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The map label for this gene is bkdA2 [H]

Identifier: 146302239

GI number: 146302239

Start: 5451323

End: 5453737

Strand: Direct

Name: bkdA2 [H]

Synonym: Fjoh_4512

Alternate gene names: 146302239

Gene position: 5451323-5453737 (Clockwise)

Preceding gene: 146302238

Following gene: 146302241

Centisome position: 89.41

GC content: 36.81

Gene sequence:

>2415_bases
ATGATAACAGAAAAAAGCAATACTACTTTAACCTTTGAAGATTTCAGAACTGAGGTCCTGAATGATTACAGAATTGCCGT
AACAAGCCGTGAATGCAGCTTATTAGGCCGTAAAGAGGTATTAACAGGAAAAGCTAAATTCGGGATTTTTGGAGACGGAA
AAGAAGTGCCGCAGCTTGCTATGGCAAAAGCCTTTAAAGATGGGGATTTTCGTTCTGGATATTATCGTGATCAAACTTTT
ATGATGGCGATTGGCGAATTAAACGCAAAACAATTTTTTGCAGGTTTATACGGCCACACCGATTTAAATTATGATCCAAT
GTCTGCCGGAAGGCAAATGGGCGGACACTTTGTAACGCACAGTTTAAATGAAGACGGATCCTGGAAAGATTTAACAAAAC
AAAAAAATTCAAGTTCAGATATATCACCTACTGCAGGACAAATGCCAAGATTATTGGGATTAGCTCAGGCATCAAAGATT
TACAGAAATGTTGACGGAATAAAAATCAAAGACAAATTTACTGTAAACGGAAATGAAGTTGCGTGGGGAACAATAGGAAA
TGCAAGTACTTCTGAAGGTTTATTTTTTGAAACTATAAATGCTGCCGGAGTTTTACAAGTTCCGATGGTAATGAGCGTTT
GGGATGATGAATACGGAATTTCGGTTCATGCAAAACACCAGACAACAAAAGAAAATATTTCTGAAATACTTAAAGGTTAT
CAGCGTGATGAAGATTCTAAAGGATATGAAATCTTTAGAGTAAAAGGATGGGATTATGCCGAGTTGGTTTCGACTTACGA
AAGAGCCGGCGCCGTTGCACGCGAAGAACATATTCCAATTTTAATTCACGTAAACGAATTGACACAGCCGCAGGGCCACT
CTACTTCTGGTTCTCACGAACGTTACAAAAGTGCTGAAAGACTTGCCTGGGAAAGAGATTTTGATTGTATCCGTCAAATG
CGTTTATGGATGATTGCCATCAATATTGCCTCTCCGGAAGAATTAGCAGAACTTGATGCTGAATTGAAAAAAGAAGTTCT
TGAAGCTAAAAAAGAAGCCTGGAACGATTTTATTAATCCAATTATAGAAGAACAAAATAATCTTTTAGATTTATTGGAGC
AGATTGCTGAAGCCAGCATCAACCATAAAGAAAGAATTAGAAAATATATTTCAGAATTAAAAGCCATTAAAGCGCCTTTA
AAGAAAGAATTACTGGTTTATGCCCGTAAAATTCTTCGCTTTATAGAAGTTCCAAACAGCAAAGTTATTCTGTCAAACTG
GATTACGAATTTTATTGAAGCAACTCAGGAAAAATTCAGCAGCAACCTGCATTCAGAATCAGCACAAAATGTATTTTCTG
TACAAAAAGTGCTTCCTAAATATGCTGAAAATGCAAAACCGGATTTAGACGGAAGAATGGTAATTCGTGATAACTTTGAT
GCTTTATTCAATAAATATCCTGAATTATTGATTTTTGGTGAAGATGTTGGAAACATTGGCGACGTAAATCAAGGACTTGA
AGGCATGCAGGAAAAATACGGAGAACTTCGTGTTGCCGATGTCGGAATTCGTGAAGCAACCATTATTGGTCAGGGAATTG
GAATGGCTTTGAGAGGTCTGCGTCCAATTGCTGAAATCCAGTATTTAGATTATTTATTGTACGCGATTCAAATCATGAGT
GATGATTTGGCTACTTTACAATACAGAACAGTTGGAAAACAAAAAGCACCATTAATTATCAGAACCCGCGGACACCGTTT
AGAAGGTATCTGGCATTCTGGTTCTCCAATGGGAATGATTATAAACGCTATCCGAGGAATTCACGTTTTGGTTCCTAGAG
ATATGACACAAGCAGCAGGATTTTACAATACTCTTTTAGAGTGTGATGAACCTGCTTTAGTAATTGAATGTTTAAATGGT
TACCGTTTAAAAGAAAAAACACCTTTAAATTTTGGTGAATTCAAAACGCCGATTGGTGTGGTTGAAACTTTAAAAGAAGG
TGCAGATATTACTTTAGTTTCTTACGGATCGACTTTAAGACTCGTTCAACAGGCAGCAACAGAGTTATTAGATTTAGGAA
TTGACTGTGAAATTATTGATATTCAGTCTTTACTTCCGTTTGACGTTAATAAAGATATTGTAAAAAGTATCGCAAAAACA
AATCGTCTTTTAGTAATCGACGAAGATGTTCCGGGCGGTGCTTCAGCATACATATTACAACAGATTTTAGAAGAACAAGA
TGCTTACAAATATCTTGACAGCAAACCGCAGACTCTTGCTGCAAAAGCCCACAGACCTGCTTATGGAACTGACGGCGATT
ATTTCTCTAAACCTTCTGCCGAAGATATTTTTGAGAAAGTATACAGCATGATGAACGAAGTTAATCCTTCTAAATTTCCA
AATTTATACCAGTAA

Upstream 100 bases:

>100_bases
GTTTTAAATACAAATAATTGAATTATATTTATTTTAAAGAATTATGATTATTGATTGTTTTTAAGTAATTTCGCAGACTC
AACATGACCCCTACAAGATT

Downstream 100 bases:

>100_bases
TTTAAACTGTTTTAAATAATAAAAAAAGCTCCAAAATTTTGGAGCTTTTTTTATCATACAAAGTCAAGGTCATTGCGAGG
AACCAAGCAATCACACTAAC

Product: transketolase domain-containing protein

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 804; Mature: 804

Protein sequence:

>804_residues
MITEKSNTTLTFEDFRTEVLNDYRIAVTSRECSLLGRKEVLTGKAKFGIFGDGKEVPQLAMAKAFKDGDFRSGYYRDQTF
MMAIGELNAKQFFAGLYGHTDLNYDPMSAGRQMGGHFVTHSLNEDGSWKDLTKQKNSSSDISPTAGQMPRLLGLAQASKI
YRNVDGIKIKDKFTVNGNEVAWGTIGNASTSEGLFFETINAAGVLQVPMVMSVWDDEYGISVHAKHQTTKENISEILKGY
QRDEDSKGYEIFRVKGWDYAELVSTYERAGAVAREEHIPILIHVNELTQPQGHSTSGSHERYKSAERLAWERDFDCIRQM
RLWMIAINIASPEELAELDAELKKEVLEAKKEAWNDFINPIIEEQNNLLDLLEQIAEASINHKERIRKYISELKAIKAPL
KKELLVYARKILRFIEVPNSKVILSNWITNFIEATQEKFSSNLHSESAQNVFSVQKVLPKYAENAKPDLDGRMVIRDNFD
ALFNKYPELLIFGEDVGNIGDVNQGLEGMQEKYGELRVADVGIREATIIGQGIGMALRGLRPIAEIQYLDYLLYAIQIMS
DDLATLQYRTVGKQKAPLIIRTRGHRLEGIWHSGSPMGMIINAIRGIHVLVPRDMTQAAGFYNTLLECDEPALVIECLNG
YRLKEKTPLNFGEFKTPIGVVETLKEGADITLVSYGSTLRLVQQAATELLDLGIDCEIIDIQSLLPFDVNKDIVKSIAKT
NRLLVIDEDVPGGASAYILQQILEEQDAYKYLDSKPQTLAAKAHRPAYGTDGDYFSKPSAEDIFEKVYSMMNEVNPSKFP
NLYQ

Sequences:

