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The map label for this gene is gcvT [H]

Identifier: 146302182

GI number: 146302182

Start: 5370033

End: 5371142

Strand: Direct

Name: gcvT [H]

Synonym: Fjoh_4451

Alternate gene names: 146302182

Gene position: 5370033-5371142 (Clockwise)

Preceding gene: 146302181

Following gene: 146302183

Centisome position: 88.08

GC content: 38.11

Gene sequence:

>1110_bases
ATGGAAAATCAAAGCGTAAATATCAAAAAAACAGCCCTTAATGCAATTCATCATGACCTTGGCGGGAAAATGACCCCATT
TGCCGGTTATGAAATGCCGGTTCAATATGCAGGTGTAAATCATGAACATGAAACCGTTAGAAATGCTGTAGGTGTTTTTG
ATGTTTCCCACATGGGGGAGATTCTTATACAGGGAAAAGATGCCCTGGCACTCATTCAGAAAATAAGTTCAAACGATGCC
TCAAAGCTTTTTCCTGGAAAAATACAATACAGCTGTATGCCAAATAAAACTGGCGGTATTGTAGATGATCTGCTGATATA
TATGATGAGTGAAAAGGATTATTTACTGGTGGTAAATGCTTCAAATATCCAAAAAGACTGGGACTGGATAAGTACTATAG
CCCTTGATTATTTAGATCTTACCATAACAAACCTTTCCGATATAATTTCCCTACTGGCTGTTCAAGGCCCTTTGGCCGCA
AAATCCCTGCAAAAATTGACCAGTATCAATTTGAATGAGATGAAATATTATACGTTTGAAATAGGCGAATTTGCAGGTAT
TCCAAATGCTATAGTATCTGCCACCGGATATACCGGGGCAGGCGGATTTGAAATATATGTACAGAATAAGTATGCAGAAC
TATTATGGGATGCCATTTTCGAGGCAGGAAAAGAGTATAACATTGAGCCTATTGGACTCGCTGCCAGGGATACACTGCGA
TTGGAAATGGGATACTGTTTGTATGGCAATGATATCAATGATACGACTTCGCCATTAGAAGCCGGACTGGAATGGATTAC
TAAATTCACTAAAGAATTTATTCAAAGTGATTCTCTCAAAATTCAAAAAGAAAATGGAGTAACAAGGAAATTAGTAGGAT
TTGAAATGACTGGCAAAGGCATTCCCCGTCATGCTTACGAAATTTGGGATGAAAACCAGCAAATTATAGGCACCGTTACC
TCGGGTACCATGTCGCCTACTTTAAAAAAGGCTGTAGGAATGGGGTATGTTACTGCTGAAAAATCAAATATTGGCAGTGA
GATTTTTATCAATATCAGAAACAAACCAGTTAAGGCAATTATTGTTCAGACTCCTTTTGTTCAAATCTAA

Upstream 100 bases:

>100_bases
TATGATGAGGGCTGGATGATTAAAATAAAAATTGAAAACAATACAGAAATTGATGCATTACTGAAATCCGATACCTACGC
ATCCTTAATAGGTTTATGAT

Downstream 100 bases:

>100_bases
ATCTTCGAGATATGTTTATTCCTAAATCGCTATATTATACTAAAAATCACTTGTGGTTAAGACAAGTTGGATTATACGAT
TATTTTGTCGGTATTACTGA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MENQSVNIKKTALNAIHHDLGGKMTPFAGYEMPVQYAGVNHEHETVRNAVGVFDVSHMGEILIQGKDALALIQKISSNDA
SKLFPGKIQYSCMPNKTGGIVDDLLIYMMSEKDYLLVVNASNIQKDWDWISTIALDYLDLTITNLSDIISLLAVQGPLAA
KSLQKLTSINLNEMKYYTFEIGEFAGIPNAIVSATGYTGAGGFEIYVQNKYAELLWDAIFEAGKEYNIEPIGLAARDTLR
LEMGYCLYGNDINDTTSPLEAGLEWITKFTKEFIQSDSLKIQKENGVTRKLVGFEMTGKGIPRHAYEIWDENQQIIGTVT
SGTMSPTLKKAVGMGYVTAEKSNIGSEIFINIRNKPVKAIIVQTPFVQI

Sequences:

>Translated_369_residues
MENQSVNIKKTALNAIHHDLGGKMTPFAGYEMPVQYAGVNHEHETVRNAVGVFDVSHMGEILIQGKDALALIQKISSNDA
SKLFPGKIQYSCMPNKTGGIVDDLLIYMMSEKDYLLVVNASNIQKDWDWISTIALDYLDLTITNLSDIISLLAVQGPLAA
KSLQKLTSINLNEMKYYTFEIGEFAGIPNAIVSATGYTGAGGFEIYVQNKYAELLWDAIFEAGKEYNIEPIGLAARDTLR
LEMGYCLYGNDINDTTSPLEAGLEWITKFTKEFIQSDSLKIQKENGVTRKLVGFEMTGKGIPRHAYEIWDENQQIIGTVT
SGTMSPTLKKAVGMGYVTAEKSNIGSEIFINIRNKPVKAIIVQTPFVQI
>Mature_369_residues
MENQSVNIKKTALNAIHHDLGGKMTPFAGYEMPVQYAGVNHEHETVRNAVGVFDVSHMGEILIQGKDALALIQKISSNDA
SKLFPGKIQYSCMPNKTGGIVDDLLIYMMSEKDYLLVVNASNIQKDWDWISTIALDYLDLTITNLSDIISLLAVQGPLAA
KSLQKLTSINLNEMKYYTFEIGEFAGIPNAIVSATGYTGAGGFEIYVQNKYAELLWDAIFEAGKEYNIEPIGLAARDTLR
LEMGYCLYGNDINDTTSPLEAGLEWITKFTKEFIQSDSLKIQKENGVTRKLVGFEMTGKGIPRHAYEIWDENQQIIGTVT
SGTMSPTLKKAVGMGYVTAEKSNIGSEIFINIRNKPVKAIIVQTPFVQI

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=369, Percent_Identity=36.0433604336043, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI257796258, Length=359, Percent_Identity=35.6545961002786, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI257796254, Length=365, Percent_Identity=32.6027397260274, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI257796256, Length=313, Percent_Identity=35.4632587859425, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI24797151, Length=338, Percent_Identity=31.6568047337278, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI194306651, Length=319, Percent_Identity=28.2131661442006, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI197927446, Length=327, Percent_Identity=26.605504587156, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI21361378, Length=327, Percent_Identity=26.605504587156, Blast_Score=118, Evalue=9e-27,
Organism=Escherichia coli, GI1789272, Length=371, Percent_Identity=35.5795148247978, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17560118, Length=372, Percent_Identity=37.6344086021505, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32563613, Length=323, Percent_Identity=26.0061919504644, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71994045, Length=344, Percent_Identity=25, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71994052, Length=344, Percent_Identity=25, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6320222, Length=386, Percent_Identity=33.160621761658, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129441, Length=376, Percent_Identity=36.1702127659575, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI28571104, Length=269, Percent_Identity=28.6245353159851, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI20130091, Length=352, Percent_Identity=21.3068181818182, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40800; Mature: 40800

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENQSVNIKKTALNAIHHDLGGKMTPFAGYEMPVQYAGVNHEHETVRNAVGVFDVSHMGE
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHEEHHHCCC
ILIQGKDALALIQKISSNDASKLFPGKIQYSCMPNKTGGIVDDLLIYMMSEKDYLLVVNA
EEECCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEC
SNIQKDWDWISTIALDYLDLTITNLSDIISLLAVQGPLAAKSLQKLTSINLNEMKYYTFE
CCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEE
IGEFAGIPNAIVSATGYTGAGGFEIYVQNKYAELLWDAIFEAGKEYNIEPIGLAARDTLR
CHHHCCCCHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCEECEECCCEEE
LEMGYCLYGNDINDTTSPLEAGLEWITKFTKEFIQSDSLKIQKENGVTRKLVGFEMTGKG
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEECCCC
IPRHAYEIWDENQQIIGTVTSGTMSPTLKKAVGMGYVTAEKSNIGSEIFINIRNKPVKAI
CCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCEEEECCCCCCCEEEEEECCCCEEEE
IVQTPFVQI
EEECCCCCC
>Mature Secondary Structure
MENQSVNIKKTALNAIHHDLGGKMTPFAGYEMPVQYAGVNHEHETVRNAVGVFDVSHMGE
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHEEHHHCCC
ILIQGKDALALIQKISSNDASKLFPGKIQYSCMPNKTGGIVDDLLIYMMSEKDYLLVVNA
EEECCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEC
SNIQKDWDWISTIALDYLDLTITNLSDIISLLAVQGPLAAKSLQKLTSINLNEMKYYTFE
CCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEE
IGEFAGIPNAIVSATGYTGAGGFEIYVQNKYAELLWDAIFEAGKEYNIEPIGLAARDTLR
CHHHCCCCHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCEECEECCCEEE
LEMGYCLYGNDINDTTSPLEAGLEWITKFTKEFIQSDSLKIQKENGVTRKLVGFEMTGKG
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEECCCC
IPRHAYEIWDENQQIIGTVTSGTMSPTLKKAVGMGYVTAEKSNIGSEIFINIRNKPVKAI
CCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCEEEECCCCCCCEEEEEECCCCEEEE
IVQTPFVQI
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA