISQLVLRWTTLQKGISIVLAGARNAEQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHH
AISNAKTMDFDLSASELEFINHAIAKIK
HHHCCCCEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]