>Translated_804_residues
MITEKSNTTLTFEDFRTEVLNDYRIAVTSRECSLLGRKEVLTGKAKFGIFGDGKEVPQLAMAKAFKDGDFRSGYYRDQTF
MMAIGELNAKQFFAGLYGHTDLNYDPMSAGRQMGGHFVTHSLNEDGSWKDLTKQKNSSSDISPTAGQMPRLLGLAQASKI
YRNVDGIKIKDKFTVNGNEVAWGTIGNASTSEGLFFETINAAGVLQVPMVMSVWDDEYGISVHAKHQTTKENISEILKGY
QRDEDSKGYEIFRVKGWDYAELVSTYERAGAVAREEHIPILIHVNELTQPQGHSTSGSHERYKSAERLAWERDFDCIRQM
RLWMIAINIASPEELAELDAELKKEVLEAKKEAWNDFINPIIEEQNNLLDLLEQIAEASINHKERIRKYISELKAIKAPL
KKELLVYARKILRFIEVPNSKVILSNWITNFIEATQEKFSSNLHSESAQNVFSVQKVLPKYAENAKPDLDGRMVIRDNFD
ALFNKYPELLIFGEDVGNIGDVNQGLEGMQEKYGELRVADVGIREATIIGQGIGMALRGLRPIAEIQYLDYLLYAIQIMS
DDLATLQYRTVGKQKAPLIIRTRGHRLEGIWHSGSPMGMIINAIRGIHVLVPRDMTQAAGFYNTLLECDEPALVIECLNG
YRLKEKTPLNFGEFKTPIGVVETLKEGADITLVSYGSTLRLVQQAATELLDLGIDCEIIDIQSLLPFDVNKDIVKSIAKT
NRLLVIDEDVPGGASAYILQQILEEQDAYKYLDSKPQTLAAKAHRPAYGTDGDYFSKPSAEDIFEKVYSMMNEVNPSKFP
NLYQ
>Mature_804_residues
MITEKSNTTLTFEDFRTEVLNDYRIAVTSRECSLLGRKEVLTGKAKFGIFGDGKEVPQLAMAKAFKDGDFRSGYYRDQTF
MMAIGELNAKQFFAGLYGHTDLNYDPMSAGRQMGGHFVTHSLNEDGSWKDLTKQKNSSSDISPTAGQMPRLLGLAQASKI
YRNVDGIKIKDKFTVNGNEVAWGTIGNASTSEGLFFETINAAGVLQVPMVMSVWDDEYGISVHAKHQTTKENISEILKGY
QRDEDSKGYEIFRVKGWDYAELVSTYERAGAVAREEHIPILIHVNELTQPQGHSTSGSHERYKSAERLAWERDFDCIRQM
RLWMIAINIASPEELAELDAELKKEVLEAKKEAWNDFINPIIEEQNNLLDLLEQIAEASINHKERIRKYISELKAIKAPL
KKELLVYARKILRFIEVPNSKVILSNWITNFIEATQEKFSSNLHSESAQNVFSVQKVLPKYAENAKPDLDGRMVIRDNFD
ALFNKYPELLIFGEDVGNIGDVNQGLEGMQEKYGELRVADVGIREATIIGQGIGMALRGLRPIAEIQYLDYLLYAIQIMS
DDLATLQYRTVGKQKAPLIIRTRGHRLEGIWHSGSPMGMIINAIRGIHVLVPRDMTQAAGFYNTLLECDEPALVIECLNG
YRLKEKTPLNFGEFKTPIGVVETLKEGADITLVSYGSTLRLVQQAATELLDLGIDCEIIDIQSLLPFDVNKDIVKSIAKT
NRLLVIDEDVPGGASAYILQQILEEQDAYKYLDSKPQTLAAKAHRPAYGTDGDYFSKPSAEDIFEKVYSMMNEVNPSKFP
NLYQ

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=279, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI34101272, Length=279, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI156564403, Length=335, Percent_Identity=25.3731343283582, Blast_Score=107, Evalue=6e-23,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=25.1533742331288, Blast_Score=98, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17538422, Length=337, Percent_Identity=24.6290801186944, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17506935, Length=247, Percent_Identity=34.412955465587, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319698, Length=314, Percent_Identity=27.3885350318471, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21358145, Length=366, Percent_Identity=25.1366120218579, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24650940, Length=366, Percent_Identity=25.1366120218579, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI160714832, Length=261, Percent_Identity=31.4176245210728, Blast_Score=109, Evalue=9e-24,
Organism=Drosophila melanogaster, GI160714828, Length=261, Percent_Identity=31.4176245210728, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 90461; Mature: 90461

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITEKSNTTLTFEDFRTEVLNDYRIAVTSRECSLLGRKEVLTGKAKFGIFGDGKEVPQLA
CCCCCCCCEEEHHHHHHHHHCCEEEEEECCHHHHCCCHHHHCCCCCCCCCCCCCHHHHHH
MAKAFKDGDFRSGYYRDQTFMMAIGELNAKQFFAGLYGHTDLNYDPMSAGRQMGGHFVTH
HHHHHCCCCCCCCCCCCCCCEEEHHCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEE
SLNEDGSWKDLTKQKNSSSDISPTAGQMPRLLGLAQASKIYRNVDGIKIKDKFTVNGNEV
CCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEE
AWGTIGNASTSEGLFFETINAAGVLQVPMVMSVWDDEYGISVHAKHQTTKENISEILKGY
EEEECCCCCCCCCEEEEECCCCCEEECCHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHH
QRDEDSKGYEIFRVKGWDYAELVSTYERAGAVAREEHIPILIHVNELTQPQGHSTSGSHE
CCCCCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHCCCEEEEEECCCCCCCCCCCCCCHH
RYKSAERLAWERDFDCIRQMRLWMIAINIASPEELAELDAELKKEVLEAKKEAWNDFINP
HHHHHHHHHHHCCHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIEEQNNLLDLLEQIAEASINHKERIRKYISELKAIKAPLKKELLVYARKILRFIEVPNS
HHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KVILSNWITNFIEATQEKFSSNLHSESAQNVFSVQKVLPKYAENAKPDLDGRMVIRDNFD
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHH
ALFNKYPELLIFGEDVGNIGDVNQGLEGMQEKYGELRVADVGIREATIIGQGIGMALRGL
HHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCHHEEECCCHHHHHHCC
RPIAEIQYLDYLLYAIQIMSDDLATLQYRTVGKQKAPLIIRTRGHRLEGIWHSGSPMGMI
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCHHHH
INAIRGIHVLVPRDMTQAAGFYNTLLECDEPALVIECLNGYRLKEKTPLNFGEFKTPIGV
HHHHCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEHHCCCEECCCCCCCCCCCCCCHHH
VETLKEGADITLVSYGSTLRLVQQAATELLDLGIDCEIIDIQSLLPFDVNKDIVKSIAKT
HHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCCHHHHHHHHHC
NRLLVIDEDVPGGASAYILQQILEEQDAYKYLDSKPQTLAAKAHRPAYGTDGDYFSKPSA
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCH
EDIFEKVYSMMNEVNPSKFPNLYQ
HHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MITEKSNTTLTFEDFRTEVLNDYRIAVTSRECSLLGRKEVLTGKAKFGIFGDGKEVPQLA
CCCCCCCCEEEHHHHHHHHHCCEEEEEECCHHHHCCCHHHHCCCCCCCCCCCCCHHHHHH
MAKAFKDGDFRSGYYRDQTFMMAIGELNAKQFFAGLYGHTDLNYDPMSAGRQMGGHFVTH
HHHHHCCCCCCCCCCCCCCCEEEHHCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEE
SLNEDGSWKDLTKQKNSSSDISPTAGQMPRLLGLAQASKIYRNVDGIKIKDKFTVNGNEV
CCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEE
AWGTIGNASTSEGLFFETINAAGVLQVPMVMSVWDDEYGISVHAKHQTTKENISEILKGY
EEEECCCCCCCCCEEEEECCCCCEEECCHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHH
QRDEDSKGYEIFRVKGWDYAELVSTYERAGAVAREEHIPILIHVNELTQPQGHSTSGSHE
CCCCCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHCCCEEEEEECCCCCCCCCCCCCCHH
RYKSAERLAWERDFDCIRQMRLWMIAINIASPEELAELDAELKKEVLEAKKEAWNDFINP
HHHHHHHHHHHCCHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIEEQNNLLDLLEQIAEASINHKERIRKYISELKAIKAPLKKELLVYARKILRFIEVPNS
HHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KVILSNWITNFIEATQEKFSSNLHSESAQNVFSVQKVLPKYAENAKPDLDGRMVIRDNFD
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHH
ALFNKYPELLIFGEDVGNIGDVNQGLEGMQEKYGELRVADVGIREATIIGQGIGMALRGL
HHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCHHEEECCCHHHHHHCC
RPIAEIQYLDYLLYAIQIMSDDLATLQYRTVGKQKAPLIIRTRGHRLEGIWHSGSPMGMI
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCHHHH
INAIRGIHVLVPRDMTQAAGFYNTLLECDEPALVIECLNGYRLKEKTPLNFGEFKTPIGV
HHHHCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEHHCCCEECCCCCCCCCCCCCCHHH
VETLKEGADITLVSYGSTLRLVQQAATELLDLGIDCEIIDIQSLLPFDVNKDIVKSIAKT
HHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCCHHHHHHHHHC
NRLLVIDEDVPGGASAYILQQILEEQDAYKYLDSKPQTLAAKAHRPAYGTDGDYFSKPSA
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCH
EDIFEKVYSMMNEVNPSKFPNLYQ
HHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3416875; 10426958 [H]